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Search results 401 to 500 out of 2075 for Numb

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Type Details Score
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST13582F8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST13691F11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST13869A9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14049B9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14052A5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14064C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14181B7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14218F11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14301G11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14461D2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14481A7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14758B11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: NUMB endocytic adaptor protein; gene trap IST14709A8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Genotype
Symbol: Numb/Numb
Background: involves: 129/Sv * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb
Background: involves: 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
GXD Expression
Probe: MGI:5698943
Assay Type: Immunohistochemistry
Annotation Date: 2015-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5698993
Age: embryonic day 10.5
Image: S2B
Note: Expression was detected in the periventricular zone and neuroepithelium. Expression was also in the intermediate zone and in the ganglionic eminences. Staining was distinct from the pattern of Numb staining.
Specimen Label: S2B
Detected: true
Specimen Num: 2
Publication
First Author: Imai T
Year: 2001
Journal: Mol Cell Biol
Title: The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.
Volume: 21
Issue: 12
Pages: 3888-900
Publication
First Author: Bechara EG
Year: 2013
Journal: Mol Cell
Title: RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Volume: 52
Issue: 5
Pages: 720-33
Publication
First Author: Wang Z
Year: 2009
Journal: EMBO J
Title: Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling.
Volume: 28
Issue: 16
Pages: 2360-73
Strain
Attribute String: mutant strain, coisogenic, transgenic
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Genotype
Symbol: Numb/Numb Tg(Nes-cre)1Wmz/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Tg(En2-cre)3Alj/?
Background: involves: 129/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Tg(Vil1-cre/ERT2)23Syr/?
Background: involves: 129/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Allele
Name: transgene insertion JL166, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Genotype
Symbol: Numb/Numb Numbl/Numbl<+>
Background: involves: 129 * 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Strain
Attribute String: mutant strain, targeted mutation
Genotype
Symbol: Numb/Numb Numbl/Numbl Tg(Nes-cre)1Wmz/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Emx1/Emx1<+> Numb/Numb
Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Numbl/Numbl Tg(Nes-cre/Esr1*)4Ynj/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Numbl/Numbl Tg(Mx1-cre)1Cgn/?
Background: involves: 129/Sv * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Strain
Attribute String: mutant stock, transgenic
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Genotype
Symbol: Emx1/Emx1<+> Numb/Numb Numbl/Numbl
Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Numbl/Numbl Nkx2-5/Nkx2-5<+>
Background: involves: 129S1/Sv
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Numb/Numb Numbl/Numbl Nkx2-5/Nkx2-5<+>
Background: involves: 129 * 129S1/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Kawase S
Year: 2014
Journal: Stem Cells Dev
Title: Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Volume: 23
Issue: 18
Pages: 2250-61
Publication
First Author: Juven-Gershon T
Year: 1998
Journal: Mol Cell Biol
Title: The Mdm2 oncoprotein interacts with the cell fate regulator Numb.
Volume: 18
Issue: 7
Pages: 3974-82
Publication
First Author: Kwon C
Year: 2011
Journal: Nat Cell Biol
Title: Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
Volume: 13
Issue: 10
Pages: 1244-51
Publication
First Author: Wang H
Year: 2019
Journal: Cell
Title: Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Volume: 178
Issue: 1
Pages: 135-151.e19
Publication
First Author: Wu MJ
Year: 2019
Journal: Cell Metab
Title: Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin.
Volume: 29
Issue: 4
Pages: 993-1002.e6
Publication
First Author: Will B
Year: 2013
Journal: Nat Immunol
Title: Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.
Volume: 14
Issue: 5
Pages: 437-45
Publication
First Author: Llaó-Cid C
Year: 2024
Journal: Nat Commun
Title: Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.
Volume: 15
Issue: 1
Pages: 10372
Publication
First Author: Pham K
Year: 2015
Journal: J Cell Biol
Title: Asymmetric cell division during T cell development controls downstream fate.
Volume: 210
Issue: 6
Pages: 933-50
Publication
First Author: Zhao Y
Year: 2020
Journal: Geroscience
Title: CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
Volume: 42
Issue: 2
Pages: 595-611
Publication
First Author: Xu J
Year: 2023
Journal: Cell Rep
Title: Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation.
Volume: 42
Issue: 7
Pages: 112677
Publication
First Author: Liu XD
Year: 2018
Journal: J Cell Biol
Title: Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.
Volume: 217
Issue: 11
Pages: 4007-4024
Publication
First Author: Xie Y
Year: 2001
Journal: Biochem Genet
Title: Identification of a human LNX protein containing multiple PDZ domains.
Volume: 39
Issue: 3-4
Pages: 117-26
Publication
First Author: Bultje RS
Year: 2009
Journal: Neuron
Title: Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.
Volume: 63
Issue: 2
Pages: 189-202
Publication  
First Author: Sun M
Year: 2016
Journal: Neurobiol Dis
Title: The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.
