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Search results 401 to 500 out of 844 for Pam

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Type Details Score
Protein
Q7TPH6
Organism: Mus musculus/domesticus
Length: 4749  
Fragment?: false
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Publication
33207196 | J:353214
First Author: Apaydin DC
Year: 2020
Journal: Cell Rep
Title: Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance.
Volume: 33
Issue: 7
Pages: 108404
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Publication
31152133 | J:277443
First Author: Lakhal-Littleton S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.
Volume: 116
Issue: 26
Pages: 13122-13130
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Protein
Q7TPH6-2
Organism: Mus musculus/domesticus
Length: 4746  
Fragment?: false
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Publication
29748232 | -
First Author: Yuan M
Year: 2018
Journal: Biochem J
Title: An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Volume: 475
Issue: 10
Pages: 1821-1837
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Protein Coding Gene
MGI:1913699 | Pam16
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97343
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Allele
Brip1<em3Peco> | MGI:7616327
Name: BRCA1 interacting protein C-terminal helicase 1; endonuclease-mediated mutation 3, Paula E Cohen
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag
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HT Experiment
GSE123024 | Deep single-cell RNAseq of Gpnmb+Clec7a+ microglia from postnatal day 7 cerebellum
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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GO Term
GO:0004504 | peptidylglycine monooxygenase activity
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Protein Coding Gene
MGI:1334416 | Grpel2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914963 | Dnajc19
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1334417 | Grpel1
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Mpz<em4Tcp> | MGI:7256899
Name: myelin protein zero; endonuclease-mediated mutation 4, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:7258020 | C57BL/6NCrl-Mpz<em4Tcp>/Tcp
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7720788 | C57BL/6J-Brip1<em3Peco>/Mmjax
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Muc13<em1Gltr> | MGI:7707731
Name: mucin 13, epithelial transmembrane; endonuclease-mediated mutation 1, Alban Gaultier
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Coding Gene
MGI:1913398 | Dnajc15
Type: protein_coding_gene
Organism: mouse, laboratory
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HT Experiment
GSE123022 | Deep single-cell RNAseq of postnatal day 7 microglia from wild type and Trem2 knockout brains
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:2179432 | Mycbp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Nxph4<em1Hzo> | MGI:6307097
Name: neurexophilin 4; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag
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Allele
Myh7<em1Dsr> | MGI:6360203
Name: myosin, heavy polypeptide 7, cardiac muscle, beta; endonuclease-mediated mutation 1, Deepak Srivastava
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Mrtfb<em1Dsr> | MGI:6360207
Name: myocardin related transcription factor B; endonuclease-mediated mutation 1, Deepak Srivastava
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Kcnb1<em3Kea> | MGI:6755225
Name: potassium voltage gated channel, Shab-related subfamily, member 1; endonuclease-mediated mutation 3, Jennifer Kearney
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Kcnq2<em8Lutzy> | MGI:6883657
Name: potassium voltage-gated channel, subfamily Q, member 2; endonuclease-mediated mutation 8, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Lhcgr<em1Laj> | MGI:7482672
Name: luteinizing hormone/choriogonadotropin receptor; endonuclease-mediated mutation 1, Laurinda Jaffe
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag
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Allele
Alas2<em2Mdf> | MGI:7780118
 
Name: aminolevulinic acid synthase 2, erythroid; endonuclease-mediated mutation 2, Mark D Fleming
Allele Type: Endonuclease-mediated
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Allele
Alas2<em3Mdf> | MGI:7780120
 
Name: aminolevulinic acid synthase 2, erythroid; endonuclease-mediated mutation 3, Mark D Fleming
Allele Type: Endonuclease-mediated
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Allele
Azin1<em1Hato> | MGI:7857185
 
Name: antizyme inhibitor 1; endonuclease-mediated mutation 1, Takashi Hato
Allele Type: Endonuclease-mediated
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Allele
Azin1<em2Hato> | MGI:7857186
 
