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Search results 401 to 500 out of 506 for Mip

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Type Details Score
Publication
24142690 | J:276637
First Author: Matsuyama M
Year: 2013
Journal: J Biol Chem
Title: Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.
Volume: 288
Issue: 50
Pages: 35626-35
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Publication
7590745 | J:26632
First Author: Danciger M
Year: 1995
Journal: Genomics
Title: Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens.
Volume: 28
Issue: 1
Pages: 39-43
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Publication
19367412 | J:151683
First Author: Parreira KS
Year: 2009
Journal: Pflugers Arch
Title: Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.
Volume: 458
Issue: 4
Pages: 745-59
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Publication
12072567 | J:77351
First Author: Goudreau G
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.
Volume: 99
Issue: 13
Pages: 8719-24
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Publication
9560157 | J:46940
First Author: Zambrowicz BP
Year: 1998
Journal: Nature
Title: Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.
Volume: 392
Issue: 6676
Pages: 608-11
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Publication
28763805 | J:258463
First Author: Wang Y
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.
Volume: 58
Issue: 10
Pages: 3896-3922
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Publication
27596755 | J:236785
First Author: Pathania M
Year: 2016
Journal: Differentiation
Title: β1-integrin controls cell fate specification in early lens development.
Volume: 92
Issue: 4
Pages: 133-147
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Publication
24161570 | J:207861
 
First Author: Manthey AL
Year: 2014
Journal: Mech Dev
Title: Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.
Volume: 131
Pages: 86-110
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Publication
26212757 | J:226036
First Author: Maddala R
Year: 2015
Journal: Dev Biol
Title: Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
Volume: 406
Issue: 1
Pages: 74-91
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Publication
27633990 | J:237527
First Author: Thein T
Year: 2016
Journal: Development
Title: Control of lens development by Lhx2-regulated neuroretinal FGFs.
Volume: 143
Issue: 21
Pages: 3994-4002
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Publication
27631609 | J:251150
First Author: Aoki H
Year: 2016
Journal: PLoS One
Title: Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.
Volume: 11
Issue: 9
Pages: e0163042
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Publication
30352686 | J:270543
First Author: Tanahashi H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deletion of Lrp4 increases the incidence of microphthalmia.
Volume: 506
Issue: 3
Pages: 478-484
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Publication
- | J:169366
     
First Author: MouseBookTM
Year: 2005
Journal: Unpublished
Title: Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:71230
   
First Author: Waeber G
Year: 1997
Journal: GenBank Submission
Title: Mus musculus MIP gene, promoter and partial exon 1 sequence
Pages: AF033192
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Protein
A6H611
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
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Publication
11705786 | J:73267
First Author: Virkki LV
Year: 2001
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Cloning and functional expression of an MIP (AQP0) homolog from killifish (Fundulus heteroclitus) lens.
Volume: 281
Issue: 6
Pages: R1994-2003
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Publication
7516906 | -
First Author: Ludwig B
Year: 1994
Journal: FEMS Microbiol Lett
Title: Characterization of Mip proteins of Legionella pneumophila.
Volume: 118
Issue: 1-2
Pages: 23-30
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Interaction Term
MI:0946 | miniaturized immunoprecipitation
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Publication
1379319 | -
First Author: Fischer G
Year: 1992
Journal: Mol Microbiol
Title: Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity.
Volume: 6
Issue: 10
Pages: 1375-83
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Allele
Mip<Cat-Fr> | MGI:1857104
 
Name: major intrinsic protein of lens fiber; dominant cataract Fraser
Allele Type: Spontaneous
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Protein
Q9JHU9
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
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Genotype
Genotype
Symbol: Mip/Mip
Background: involves: A/J
Zygosity: hm
Has Mutant Allele: true
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Allele
Mip<Hfi> | MGI:1856608
 
Name: major intrinsic protein of lens fiber; hydropic fibers
Allele Type: Radiation induced
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Allele
Mip<Cat-Lop> | MGI:1857105
 
