| Type |
Details |
Score |
| Publication |
| First Author: |
Patnaik SR |
| Year: |
2019 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation. |
| Volume: |
76 |
| Issue: |
4 |
| Pages: |
757-775 |
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•
•
•
•
•
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| Publication |
| First Author: |
Abramova N |
| Year: |
2005 |
| Journal: |
Dev Biol |
| Title: |
Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. |
| Volume: |
283 |
| Issue: |
2 |
| Pages: |
269-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nef S |
| Year: |
2005 |
| Journal: |
Dev Biol |
| Title: |
Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. |
| Volume: |
287 |
| Issue: |
2 |
| Pages: |
361-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong W |
| Year: |
2023 |
| Journal: |
PLoS Biol |
| Title: |
An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold. |
| Volume: |
21 |
| Issue: |
8 |
| Pages: |
e3002212 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Garcia-Ortiz JE |
| Year: |
2009 |
| Journal: |
BMC Dev Biol |
| Title: |
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. |
| Volume: |
9 |
|
| Pages: |
36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mager J |
| Year: |
2006 |
| Journal: |
Mamm Genome |
| Title: |
Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. |
| Volume: |
17 |
| Issue: |
9 |
| Pages: |
941-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jones MR |
| Year: |
2018 |
| Journal: |
Front Genet |
| Title: |
A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. |
| Volume: |
9 |
|
| Pages: |
746 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Copeland NG |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data |
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•
•
•
•
•
|
| Publication |
| First Author: |
Desai J |
| Year: |
2006 |
| Journal: |
Hum Mol Genet |
| Title: |
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. |
| Volume: |
15 |
| Issue: |
8 |
| Pages: |
1329-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sansom SN |
| Year: |
2009 |
| Journal: |
PLoS Genet |
| Title: |
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. |
| Volume: |
5 |
| Issue: |
6 |
| Pages: |
e1000511 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
Data Curation Using Mouse Genome Assembly |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jin Y |
| Year: |
2014 |
| Journal: |
Int J Cancer |
| Title: |
NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition. |
| Volume: |
134 |
| Issue: |
10 |
| Pages: |
2294-304 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5428716 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-07-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756620 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:5428873 |
| Age: |
embryonic day 12.5 |
| Image: |
4A |
| Note: |
There was some overlap with Nedd9 expression. |
| Specimen Label: |
4A |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogel T |
| Year: |
2010 |
| Journal: |
Cereb Cortex |
| Title: |
Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component. |
| Volume: |
20 |
| Issue: |
3 |
| Pages: |
661-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Purazo ML |
| Year: |
2023 |
| Journal: |
Cancers (Basel) |
| Title: |
NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer. |
| Volume: |
15 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5428713 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616415 |
| Pattern: |
Regionally restricted |
| Stage: |
TS15 |
| Assay Id: |
MGI:5428735 |
| Age: |
embryonic day 9.5 |
| Image: |
2B |
| Note: |
Expression was detected in regions of the dorsal-ventral axis of neuroepithelium overlapping with Nedd9 expression. Expression was seen in the emerging marginal zone. |
| Specimen Label: |
2B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5428713 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616417 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:5428735 |
| Age: |
embryonic day 10.5 |
| Image: |
2E |
| Note: |
Expression is found in 2 discrete dorso-ventral domains. There is some overlap with Nedd9 expression in the ventricular zone. Highest expression was in the non-overlapping intermediate zone. |
| Specimen Label: |
2E |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Allele |
| Name: |
neural precursor cell expressed, developmentally down-regulated gene 9; mutation 1, Bruce Beutler |
| Allele Type: |
Chemically induced (ENU) |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nedd9/Nedd9 |
| Background: |
C57BL/6J-Nedd9 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tomlins SA |
| Year: |
2006 |
| Journal: |
Cancer Cell |
| Title: |
Of mice and men: cancer gene discovery using comparative oncogenomics. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
2-4 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Enhancer of filamentation 1 (also known as NEDD9 or Cas-L) is a member of the CAS family. It is a scaffolding protein that assembles signaling complexes regulating multiple cellular processes, such as cell adhesion, migration, invasion, and metastasis. It is commonly dysregulated during cancer progression. It interacts with Aurora-A kinase to control ciliary resorption, and with Src and other partners to influence proliferative signaling pathways often activated in autosomal dominant polycystic kidney disease [].CAS (Crk-associated substrate) family members are adaptor proteins that contain a highly conserved N-terminal SH3 domain, an adjacent unstructured domain (substrate domain) containing multiple tyrosine phosphorylation sites that enable binding by SH2-domain containing proteins, a serine-rich four-helix bundle, and a FAT-like C-terminal domain. Most of these domains mediate protein-protein interactions. Through these interactions, they assemble larger signaling complexes that are essential for cell proliferation, survival, migration, and other processes []. The CAS family consists of four members: BCAR1, HEF1, EFS, and CASS4 []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McManus S |
| Year: |
2011 |
| Journal: |
EMBO J |
| Title: |
The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. |
| Volume: |
30 |
| Issue: |
12 |
| Pages: |
2388-404 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanooka H |
| Year: |
2020 |
| Journal: |
Mol Cancer Res |
| Title: |
Bacterial SOS Genes mucAB/umuDC Promote Mouse Tumors by Activating Oncogenes Nedd9/Aurkb via a miR-145 Sponge. |
| Volume: |
18 |
| Issue: |
9 |
| Pages: |
1271-1277 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng Y |
| Year: |
2012 |
| Journal: |
Cancer Res |
| Title: |
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss. |
| Volume: |
72 |
| Issue: |
24 |
| Pages: |
6502-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2011 |
| Journal: |
Oncogene |
| Title: |
HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. |
| Volume: |
30 |
| Issue: |
23 |
| Pages: |
2633-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee KH |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. |
| Volume: |
293 |
| Issue: |
3 |
| Pages: |
847-862 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garron ML |
| Year: |
2009 |
| Journal: |
J Mol Biol |
| Title: |
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. |
| Volume: |
386 |
| Issue: |
1 |
| Pages: |
190-203 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nikonova AS |
| Year: |
2014 |
| Journal: |
IUBMB Life |
| Title: |
CAS proteins in health and disease: an update. |
| Volume: |
66 |
| Issue: |
6 |
| Pages: |
387-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deneka A |
| Year: |
2015 |
| Journal: |
Gene |
| Title: |
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members. |
| Volume: |
570 |
| Issue: |
1 |
| Pages: |
25-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Titz B |
| Year: |
2010 |
| Journal: |
Oncogene |
| Title: |
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. |
| Volume: |
29 |
| Issue: |
44 |
| Pages: |
5895-910 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
194
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
833
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
833
 |
| Fragment?: |
false |
|
•
•
•
•
•
|