| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
mitochondrial pyruvate carrier 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
109
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
127
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
86
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
167
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
167
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
109
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
78
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
85
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
109
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the mitochondrial pyruvate carrier proteins, including Mpc 1/2 and their homologues. They mediate the uptake of pyruvate into mitochondria []. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Korner J |
| Year: |
1991 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1. |
| Volume: |
88 |
| Issue: |
15 |
| Pages: |
6834-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goodman LJ |
| Year: |
1994 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Autoproteolytic activation of the mouse prohormone convertase mPC1. |
| Volume: |
201 |
| Issue: |
2 |
| Pages: |
795-804 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seidah NG |
| Year: |
1990 |
| Journal: |
DNA Cell Biol |
| Title: |
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
415-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seidah NG |
| Year: |
1991 |
| Journal: |
Mol Endocrinol |
| Title: |
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. |
| Volume: |
5 |
| Issue: |
1 |
| Pages: |
111-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McCommis KS |
| Year: |
2020 |
| Journal: |
Nat Metab |
| Title: |
Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. |
| Volume: |
2 |
| Issue: |
11 |
| Pages: |
1232-1247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Herzig S |
| Year: |
2023 |
| Journal: |
Biochim Biophys Acta Gen Subj |
| Title: |
Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes. |
| Volume: |
1867 |
| Issue: |
12 |
| Pages: |
130492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Colca JR |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. |
| Volume: |
8 |
| Issue: |
5 |
| Pages: |
e61551 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jutras I |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Two activation states of the prohormone convertase PC1 in the secretory pathway. |
| Volume: |
272 |
| Issue: |
24 |
| Pages: |
15184-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rauckhorst AJ |
| Year: |
2023 |
| Journal: |
Mol Metab |
| Title: |
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury. |
| Volume: |
79 |
|
| Pages: |
101849 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McCommis KS |
| Year: |
2015 |
| Journal: |
Biochem J |
| Title: |
Mitochondrial pyruvate transport: a historical perspective and future research directions. |
| Volume: |
466 |
| Issue: |
3 |
| Pages: |
443-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vanderperre B |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. |
| Volume: |
291 |
| Issue: |
32 |
| Pages: |
16448-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vigueira PA |
| Year: |
2017 |
| Journal: |
Exp Physiol |
| Title: |
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. |
| Volume: |
102 |
| Issue: |
8 |
| Pages: |
985-999 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ftouhi N |
| Year: |
1994 |
| Journal: |
DNA Cell Biol |
| Title: |
Gene organization of the mouse pro-hormone and pro-protein convertase PC1. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
395-407 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu W |
| Year: |
2019 |
| Journal: |
BMC Complement Altern Med |
| Title: |
Weipiling ameliorates gastric precancerous lesions in Atp4a-/- mice. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
318 |
|
•
•
•
•
•
|