Name: antizyme inhibitor 1; endonuclease-mediated mutation 2, Takashi Hato
Allele Type: Endonuclease-mediated
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Publication
24634220 | -
First Author: Chen H
Year: 2014
Journal: J Biol Chem
Title: Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease.
Volume: 289
Issue: 19
Pages: 13284-94
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Protein Domain
IPR032237 | Cas9_PI
Type: Domain
Description: This entry represents a domain found in the C-terminal of bacterial type II CRISPR system Cas9 endonuclease. This domain adopts a novel protein fold that is unique to the Cas9 family. It is positioned in the structure-DNA-complex to recognise the PAM sequence on the non-complementary DNA strand of the crRNA. PAM sequence is protospacer-adjacent motifs on DNA. Cas9 carries two nuclease domains, HNH and RuvC, which cleave the DNA strands that are complementary and non-complementary to the 20 nucleotide guide sequence in crRNAs, respectively [].
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Protein Domain
IPR017303 | Tim44
Type: Family
Description: Tim44 is an essential component of the PAM complex, which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. It recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source [].
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Allele
Kcnb1<em1Kea> | MGI:6272702
Name: potassium voltage gated channel, Shab-related subfamily, member 1; endonuclease-mediated mutation 1, Jennifer Kearney
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Gsdmd<em2Broz> | MGI:6285140
Name: gasdermin D; endonuclease-mediated mutation 2, Petr Broz
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6307098 | C57BL/6J-Nxph4<em1Hzo>/J
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
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Allele
Polr3b<em5Tcp> | MGI:6323011
Name: polymerase (RNA) III (DNA directed) polypeptide B; endonuclease-mediated mutation 5, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Arc<em1Pfw> | MGI:6356322
Name: activity regulated cytoskeletal-associated protein; endonuclease-mediated mutation 1, Paul Worley
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Tnni3k<em4Hsv> | MGI:6506814
Name: TNNI3 interacting kinase; endonuclease-mediated mutation 4, Henry M Sucov
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Gabrg1<em1Ktka> | MGI:6506870
Name: gamma-aminobutyric acid type A receptor subunit gamma 1; endonuclease-mediated mutation 1, Kristopher T Kahle
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Strain
MGI:7607863 | STOCK Kcnb1<em3Kea>/Mmucd
Attribute String: mutant stock, endonuclease-mediated mutation
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Allele
L1cam<em2Msch> | MGI:6782865
Name: L1 cell adhesion molecule; endonuclease-mediated mutation 2, Melitta Schachner
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:6883658 | C57BL/6J-Kcnq2<em8Lutzy>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7482673 | C57BL/6J-Lhcgr<em1Laj>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
37847612 | J:347914
First Author: Owen CM
Year: 2024
Journal: Biol Reprod
Title: Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle†.
Volume: 110
Issue: 2
Pages: 288-299
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Allele
Kcnq2<em3Frk> | MGI:7384667
Name: potassium voltage-gated channel, subfamily Q, member 2; endonuclease-mediated mutation 3, Wayne Frankel
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Sptlc1<em2Rwb> | MGI:7427573
Name: serine palmitoyltransferase, long chain base subunit 1; endonuclease-mediated mutation 2, Robert W Burgess
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Il1a<em1Tdk> | MGI:7431279
Name: interleukin 1 alpha; endonuclease-mediated mutation 1, Thirumala-Devi Kanneganti
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mmut<em2Cpv> | MGI:7431126
Name: methylmalonyl-Coenzyme A mutase; endonuclease-mediated mutation 2, Charles P Venditti
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Matr3<em3Lutzy> | MGI:7451262
Name: matrin 3; endonuclease-mediated mutation 3, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Gt(ROSA)26Sor<em1Crx> | MGI:7461949
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Colin Ross
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Allele
Dnmt3a<em1Tcp> | MGI:7587755
Name: DNA methyltransferase 3A; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:7707732 | C57BL/6J-Muc13<em1Gltr>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
38579936 | J:352635
 
First Author: Rivet-Noor CR
Year: 2024
Journal: Brain Behav Immun
Title: Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors.
Volume: 119
Pages: 665-680
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Allele
Alas2<em1Mdf> | MGI:7780116
 
Name: aminolevulinic acid synthase 2, erythroid; endonuclease-mediated mutation 1, Mark D Fleming
Allele Type: Endonuclease-mediated
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Strain
MGI:7780119 | C57BL/6N-Alas2<em2Mdf>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7780121 | C57BL/6N-Alas2<em3Mdf>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Alas2<em7Mdf> | MGI:7780128
 
Name: aminolevulinic acid synthase 2, erythroid; endonuclease-mediated mutation 7, Mark D Fleming
Allele Type: Endonuclease-mediated
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Allele
Hdac8<em1Lutzy> | MGI:7783542
Name: histone deacetylase 8; endonuclease-mediated mutation 1, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Strain
MGI:7860815 | C57BL/6J-Azin1<em1Hato>/J
Attribute String: coisogenic, endonuclease-mediated mutation, inbred strain
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Strain
MGI:7860818 | C57BL/6J-Azin1<em2Hato>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Myh7/Myh7
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myh7/Myh7<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrtfb/Mrtfb
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
9837933 | J:51422
First Author: Chen L
Year: 1998
Journal: J Biol Chem
Title: P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.
Volume: 273
Issue: 50
Pages: 33524-32
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Publication
10339406 | J:55629
First Author: Bauer MF
Year: 1999
Journal: J Mol Biol
Title: Genetic and structural characterization of the human mitochondrial inner membrane translocase.
Volume: 289
Issue: 1
Pages: 69-82
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Publication
28306506 | -
First Author: Yamada M
Year: 2017
Journal: Mol Cell
Title: Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.
Volume: 65
Issue: 6
Pages: 1109-1121.e3
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Protein Domain
IPR039544 | Tim44-like
Type: Family
Description: This entry includes mitochondrial import inner membrane translocase subunit Tim44 andits bacterial homologues. All possess a Tim44-like domain.Tim44 is an essential component of the PAM complex, which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. It recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source [].
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Protein Domain
IPR040555 | Cas9_PI2
Type: Domain
Description: This domain is found in Cas9 proteins from some bacteria, such as Staphylococcus aureus. Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. When this domain is combined with the C-terminal domain it is called the Pam-interacting (PI) domain. The Cas9 orthologs from different microbes have highly divergent sequences but their PI domains share a conserved core fold andrecognize distinct PAM sequences [].
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Publication
31151856 | J:276388
First Author: Zhang W
Year: 2019
Journal: Mol Cell
Title: Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.
Volume: 75
Issue: 1
Pages: 13-25.e5
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Allele
Polr3a<em1(IMPC)Tcp> | MGI:5755028
Name: polymerase (RNA) III (DNA directed) polypeptide A; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Hsd17b4<em1(IMPC)Tcp> | MGI:6156445
Name: hydroxysteroid (17-beta) dehydrogenase 4; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6865942 | C57BL/6J-Kcnb1<em1Kea>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
30902848 | J:272519
     
