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Search results 401 to 500 out of 1091 for Pth

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Type Details Score
Publication
16455048 | J:105866
First Author: Hurley MM
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.
Volume: 341
Issue: 4
Pages: 989-94
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Publication
19851510 | J:154038
First Author: Yu S
Year: 2009
Journal: PLoS One
Title: Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone.
Volume: 4
Issue: 10
Pages: e7583
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Publication
22623742 | J:186648
First Author: Muehleisen B
Year: 2012
Journal: Sci Transl Med
Title: PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.
Volume: 4
Issue: 135
Pages: 135ra66
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Publication
28162969 | J:256743
First Author: Fan Y
Year: 2017
Journal: Cell Metab
Title: Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.
Volume: 25
Issue: 3
Pages: 661-672
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Publication
30902975 | J:273371
First Author: Saito H
Year: 2019
Journal: Nat Commun
Title: TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
Volume: 10
Issue: 1
Pages: 1354
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Publication
9751523 | J:148679
First Author: Li YC
Year: 1998
Journal: Endocrinology
Title: Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice.
Volume: 139
Issue: 10
Pages: 4391-6
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Publication
23109343 | J:193763
First Author: Liu L
Year: 2012
Journal: J Biol Chem
Title: Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis.
Volume: 287
Issue: 52
Pages: 43312-21
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Publication
36729662 | J:353045
 
First Author: Alekos NS
Year: 2023
Journal: JCI Insight
Title: Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation.
Volume: 8
Issue: 6
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Publication
16303601 | J:112753
First Author: Zhan P
Year: 2005
Journal: Prostaglandins Other Lipid Mediat
Title: Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotes.
Volume: 78
Issue: 1-4
Pages: 19-26
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Publication
27759007 | J:240495
 
First Author: Wein MN
Year: 2016
Journal: Nat Commun
Title: SIKs control osteocyte responses to parathyroid hormone.
Volume: 7
Pages: 13176
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Publication
21427221 | J:173962
First Author: Christov M
Year: 2011
Journal: Endocrinology
Title: Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis.
Volume: 152
Issue: 5
Pages: 2031-6
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Publication
1973379 | J:10623
First Author: Hendy GN
Year: 1990
Journal: Cytogenet Cell Genet
Title: Gene for parathyroid hormone-like peptide is on mouse chromosome 6.
Volume: 53
Issue: 2-3
Pages: 80-2
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Publication
8900396 | J:35879
First Author: Darwish HM
Year: 1996
Journal: Arch Biochem Biophys
Title: Analysis of binding of the 1,25-dihydroxyvitamin D3 receptor to positive and negative vitamin D response elements.
Volume: 334
Issue: 2
Pages: 223-34
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Publication
18680714 | J:140132
First Author: Gao Y
Year: 2008
Journal: Cell Metab
Title: T cells potentiate PTH-induced cortical bone loss through CD40L signaling.
Volume: 8
Issue: 2
Pages: 132-45
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Publication
20032048 | J:160031
First Author: Naveh-Many T
Year: 2010
Journal: Endocrinology
Title: Minireview: the play of proteins on the parathyroid hormone messenger ribonucleic Acid regulates its expression.
Volume: 151
Issue: 4
Pages: 1398-402
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Publication
25917456 | J:225853
 