Name: major intrinsic protein of lens fiber; cataract lens opacity
Allele Type: Spontaneous
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Allele
Mip<Cts> | MGI:1860482
 
Name: major intrinsic protein of lens fiber; cataract and small eye
Allele Type: Spontaneous
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Allele
Mip<Cat-Tohm> | MGI:2657065
 
Name: major intrinsic protein of lens fiber; dominant cataract Tohoku
Allele Type: Spontaneous
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Allele
Mip<em1Smoc> | MGI:7291079
Name: major intrinsic protein of lens fiber; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
11927981 | -
First Author: Bumbaugh AC
Year: 2002
Journal: Curr Microbiol
Title: Sequence polymorphism of dotA and mip alleles mediating invasion and intracellular replication of Legionella pneumophila.
Volume: 44
Issue: 5
Pages: 314-22
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Strain
MGI:6355020 | C57BL/6JSmoc-Mip<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Mip/Mip
Background: involves: DDI
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mip/Mip
Background: involves: 101 * C3H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mip/Mip<+>
Background: involves: 101 * C3H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mip/Mip<+>
Background: involves: STOCK Rb(6.15)1Ald
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mip/Mip
Background: CTS/Shi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mip/Mip<+>
Background: involves: C57BL/6J * CTS/Shi
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0110251 | cataract 15 multiple types
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Allele
Mip<Cat> | MGI:1856474
 
