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Search results 401 to 496 out of 496 for Ncoa3

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Type Details Score
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26105073 | J:225735
First Author: Störchel PH
Year: 2015
Journal: EMBO J
Title: A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function.
Volume: 34
Issue: 17
Pages: 2237-54
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Allele
Ncoa3<tm1Smoc> | MGI:7291253
Name: nuclear receptor coactivator 3; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ncoa3<tm1Rsd> | MGI:1931861
Name: nuclear receptor coactivator 3; targeted mutation 1, Michael G Rosenfeld
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(MMTV-NCOA3)#Mybr | MGI:5762986
Name: transgene insertion, Myles Brown
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6355044 | B6;129S-Ncoa3<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Ncoa3/Ncoa3
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:5762987 | FVB/N-Tg(MMTV-NCOA3)#Mybr
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(MMTV-NCOA3)#Mybr/?
Background: FVB/N-Tg(MMTV-NCOA3)#Mybr
Zygosity: ot
Has Mutant Allele: true
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Publication
15145939 | -
First Author: Arimura A
Year: 2004
Journal: J Biol Chem
Title: The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.
Volume: 279
Issue: 30
Pages: 31105-12
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Publication
19716257 | -
First Author: Gojis O
Year: 2010
Journal: Eur J Surg Oncol
Title: The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease.
Volume: 36
Issue: 3
Pages: 224-9
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Protein Domain
IPR014920 | Nuc_rcpt_coact_Ncoa-typ
Type: Domain
Description: This entry represents the interlocking domain of the eukaryotic nuclear receptor coactivators Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. In addition to their role as coactivators of various nuclear receptors, Ncoa1 and Ncoa3 both have histone acetyltransferase activity (), but Ncoa2 does not [, ].
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Protein Domain
IPR032565 | NCOA2/3_DUF4927
Type: Domain
Description: This entry represents a domain found in Nuclear receptor coactivators 2/3 (NCOA2/3), which are ligand-dependent transcription factors []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, , ].
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Protein Domain
IPR037077 | Nuc_rcpt_coact_Ncoa_int_sf
Type: Homologous_superfamily
Description: This entry represents the interlockingdomain superfamily of the eukaryotic nuclear receptor coactivators Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. In addition to their role as coactivators of various nuclear receptors, Ncoa1 and Ncoa3 both have histone acetyltransferase activity (), but Ncoa2 does not [, ].
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Protein Domain
IPR009110 | Nuc_rcpt_coact
Type: Homologous_superfamily
Description: This superfamily represents the interlocking domain of various eukaryotic nuclear receptor coactivators, including CREBP, P300, Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein), P300 and ACTR (activator for thyroid and retinoid receptors) []. CBP and P300 both have histone acetyltransferase activity (). CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1 [].Ncoa1, Ncoa2 and Ncoa3 are all coactivators of various nuclear receptors. In addition, Ncoa1 and Ncoa3 both have histone acetyltransferase activity, but Ncoa2 does not [, ].
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Publication
25531332 | J:224797
First Author: Kumar S
Year: 2015
Journal: Oncogene
Title: NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer.
Volume: 34
Issue: 37
Pages: 4879-89
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Publication
19357364 | J:152981
First Author: An BS
Year: 2009
Journal: Biol Reprod
Title: Rapid effect of GNRH1 on follicle-stimulating hormone beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone receptor.
Volume: 81
Issue: 2
Pages: 243-9
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Publication
31975428 | J:297898
First Author: Feng X
Year: 2020
Journal: EMBO J
Title: UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
Volume: 39
Issue: 5
Pages: e102541
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Publication
14757047 | -
First Author: Razeto A
Year: 2004
Journal: J Mol Biol
Title: Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.
Volume: 336
Issue: 2
Pages: 319-29
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Protein
Q8CBM5
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: true
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Publication
12507421 | J:80975
First Author: Picard F
Year: 2002
Journal: Cell
Title: SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
Volume: 111
Issue: 7
Pages: 931-41
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Publication
9430642 | J:45674
First Author: Voegel JJ
Year: 1998
Journal: EMBO J
Title: The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Volume: 17
Issue: 2
Pages: 507-19
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Publication
21854393 | -
First Author: Niessen NA
Year: 2011
Journal: J Neurochem
Title: Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).
Volume: 119
Issue: 3
Pages: 579-93
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Protein Domain
IPR017426 | Nuclear_rcpt_coactivator
Type: Family
Description: This group represents the nuclear receptor coactivator family, also known as the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors []. These receptors can function as molecular switches [].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Protein Domain
IPR010011 | NCO_DUF1518
Type: Domain
Description: This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3), also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [, ].NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion []. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) []. It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors [, , ]. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors []. It can be regulated by sumoylation and ubiquitination []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, ].
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Protein
A0A1W2P7C1
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: true
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Protein
A0A1W2P7S6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: true
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Publication
11583620 | J:71923
First Author: Lin CH
Year: 2001
Journal: Mol Cell
Title: A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies.
Volume: 8
Issue: 3
Pages: 581-90
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Publication
12138096 | -
First Author: Litterst CM
Year: 2002
Journal: J Biol Chem
Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.
Volume: 277
Issue: 39
Pages: 36052-60
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Publication
9427757 | -
First Author: Kalkhoven E
Year: 1998
Journal: EMBO J
Title: Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.
Volume: 17
Issue: 1
Pages: 232-43
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Publication
12954634 | -
First Author: Litterst CM
Year: 2003
Journal: J Biol Chem
Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.
Volume: 278
Issue: 46
Pages: 45340-51
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Publication
11773079 | -
First Author: Giraud S
Year: 2002
Journal: J Biol Chem
Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
Volume: 277
Issue: 10
Pages: 8004-11
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Publication
10449719 | -
First Author: Liu Z
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
Volume: 96
Issue: 17
Pages: 9485-90
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Publication
12529333 | -
First Author: Chauchereau A
Year: 2003
Journal: J Biol Chem
Title: Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
Volume: 278
Issue: 14
Pages: 12335-43
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Protein
Q8C961
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
Q8CE59
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
Q61026
Organism: Mus musculus/domesticus
Length: 1462  
Fragment?: false
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Protein
Q7TPU7
Organism: Mus musculus/domesticus
Length: 1393  
Fragment?: false
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Protein
A6P3E3
Organism: Mus musculus/domesticus
Length: 1393  
Fragment?: false
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Protein
E9PV80
Organism: Mus musculus/domesticus
Length: 1393  
Fragment?: false
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Protein
P70365
Organism: Mus musculus/domesticus
Length: 1447  
Fragment?: false
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Protein
A0A1W2P7D7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q3U3A3
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
A0A1W2P881
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Publication
24220145 | J:227323
First Author: Pfefferle AD
Year: 2013
Journal: Genome Biol
Title: Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.
Volume: 14
Issue: 11
Pages: R125
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Protein
Q8BN74
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
A0A1W2P6K7
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
D3Z4F6
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
Q8C7Y3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q8CAG7
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Protein
B2RWS6
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
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Protein
P45481
Organism: Mus musculus/domesticus
Length: 2441  
Fragment?: false
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Protein
Q8QZV8
Organism: Mus musculus/domesticus
Length: 2429  
Fragment?: true
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Protein
A0A0U1RQB6
Organism: Mus musculus/domesticus
Length: 2403  
Fragment?: false
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Protein
F8VPR5
Organism: Mus musculus/domesticus
Length: 2441  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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