First Author: Han SI
Year: 2015
Journal: Mol Cell Endocrinol
Title: Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Volume: 411
Pages: 113-20
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Publication
30429466 | J:268410
First Author: Wu Y
Year: 2018
Journal: Nat Commun
Title: Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Volume: 9
Issue: 1
Pages: 4772
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Publication
21268064 | J:319590
First Author: Hanyu R
Year: 2011
Journal: J Cell Biochem
Title: Per-1 is a specific clock gene regulated by parathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH.
Volume: 112
Issue: 2
Pages: 433-8
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Protein Domain
IPR002170 | GPCR_2_parathyroid_rcpt
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The secretin-like GPCRs include secretin [], calcitonin [], parathyroid hormone/parathyroid hormone-related peptides []and vasoactive intestinal peptide [], all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). Their N-terminal is probably located on the extracellular side of the membrane and potentially glycosylated. This N-terminal region contains a long conserved region which allows the binding of large peptidic ligand such as glucagon, secretin, VIP and PACAP; this region contains five conserved cysteines residues which could be involved in disulphide bond. The C-terminal region of these receptor is probably cytoplasmic. Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. Parathyroid hormone (PTH) is involved in calcium homeostasis within the body in combination with calcitonin and vitamin D. PTH is released in response to hypocalcaemia and stimulates a rise in blood calcium; the converse is true for calcitonin. The principle targets for PTH are bone and kidney. Antagonists at the PTH receptor are of potential clinical use in the treatment of hyperparathyroidism and short-term hypercalcaemic states. In addition to its presence in bone and kidney, the receptor is found in lower levels in blood vessels, where it mediates vasodilation. The principle second messenger pathway is activation of adenylyl cyclase through G proteins. In addition, PTH stimulates phosphoinositide metabolism on the expressed receptor.
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Publication
24854272 | J:244742
First Author: Fenton RA
Year: 2014
Journal: J Am Soc Nephrol
Title: Renal phosphate wasting in the absence of adenylyl cyclase 6.
Volume: 25
Issue: 12
Pages: 2822-34
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Publication
29950683 | J:271705
First Author: Ehara Y
Year: 2018
Journal: Hypertens Res
Title: Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice.
Volume: 41
Issue: 9
Pages: 699-707
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Publication
21561999 | J:175280
First Author: Gattineni J
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.
Volume: 301
Issue: 2
Pages: F371-7
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Publication
20685873 | J:165676
First Author: Kawai M
Year: 2010
Journal: Endocrinology
Title: Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.
Volume: 151
Issue: 10
Pages: 4861-70
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Publication
25228504 | J:242968
First Author: Standal T
Year: 2014
Journal: J Endocrinol
Title: gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
Volume: 223
Issue: 2
Pages: 181-90
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Publication
21239498 | J:170631
First Author: Hisa I
Year: 2011
Journal: J Biol Chem
Title: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.
Volume: 286
Issue: 11
Pages: 9787-96
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Publication
27102152 | J:248011
First Author: van der Eerden BC
Year: 2016
Journal: Oncotarget
Title: Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.
Volume: 7
Issue: 18
Pages: 24928-41
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Publication
870607 | J:5804
First Author: Raisz LG
Year: 1977
Journal: J Exp Med
Title: Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators.
Volume: 145
Issue: 4
Pages: 857-65
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Publication
18505371 | J:153411
First Author: Huang MS
Year: 2008
Journal: J Bone Miner Res
Title: Hyperlipidemia impairs osteoanabolic effects of PTH.
Volume: 23
Issue: 10
Pages: 1672-9
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Publication
29662200 | J:271599
First Author: Weske S
Year: 2018
Journal: Nat Med
Title: Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss.
Volume: 24
Issue: 5
Pages: 667-678
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Publication
12933685 | J:85591
First Author: Chiusaroli R
Year: 2003
Journal: Endocrinology
Title: Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments.
Volume: 144
Issue: 9
Pages: 4106-16
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Publication
10021460 | J:53079
First Author: Zhao W
Year: 1999
Journal: J Clin Invest
Title: Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice.
Volume: 103
Issue: 4
Pages: 517-24
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Publication
33861790 | J:305397
First Author: Sakunrangsit N
Year: 2021
Journal: PLoS One
Title: Etanercept prevents TNF-α mediated mandibular bone loss in FcγRIIb-/- lupus model.
Volume: 16
Issue: 4
Pages: e0250215
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Publication
16081645 | J:129838
First Author: Koh AJ
Year: 2005
Journal: Endocrinology
Title: Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone.
Volume: 146
Issue: 11
Pages: 4584-96
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Publication
23297399 | J:195999
First Author: Cho SW
Year: 2013
Journal: J Biol Chem
Title: The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.
Volume: 288
Issue: 10
Pages: 6814-25
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Publication
15956054 | J:102452
First Author: O'Brien CA
Year: 2005
