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Search results 401 to 500 out of 3733 for Mak

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Type Details Score
Publication
First Author: Schilham MW
Year: 1993
Journal: Eur J Immunol
Title: Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
Volume: 23
Issue: 6
Pages: 1299-304
Publication
First Author: Villarino A
Year: 2003
Journal: Immunity
Title: The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Volume: 19
Issue: 5
Pages: 645-55
Publication
First Author: Komazawa N
Year: 2004
Journal: Cancer Sci
Title: Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase.
Volume: 95
Issue: 8
Pages: 639-43
Publication
First Author: Tada Y
Year: 2003
Journal: Arthritis Rheum
Title: Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1.
Volume: 48
Issue: 11
Pages: 3280-90
Publication
First Author: Jolicoeur P
Year: 2003
Journal: J Virol
Title: Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
Volume: 77
Issue: 24
Pages: 13161-70
Publication
First Author: Emoto M
Year: 1999
Journal: J Immunol
Title: Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.
Volume: 162
Issue: 9
Pages: 5094-8
Publication
First Author: Suzuki A
Year: 2008
Journal: Cancer Sci
Title: Portrait of PTEN: messages from mutant mice.
Volume: 99
Issue: 2
Pages: 209-13
Publication
First Author: Tafuri A
Year: 2001
Journal: Nature
Title: ICOS is essential for effective T-helper-cell responses.
Volume: 409
Issue: 6816
Pages: 105-9
Publication
First Author: Yeh WC
Year: 1997
Journal: Immunity
Title: Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Volume: 7
Issue: 5
Pages: 715-25
Publication
First Author: Hakem R
Year: 1998
Journal: Cell
Title: Differential requirement for caspase 9 in apoptotic pathways in vivo.
Volume: 94
Issue: 3
Pages: 339-52
Publication
First Author: Schmits R
Year: 1997
Journal: Blood
Title: CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.
Volume: 90
Issue: 6
Pages: 2217-33
Publication
First Author: McIlwain DR
Year: 2012
Journal: Science
Title: iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
Volume: 335
Issue: 6065
Pages: 229-32
Publication
First Author: Afzal S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.
Volume: 112
Issue: 4
Pages: 1119-24
Publication
First Author: Koh DR
Year: 1995
Journal: Eur J Immunol
Title: Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
Volume: 25
Issue: 9
Pages: 2558-62
Publication
First Author: Opavsky MA
Year: 1999
Journal: Circ Res
Title: Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection.
Volume: 85
Issue: 6
Pages: 551-8
Publication
First Author: Kägi D
Year: 1999
Journal: J Immunol
Title: TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.
Volume: 162
Issue: 8
Pages: 4598-605
Publication
First Author: Zhuang L
Year: 1999
Journal: J Immunol
Title: TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation.
Volume: 162
Issue: 3
Pages: 1440-7
Publication
First Author: Smookler DS
Year: 2006
Journal: J Immunol
Title: Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Volume: 176
Issue: 2
Pages: 721-5
Publication
First Author: Jack MT
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.
Volume: 99
Issue: 15
Pages: 9825-9
Publication
First Author: Bachmaier K
Year: 1999
Journal: Circulation
Title: Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Volume: 99
Issue: 14
Pages: 1885-91
Publication
First Author: Fung-Leung WP
Year: 1993
Journal: Eur J Immunol
Title: CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny.
Volume: 23
Issue: 1
Pages: 212-6
Publication
First Author: Kawai K
Year: 1995
Journal: J Exp Med
Title: Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice.
Volume: 181
Issue: 1
Pages: 345-9
Publication
First Author: Reardon C
Year: 2011
Journal: Immunity
Title: Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.
Volume: 35
Issue: 2
Pages: 223-35
Publication
First Author: Bachmann MF
Year: 1998
Journal: J Immunol
Title: Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
Volume: 160
Issue: 1
Pages: 95-100
Publication
First Author: You H
Year: 2006
Journal: J Exp Med
Title: FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
Volume: 203
Issue: 7
Pages: 1657-63
Publication
First Author: Mei Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.
