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Search results 401 to 426 out of 426 for Pik3cg

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0.019s

Type

Details

Score

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Allele

Pik3cg<em1Smoc> | MGI:7291655

Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Strain

MGI:6429359 | C57BL/6JSmoc-Pik3Cg<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Protein

Q9JHG7

Organism:	Mus musculus/domesticus
Length:	1102
Fragment?:	false

•

Allele

Pik3cg<tm1Dwu> | MGI:1858011

Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 1, Dianqing Wu
Allele Type:	Targeted
Attribute String:	Null/knockout, Reporter

•

Strain

MGI:4358210 | B6.Cg-Pik3cg<tm1Dwu>

Attribute String:

targeted mutation, mutant strain, congenic

•

Strain

MGI:5532939 | B6N.129-Pik3cg<tm1Dwu>/J

Attribute String:

congenic, mutant strain, targeted mutation

•

Genotype

Symbol:	Pik3cg/Pik3cg
Background:	Not Specified
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Pik3cg/Pik3cg
Background:	B6.Cg-Pik3cg
Zygosity:	hm
Has Mutant Allele:	true

•

HT Experiment

E-GEOD-26111 | Whole-genome gene expression profiling of Pik3cg-depleted mice

Series Id:	GSE26111
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Strain

MGI:4358309 | B6.Cg-Apoe<tm1Unc> Pik3cg<tm1Dwu>

Attribute String:

congenic, mutant strain, targeted mutation

•

Genotype

Symbol:	Apoe/Apoe Pik3cg/Pik3cg
Background:	B6.Cg-Apoe Pik3cg
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

23428429 | J:198151

First Author:	Nguyen AH
Year:	2013
Journal:	Hum Mol Genet
Title:	Gata3 antagonizes cancer progression in Pten-deficient prostates.
Volume:	22
Issue:	12
Pages:	2400-10

•

Publication

21738486 | J:356916

First Author:	Paul DS
Year:	2011
Journal:	PLoS Genet
Title:	Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.
Volume:	7
Issue:	6
Pages:	e1002139

•

Publication

11136978 | -

First Author:	Pacold ME
Year:	2000
Journal:	Cell
Title:	Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.
Volume:	103
Issue:	6
Pages:	931-43

•

Protein Domain

IPR045580 | PIK3CG_ABD

Type:

Domain

Description:

This entry represents the N-terminal domain of PI3-kinase catalytic subunit gamma (PIK3CG, also known as p110 catalytic subunit gamma). This domain contains the adaptor-binding domain (ABD). PIK3CG interacts with the regulatory subunit of the p101 type [, , ].Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped into three classes based on their domain organisation. Class I PI3Ks are heterodimers consisting of a p110 catalytic subunit and a regulatory subunit of either the p85 type (associated with the class IA p110 isoforms p110alpha, p110beta or p110delta) or the p101 type (associated with the class IB p110isoform p110gamma). Common to all catalytic subunits are an N-terminal adaptor-binding domain (ABD) that binds to p85/p101, a Ras-binding domain (RBD), a putative membrane-binding domain (C2), a helical domain of unknown function, and a kinase catalytic domain [, , ].PI3K_ABD is a small globular domain of about 100 residues in length with an alpha/β-sandwich topology [, , ].

•

Genotype

Symbol:	Pik3cg/Pik3cg Tg(TcraTcrb)1100Mjb/?
Background:	involves: C57BL/6
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

20081827 | -

First Author:	Berndt A
Year:	2010
Journal:	Nat Chem Biol
Title:	The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Volume:	6
Issue:	2
Pages:	117-24

•

Publication

17626883 | -

First Author:	Miled N
Year:	2007
Journal:	Science
Title:	Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
Volume:	317
Issue:	5835
Pages:	239-42

•

Publication

18079394 | -

First Author:	Huang CH
Year:	2007
Journal:	Science
Title:	The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Volume:	318
Issue:	5857
Pages:	1744-8

•

Protein

Q9EQL1

Organism:	Mus musculus/domesticus
Length:	1113
Fragment?:	false

•

Protein

Q3V1C0

Organism:	Mus musculus/domesticus
Length:	1102
Fragment?:	false

•

Protein

A0A1W2P8F6

Organism:	Mus musculus/domesticus
Length:	1024
Fragment?:	false

•

Protein

Q3UVA4

Organism:	Mus musculus/domesticus
Length:	1102
Fragment?:	false

•

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