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Search results 401 to 500 out of 558 for Mlh1

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Type Details Score
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA mismatch repair protein Mlh1
Type: chain
End: 760
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Protein
F6R1G0
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Publication
10644444 | J:60262
First Author: Geeta Vani R
Year: 1999
Journal: Genomics
Title: Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6, and MLH1 during spermatogenesis.
Volume: 62
Issue: 3
Pages: 460-7
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Protein
Q9JK91
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Publication
10082584 | J:53934
First Author: Shcherbakova PV
Year: 1999
Journal: Mol Cell Biol
Title: Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.
Volume: 19
Issue: 4
Pages: 3177-83
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Allele
Mlh1fc1<CAST/EiJ> | MGI:6400595
 
Name: MLH1 foci count 1; CAST/EiJ
Allele Type: QTL
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Allele
Mlh1fc1<PWD/PhJ> | MGI:6400596
 
Name: MLH1 foci count 1; PWD/PhJ
Allele Type: QTL
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Allele
Mlh1fc2<CAST/EiJ> | MGI:6400597
 
Name: MLH1 foci count 2; CAST/EiJ
Allele Type: QTL
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Allele
Mlh1fc2<PWD/PhJ> | MGI:6400598
 
Name: MLH1 foci count 2; PWD/PhJ
Allele Type: QTL
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Allele
Mlh1fc3<CAST/EiJ> | MGI:6400599
 
Name: MLH1 foci count 3; CAST/EiJ
Allele Type: QTL
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Allele
Mlh1fc3<PWD/PhJ> | MGI:6400600
 
Name: MLH1 foci count 3; PWD/PhJ
Allele Type: QTL
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Allele
Mlh1fc4<GI/Wisc> | MGI:6400601
 
Name: MLH1 foci count 4; GI/Wisc
Allele Type: QTL
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Allele
Mlh1fc4<WSB/EiJ> | MGI:6400602
 
Name: MLH1 foci count 4; WSB/EiJ
Allele Type: QTL
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Protein
A0A0G2JDY9
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein
A0A0G2JH14
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: false
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Publication
17298983 | J:120753
First Author: de Boer E
Year: 2007
Journal: J Cell Sci
Title: Meiotic interference among MLH1 foci requires neither an intact axial element structure nor full synapsis.
Volume: 120
Issue: Pt 5
Pages: 731-6
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Publication
19502488 | J:150052
First Author: Ruzov A
Year: 2009
Journal: Development
Title: MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.
Volume: 136
Issue: 13
Pages: 2277-86
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Allele
Sccor1<CAST/EiJ> | MGI:6400603
 
Name: synaptonemal complex length to mean MLH1 count ratio 1; CAST/EiJ
Allele Type: QTL
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Allele
Sccor1<PWD/PhJ> | MGI:6400604
 
Name: synaptonemal complex length to mean MLH1 count ratio 1; PWD/PhJ
Allele Type: QTL
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Allele
Sccor2<CAST/EiJ> | MGI:6400605
 
Name: synaptonemal complex length to mean MLH1 count ratio 2; CAST/EiJ
Allele Type: QTL
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Allele
Sccor2<PWD/PhJ> | MGI:6400606
 
Name: synaptonemal complex length to mean MLH1 count ratio 2; PWD/PhJ
Allele Type: QTL
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Allele
Sccor3<GI/Wisc> | MGI:6400607
 
Name: synaptonemal complex length to mean MLH1 count ratio 3; GI/Wisc
Allele Type: QTL
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Allele
Sccor3<WSB/EiJ> | MGI:6400608
 