Volume: 106
Issue: 13
Pages: 5153-8
Publication
First Author: Tu S
Year: 2006
Journal: Nat Cell Biol
Title: In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Volume: 8
Issue: 1
Pages: 72-7
Publication
First Author: Lal G
Year: 2001
Journal: Cancer Res
Title: Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.
Volume: 61
Issue: 16
Pages: 6131-6
Publication
First Author: Ruland J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
Volume: 98
Issue: 4
Pages: 1859-64
Publication
First Author: Wallace VA
Year: 1994
Journal: Eur J Immunol
Title: A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice.
Volume: 24
Issue: 6
Pages: 1463-6
Publication
First Author: Lohoff M
Year: 2000
Journal: J Exp Med
Title: Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.
Volume: 192
Issue: 3
Pages: 325-36
Publication
First Author: Fehr T
Year: 1997
Journal: J Exp Med
Title: Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis.
Volume: 185
Issue: 5
Pages: 921-31
Publication
First Author: Hara H
Year: 2002
Journal: J Immunol
Title: The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
Volume: 168
Issue: 5
Pages: 2288-95
Publication
First Author: Suzuki A
Year: 2003
Journal: J Exp Med
Title: Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.
Volume: 197
Issue: 5
Pages: 657-67
Publication
First Author: Klemm S
Year: 2006
Journal: J Exp Med
Title: The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
Volume: 203
Issue: 2
Pages: 337-47
Publication
First Author: Wallace VA
Year: 1997
Journal: J Immunol
Title: Alterations in the level of CD45 surface expression affect the outcome of thymic selection.
Volume: 158
Issue: 7
Pages: 3205-14
Publication
First Author: Prevot N
Year: 2010
Journal: Eur J Immunol
Title: Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system.
Volume: 40
Issue: 8
Pages: 2267-76
Publication
First Author: Yeh WC
Year: 2000
Journal: Immunity
Title: Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
Volume: 12
Issue: 6
Pages: 633-42
Publication
First Author: Suh WK
Year: 2004
Journal: J Immunol
Title: The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.
Volume: 172
Issue: 10
Pages: 5917-23
Publication
First Author: Suzuki A
Year: 1998
Journal: Curr Biol
Title: High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Volume: 8
Issue: 21
Pages: 1169-78
Publication
First Author: Suzuki A
Year: 2003
Journal: Cancer Res
Title: Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
Volume: 63
Issue: 3
Pages: 674-81
Publication
First Author: Okada H
Year: 2004
Journal: J Exp Med
Title: Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
Volume: 199
Issue: 3
Pages: 399-410
Publication
First Author: de la Pompa JL
Year: 1998
Journal: Nature
Title: Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.
Volume: 392
Issue: 6672
Pages: 182-6
Publication
First Author: Yoshida H
Year: 1998
Journal: Immunity
Title: The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Volume: 8
Issue: 1
Pages: 115-24
Publication
First Author: Backman SA
Year: 2001
Journal: Nat Genet
Title: Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.
Volume: 29
Issue: 4
Pages: 396-403
Publication
First Author: Berger T
Year: 2013
Journal: Oncogene
Title: Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model.
Volume: 32
Issue: 41
Pages: 4989-94
Publication
First Author: Araos P
Year: 2019
Journal: J Hypertens
Title: Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation.
Volume: 37
Issue: 7
Pages: 1482-1492
Publication
First Author: Schall TJ
Year: 1992
Journal: Eur J Immunol
Title: Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man.
Volume: 22
Issue: 6
Pages: 1477-81
Publication  
First Author: Allen CE
Year: 2002
Journal: BMC Immunol
Title: The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.
Volume: 3
Pages: 10
Publication
First Author: Yoshikai Y
Year: 1986
Journal: Nature
Title: Athymic mice express a high level of functional gamma-chain but greatly reduced levels of alpha- and beta-chain T-cell receptor messages.
Volume: 324
Issue: 6096
Pages: 482-5
Publication
First Author: Fiol DF
Year: 2007
Journal: FEBS J
Title: Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress.
