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Search results 401 to 500 out of 2635 for Prc1

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Type Details Score
Publication
23028147 | J:188258
First Author: Golden MG
Year: 2012
Journal: Genes Dev
Title: Polycomb repressive complex 1 activities determine the columnar organization of motor neurons.
Volume: 26
Issue: 19
Pages: 2236-50
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Publication
31043422 | J:284122
 
First Author: Menon DU
Year: 2019
Journal: Development
Title: Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.
Volume: 146
Issue: 19
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Publication
12167701 | J:78427
First Author: Levine SS
Year: 2002
Journal: Mol Cell Biol
Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
Volume: 22
Issue: 17
Pages: 6070-8
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Publication
22269950 | J:183700
First Author: Hisada K
Year: 2012
Journal: Mol Cell Biol
Title: RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.
Volume: 32
Issue: 6
Pages: 1139-49
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Publication
19585519 | J:152848
First Author: Martínez-Romero C
Year: 2009
Journal: J Pathol
Title: The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
Volume: 219
Issue: 2
Pages: 205-13
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Publication
20808772 | J:198334
First Author: Negishi M
Year: 2010
Journal: PLoS One
Title: A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.
Volume: 5
Issue: 8
Pages: e12373
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Publication
16625203 | J:109026
First Author: Boyer LA
Year: 2006
Journal: Nature
Title: Polycomb complexes repress developmental regulators in murine embryonic stem cells.
Volume: 441
Issue: 7091
Pages: 349-53
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Publication
23727134 | J:205366
First Author: Qi L
Year: 2013
Journal: Int J Dev Neurosci
Title: The dynamics of polycomb group proteins in early embryonic nervous system in mouse and human.
Volume: 31
Issue: 7
Pages: 487-95
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HT Experiment
GSE153496 | H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
19462008 | J:148837
First Author: Agherbi H
Year: 2009
Journal: PLoS One
Title: Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
Volume: 4
Issue: 5
Pages: e5622
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Protein
H3BK63
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Publication
9199346 | -
First Author: Satijn DP
Year: 1997
Journal: Mol Cell Biol
Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
Volume: 17
Issue: 7
Pages: 4105-13
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Publication
14999091 | -
First Author: Qin H
Year: 2004
Journal: Nucleic Acids Res
Title: RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.
Volume: 32
Issue: 4
Pages: 1492-501
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Publication
9858531 | -
First Author: Satijn DP
Year: 1999
Journal: Mol Cell Biol
Title: RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
Volume: 19
Issue: 1
Pages: 57-68
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Protein Domain
IPR043540 | RING1/RING2
Type: Family
Description: E3 ubiquitin-protein ligase RING1 () is one of the three E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, which is a specific tag for repression of epigenetic transcription and particularly for inactivation of chromosome X of female mammals [, ]. RING1 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, the repressive BCOR complex [], and the the E2F6.com-1 complex in G0 phase []. RING1 has a RING-type zinc finger.E3 ubiquitin-protein ligase RING2 () mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex [].This entry includes E3 ubiquitin-protein ligase RING1/RING2.
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Protein Domain
IPR042741 | RING1_RING-HC
Type: Domain
Description: RING1 is a transcriptional repressor associated with the Polycomb group (PcG) protein complex involved in stable repression of gene activity. It is a core component of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase that transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119 []. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing []. RING1 interacts with multiple PcG proteins and displays tumorigenic activity[]. It also shows zinc-dependent DNA binding activity. Moreover, RING1 inhibits transactivation of the DNA-binding protein recombination signal binding protein-Jkappa (RBP-J) by Notch through interaction with the LIM domains of KyoT2 []. RING1 contains a C3HC4-type RING-HC finger [].
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Protein
E9Q796
Organism: Mus musculus/domesticus
Length: 901  
Fragment?: false
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Protein
Q99MW4
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
B1AVB1
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
B1AVB5
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
B1AVB4
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q8BYC8
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
B1AVB2
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Publication
20445021 | J:163504
First Author: Majewski IJ
Year: 2010
Journal: Blood
Title: Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.
Volume: 116
Issue: 5
Pages: 731-9
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Publication
34113809 | J:354990
First Author: Maat H
Year: 2021
Journal: iScience
Title: The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.
Volume: 24
Issue: 5
Pages: 102435
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Publication
34857746 | J:316496
First Author: Mochizuki K
Year: 2021
Journal: Nat Commun
Title: Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
Volume: 12
Issue: 1
Pages: 7020
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Publication
20417598 | J:162938
First Author: Kang X
Year: 2010
Journal: Mol Cell
Title: SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
Volume: 38
Issue: 2
Pages: 191-201
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Publication
28304275 | J:258919
   
