| Type |
Details |
Score |
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST13582F8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST13691F11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST13869A9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14049B9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14052A5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14064C9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14181B7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14218F11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14301G11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14461D2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14481A7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14758B11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NUMB endocytic adaptor protein; gene trap IST14709A8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb |
| Background: |
involves: 129/Sv * FVB/N |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
728
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
628
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
257
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5698943 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2015-12-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689417 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:5698993 |
| Age: |
embryonic day 10.5 |
| Image: |
S2B |
| Note: |
Expression was detected in the periventricular zone and neuroepithelium. Expression was also in the intermediate zone and in the ganglionic eminences. Staining was distinct from the pattern of Numb staining. |
| Specimen Label: |
S2B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Imai T |
| Year: |
2001 |
| Journal: |
Mol Cell Biol |
| Title: |
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. |
| Volume: |
21 |
| Issue: |
12 |
| Pages: |
3888-900 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bechara EG |
| Year: |
2013 |
| Journal: |
Mol Cell |
| Title: |
RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation. |
| Volume: |
52 |
| Issue: |
5 |
| Pages: |
720-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2009 |
| Journal: |
EMBO J |
| Title: |
Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling. |
| Volume: |
28 |
| Issue: |
16 |
| Pages: |
2360-73 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Tg(Nes-cre)1Wmz/? |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Tg(En2-cre)3Alj/? |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Tg(Vil1-cre/ERT2)23Syr/? |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion JL166, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl<+> |
| Background: |
involves: 129 * 129S1/Sv * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl Tg(Nes-cre)1Wmz/? |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Emx1/Emx1<+> Numb/Numb |
| Background: |
involves: 129S2/SvPas * 129X1/SvJ * CD-1 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl Tg(Nes-cre/Esr1*)4Ynj/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl Tg(Mx1-cre)1Cgn/? |
| Background: |
involves: 129/Sv * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Emx1/Emx1<+> Numb/Numb Numbl/Numbl |
| Background: |
involves: 129S2/SvPas * 129X1/SvJ * CD-1 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl Nkx2-5/Nkx2-5<+> |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Numb/Numb Numbl/Numbl Nkx2-5/Nkx2-5<+> |
| Background: |
involves: 129 * 129S1/Sv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawase S |
| Year: |
2014 |
| Journal: |
Stem Cells Dev |
| Title: |
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. |
| Volume: |
23 |
| Issue: |
18 |
| Pages: |
2250-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Juven-Gershon T |
| Year: |
1998 |
| Journal: |
Mol Cell Biol |
| Title: |
The Mdm2 oncoprotein interacts with the cell fate regulator Numb. |
| Volume: |
18 |
| Issue: |
7 |
| Pages: |
3974-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kwon C |
| Year: |
2011 |
| Journal: |
Nat Cell Biol |
| Title: |
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. |
| Volume: |
13 |
| Issue: |
10 |
| Pages: |
1244-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang H |
| Year: |
2019 |
| Journal: |
Cell |
| Title: |
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. |
| Volume: |
178 |
| Issue: |
1 |
| Pages: |
135-151.e19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu MJ |
| Year: |
2019 |
| Journal: |
Cell Metab |
| Title: |
Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. |
| Volume: |
29 |
| Issue: |
4 |
| Pages: |
993-1002.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Will B |
| Year: |
2013 |
| Journal: |
Nat Immunol |
| Title: |
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. |
| Volume: |
14 |
| Issue: |
5 |
| Pages: |
437-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Llaó-Cid C |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
10372 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pham K |
| Year: |
2015 |
| Journal: |
J Cell Biol |
| Title: |
Asymmetric cell division during T cell development controls downstream fate. |
| Volume: |
210 |
| Issue: |
6 |
| Pages: |
933-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao Y |
| Year: |
2020 |
| Journal: |
Geroscience |
| Title: |
CD82-TRPM7-Numb signaling mediates age-related cognitive impairment. |
| Volume: |
42 |
| Issue: |
2 |
| Pages: |
595-611 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu J |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation. |
| Volume: |
42 |
| Issue: |
7 |
| Pages: |
112677 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu XD |
| Year: |
2018 |
| Journal: |
J Cell Biol |
| Title: |
Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1. |
| Volume: |
217 |
| Issue: |
11 |
| Pages: |
4007-4024 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xie Y |
| Year: |
2001 |
| Journal: |
Biochem Genet |
| Title: |
Identification of a human LNX protein containing multiple PDZ domains. |
| Volume: |
39 |
| Issue: |
3-4 |
| Pages: |
117-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bultje RS |
| Year: |
2009 |
| Journal: |
Neuron |
| Title: |
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. |
| Volume: |
63 |
| Issue: |
2 |
| Pages: |
189-202 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun M |
| Year: |
2016 |
| Journal: |
Neurobiol Dis |
| Title: |
The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. |
| Volume: |
93 |
|
| Pages: |
1-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Man J |
| Year: |
2018 |
| Journal: |
Cell Stem Cell |
| Title: |
Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells. |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
104-118.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Amson R |
| Year: |
2011 |
| Journal: |