Name: synaptonemal complex length to mean MLH1 count ratio 3; WSB/EiJ
Allele Type: QTL
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DO Term
DOID:0070274 | hereditary nonpolyposis colorectal cancer type 2
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Allele
Mlh1<em1Smoc> | MGI:7291103
Name: mutL homolog 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
8264608 | -
First Author: Prolla TA
Year: 1994
Journal: Mol Cell Biol
Title: Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
Volume: 14
Issue: 1
Pages: 407-15
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Interaction Experiment
Goold R (2021)
Description: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntingtons disease.
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Publication
11717305 | -
First Author: Hall MC
Year: 2002
Journal: J Biol Chem
Title: Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins.
Volume: 277
Issue: 5
Pages: 3673-9
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HT Experiment
GSE229811 | Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous mice [Mlh1]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE237510 | Transcriptional profiling of cortex from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous and homozygous mice [Mlh1_4m]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE237544 | Transcriptional profiling of striatum from a mouse model of Huntington's disease (Q140) crossed with Mlh1 heterozygous and homozygous mice [Mlh1_4m]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
31449519 | J:279476
First Author: Wang RJ
Year: 2019
Journal: PLoS Genet
Title: A first genetic portrait of synaptonemal complex variation.
Volume: 15
Issue: 8
Pages: e1008337
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Strain
MGI:6429185 | C57BL/6JSmoc-Mlh1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
26249686 | -
First Author: Wu H
Year: 2015
Journal: Acta Crystallogr F Struct Biol Commun
Title: Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Volume: 71
Issue: Pt 8
Pages: 981-5
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Publication
23435383 | -
First Author: Gueneau E
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
Volume: 20
Issue: 4
Pages: 461-8
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GO Term
GO:0032389 | MutLalpha complex
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GO Term
GO:0032390 | MutLbeta complex
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GO Term
GO:0097587 | MutLgamma complex
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Allele
Brip1<em1Peco> | MGI:7616325
Name: BRCA1 interacting protein C-terminal helicase 1; endonuclease-mediated mutation 1, Paula E Cohen
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Publication
26490168 | J:227337
First Author: Sun X
Year: 2016
Journal: Chromosoma
Title: FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Volume: 125
Issue: 2
Pages: 237-52
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Allele
Brip1<Gt(RRI409)Byg> | MGI:4129733
Name: BRCA1 interacting protein C-terminal helicase 1; gene trap RRI409, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Allele
Mlh1<m1Btlr> | MGI:6200234
Name: mutL homolog 1; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6200235 | C57BL/6J-Mlh1<m1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Allele
Mlh1<m2Btlr> | MGI:6200239
Name: mutL homolog 1; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6200240 | C57BL/6J-Mlh1<m2Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Mlh1/Mlh1
Background: C57BL/6J-Mlh1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mlh1/Mlh1
Background: C57BL/6J-Mlh1
Zygosity: hm
Has Mutant Allele: true
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Publication
38377115 | J:346200
First Author: Horan TS
Year: 2024
Journal: PLoS Genet
Title: The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.
Volume: 20
Issue: 2
Pages: e1011175
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Genotype
Genotype
Symbol: Brip1/Brip1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
3304141 | -
 
First Author: Modrich P
Year: 1987
Journal: Annu Rev Biochem
Title: DNA mismatch correction.
Volume: 56
Pages: 435-66
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Publication
2676972 | -
First Author: Mankovich JA
Year: 1989
Journal: J Bacteriol
Title: Nucleotide sequence of the Salmonella typhimurium mutL gene required for mismatch repair: homology of MutL to HexB of Streptococcus pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae.
Volume: 171
Issue: 10
Pages: 5325-31
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Publication
2676973 | -
First Author: Prudhomme M
Year: 1989
Journal: J Bacteriol
Title: Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of Saccharomyces cerevisiae.
Volume: 171
Issue: 10
Pages: 5332-8
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Publication
12052432 | -
First Author: Bernstein C
Year: 2002
Journal: Mutat Res
Title: DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis.
Volume: 511
Issue: 2
Pages: 145-78
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Publication
9770499 | -
First Author: Flores-Rozas H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.
Volume: 95
Issue: 21
Pages: 12404-9
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Publication
10072354 | -
First Author: Kolodner RD
Year: 1999
Journal: Curr Opin Genet Dev
Title: Eukaryotic DNA mismatch repair.
Volume: 9
Issue: 1
Pages: 89-96
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Publication
15467368 | -
First Author: Hoffmann ER
Year: 2004
Journal: Cytogenet Genome Res
Title: Meiotic recombination intermediates and mismatch repair proteins.
Volume: 107
Issue: 3-4
Pages: 232-48
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Publication
16467846 | -
First Author: Jackson N
Year: 2006
Journal: EMBO J
Title: Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis.
Volume: 25
Issue: 6
Pages: 1315-23
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Protein Domain
IPR028830 | Mlh3
Type: Family
Description: Theyeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. These proteins can form three types of complexes; Mlh1 is the common component of all three complexes, interacting with Pms1, Mlh2, and Mlh3. Four mammalian MutL homologues also exist. The principal heterodimers that function in mitotic repair and meiotic reciprocal recombination are Mlh1-Pms2 (Pms1 in yeast) and Mlh1-Mlh3, respectively [, , ].This entry represents Mlh3 and its homologues from eukaryotes. Mlh3 is involved in DNA mismatch repair, correcting insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. It is a component of the MutL-beta heterodimer (a heterodimer of Mlh1 and Mlh3), which probably forms a ternary complex with the MutS-beta heterodimer that initially recognises the DNA mismatches. Mlh3 plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates [, , ].
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Protein Domain
IPR014762 | DNA_mismatch_repair_CS
Type: Conserved_site
Description: Mismatch repair contributes to the overall fidelity of DNA replication []. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The sequence of some proteins involved in mismatch repair in different organisms have been found to be evolutionarily related. These proteins include:Escherichia coli and Salmonella typhimurium mutL protein []. MutL is required for dam-dependent methyl-directed DNA repair.Streptococcus pneumoniae hexB protein []. The Hex system is nick directed.Yeast proteins PMS1 and MLH1 [].Human protein MLH1 []which is involved in a form of familial hereditary nonpolyposis colon cancer (HNPCC).This entry represents a perfectly conserved heptapeptide which is located in the N-terminal sectionof these proteins.
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Protein Domain
IPR020667 | DNA_mismatch_repair_MutL
Type: Family
Description: Mismatch repair is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. Many proteins involved in the different repair processes also play a role in apoptosis when DNA damage is excessive, thereby helping to prevent carcinogenesis []. The mismatch repair protein, Mlh1 (mutL homologue 1), has a dual role in DNA repair and apoptosis. Mlh1 acts as a heterodimer in conjunction with Pms2, Pms1 (post-meiotic segregation 1 and 2) or Mlh3 (MutL homologue 3), which function as adaptor proteins that link Msh (MutS homologue) heterodimers to the DNA repair machinery, resulting in excision and repair of the mispaired base [].This entry represents the mismatch repair protein MutL.
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Protein
D3Z0R7
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Publication
10570173 | -
First Author: Wang TF
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
Volume: 96
Issue: 24
Pages: 13914-9
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Protein Domain
IPR038973 | MutL/Mlh/Pms
Type: Family
Description: Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex []. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL homologues share a conserved ATP binding site [].
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Publication
26637282 | J:227115
First Author: Matsuzaki K
Year: 2015
Journal: Genes Dev
Title: FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Volume: 29
Issue: 24
Pages: 2532-46
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Genotype
Genotype
Symbol: Brip1/Brip1 Fancd2/Fancd2
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1202302 | Pms1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
D3YX04
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q9CTA7
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
D3Z611
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Publication
16024043 | -
First Author: Kosinski J
Year: 2005
Journal: J Mol Biol
Title: Analysis of the quaternary structure of the MutL C-terminal domain.
Volume: 351
Issue: 4
Pages: 895-909
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Publication
10946232 | -
First Author: Yang W
Year: 2000
Journal: Mutat Res
Title: Structure and function of mismatch repair proteins.
Volume: 460
Issue: 3-4
Pages: 245-56
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Protein Domain
IPR002099 | DNA_mismatch_repair_N
Type: Domain
Description: This entry represents the N-terminal domain of DNA mismatch repair proteins, such asMutL. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL proteins and their homologues share sequence homology at their N termini over the first 300-400 residues; the C termini are less well conserved, they constitute the main dimerization domain and are required for interaction between MutL and UvrD helicase []. The activity of the protein is modulated by the ATP-dependent dimerization of the N-terminal domain [].The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [].
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Publication
26436461 | -
 