First Author: Endoh M
Year: 2017
Journal: Elife
Title: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.
Volume: 6
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Publication
34504070 | J:324262
First Author: Sugishita H
Year: 2021
Journal: Nat Commun
Title: Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.
Volume: 12
Issue: 1
Pages: 5341
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Publication
25066234 | J:319964
First Author: Kakarougkas A
Year: 2014
Journal: Mol Cell
Title: Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.
Volume: 55
Issue: 5
Pages: 723-32
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Publication
19737517 | J:153894
First Author: Sing A
Year: 2009
Journal: Cell
Title: A vertebrate Polycomb response element governs segmentation of the posterior hindbrain.
Volume: 138
Issue: 5
Pages: 885-97
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Publication
20569692 | J:161360
First Author: Pereira CF
Year: 2010
Journal: Cell Stem Cell
Title: ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
Volume: 6
Issue: 6
Pages: 547-56
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Publication
20573702 | J:163855
First Author: Alder O
Year: 2010
Journal: Development
Title: Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
Volume: 137
Issue: 15
Pages: 2483-92
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Publication
23256043 | J:197876
 
First Author: Farcas AM
Year: 2012
Journal: Elife
Title: KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.
Volume: 1
Pages: e00205
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Publication
23473600 | J:198132
First Author: Simon JA
Year: 2013
Journal: Mol Cell
Title: Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.
Volume: 49
Issue: 5
Pages: 808-24
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Publication
27025988 | J:236826
 
First Author: Suzuki A
Year: 2016
Journal: Nat Commun
Title: Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells.
Volume: 7
Pages: 11056
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Publication
27317809 | J:240248
First Author: Grijzenhout A
Year: 2016
Journal: Development
Title: Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.
Volume: 143
Issue: 15
Pages: 2716-23
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Publication
29220657 | J:254686
First Author: Pintacuda G
Year: 2017
Journal: Mol Cell
Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
Volume: 68
Issue: 5
Pages: 955-969.e10
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Publication
31327655 | J:278963
First Author: Su W
Year: 2019
Journal: Cancer Cell
Title: The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
Volume: 36
Issue: 2
Pages: 139-155.e10
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Publication
32479258 | J:290220
   
First Author: Sato T
Year: 2020
Journal: Elife
Title: Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.
Volume: 9
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Publication
33990559 | J:306096
First Author: Chen L
Year: 2021
Journal: Nat Commun
Title: PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus.
Volume: 12
Issue: 1
Pages: 2829
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Publication
38228142 | J:359739
First Author: Del Vecchio A
Year: 2024
Journal: Dev Cell
Title: PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Volume: 59
Issue: 3
Pages: 368-383.e7
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Publication
35640597 | J:325355
First Author: Rong Y
Year: 2022
Journal: Nucleic Acids Res
Title: USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.
Volume: 50
Issue: 10
Pages: 5599-5616
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Publication
23523425 | -
First Author: Junco SE
Year: 2013
Journal: Structure
Title: Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Volume: 21
Issue: 4
Pages: 665-71
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Publication
27136092 | J:248956
First Author: Si S
Year: 2016
Journal: PLoS One
Title: Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.
Volume: 11
Issue: 5
Pages: e0154561
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Publication
25470042 | J:217377
First Author: Bhatnagar S
Year: 2014
Journal: Nature
Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Volume: 516
Issue: 7529
Pages: 116-20
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Publication
26699484 | J:228497
First Author: Gu Y
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.
Volume: 113
Issue: 1
Pages: E51-60
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Publication
28577303 | J:253445
First Author: Jackson JT
Year: 2017
Journal: Stem Cells
Title: Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a.
Volume: 35
Issue: 8
Pages: 1948-1957
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Publication
33821003 | J:305254
First Author: Mei H
Year: 2021
Journal: Nat Genet
Title: H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
Volume: 53
Issue: 4
Pages: 539-550
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Publication
29784807 | J:263006
First Author: Guo J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.
Volume: 115
Issue: 23
Pages: E5326-E5333
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Publication
26847029 | J:231455
First Author: Cao Q
Year: 2016
Journal: Leukemia
Title: BCOR regulates myeloid cell proliferation and differentiation.
Volume: 30
Issue: 5
Pages: 1155-65
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Publication
32439758 | J:290852
 