Name: major intrinsic protein of lens fiber; dominant cataract
Allele Type: Spontaneous
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Publication
11954550 | -
First Author: Kondoh S
Year: 2002
Journal: J Hum Genet
Title: A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet.
Volume: 47
Issue: 3
Pages: 136-9
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Protein
Q9D9F8
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
G3UVV8
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
Q3TFV9
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: true
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Protein
E9PZ24
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q3UUQ6
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
E9Q8Z7
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
Q8BXL3
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein Domain
IPR026175 | MIPOL1
Type: Family
Description: Mirror-image polydactyly of hands and feet (MIP) is a very rare congenital anomaly characterised by mirror-image duplication of digits. A chromosomal aberration involving mirror-image polydactyly gene 1 (MIPOL1) suggests this to be a good candidate gene for the MIP type of anomaly []. This entry represents the MIPOL1 protein.
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Protein Domain
IPR022357 | MIP_CS
Type: Conserved_site
Description: The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in water, small carbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport, by an energy independent mechanism. They are found ubiquitously in bacteria, archaea and eukaryotes.The MIP family contains two major groups of channels: aquaporins and glycerol facilitators. The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically important processes. Some members of the family, including the yeast FPS protein and tobacco NtTIPA may transport both water and small solutes. The structures of various members of the MIP family have been determined by means of X-ray diffraction [, , ], revealing the fold to comprise a right-handed bundle of 6 transmembrane (TM) α-helices [, , ]. Similarities in the N-and C-terminal halves of the molecule suggest that the proteins may have arisen through tandem, intragenic duplication of an ancestral protein that contained 3 TM domains []. This entry represents a conserved region which is located in the cytoplasmic loop between the second and third transmembrane regions of MIP family members.
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Publication
2925252 | -
First Author: Engleberg NC
Year: 1989
Journal: Infect Immun
Title: DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity.
Volume: 57
Issue: 4
Pages: 1263-70
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Publication
8347938 | -
First Author: Hacker J
Year: 1993
Journal: Zentralbl Bakteriol
Title: Analysis of virulence factors of Legionella pneumophila.
Volume: 278
Issue: 2-3
Pages: 348-58
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Publication
11524681 | -
First Author: Riboldi-Tunnicliffe A
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of Mip, a prolylisomerase from Legionella pneumophila.
Volume: 8
Issue: 9
Pages: 779-83
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Protein Domain
IPR023271 | Aquaporin-like
Type: Homologous_superfamily
Description: The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in water, small carbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport, by an energy independent mechanism. They are found ubiquitously in bacteria, archaea and eukaryotes.The MIP family contains two major groups of channels: aquaporins and glycerol facilitators. The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically important processes. Some members of the family, including the yeast FPS protein and tobacco NtTIPA may transport both water and small solutes. The structures of various members of the MIP family have been determined by means of X-ray diffraction [, , ], revealing the fold to comprise a right-handed bundle of 6 transmembrane (TM) α-helices [, , ]. Similarities in the N-and C-terminal halves of the molecule suggest that the proteins may have arisen through tandem, intragenic duplication of an ancestral protein that contained 3 TM domains []. This superfamily represents the aquaporin-like structural domain.
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Protein Domain
IPR008104 | INFPOTNTIATR
Type: Family
Description: Legionella pneumophila, the causative agent of Legionnaire's disease, is a facultative intracellular microbe that commonly infects human lung monocytes and macrophages and causes pneumonia []. It is water-borne and highly virulent, relying on several specific pathogenic factors to invade and infect the alveolar tissue. However, once grown to stationary phase in culture, the pathogen spontaneously converts to an avirulent state []. The major virulence factor expressed by Legionella pneumophila is the macrophage infectivity potentiator (Mip) []. Site-directed mutagenesis studies of this protein in vitro severely impaired the intracellular infection of human macrophages by L. pneumophila, causing it to lose its potent antigenic activity []. Further studies into the enzymatic activity of Mip have revealed that it plays a similar role to eukaryotic FK506-binding proteins. In vivo, it acts as a peptidyl-prolyl-cis/trans- isomerase (PPIase) on oligopeptides [], although it is unclear whether this forms part of the virulence process. Substitution of Asp142 of the mature protein by Leu severely reduces the PPIase activity of Mip []. The structure of Mip has been resolved to 2.41A by X-ray crystallography [], revealing the virulence factor to exist as a homodimer. Each monomer consists of an N-terminal dimerisation module, a long central connecting α-helix and a conserved PPIase domain at the C terminus.
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Strain
MGI:2162403 | STOCK Mip<Cat-Fr>/J
Attribute String: mutant stock, spontaneous mutation
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Strain
MGI:5649811 | MF1-Mip<Cat-Fr>
Attribute String: mutant stock, outbred stock
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Publication
29774240 | J:288132
First Author: Zhong J
Year: 2018
Journal: Sci Adv
Title: Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes.
Volume: 4
Issue: 5
Pages: eaas9864
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Publication
26402732 | J:246142
First Author: McDonald CR
Year: 2015
Journal: PLoS Pathog
Title: Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.
Volume: 11
Issue: 9
Pages: e1005140
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Publication
16280366 | J:274236
First Author: McColl SR
Year: 2006
Journal: FASEB J
Title: Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils.
Volume: 20
Issue: 1
Pages: 187-9
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Protein
Q8BYF0
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
A0A0X1KG63
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Publication
9388476 | J:44349
First Author: Ma T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart.
Volume: 240
Issue: 2
Pages: 324-8
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Publication
17822444 | J:126350
First Author: Hsu A
Year: 2007
Journal: Clin Exp Immunol
Title: Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.
Volume: 150
Issue: 2
Pages: 332-9
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Publication
25593326 | J:220345
First Author: Kumar P
Year: 2015
Journal: J Leukoc Biol
Title: Mycobacterium indicus pranii induces dendritic cell activation, survival, and Th1/Th17 polarization potential in a TLR-dependent manner.
Volume: 97
Issue: 3
Pages: 511-20
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Publication
24766519 | J:219450
First Author: Kumar P
Year: 2014
Journal: Immunology
Title: Mycobacterium indicus pranii and Mycobacterium bovis BCG lead to differential macrophage activation in Toll-like receptor-dependent manner.
Volume: 143
Issue: 2
Pages: 258-68
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