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Search results 401 to 453 out of 453 for Nfix

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Type Details Score
Allele
Nfix<em2H> | MGI:6307062
Name: nuclear factor I/X; endonuclease-mediated mutation 2, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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Publication
35618846 | J:342577
First Author: Qin K
Year: 2022
Journal: Nat Genet
Title: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.
Volume: 54
Issue: 6
Pages: 874-884
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Protein
A0A3Q8CJ53
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
F6XYU7
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
F7CDR2
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: true
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Publication
2504497 | -
First Author: Mermod N
Year: 1989
Journal: Cell
Title: The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.
Volume: 58
Issue: 4
Pages: 741-53
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Publication
8543151 | -
First Author: Alevizopoulos A
Year: 1995
Journal: Genes Dev
Title: A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.
Volume: 9
Issue: 24
Pages: 3051-66
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Publication
2339052 | -
First Author: Rupp RA
Year: 1990
Journal: Nucleic Acids Res
Title: Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes.
Volume: 18
Issue: 9
Pages: 2607-16
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Publication
6216480 | -
First Author: Nagata K
Year: 1982
Journal: Proc Natl Acad Sci U S A
Title: Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex.
Volume: 79
Issue: 21
Pages: 6438-42
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Publication
19584245 | -
First Author: Whittle CM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.
Volume: 106
Issue: 29
Pages: 12049-54
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Publication
28962832 | J:249329
 
First Author: Chen KS
Year: 2017
Journal: Cancer Lett
Title: The convergent roles of the nuclear factor I transcription factors in development and cancer.
Volume: 410
Pages: 124-138
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Protein Domain
IPR000647 | CTF/NFI
Type: Family
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [, , ](also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication []. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) []. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans []. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [].
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Protein Domain
IPR020604 | CTF/NFI_DNA-bd-dom
Type: Domain
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [, , ](also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication []. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) []. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans []. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [].This entry represents the 200 amino-acid DNA-binding domain found in N-terminal of CTF/NF1 proteins. It mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The CTF/NF-I DNA-binding domain contains four conserved Cys residues, which are required for its DNA-binding activity [].
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Publication
29700358 | J:263079
First Author: Sakai-Takemura F
Year: 2018
Journal: Sci Rep
Title: Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors.
Volume: 8
Issue: 1
Pages: 6555
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Publication
18335562 | J:137253
First Author: Plachez C
Year: 2008
Journal: J Comp Neurol
Title: Nuclear factor I gene expression in the developing forebrain.
Volume: 508
Issue: 3
Pages: 385-401
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Publication
12514217 | J:81202
First Author: Shu T
Year: 2003
Journal: J Neurosci
Title: Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice.
Volume: 23
Issue: 1
Pages: 203-12
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Publication
24895400 | J:216247
First Author: Deák F
Year: 2014
Journal: J Cell Sci
Title: Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.
Volume: 127
Issue: Pt 15
Pages: 3240-56
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Publication
22886731 | J:187373
First Author: Plachez C
Year: 2012
Journal: J Comp Neurol
Title: Expression of nuclear factor one A and -B in the olfactory bulb.
Volume: 520
Issue: 14
Pages: 3135-49
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Genotype
Genotype
Symbol: Nfia/Nfia Nfib/Nfib Nfix/Nfix Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129S4/SvJae * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nfia/Nfia<+> Nfib/Nfib<+> Nfix/Nfix<+> Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129S4/SvJae * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
1618796 | -
First Author: Novak A
Year: 1992
Journal: J Biol Chem
Title: Four conserved cysteine residues are required for the DNA binding activity of nuclear factor I.
Volume: 267
Issue: 18
Pages: 12986-90
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Protein
P97863
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
P70257
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q02780
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
P70255
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q3UTK6
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q8C434
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
I7HIP8
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
Q3TYK3
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A2BG77
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Q6GSP7
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
Q69ZJ5
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: true
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Protein
Q3UHA6
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q5CZY4
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: true
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Protein
A0A1B0GX74
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
B1AUB8
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
A0A1Y7VK55
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
D3YZ00
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: true
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Protein
Q05B39
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
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Protein
Q6DI81
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
B1AUC0
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
E9PUH7
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
B1AUB6
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
B1AUB9
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Protein
Q8BN68
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
A2ADI3
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
Q3UFE1
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
A2BG76
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
A2BG75
Organism: Mus musculus/domesticus
Length: 560  
Fragment?: false
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Protein Domain
IPR019548 | CTF/NFI_DNA-bd_N
Type: Domain
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [, , ](also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication []. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) []. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans []. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNAreplication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [].This entry represents the N terminus, of which 200 residues contain the DNA-binding and dimerisation domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerisation-ability and the stimulation of adenovirus DNA replication [].
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Protein Domain
IPR019739 | CTF/NFI_DNA-bd_CS
Type: Conserved_site
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [, , ](also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication []. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) []. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans []. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [].This entry represents a specific signature for this family of proteins, which includes the four vertebrate members NFIA, NFIB, NFIC and NFIX. The signature is a perfectly conserved, highly charged 12-residue peptide located in the DNA-binding domain of CTF/NF-I. It does not contain the four conserved Cys residues, which are required for its DNA-binding activity [].
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Publication
37775301 | J:346239
First Author: Keeley PW
Year: 2023
Journal: J Neurosci
Title: Nfia Is Critical for AII Amacrine Cell Production: Selective Bipolar Cell Dependencies and Diminished ERG.
Volume: 43
Issue: 49
Pages: 8367-8384
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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