Volume: 93
Pages: 1-11
Publication
First Author: Man J
Year: 2018
Journal: Cell Stem Cell
Title: Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells.
Volume: 22
Issue: 1
Pages: 104-118.e6
Publication
First Author: Amson R
Year: 2011
Journal: Nat Med
Title: Reciprocal repression between P53 and TCTP.
Volume: 18
Issue: 1
Pages: 91-9
Publication
First Author: Sharma D
Year: 2022
Journal: Commun Biol
Title: IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy.
Volume: 5
Issue: 1
Pages: 479
Publication  
First Author: Benamar M
Year: 2023
Journal: J Clin Invest
Title: The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Volume: 133
Issue: 1
Publication
First Author: Uemura T
Year: 1989
Journal: Cell
Title: numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.
Volume: 58
Issue: 2
Pages: 349-60
Publication
First Author: Jafar-Nejad H
Year: 2002
Journal: Dev Cell
Title: Numb: "Adapting" notch for endocytosis.
Volume: 3
Issue: 2
Pages: 155-6
Publication
First Author: Zhang L
Year: 2001
Journal: J Biol Chem
Title: A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.
Volume: 276
Issue: 13
Pages: 10463-75
Publication
First Author: Fineberg SK
Year: 2012
Journal: PLoS One
Title: MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation.
Volume: 7
Issue: 6
Pages: e38562
Publication
First Author: Tao T
Year: 2012
Journal: Mol Biol Cell
Title: Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.
Volume: 23
Issue: 14
Pages: 2635-44
Publication
First Author: Gulino A
Year: 2010
Journal: Exp Cell Res
Title: The multiple functions of Numb.
Volume: 316
Issue: 6
Pages: 900-6
Protein Domain
Type: Family
Description: This group represents Protein numb and similar proteins from animals. This protein plays key roles in cell fate determination []. Members of this protein family contain a PID domain, a type of PTB domain []. NUMB from Drosophila is required in determination of cell fate during sensory organ formation in embryos []. It recruits alpha-Adaptin, and this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch [, ]. Numb-related protein 1 (NUMB1) from Caenorhabditis elegans is involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase []. Mammalian Numb-like protein (NUMBL) plays a role in the process of neurogenesis and is required throughout embryonic neurogenesis to maintain neural progenitor cells []. It inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation []. It has a role in tumorigenesis [].
Publication
First Author: Yu F
Year: 2003
Journal: J Cell Sci
Title: A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts.
Volume: 116
Issue: Pt 5
Pages: 887-96
Publication
First Author: Lenihan JA
Year: 2014
Journal: Gene
Title: Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.
Volume: 552
Issue: 1
Pages: 39-50
Publication
First Author: Yuan FP
Year: 2006
Journal: Hum Reprod
Title: Cryptorchidism in LhrKO animals and the effect of testosterone-replacement therapy.
Volume: 21
Issue: 4
Pages: 936-42
Publication
First Author: Yin FT
Year: 2015
Journal: Stem Cells Dev
Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
Volume: 24
Issue: 5
Pages: 640-52
Publication
First Author: Cottage CT
Year: 2010
Journal: Circ Res
Title: Cardiac progenitor cell cycling stimulated by pim-1 kinase.
Volume: 106
Issue: 5
Pages: 891-901
Publication
First Author: Lenihan JA
Year: 2017
Journal: PLoS One
Title: Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.
Volume: 12
Issue: 11
Pages: e0187352
Publication
First Author: Coffey AR
Year: 2019
Journal: Physiol Genomics
Title: microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.
Volume: 51
Issue: 2
Pages: 59-71
Publication  
First Author: Lee SJ
Year: 2023
Journal: Int J Mol Sci
Title: Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos.
Volume: 24
Issue: 2
Publication
First Author: Choi HY
Year: 2024
Journal: Exp Mol Med
Title: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.
Volume: 56
Issue: 2
Pages: 461-477
Publication
First Author: El-Hashash AH
Year: 2011
Journal: Development
Title: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium.
Volume: 138
Issue: 7
Pages: 1395-407
Protein
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 36  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Smith WJ
Year: 2003
Journal: J Biol Chem
Title: Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions.
Volume: 278
Issue: 7
Pages: 4949-56
Protein Domain
Type: Homologous_superfamily
Description: Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [, , ]. PH domains have a partly opened β-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1) [], Shc adaptor and Numb []; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1 []; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein []; and to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin [].This superfamily represents the PH domain and structurally related domains.
Publication  
First Author: Glazer RI
Year: 2012
Journal: Front Biosci (Landmark Ed)
Title: Musashi1: an RBP with versatile functions in normal and cancer stem cells.
Volume: 17
Pages: 54-64
Publication
First Author: Kawahara H
Year: 2008
Journal: J Cell Biol
Title: Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.
Volume: 181
Issue: 4
Pages: 639-53
Publication
First Author: Wuebben EL
Year: 2012
Journal: PLoS One
Title: Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells.
Volume: 7
Issue: 4
Pages: e34827