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Search results 401 to 458 out of 458 for Plcg1

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 794
Description: Interaction with PLCG1
Type: site
End: 794
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UniProt Feature
UniProt Feature
Begin: 816
Description: Interaction with PLCG1
Type: site
End: 816
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Publication
9048927 | J:38343
First Author: Argyrokastritis A
Year: 1997
Journal: Hum Genet
Title: Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17.
Volume: 99
Issue: 2
Pages: 233-6
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Publication
32973083 | J:299181
First Author: Kim KB
Year: 2020
Journal: Cancer Res
Title: FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer.
Volume: 80
Issue: 22
Pages: 5051-5062
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UniProt Feature
UniProt Feature
Begin: 766
Description: Mediates interaction with PLCG1 and SHB
Type: site
End: 766
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Pathway
R-MMU-9026527 | Activated NTRK2 signals through PLCG1
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Pathway
R-MMU-9034793 | Activated NTRK3 signals through PLCG1
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Allele
Lat<tm1.1Lov> | MGI:2388631
Name: linker for activation of T cells; targeted mutation 1.1, Paul E Love
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
15194811 | -
First Author: Yin X
Year: 2004
Journal: Mol Biol Cell
Title: Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.
Volume: 15
Issue: 8
Pages: 3938-49
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Protein Domain
IPR016279 | PLC-gamma
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets. A third form, plc-3, is known from Caenorhabditis elegans [].
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Publication
11602179 | -
First Author: Wilde JI
Year: 2001
Journal: Cell Signal
Title: Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?
Volume: 13
Issue: 10
Pages: 691-701
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Publication
20807769 | -
First Author: Gresset A
Year: 2010
Journal: J Biol Chem
Title: Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.
Volume: 285
Issue: 46
Pages: 35836-47
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Publication
17229814 | -
First Author: Wang Y
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.
Volume: 292
Issue: 5
Pages: C1775-86
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Protein Domain
IPR028380 | PLC-gamma1
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.PLC-gamma-1 may have a role in actin reorganisation and cell migration [].
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Publication
16380508 | J:118835
First Author: Koonpaew S
Year: 2006
Journal: J Exp Med
Title: LAT-mediated signaling in CD4+CD25+ regulatory T cell development.
Volume: 203
Issue: 1
Pages: 119-29
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Genotype
Genotype
Symbol: Lat/Lat
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:97384 | Ntrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88145 | Bdnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97380 | Ntf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97381 | Ntf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97385 | Ntrk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P21237
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
P20181
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
Q6VNS1
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
Q80VU4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
P15209
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Publication
22236196 | -
First Author: Ombrello MJ
Year: 2012
Journal: N Engl J Med
Title: Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
Volume: 366
Issue: 4
Pages: 330-8
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Publication
23000145 | -
First Author: Zhou Q
Year: 2012
Journal: Am J Hum Genet
Title: A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
Volume: 91
Issue: 4
Pages: 713-20
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Protein Domain
IPR028381 | PLC-gamma2
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.This entry represents PLCg2. Mutations in PLCg2 gene cause familial cold autoinflammatory syndrome 3 (FCAS3), whcih is an autosomal dominant immune disorder charactersed by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure []. Mutations in PLCg2 gene also cause autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID), which is an autosomal dominant systemic disorder characterised by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues [].
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Publication
23825558 | J:203457
First Author: Sommers CL
Year: 2013
Journal: PLoS One
Title: miRNA signature of mouse helper T cell hyper-proliferation.
Volume: 8
Issue: 6
Pages: e66709
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Genotype
Genotype
Symbol: Lat/Lat Lat2/Lat2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Publication
19667175 | J:151946
First Author: Miyaji M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Volume: 106
Issue: 34
Pages: 14502-7
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Publication
15795236 | J:98048
First Author: Sommers CL
Year: 2005
Journal: J Exp Med
Title: Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
Volume: 201
Issue: 7
Pages: 1125-34
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Protein
Q9Z2S5
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Protein
Q3TUJ5
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
G3V016
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
17081783 | J:116157
First Author: Zhu M
Year: 2006
Journal: Immunity
Title: Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.
Volume: 25
Issue: 5
Pages: 757-68
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Publication
26121028 | J:233886
First Author: Rouquette-Jazdanian AK
Year: 2015
Journal: PLoS One
Title: miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.
Volume: 10
Issue: 6
Pages: e0131823
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Protein
F6SLL0
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
G3UXP4
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Protein
Q8CIH5
Organism: Mus musculus/domesticus
Length: 1265  
Fragment?: false
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Protein
Q2M4I9
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
Q3UZ68
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
A2A4A6
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
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