First Author: Postlmayr A
Year: 2020
Journal: Development
Title: Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
Volume: 147
Issue: 11
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Publication
37266576 | J:350447
   
First Author: Nakajima-Takagi Y
Year: 2023
Journal: Elife
Title: Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.
Volume: 12
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Publication
30097555 | J:267035
 
First Author: Maezawa S
Year: 2018
Journal: J Cell Sci
Title: SCML2 promotes heterochromatin organization in late spermatogenesis.
Volume: 131
Issue: 17
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Publication
31171700 | J:284182
First Author: Plys AJ
Year: 2019
Journal: Genes Dev
Title: Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
Volume: 33
Issue: 13-14
Pages: 799-813
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Publication
31471323 | J:294563
First Author: Isshiki Y
Year: 2019
Journal: Blood Adv
Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
Volume: 3
Issue: 17
Pages: 2537-2549
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Publication
22012622 | J:177487
First Author: Grau DJ
Year: 2011
Journal: Genes Dev
Title: Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge.
Volume: 25
Issue: 20
Pages: 2210-21
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Publication
22396653 | J:183399
First Author: Dietrich N
Year: 2012
Journal: PLoS Genet
Title: REST-mediated recruitment of polycomb repressor complexes in mammalian cells.
Volume: 8
Issue: 3
Pages: e1002494
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Publication
23257781 | J:196910
First Author: Radulović V
Year: 2013
Journal: Leukemia
Title: Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms.
Volume: 27
Issue: 3
Pages: 523-33
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Publication
24285299 | J:212360
First Author: Basu A
Year: 2014
Journal: Nucleic Acids Res
Title: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.
Volume: 42
Issue: 4
Pages: 2208-23
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Publication
27081692 | J:233752
First Author: Eid A
Year: 2016
Journal: Epigenetics
Title: Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.
Volume: 11
Issue: 6
Pages: 389-97
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Publication
27170439 | J:236330
First Author: Klaus ES
Year: 2016
Journal: Biol Reprod
Title: Murine and Human Spermatids Are Characterized by Numerous, Newly Synthesized and Differentially Expressed Transcription Factors and Bromodomain-Containing Proteins.
Volume: 95
Issue: 1
Pages: 4
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Publication
29959227 | J:270662
First Author: Zhao W
Year: 2018
Journal: J Biol Chem
Title: The polycomb group protein Yaf2 regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.
Volume: 293
Issue: 33
Pages: 12793-12804
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Publication
32562308 | J:329438
First Author: Zhou CJ
Year: 2020
Journal: FEBS J
Title: Protein regulator of cytokinesis 1 regulates chromosome dynamics and cytoplasmic division during mouse oocyte meiotic maturation and early embryonic development.
Volume: 287
Issue: 23
Pages: 5130-5147
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Protein
Q80VG1
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
A0A087WQQ3
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein
B1AVB3
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
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Publication
32692983 | J:296645
First Author: Hamline MY
Year: 2020
Journal: Dev Biol
Title: OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR.
Volume: 468
Issue: 1-2
Pages: 110-132
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Protein Coding Gene
MGP_CAROLIEiJ_G0017061 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0017490 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0020030 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0021436 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0024905 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0026502 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_CAROLIEiJ_G0026927 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0019473 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0022090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0023551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0027126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0028805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0029254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022051 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028764 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018974 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022026 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023478 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018977 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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