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Search results 401 to 500 out of 638 for Mafa

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Type Details Score
Publication
15695803 | -
First Author: Park H
Year: 2005
Journal: J Biol Chem
Title: The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
Volume: 280
Issue: 14
Pages: 13593-9
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Publication
11470510 | J:71367
First Author: Yokota K
Year: 2001
Journal: Gene
Title: Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1.
Volume: 272
Issue: 1-2
Pages: 51-60
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Publication
16341139 | -
First Author: Brown GD
Year: 2006
Journal: Nat Rev Immunol
Title: Dectin-1: a signalling non-TLR pattern-recognition receptor.
Volume: 6
Issue: 1
Pages: 33-43
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Publication
12217400 | -
First Author: Abramson J
Year: 2002
Journal: Mol Immunol
Title: An unusual inhibitory receptor--the mast cell function-associated antigen (MAFA).
Volume: 38
Issue: 16-18
Pages: 1307-13
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Publication
11999169 | -
First Author: Wu HJ
Year: 2002
Journal: Immunol Res
Title: Positive and negative roles of CD72 in B cell function.
Volume: 25
Issue: 2
Pages: 155-66
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Protein Domain
IPR033992 | NKR-like_CTLD
Type: Domain
Description: This entry represents a C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs), including proteins similar to oxidized low density lipoprotein (OxLDL) receptor (LOX-1), CD94, CD69, NKG2-A and -D, osteoclast inhibitory lectin (OCIL), dendritic cell-associated C-type lectin-1 (dectin-1), human myeloid inhibitory C-type lectin-like receptor (MICL), mast cell-associated functional antigen (MAFA), killer cell lectin-like receptors: subfamily F, member 1 (KLRF1) and subfamily B, member 1 (KLRB1), and lys49 receptors. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins [].NKRs are variously associated with activation or inhibition of natural killer (NK) cells. Activating NKRs stimulate cytolysis by NK cells of virally infected or transformed cells; inhibitory NKRs block cytolysis upon recognition of markers of healthy self cells. Most Lys49 receptors are inhibitory; some are stimulatory. OCIL inhibits NK cell function via binding to the receptor NKRP1D. Murine OCIL in addition to inhibiting NK cell function inhibits osteoclast differentiation []. MAFA clusters with the type I Fc epsilon receptor (FcepsilonRI) and inhibits the mast cells secretory response to FcepsilonRI stimulus [, ]. CD72 is a regulator of B cell receptor signaling []. NKG2D is an activating receptor for stress-induced antigens; human NKG2D ligands include the stress induced MHC-I homologs, MICA, MICB, and ULBP family of glycoproteins. Several NKRs have a carbohydrate-binding capacity which is not mediated through calcium ions (e.g. OCIL binds a range of high molecular weight sulfated glycosaminoglycans including dextran sulfate, fucoidan, and gamma-carrageenan sugars) []. Dectin-1 binds fungal beta-glucans and is involved in the innate immune responses to fungal pathogens [, ]. MAFA binds saccharides having terminal alpha-D mannose residues in a calcium-dependent manner. LOX-1 is the major receptor for OxLDL in endothelial cells and thought to play a role in the pathology of atherosclerosis []. Some NKRs exist as homodimers (e.g.Lys49, NKG2D, CD69, LOX-1) and some as heterodimers (e.g. CD94/NKG2A). Dectin-1 can function as a monomer in vitro.
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Publication
9862378 | J:52111
First Author: Hanke T
Year: 1998
Journal: Eur J Immunol
Title: 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells.
Volume: 28
Issue: 12
Pages: 4409-17
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Publication
23382704 | J:195153
First Author: Schaffer AE
Year: 2013
Journal: PLoS Genet
Title: Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Volume: 9
Issue: 1
Pages: e1003274
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Publication
26313443 | J:329859
First Author: You L
Year: 2016
Journal: J Cell Physiol
Title: Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells.
Volume: 231
Issue: 4
Pages: 852-62
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Publication
32086291 | J:291668
First Author: Wu T
Year: 2020
Journal: Diabetes
Title: HRD1, an Important Player in Pancreatic β-Cell Failure and Therapeutic Target for Type 2 Diabetic Mice.
Volume: 69
Issue: 5
Pages: 940-953
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Publication
29914854 | J:315908
 
First Author: Burke SJ
Year: 2018
Journal: Mol Metab
Title: Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
Volume: 14
Pages: 95-107
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Publication
28017717 | J:241963
First Author: Yamamoto Y
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Preserving expression of Pdx1 improves β-cell failure in diabetic mice.
Volume: 483
Issue: 1
Pages: 418-424
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Publication
27653523 | J:238757
First Author: Wu RT
Year: 2017
Journal: Aging Cell
Title: Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice.
Volume: 16
Issue: 1
Pages: 125-135
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Publication
24770644 | J:208032
First Author: Hasegawa Y
Year: 2014
Journal: Exp Anim
Title: Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination.
Volume: 63
Issue: 2
Pages: 183-91
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Publication
30397183 | J:268920
First Author: Gupta D
Year: 2018
Journal: J Biol Chem
Title: β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation.
Volume: 293
Issue: 52
Pages: 20295-20306
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Publication
21521872 | J:177953
First Author: Hu He KH
Year: 2011
Journal: Diabetes
Title: In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Volume: 60
Issue: 6
Pages: 1705-15
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Publication
31160417 | J:278248
 