Volume: 274
Issue: 1
Pages: 109-24
Publication  
First Author: Berger T
Year: 2013
Journal: Cold Spring Harb Symp Quant Biol
Title: Dissection of signaling in inflammation: three novel inflammatory regulators.
Volume: 78
Pages: 141-7
Publication
First Author: Webb BA
Year: 2006
Journal: Exp Cell Res
Title: Cortactin regulates podosome formation: roles of the protein interaction domains.
Volume: 312
Issue: 6
Pages: 760-9
Publication
First Author: Chojnacki A
Year: 2011
Journal: J Neurosci
Title: PDGFRα expression distinguishes GFAP-expressing neural stem cells from PDGF-responsive neural precursors in the adult periventricular area.
Volume: 31
Issue: 26
Pages: 9503-12
Publication
First Author: Kane E
Year: 2024
Journal: iScience
Title: MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets.
Volume: 27
Issue: 7
Pages: 110332
Publication
First Author: D'Souza CA
Year: 2002
Journal: J Biol Chem
Title: The up-regulation of stromelysin-1 (MMP-3) in a spontaneously demyelinating transgenic mouse precedes onset of disease.
Volume: 277
Issue: 16
Pages: 13589-96
Publication
First Author: Shibuya T
Year: 1982
Journal: J Exp Med
Title: Erythroleukemia induction by Friend leukemia virus. A host gene locus controlling early anemia or polycythemia and the rate of proliferation of late erythroid cells.
Volume: 156
Issue: 2
Pages: 398-414
Publication
First Author: Yeung RS
Year: 1993
Journal: Curr Opin Immunol
Title: Genetically modified animals and immunodeficiency.
Volume: 5
Issue: 4
Pages: 585-94
Publication
First Author: Yeung RS
Year: 1994
Journal: Curr Opin Immunol
Title: T-cell development and function in gene-knockout mice.
Volume: 6
Issue: 2
Pages: 298-307
Publication
First Author: Fortin J
Year: 2016
Journal: Nat Med
Title: PTEN enables the development of pre-B acute lymphoblastic leukemia.
Volume: 22
Issue: 4
Pages: 339-40
Publication
First Author: Dufner A
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
Volume: 103
Issue: 4
Pages: 988-93
Publication
First Author: Weber GF
Year: 2002
Journal: Cancer Res
Title: Absence of the CD44 gene prevents sarcoma metastasis.
Volume: 62
Issue: 8
Pages: 2281-6
Publication
First Author: Calzascia T
Year: 2007
Journal: J Clin Invest
Title: TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.
Volume: 117
Issue: 12
Pages: 3833-45
Publication
First Author: Hakem R
Year: 1997
Journal: Nat Genet
Title: Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.
Volume: 16
Issue: 3
Pages: 298-302
Publication
First Author: Calzascia T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.
Volume: 105
Issue: 8
Pages: 2999-3004
Publication
First Author: Niklison-Chirou MV
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor.
Volume: 110
Issue: 47
Pages: 18952-7
Publication
First Author: Cheung AM
Year: 2004
Journal: Cancer Res
Title: Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
Volume: 64
Issue: 6
Pages: 1959-65
Publication
First Author: Jost PJ
Year: 2007
Journal: J Immunol
Title: Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.
Volume: 178
Issue: 2
Pages: 953-60
Publication
First Author: Gigoux M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
Volume: 106
Issue: 48
Pages: 20371-6
Publication  
First Author: Dadson K
Year: 2017
Journal: Sci Rep
Title: The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.
Volume: 7
Pages: 41490
Publication
First Author: Lomaga MA
Year: 1999
Journal: Genes Dev
Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Volume: 13
Issue: 8
Pages: 1015-24
Publication
First Author: Perez GI
Year: 2007
Journal: Cell Death Differ
Title: Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure.
Volume: 14
Issue: 3
Pages: 524-33
Publication  
First Author: Sundaram B
Year: 2019
Journal: Sci Signal
Title: iRhom2 inhibits bile duct obstruction-induced liver fibrosis.
Volume: 12
Issue: 605
Publication  
First Author: Beck S
Year: 2020
Journal: Front Immunol
Title: ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.