Journal: Am J Physiol Endocrinol Metab
Title: IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.
Volume: 289
Issue: 5
Pages: E784-93
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Publication
23291186 | J:198076
First Author: Lu J
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.
Volume: 431
Issue: 1
Pages: 19-24
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Publication
20489161 | J:175050
First Author: Cheng SL
Year: 2010
Journal: Circ Res
Title: Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis.
Volume: 107
Issue: 2
Pages: 271-82
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Publication
35622784 | J:325119
First Author: Wanna-Udom S
Year: 2022
Journal: PLoS One
Title: High phosphate intake induces bone loss in nephrectomized thalassemic mice.
Volume: 17
Issue: 5
Pages: e0268732
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Publication
32344432 | J:301310
First Author: Aprile A
Year: 2020
Journal: Blood
Title: Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche.
Volume: 136
Issue: 5
Pages: 610-622
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Publication
1309337 | J:1785
First Author: Capparelli AW
Year: 1992
Journal: Endocrinology
Title: Altered proximal tubule glucose metabolism in X-linked hypophosphatemic mice.
Volume: 130
Issue: 1
Pages: 328-34
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Publication
9269633 | J:43890
First Author: Marks KH
Year: 1997
Journal: Nephrol Dial Transplant
Title: Parathyroid hormone gene expression in Hyp mice fed a low-phosphate diet.
Volume: 12
Issue: 8
Pages: 1581-5
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Publication
19952276 | J:158461
First Author: Brownstein CA
Year: 2010
Journal: Endocrinology
Title: Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.
Volume: 151
Issue: 2
Pages: 492-501
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Publication
10727451 | J:124756
First Author: Okada Y
Year: 2000
Journal: J Clin Invest
Title: Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture.
Volume: 105
Issue: 6
Pages: 823-32
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Publication
24140714 | J:206528
First Author: David V
Year: 2013
Journal: Endocrinology
Title: Calcium regulates FGF-23 expression in bone.
Volume: 154
Issue: 12
Pages: 4469-82
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Publication
15124025 | J:89721
First Author: MacLean HE
Year: 2004
Journal: J Clin Invest
Title: The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes.
Volume: 113
Issue: 9
Pages: 1334-43
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Publication
12665515 | J:133244
First Author: Okada Y
Year: 2003
Journal: J Biol Chem
Title: Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone.
Volume: 278
Issue: 23
Pages: 21258-66
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Publication
24705625 | J:215020
First Author: Lu R
Year: 2014
Journal: PLoS One
Title: Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice.
Volume: 9
Issue: 4
Pages: e93864
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Publication
11306604 | J:110928
First Author: Kovacs CS
Year: 2001
Journal: J Clin Invest
Title: Fetal parathyroids are not required to maintain placental calcium transport.
Volume: 107
Issue: 8
Pages: 1007-15
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Publication
22538810 | J:184803
First Author: Hanyu R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor.
Volume: 109
Issue: 19
Pages: 7433-8
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Publication
10218975 | J:114260
First Author: Murayama A
Year: 1999
Journal: Endocrinology
Title: Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals.
Volume: 140
Issue: 5
Pages: 2224-31
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Publication
20558734 | J:166187
First Author: Pierroz DD
Year: 2010
Journal: J Biol Chem
Title: Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.
Volume: 285
Issue: 36
Pages: 28164-73
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Publication
30082316 | J:272828
First Author: Koduru SV
Year: 2018
Journal: J Biol Chem
Title: The contribution of cross-talk between the cell-surface proteins CD36 and CD47-TSP-1 in osteoclast formation and function.
Volume: 293
Issue: 39
Pages: 15055-15069
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Publication
10910362 | J:63291
First Author: Günther T
Year: 2000
Journal: Nature
Title: Genetic ablation of parathyroid glands reveals another source of parathyroid hormone.
Volume: 406
Issue: 6792
Pages: 199-203
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Publication
11796525 | J:74973
First Author: Yoshida T
Year: 2002
Journal: Endocrinology
Title: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
Volume: 143
Issue: 2
Pages: 683-9
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Publication
21220409 | J:170229
First Author: Powell WF Jr
Year: 2011
Journal: J Endocrinol
Title: Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses.
Volume: 209
Issue: 1
Pages: 21-32
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Publication
26211511 | J:323224
First Author: Reyes-Fernandez PC
Year: 2016
Journal: J Bone Miner Res
Title: Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin D Receptor (VDR) From the Distal Intestine and Kidney of Mice.
Volume: 31
Issue: 1
Pages: 143-51
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Publication
9886812 | J:52026
First Author: Clément-Lacroix P
Year: 1999
Journal: Endocrinology
Title: Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice.
Volume: 140
Issue: 1
Pages: 96-105
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Publication
31467425 | J:293434
First Author: Tourkova IL
Year: 2019
Journal: Lab Invest
Title: The high-density lipoprotein receptor Scarb1 is required for normal bone differentiation in vivo and in vitro.
Volume: 99
Issue: 12
Pages: 1850-1860
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Publication
24161214 | J:337166
 