Nat Med |
| Title: |
Reciprocal repression between P53 and TCTP. |
| Volume: |
18 |
| Issue: |
1 |
| Pages: |
91-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma D |
| Year: |
2022 |
| Journal: |
Commun Biol |
| Title: |
IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy. |
| Volume: |
5 |
| Issue: |
1 |
| Pages: |
479 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Benamar M |
| Year: |
2023 |
| Journal: |
J Clin Invest |
| Title: |
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. |
| Volume: |
133 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uemura T |
| Year: |
1989 |
| Journal: |
Cell |
| Title: |
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. |
| Volume: |
58 |
| Issue: |
2 |
| Pages: |
349-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jafar-Nejad H |
| Year: |
2002 |
| Journal: |
Dev Cell |
| Title: |
Numb: "Adapting" notch for endocytosis. |
| Volume: |
3 |
| Issue: |
2 |
| Pages: |
155-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang L |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. |
| Volume: |
276 |
| Issue: |
13 |
| Pages: |
10463-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fineberg SK |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation. |
| Volume: |
7 |
| Issue: |
6 |
| Pages: |
e38562 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tao T |
| Year: |
2012 |
| Journal: |
Mol Biol Cell |
| Title: |
Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation. |
| Volume: |
23 |
| Issue: |
14 |
| Pages: |
2635-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gulino A |
| Year: |
2010 |
| Journal: |
Exp Cell Res |
| Title: |
The multiple functions of Numb. |
| Volume: |
316 |
| Issue: |
6 |
| Pages: |
900-6 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This group represents Protein numb and similar proteins from animals. This protein plays key roles in cell fate determination []. Members of this protein family contain a PID domain, a type of PTB domain []. NUMB from Drosophila is required in determination of cell fate during sensory organ formation in embryos []. It recruits alpha-Adaptin, and this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch [, ]. Numb-related protein 1 (NUMB1) from Caenorhabditis elegans is involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase []. Mammalian Numb-like protein (NUMBL) plays a role in the process of neurogenesis and is required throughout embryonic neurogenesis to maintain neural progenitor cells []. It inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation []. It has a role in tumorigenesis []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu F |
| Year: |
2003 |
| Journal: |
J Cell Sci |
| Title: |
A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. |
| Volume: |
116 |
| Issue: |
Pt 5 |
| Pages: |
887-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lenihan JA |
| Year: |
2014 |
| Journal: |
Gene |
| Title: |
Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability. |
| Volume: |
552 |
| Issue: |
1 |
| Pages: |
39-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan FP |
| Year: |
2006 |
| Journal: |
Hum Reprod |
| Title: |
Cryptorchidism in LhrKO animals and the effect of testosterone-replacement therapy. |
| Volume: |
21 |
| Issue: |
4 |
| Pages: |
936-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yin FT |
| Year: |
2015 |
| Journal: |
Stem Cells Dev |
| Title: |
Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells. |
| Volume: |
24 |
| Issue: |
5 |
| Pages: |
640-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cottage CT |
| Year: |
2010 |
| Journal: |
Circ Res |
| Title: |
Cardiac progenitor cell cycling stimulated by pim-1 kinase. |
| Volume: |
106 |
| Issue: |
5 |
| Pages: |
891-901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lenihan JA |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase. |
| Volume: |
12 |
| Issue: |
11 |
| Pages: |
e0187352 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Coffey AR |
| Year: |
2019 |
| Journal: |
Physiol Genomics |
| Title: |
microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO. |
| Volume: |
51 |
| Issue: |
2 |
| Pages: |
59-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SJ |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos. |
| Volume: |
24 |
| Issue: |
2 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi HY |
| Year: |
2024 |
| Journal: |
Exp Mol Med |
| Title: |
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. |
| Volume: |
56 |
| Issue: |
2 |
| Pages: |
461-477 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
El-Hashash AH |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. |
| Volume: |
138 |
| Issue: |
7 |
| Pages: |
1395-407 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
46
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
117
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
67
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
105
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
36
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
95
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
160
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
123
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
48
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
51
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
243
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
200
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
146
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
147
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
193
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
192
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith WJ |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. |
| Volume: |
278 |
| Issue: |
7 |
| Pages: |
4949-56 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [, , ]. PH domains have a partly opened β-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1) [], Shc adaptor and Numb []; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1 []; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein []; and to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin [].This superfamily represents the PH domain and structurally related domains. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Glazer RI |
| Year: |
2012 |
| Journal: |
Front Biosci (Landmark Ed) |
| Title: |
Musashi1: an RBP with versatile functions in normal and cancer stem cells. |
| Volume: |
17 |
|
| Pages: |
54-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawahara H |
| Year: |
2008 |
| Journal: |
J Cell Biol |
| Title: |
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. |
| Volume: |
181 |
| Issue: |
4 |
| Pages: |
639-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wuebben EL |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
e34827 |
|
•
•
•
•
•
|