First Author: Kunkel TA
Year: 2015
Journal: Annu Rev Genet
Title: Eukaryotic Mismatch Repair in Relation to DNA Replication.
Volume: 49
Pages: 291-313
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Protein
Q8R407
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: true
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Protein
Q8BZC3
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Publication
26300262 | J:228092
First Author: Traver S
Year: 2015
Journal: Mol Cell
Title: MCM9 Is Required for Mammalian DNA Mismatch Repair.
Volume: 59
Issue: 5
Pages: 831-9
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Publication
33338425 | J:300351
First Author: Lu C
Year: 2021
Journal: Cancer Cell
Title: DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Volume: 39
Issue: 1
Pages: 96-108.e6
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Publication
21113599 | J:166751
First Author: Murdoch B
Year: 2010
Journal: Mamm Genome
Title: Multiple loci contribute to genome-wide recombination levels in male mice.
Volume: 21
Issue: 11-12
Pages: 550-5
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Publication
7980603 | J:21954
First Author: Horii A
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes.
Volume: 204
Issue: 3
Pages: 1257-64
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Publication
9110401 | J:40099
First Author: Prolla TA
Year: 1996
Journal: Semin Cancer Biol
Title: DNA mismatch repair deficient mice in cancer research.
Volume: 7
Issue: 5
Pages: 241-7
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Publication
12483518 | J:81236
First Author: Mukai T
Year: 2002
Journal: Oncogene
Title: Gene silencing in phenomena related to DNA repair.
Volume: 21
Issue: 58
Pages: 9033-42
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Publication
15184874 | J:91458
First Author: Sansom OJ
Year: 2004
Journal: Oncogene
Title: MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.
Volume: 23
Issue: 33
Pages: 5693-6
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Publication
37315918 | J:360449
 
First Author: Bai D
Year: 2023
Journal: Prog Neurobiol
Title: Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.
Volume: 227
Pages: 102484
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Publication
29560090 | J:320563
First Author: Martín-López J
Year: 2018
Journal: Oncotarget
Title: Mutation of TGFβ-RII eliminates NSAID cancer chemoprevention.
Volume: 9
Issue: 16
Pages: 12554-12561
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Protein
Q99L38
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
Q3TRU3
Organism: Mus musculus/domesticus
Length: 997  
Fragment?: true
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Protein
A0A1Y7VJX4
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
Q8C0U7
Organism: Mus musculus/domesticus
Length: 934  
Fragment?: false
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Publication
14527292 | -
 
First Author: Schofield MJ
Year: 2003
Journal: Annu Rev Microbiol
Title: DNA mismatch repair: molecular mechanisms and biological function.
Volume: 57
Pages: 579-608
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Publication
12222686 | -
First Author: Drotschmann K
Year: 2002
Journal: Biol Chem
Title: DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers.
Volume: 383
Issue: 6
Pages: 969-75
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Protein
E9QLM4
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q8CAP8
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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