First Author: Chen KW
Year: 2019
Journal: EMBO J
Title: Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
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Allele
Hsd17b4<em2(IMPC)Tcp> | MGI:6316190
Name: hydroxysteroid (17-beta) dehydrogenase 4; endonuclease-mediated mutation 2, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Ano6<em2Tcp> | MGI:6323004
Name: anoctamin 6; endonuclease-mediated mutation 2, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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Allele
Slc17a8<em1(icre/ERT2)Zyliu> | MGI:6384614
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; endonuclease-mediated mutation 1, Zhiyong Liu
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:6384618 | B6(Cg)-Slc17a8<em1(icre/ERT2)Zyliu>/J
Attribute String: mutant strain, endonuclease-mediated mutation
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Allele
Tnni3k<em1Hsv> | MGI:6384879
Name: TNNI3 interacting kinase; endonuclease-mediated mutation 1, Henry M Sucov
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Atxn1<em1Hzo> | MGI:6501714
Name: ataxin 1; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Strain
MGI:6501715 | C57BL/6J-Atxn1<em1Hzo>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Atxn1<em2Hzo> | MGI:6501717
 
Name: ataxin 1; endonuclease-mediated mutation 2, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
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Publication
33083721 | J:299761
First Author: Dong W
Year: 2020
Journal: iScience
Title: Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.
Volume: 23
Issue: 10
Pages: 101552
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Allele
Adamts7<em1Macb> | MGI:6779988
 
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7; endonuclease-mediated mutation 1, Bryan MacDonald
Allele Type: Endonuclease-mediated
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Strain
MGI:6779989 | C57BL/6J-Adamts7<em1Macb>/Mmjax
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Sar1b<em2Emle> | MGI:7331422
Name: secretion associated Ras related GTPase 1B; endonuclease-mediated mutation 2, Emile Levy
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Fxn<em10Lutzy> | MGI:7316637
Name: frataxin; endonuclease-mediated mutation 10, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Dmrt1<em1Zark> | MGI:7366910
Name: doublesex and mab-3 related transcription factor 1; endonuclease-mediated mutation 1, David Zarkower
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Strain
MGI:7384668 | B6.Cg-Kcnq2<em3Frk>/Mmjax
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7427574 | C57BL/6J-Sptlc1<em2Rwb>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7431280 | C57BL/6J-Il1a<em1Tdk>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7451263 | C57BL/6J-Matr3<em3Lutzy>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
36689813 | J:334515
 
First Author: Dominick M
Year: 2023
Journal: Biochem Biophys Res Commun
Title: MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
Volume: 645
Pages: 164-172
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Strain
MGI:7461950 | C57BL/6J-Gt(ROSA)26Sor<em1Crx>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Flrt2<em1Jnk> | MGI:7505615
 
Name: fibronectin leucine rich transmembrane protein 2; endonuclease-mediated mutation 1, Jeremy Kay
Allele Type: Endonuclease-mediated
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Allele
Atxn1<em1Horr> | MGI:7565688
 
Name: ataxin 1; endonuclease-mediated mutation 1, Harry T Orr
Allele Type: Endonuclease-mediated
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Strain
MGI:7567388 | B6(129S7)-Atxn1<em1Horr>
Attribute String: endonuclease-mediated mutation, mutant strain
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Allele
Hapln1<em2Mbp> | MGI:7606965
Name: hyaluronan and proteoglycan link protein 1; endonuclease-mediated mutation 2, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Ntrk2<em1(cre)Bxu> | MGI:7612056
Name: neurotrophic tyrosine kinase, receptor, type 2; endonuclease-mediated mutation 1,Baoji Xu
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Strain
MGI:7612057 | C57BL/6J-Ntrk2<em1(cre)Bxu>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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