Type |
Details |
Score |
Allele |
Name: |
MAS1 oncogene; endonuclease-mediated mutation 28, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
MAS1 oncogene; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Genotype |
Symbol: |
Mas1/Mas1 |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
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Genotype |
Symbol: |
Mas1/Mas1 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
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•
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Genotype |
Symbol: |
Mas1/Mas1 |
Background: |
C57BL/6N-Mas1/Ucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Allele |
Name: |
transgene insertion A, Takashi Iwamoto |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
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Allele |
Name: |
transgene insertion B, Takashi Iwamoto |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
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Genotype |
Symbol: |
Mas1/Mas1<+> |
Background: |
C57BL/6N-Mas1/Ucd |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
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•
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Strain |
Attribute String: |
mutant stock, transgenic |
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Strain |
Attribute String: |
mutant stock, transgenic |
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Genotype |
Symbol: |
Mas1/Mas1<+> |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Publication |
First Author: |
Premzl M |
Year: |
2014 |
Journal: |
Gene |
Title: |
Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. |
Volume: |
540 |
Issue: |
1 |
Pages: |
16-9 |
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•
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Publication |
First Author: |
Gakh O |
Year: |
2002 |
Journal: |
Biochim Biophys Acta |
Title: |
Mitochondrial processing peptidases. |
Volume: |
1592 |
Issue: |
1 |
Pages: |
63-77 |
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Publication |
First Author: |
Witte C |
Year: |
1988 |
Journal: |
EMBO J |
Title: |
MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. |
Volume: |
7 |
Issue: |
5 |
Pages: |
1439-47 |
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Protein Domain |
Type: |
Family |
Description: |
Mitochondrial-processing peptidase complex removes the first transit peptide from the N terminus of proteins synthesised in the cytoplasm but destined for the mitochondrion []. The complex is a heterodimer of an alpha and a beta subunit. This entry includes the beta subunit (MAS1 or MPPB; ; MEROPS identifier M16.003), which is a zinc-dependent metallo-endopeptidase that binds one zinc ion via the histidines in an HXXEH motif and a Glu C-terminal to this motif []. MAS1 is itself synthesised in the cytoplasm and has an N-terminal transit peptide []. |
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Publication |
First Author: |
Santos RA |
Year: |
2007 |
Journal: |
Curr Opin Nephrol Hypertens |
Title: |
Angiotensin-(1-7) and the renin-angiotensin system. |
Volume: |
16 |
Issue: |
2 |
Pages: |
122-8 |
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Publication |
First Author: |
Santos RA |
Year: |
2006 |
Journal: |
Cardiovasc Drug Rev |
Title: |
Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist. |
Volume: |
24 |
Issue: |
3-4 |
Pages: |
239-46 |
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Protein Domain |
Type: |
Family |
Description: |
The mas proto-oncogene was intially discovered following co-transfection with DNA isolated from a human epidermal carcinoma. It efficiently induces tumorigenicity and has weak focus-inducing activity in NIH 3T3 cells. To date, it is the only oncogene to have been sequenced that encodes a 7TM protein. The oncogene is a GPCR which binds the angiotensin-II metabolite angiotensin (1-7) [, ]. It is therefore thought that MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure []. In the CNS, high levels of the mas proto-oncogene transcript are present in the cerebral cortex, with lower amounts in the hippocampus and cerebellum. In the periphery, it is expressed in low levels in the kidney, adrenals and liver. The rat RTA protein has some similarity to the mas proto-oncogene sequence. |
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Publication |
First Author: |
Duan R |
Year: |
2020 |
Journal: |
Aging (Albany NY) |
Title: |
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice. |
Volume: |
12 |
Issue: |
14 |
Pages: |
14819-14829 |
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Publication |
First Author: |
Premzl M |
Year: |
2016 |
Journal: |
Data Brief |
Title: |
Curated eutherian third party data gene data sets. |
Volume: |
6 |
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Pages: |
208-13 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
50
 |
Fragment?: |
true |
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Publication |
First Author: |
Taylor AB |
Year: |
2001 |
Journal: |
Structure |
Title: |
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences. |
Volume: |
9 |
Issue: |
7 |
Pages: |
615-25 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
324
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
324
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
489
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
480
 |
Fragment?: |
true |
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•
•
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•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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