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Search results 401 to 448 out of 448 for Kmt2a

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Type Details Score
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Kmt2a<em1Lutzy> | MGI:6883716
Name: lysine (K)-specific methyltransferase 2A; endonuclease-mediated mutation 1, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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DO Term
DOID:0080644 | B-lymphoblastic leukemia/lymphoma MLL rearranged
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Allele
Kmt2a<tm1Smoc> | MGI:7290747
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein
P55200-2
Organism: Mus musculus/domesticus
Length: 3963  
Fragment?: false
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Strain
MGI:6354973 | C57BL/6JSmoc-Kmt2a<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Protein Domain
IPR044133 | KMT2A_PHD3
Type: Domain
Description: Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasing products N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.This entry represents the third PHD domain of KMT2A.
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Protein Domain
IPR042025 | KMT2A_PHD2
Type: Domain
Description: This entry represents the second PHD domain of KMT2A.Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasing products N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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Protein Domain
IPR042023 | KMT2A_PHD1
Type: Domain
Description: This entry represents the first PHD domain of KMT2A.Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasing products N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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Allele
Kmt2a<tm2(MLLT3)Thr> | MGI:2671905
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 2, Terence H Rabbitts
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:3847934 | STOCK Kmt2a<tm2(MLLT3)Thr>/KsyJ
Attribute String: mutant stock, targeted mutation
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Allele
Hprt1<tm1(tetO-KMT2A/MLLT3)Sguo> | MGI:6385058
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Shangqin Guo
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Kmt2a/Kmt2a
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kmt2a/Kmt2a<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kmt2a/Kmt2a
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
16990798 | -
First Author: Allen MD
Year: 2006
Journal: EMBO J
Title: Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
Volume: 25
Issue: 19
Pages: 4503-12
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Publication
12453419 | -
First Author: Nakamura T
Year: 2002
Journal: Mol Cell
Title: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Volume: 10
Issue: 5
Pages: 1119-28
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Publication
26886794 | -
First Author: Li Y
Year: 2016
Journal: Nature
Title: Structural basis for activity regulation of MLL family methyltransferases.
Volume: 530
Issue: 7591
Pages: 447-52
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Protein Domain
IPR041958 | KMT2A_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2A (KMT2A), which is a histone methyltransferase that belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2). It regulates chromatin-mediated transcription through the catalysis of methylation of histone 3 lysine 4 (H3K4), and is frequently rearranged in acute leukemia []. KMT2A functions as the catalytic subunit in the MLL1 complex, which also contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex [, ]. The MLL1 complex is highly active and specific for H3K4 methylation. KMT2A contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, a Bromodomain domain, this extended PHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain [].
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HT Experiment
GSE185182 | Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
25998713 | J:223408
First Author: Rao RC
Year: 2015
Journal: Nat Rev Cancer
Title: Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Volume: 15
Issue: 6
Pages: 334-46
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Publication
34806773 | J:317835
First Author: Michurina A
Year: 2022
Journal: EMBO J
Title: Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes.
Volume: 41
Issue: 1
Pages: e106459
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Publication
30232013 | J:271715
First Author: Bouchard C
Year: 2018
Journal: Cell Rep
Title: Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes.
Volume: 24
Issue: 12
Pages: 3339-3352
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Publication
29720585 | J:262915
First Author: Hyrenius-Wittsten A
Year: 2018
Journal: Nat Commun
Title: De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Volume: 9
Issue: 1
Pages: 1770
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Publication
30355503 | J:271657
First Author: Barbagiovanni G
Year: 2018
Journal: Cell Rep
Title: KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.
Volume: 25
Issue: 4
Pages: 988-1001
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Strain
MGI:6385061 | STOCK Gt(ROSA)26Sor<tm1(rtTA*M2)Jae> Hprt1<tm1(tetO-KMT2A/MLLT3)Sguo>/J
Attribute String: targeted mutation, mutant stock
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Publication
31852898 | J:282726
First Author: Chen X
Year: 2019
Journal: Nat Commun
Title: MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors.
Volume: 10
Issue: 1
Pages: 5767
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Publication
19556245 | -
First Author: Patel A
Year: 2009
Journal: J Biol Chem
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume: 284
Issue: 36
Pages: 24242-56
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Publication
37509285 | J:338812
 
First Author: Barone C
Year: 2023
Journal: Cancers (Basel)
Title: Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation.
Volume: 15
Issue: 14
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Publication
39380002 | J:357666
First Author: Sheridan M
Year: 2024
Journal: J Hematol Oncol
Title: The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Volume: 17
Issue: 1
Pages: 91
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