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Search results 401 to 500 out of 519 for Pdxk

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Image: MH967; Specimen C1101
Specimen Label: MH967; Specimen C1101
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1789623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_12
Specimen Label: euxassay_007254_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Specimen Label: MH967; Specimen C1101
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Specimen Label: MH967; Specimen C1101
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Specimen Label: MH967; Specimen C1101
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_11
Specimen Label: euxassay_007254_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_12
Specimen Label: euxassay_007254_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_17
Specimen Label: euxassay_007254_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_18
Specimen Label: euxassay_007254_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:2663949
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666370
Age: embryonic day 10.5
Image: 2
Note: This is one of the tissues with the strongest expression level.
Specimen Label: 2
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_07
Specimen Label: euxassay_007254_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_09
Specimen Label: euxassay_007254_09
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_10
Specimen Label: euxassay_007254_10
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_18
Specimen Label: euxassay_007254_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH967; Specimen C1101
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_11
Specimen Label: euxassay_007254_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_12
Specimen Label: euxassay_007254_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_15
Specimen Label: euxassay_007254_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_16
Specimen Label: euxassay_007254_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_17
Specimen Label: euxassay_007254_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724713
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421370
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH967; Specimen C1101
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_07
Specimen Label: euxassay_007254_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_08
Specimen Label: euxassay_007254_08
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_09
Specimen Label: euxassay_007254_09
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_10
Specimen Label: euxassay_007254_10
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_11
Specimen Label: euxassay_007254_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_12
Specimen Label: euxassay_007254_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_13
Specimen Label: euxassay_007254_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_14
Specimen Label: euxassay_007254_14
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_15
Specimen Label: euxassay_007254_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:451882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827140
Age: embryonic day 14.5
Image: euxassay_007254_16
Specimen Label: euxassay_007254_16
Detected: true
Specimen Num: 16
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•
Publication
35850054 | J:327503
 
First Author: Xu Z
Year: 2022
Journal: Int Immunopharmacol
Title: Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.
Volume: 110
Pages: 108941
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Publication
38060382 | J:344223
First Author: Zhang W
Year: 2023
Journal: Cell Rep
Title: NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.
Volume: 42
Issue: 12
Pages: 113531
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Publication
27434733 | J:238763
First Author: Choo HJ
Year: 2016
Journal: Stem Cells
Title: Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
Volume: 34
Issue: 11
Pages: 2784-2797
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Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
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Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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•
•
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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•
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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•
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Dp(10Prmt2-Pdxk)2Yey | MGI:4461400
 
Name: duplication, Chr 10, Y Eugene Yu 2
Allele Type: Targeted
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Allele
Del(10Prmt2-Pdxk)4Yey | MGI:4818358
Name: deletion, Chr 10, Y Eugene Yu 4
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:4461782 | B6.129S7-Dp(10Prmt2-Pdxk)2Yey
Attribute String: targeted mutation, congenic, duplication, mutant strain
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Strain
MGI:6148940 | B6JNimr.129S7-Dp(10Prmt2-Pdxk)2Yey/YeyH
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:5657901 | B6;129S7-Dp(10Prmt2-Pdxk)2Yey/J
Attribute String: mutant stock, duplication
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Publication
26557979 | J:273979
 
First Author: Block A
Year: 2015
Journal: Biol Sex Differ
Title: Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome.
Volume: 6
Pages: 24
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Strain
MGI:4818581 | 129S/SvEv-Del(10Prmt2-Pdxk)129S/SvEv-Del(10Prmt2-Pdxk)4Yey
Attribute String: targeted mutation, mutant strain, deletion, coisogenic
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Strain
MGI:5285625 | 129S-Del(10Prmt2-Pdxk)4Yey/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Dp(10Prmt2-Pdxk)2Yey/?
Background: B6.129S7-Dp(10Prmt2-Pdxk)2Yey
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(10Prmt2-Pdxk)4Yey/+
Background: 129S/SvEv-Del(10Prmt2-Pdxk)129S/SvEv-Del(10Prmt2-Pdxk)4Yey
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR004625 | PyrdxlKinase
Type: Family
Description: Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the ε-amino group of an active site lysine residue on the enzyme. The α-amino group of the substrate displaces the lysine ε-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents pyridoxal kinase (), which is required for the synthesis of pyridoxal-5-phosphate from vitamin B6, and catalyses the conversion of pyridoxal to pyridoxal 5'-phosphate in the presence of ATP. Escherichia coli has an enzyme PdxK that acts in vitroas a pyridoxine/pyridoxal/pyridoxamine kinase,but mutants lacking PdxK activity retain a specific pyridoxamine kinase, PdxY []. PdxY acts in the salvage pathway of pyridoxal 5'-phosphate biosynthesis. Mammalian forms of pyridoxal kinase are more similar to PdxY than to PdxK.
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Strain
MGI:4461778 | B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey
Attribute String: targeted mutation, mutant strain, duplication, congenic
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Strain
MGI:4461780 | B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(17Abcg1-Rrp1b)3Yey
Attribute String: congenic, duplication, mutant strain, targeted mutation
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Publication
28970008 | J:253867
First Author: Gally F
Year: 2018
Journal: Biochim Biophys Acta
Title: The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome.
Volume: 1864
Issue: 1
Pages: 126-132
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Genotype
Genotype
Symbol: Dp(10Prmt2-Pdxk)2Yey/? Dp(17Abcg1-Rrp1b)3Yey/?
Background: B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(17Abcg1-Rrp1b)3Yey
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dp(10Prmt2-Pdxk)2Yey/? Dp(16Lipi-Zbtb21)1Yey/?
Background: B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:4461776 | B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey
Attribute String: congenic, duplication, mutant strain, targeted mutation
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Publication
31628327 | J:281677
First Author: Powers RK
Year: 2019
Journal: Nat Commun
Title: Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Volume: 10
Issue: 1
Pages: 4766
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Publication
39120971 | J:357279
First Author: Donovan MG
Year: 2024
Journal: Cell Rep
Title: Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome.
Volume: 43
Issue: 8
Pages: 114599
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Publication
36656118 | J:332837
   
First Author: Jewett CE
Year: 2023
Journal: Elife
Title: Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development.
Volume: 12
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Publication
26230397 | J:238605
First Author: Belichenko PV
Year: 2015
Journal: PLoS One
Title: Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.
Volume: 10
Issue: 7
Pages: e0134861
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Publication
20932954 | J:166931
 
First Author: Yu T
Year: 2010
Journal: Brain Res
Title: Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.
Volume: 1366
Pages: 162-71
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Publication
33207208 | J:300601
First Author: Tuttle KD
Year: 2020
Journal: Cell Rep
Title: JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.
Volume: 33
Issue: 7
Pages: 108407
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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