Volume: 11
Pages: 450
Publication
First Author: Reilly PT
Year: 2010
Journal: PLoS One
Title: Generation and characterization of the Anp32e-deficient mouse.
Volume: 5
Issue: 10
Pages: e13597
Publication
First Author: Ye SK
Year: 2001
Journal: J Immunol
Title: Differential roles of cytokine receptors in the development of epidermal gamma delta T cells.
Volume: 167
Issue: 4
Pages: 1929-34
Publication
First Author: Kimura T
Year: 2003
Journal: Development
Title: Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.
Volume: 130
Issue: 8
Pages: 1691-700
Publication
First Author: Berube C
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Volume: 102
Issue: 40
Pages: 14314-20
Publication
First Author: Radziszewska A
Year: 2009
Journal: J Biol Chem
Title: PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.
Volume: 284
Issue: 5
Pages: 2917-22
Publication  
First Author: Fang R
Year: 2020
Journal: Int J Mol Sci
Title: Role of iRhoms 1 and 2 in Endochondral Ossification.
Volume: 21
Issue: 22
Publication
First Author: Viau A
Year: 2010
Journal: J Clin Invest
Title: Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.
Volume: 120
Issue: 11
Pages: 4065-76
Publication
First Author: Cheung CC
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.
Volume: 107
Issue: 26
Pages: 11883-8
Publication
First Author: Revelo XS
Year: 2015
Journal: Diabetes
Title: Perforin is a novel immune regulator of obesity-related insulin resistance.
Volume: 64
Issue: 1
Pages: 90-103
Publication
First Author: Nishina H
Year: 1997
Journal: J Exp Med
Title: Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
Volume: 186
Issue: 6
Pages: 941-53
Publication
First Author: Qing X
Year: 2018
Journal: J Clin Invest
Title: iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.
Volume: 128
Issue: 4
Pages: 1397-1412
Publication
First Author: Kimura T
Year: 1996
Journal: Genes Cells
Title: Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.
Volume: 1
Issue: 1
Pages: 115-24
Publication
First Author: Agostini M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.
Volume: 108
Issue: 52
Pages: 21093-8
Publication
First Author: Tada K
Year: 2001
Journal: J Biol Chem
Title: Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.
Volume: 276
Issue: 39
Pages: 36530-4
Publication
First Author: Woo M
Year: 2003
Journal: Nat Immunol
Title: Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Volume: 4
Issue: 10
Pages: 1016-22
Publication
First Author: Kuroda S
Year: 2008
Journal: Eur J Immunol
Title: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages.
Volume: 38
Issue: 5
Pages: 1331-40
Publication
First Author: Aboualaiwi WA
Year: 2014
Journal: Circulation
Title: Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.
Volume: 129
Issue: 6
Pages: 660-72
Publication
First Author: Wang L
Year: 2014
Journal: Diabetologia
Title: Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.
Volume: 57
Issue: 9
Pages: 1889-98
Publication
First Author: Bassi C
Year: 2021
Journal: Cell Death Differ
Title: The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.
Volume: 28
Issue: 11
Pages: 3036-3051
Publication  
First Author: Jiang ZZ
Year: 2014
Journal: Cell Death Dis
Title: Survivin is essential for fertile egg production and female fertility in mice.
Volume: 5
Pages: e1154
Publication
First Author: Ye J
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.
Volume: 114
Issue: 2
Pages: 292-297
Publication
First Author: Ma W
Year: 2011
Journal: Cell Res
Title: Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
Volume: 21
Issue: 11
Pages: 1564-77
Publication
First Author: Kondo S
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
Volume: 100
Issue: 9
Pages: 5431-6
Publication
First Author: Suh WK
Year: 2006
Journal: Mol Cell Biol
Title: Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Volume: 26
Issue: 17
Pages: 6403-11
Publication
First Author: Amakawa R
Year: 1996
Journal: Cell
Title: Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.
Volume: 84
Issue: 4
Pages: 551-62
Publication
First Author: Suzuki A
Year: 1997
Journal: Genes Dev
Title: Brca2 is required for embryonic cellular proliferation in the mouse.
Volume: 11
Issue: 10
Pages: 1242-52