First Author: Chen C
Year: 2019
Journal: Development
Title: Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology.
Volume: 146
Issue: 13
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Publication
29605295 | J:270542
First Author: Matsuzawa T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion.
Volume: 499
Issue: 3
Pages: 688-695
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Publication
29220426 | J:258318
First Author: Jung Y
Year: 2018
Journal: Endocrinology
Title: Isl1β Overexpression With Key β Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion.
Volume: 159
Issue: 2
Pages: 869-882
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Publication
22949652 | J:190153
First Author: Banga A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts.
Volume: 109
Issue: 38
Pages: 15336-41
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Publication
25028525 | J:230123
First Author: Ediger BN
Year: 2014
Journal: Diabetes
Title: Islet-1 Is essential for pancreatic β-cell function.
Volume: 63
Issue: 12
Pages: 4206-17
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Publication
27653037 | J:240476
First Author: Boortz KA
Year: 2016
Journal: Endocrinology
Title: G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.
Volume: 157
Issue: 11
Pages: 4133-4145
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Publication
17456846 | J:126460
First Author: Doyle MJ
Year: 2007
Journal: Diabetes
Title: Nkx2.2 regulates beta-cell function in the mature islet.
Volume: 56
Issue: 8
Pages: 1999-2007
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Publication
19264802 | J:173035
First Author: Yang Y
Year: 2009
Journal: Nucleic Acids Res
Title: The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription.
Volume: 37
Issue: 8
Pages: 2529-38
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Publication
10741410 | J:60892
First Author: Corral L
Year: 2000
Journal: Eur J Immunol
Title: NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules.
Volume: 30
Issue: 3
Pages: 920-30
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Publication
26693711 | J:232588
First Author: Cavelti-Weder C
Year: 2016
Journal: Diabetologia
Title: Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.
Volume: 59
Issue: 3
Pages: 522-32
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Publication
28424159 | J:246321
First Author: Isaac R
Year: 2017
Journal: Diabetes
Title: Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo.
Volume: 66
Issue: 7
Pages: 1879-1889
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Publication
29625991 | J:264811
First Author: Aguayo-Mazzucato C
Year: 2018
Journal: Diabetes
Title: T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.
Volume: 67
Issue: 7
Pages: 1322-1331
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Publication
33839409 | J:305300
 
First Author: Nagai Y
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Glucotoxicity-induced suppression of Cox6a2 expression provokes β-cell dysfunction via augmented ROS production.
Volume: 556
Pages: 134-141
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Publication
23595988 | J:315258
First Author: Furuya F
Year: 2013
Journal: J Biol Chem
Title: Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells.
Volume: 288
Issue: 22
Pages: 16155-66
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Publication
21144823 | J:167443
First Author: Kawashima S
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice.
Volume: 404
Issue: 1
Pages: 534-40
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Publication
38307325 | J:345670
 
First Author: Patel S
Year: 2024
Journal: Metabolism
Title: Intermittent fasting protects β-cell identity and function in a type-2 diabetes model.
Volume: 153
Pages: 155813
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Publication
27715254 | J:240655
First Author: Sahr A
Year: 2016
Journal: Endocrinology
Title: The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.
Volume: 157
Issue: 12
Pages: 4677-4690
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Publication
32229246 | J:321040
 
First Author: Rodríguez-Comas J
Year: 2020
Journal: Mol Metab
Title: Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction.
Volume: 37
Pages: 100984
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Publication
37478155 | J:344265
First Author: Sohn P
Year: 2023
Journal: Diabetes
Title: Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein-Coupled Estrogen Receptor 1 Signaling.
Volume: 72
Issue: 10
Pages: 1433-1445
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Publication
35272070 | J:330347
 
First Author: Al-Mass A
Year: 2022
Journal: Mol Metab
Title: Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress.
Volume: 60
Pages: 101471
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Protein
E0CX93
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Publication
35802167 | J:331554
First Author: Habibe JJ
Year: 2022
Journal: Diabetologia
Title: Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes.
Volume: 65
Issue: 10
Pages: 1721-1733
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Publication
20865670 | -
First Author: Kang HS
Year: 2010
Journal: Histol Histopathol
Title: Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease.
Volume: 25
Issue: 11
Pages: 1481-96
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Protein
Q60653
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
P27811
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: false
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Protein
P37217
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
Q9EQ09
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q60654
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
O54707
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
P27814
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q60652
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q60682
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q60660
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q64329
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q60651
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
Q8CJC7
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: false
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Protein
Q3UM83
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
B2KG20
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
Q5DT36
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
P20937
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
P27812
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q99JB4
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
O54709
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q8BWY2
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q9JL99
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
Q91V08
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q80XD9
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
Q8VI21
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Protein
Q9D676
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q8C1T8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q9WVF9
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
P0C7M9
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q9R007
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
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Protein
Q6QLQ4
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Protein
Q504P2
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
Q149M0
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q0ZUP1
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
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Protein
Q8VD98
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
Q6P3B5
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
A4FUT3
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
A0A1U9W192
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q791D0
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
Q6DUV0
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: false
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Protein
Q8CB89
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
Q9JIP9
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
A0A0R4J0A7
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q9WTJ9
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
Q9JIQ1
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
G4WMX8
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
G4WMY1
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
Q9EP94
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
Q9EPB2
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
Q3KNP3
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q548T4
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
B7ZNR7
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
Q9JHV3
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q4FJM0
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q9JHV5
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
F2YRQ5
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
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Protein
I1W6W7
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
Q3TCW7
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
A0A0N4SUM0
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein
Q3UU75
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q9JHN9
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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