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Search results 401 to 472 out of 472 for Pim1

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0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
A0A0N4SWG1
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
E9QA84
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
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Protein
A0A067XG46
Organism: Mus musculus/domesticus
Length: 1039  
Fragment?: false
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Protein
E9QA48
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
A0A0N4SVW7
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Protein
G3UZ62
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
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Protein
A2ADP2
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
F6ZTZ2
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
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Protein
F6X7I4
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
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Protein
Q9D5K7
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: false
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Protein
A0A1L1SUM5
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q3UTY5
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
E9Q7J4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A0A668KLT2
Organism: Mus musculus/domesticus
Length: 882  
Fragment?: false
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Protein
A0A1W2P735
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: false
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Protein
Q548B0
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
A2ADP5
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
A0A087WSC7
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Protein
Q8CAJ5
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
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Protein
E9Q3W8
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
A2CER2
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
Q9D3M1
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q3U6D2
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q8CDM3
Organism: Mus musculus/domesticus
Length: 972  
Fragment?: false
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Publication
8331083 | -
First Author: Tojo N
Year: 1993
Journal: J Bacteriol
Title: The lonD gene is homologous to the lon gene encoding an ATP-dependent protease and is essential for the development of Myxococcus xanthus.
Volume: 175
Issue: 14
Pages: 4545-9
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Protein Domain
IPR008268 | Peptidase_S16_AS
Type: Active_site
Description: Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].This signature defines the active site of the serine peptidases belonging to the MEROPS peptidase family S16 (lon protease family, clan SF). These proteases which are dependent on the hydrolysis of ATP for their activity and have a serine in their active site, they include:Bacterial ATP-dependent proteases [, ]. The prototype of those bacterial enzymes is the Escherichia coli La protease () (gene lon). La is capable of hydrolysing large proteins; it degrades short-lived regulatory (such as rcsA and sulA) and abnormal proteins. It is a cytoplasmic protein of 87kDa that associates as an homotetramer. Its proteolytic activity is stimulated by single-stranded DNA.Eukaryotic mitochondrial matrix proteases [, ]. The prototype of these enzymes is the yeast PIM1 protease. It is a mitochondrial matrix protein of 120kDa that associated as an homohexamer. It catalyses the initial step of mitochondrial protein degradation.Haemophilus influenzae lon-B (HI1324), a protein which does not contain the ATP-binding domain, but possess a slightly divergent form of the catalytic domain.
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Protein
Q8C7D2
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Publication
8294008 | -
First Author: Thomas CD
Year: 1993
Journal: Gene
Title: Controlled high-level expression of the lon gene of Escherichia coli allows overproduction of Lon protease.
Volume: 136
Issue: 1-2
Pages: 237-42
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Protein
Q9D417
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q6NXM2
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
Q99LJ7
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q8CGK3
Organism: Mus musculus/domesticus
Length: 949  
Fragment?: false
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Protein
Q9DBN5
Organism: Mus musculus/domesticus
Length: 852  
Fragment?: false
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Protein
F2Z461
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: false
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Protein
Q6PAV2
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
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Protein
Q9CYM1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
E9Q3B1
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q80U90
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: true
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Protein
Q8BTL0
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
Q3V2D0
Organism: Mus musculus/domesticus
Length: 953  
Fragment?: false
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Protein
Q8CFQ0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Protein
G5E876
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
A0A0R4J025
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
A6H6S0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Publication
9425059 | -
First Author: Roudiak SG
Year: 1998
Journal: Biochemistry
Title: The lon protease from Mycobacterium smegmatis: molecular cloning, sequence analysis, functional expression, and enzymatic characterization.
Volume: 37
Issue: 1
Pages: 377-86
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Publication
3042779 | -
First Author: Chin DT
Year: 1988
Journal: J Biol Chem
Title: Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La.
Volume: 263
Issue: 24
Pages: 11718-28
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Publication
8226758 | -
First Author: Fischer H
Year: 1993
Journal: J Biol Chem
Title: ATP hydrolysis is not stoichiometrically linked with proteolysis in the ATP-dependent protease La from Escherichia coli.
Volume: 268
Issue: 30
Pages: 22502-7
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Publication
10672180 | -
First Author: Robertson GT
Year: 2000
Journal: Mol Microbiol
Title: The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB/c mice.
Volume: 35
Issue: 3
Pages: 577-88
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Publication
17216028 | -
First Author: Lee I
Year: 2006
Journal: Mol Biosyst
Title: Recent developments in the mechanistic enzymology of the ATP-dependent Lon protease from Escherichia coli: highlights from kinetic studies.
Volume: 2
Issue: 10
Pages: 477-83
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Protein
Q56A16
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: true
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Protein
Q6ZPR6
Organism: Mus musculus/domesticus
Length: 1352  
Fragment?: false
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Protein
Q9Z0Z7
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q9D1A6
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
A0A087WNN3
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
Q923C0
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
D3YY23
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: false
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Protein
Q9D4H7
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
A0A182DWE6
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Protein
F6ZE64
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
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Protein
B2RT44
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
Q8K1R7
Organism: Mus musculus/domesticus
Length: 984  
Fragment?: false
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Protein
Q69Z43
Organism: Mus musculus/domesticus
Length: 1005  
Fragment?: true
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Protein
Q920R0
Organism: Mus musculus/domesticus
Length: 1651  
Fragment?: false
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Protein
Q91ZR4
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
Q8BK80
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
E9PZP8
Organism: Mus musculus/domesticus
Length: 4859  
Fragment?: false
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Protein
Q4U2R1
Organism: Mus musculus/domesticus
Length: 4836  
Fragment?: false
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Protein
Q7TPH6
Organism: Mus musculus/domesticus
Length: 4749  
Fragment?: false
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Protein
F6SMY7
Organism: Mus musculus/domesticus
Length: 4636  
Fragment?: true
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Protein
C6EQH2
Organism: Mus musculus/domesticus
Length: 4746  
Fragment?: false
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Publication
7845208 | -
 
First Author: Rawlings ND
Year: 1994
Journal: Methods Enzymol
Title: Families of serine peptidases.
Volume: 244
Pages: 19-61
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Publication
8439290 | -
 
First Author: Rawlings ND
Year: 1993
Journal: Biochem J
Title: Evolutionary families of peptidases.
Volume: 290 ( Pt 1)
Pages: 205-18
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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