First Author: Guerra-Menéndez L
Year: 2013
Journal: J Transl Med
Title: IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand.
Volume: 11
Pages: 271
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Publication
31675485 | J:298636
First Author: Conaway HH
Year: 2019
Journal: FASEB J
Title: Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.
Volume: 33
Issue: 12
Pages: 14394-14409
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Publication
11278791 | J:68872
First Author: Ihara H
Year: 2001
Journal: J Biol Chem
Title: Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.
Volume: 276
Issue: 16
Pages: 13065-71
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Publication
12697722 | J:115708
First Author: Kitahara K
Year: 2003
Journal: Endocrinology
Title: Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation.
Volume: 144
Issue: 5
Pages: 2132-40
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Publication
18417476 | J:138541
First Author: Ono N
Year: 2008
Journal: J Biol Chem
Title: Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts.
Volume: 283
Issue: 28
Pages: 19400-9
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Publication
27253995 | J:239764
First Author: Kedlaya R
Year: 2016
Journal: Endocrinology
Title: Adult-Onset Deletion of β-Catenin in (10kb)Dmp1-Expressing Cells Prevents Intermittent PTH-Induced Bone Gain.
Volume: 157
Issue: 8
Pages: 3047-57
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Publication
16914731 | J:112132
First Author: Fu Q
Year: 2006
Journal: Mol Cell Biol
Title: Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.
Volume: 26
Issue: 17
Pages: 6453-68
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Publication
23782944 | J:202283
First Author: Mamillapalli R
Year: 2013
Journal: Endocrinology
Title: Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.
Volume: 154
Issue: 9
Pages: 3031-42
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Publication
9671744 | J:49340
First Author: Yu S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Volume: 95
Issue: 15
Pages: 8715-20
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Publication
16099856 | J:103361
First Author: Germain-Lee EL
Year: 2005
Journal: Endocrinology
Title: A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene.
Volume: 146
Issue: 11
Pages: 4697-709
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Publication
16648296 | J:108341
First Author: Yakar S
Year: 2006
Journal: J Endocrinol
Title: The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.
Volume: 189
Issue: 2
Pages: 289-99
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Publication
12671051 | J:82624
First Author: Kos CH
Year: 2003
Journal: J Clin Invest
Title: The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.
Volume: 111
Issue: 7
Pages: 1021-8
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Publication
9832460 | J:108801
First Author: Lanske B
Year: 1998
Journal: Endocrinology
Title: The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.
Volume: 139
Issue: 12
Pages: 5194-204
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Publication
36692956 | J:352219
 
First Author: Swami S
Year: 2023
Journal: JCI Insight
Title: Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice.
Volume: 8
Issue: 5
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Publication
12586782 | J:115534
First Author: Qian J
Year: 2003
Journal: Endocrinology
Title: Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death.
Volume: 144
Issue: 3
Pages: 1053-61
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Publication
19113915 | J:169515
First Author: Pierroz DD
Year: 2009
Journal: J Bone Miner Res
Title: Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
Volume: 24
Issue: 5
Pages: 775-84
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Publication
15637145 | J:97178
First Author: Pi M
Year: 2005
Journal: Mol Endocrinol
Title: Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
Volume: 19
Issue: 4
Pages: 1078-87
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Publication
27641475 | J:255348
 
First Author: Perosky JE
Year: 2016
Journal: Bone
Title: Single dose of bisphosphonate preserves gains in bone mass following cessation of sclerostin antibody in Brtl/+ osteogenesis imperfecta model.
Volume: 93
Pages: 79-85
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Publication
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