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Search results 401 to 500 out of 666 for Rala

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Hits by Strain

Type Details Score
Allele
Ralbp1<Gt(E191C04)Wrst> | MGI:3918024
 
Name: ralA binding protein 1; gene trap E191C04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(Ayu21-T226)Imeg> | MGI:3923499
 
Name: ralA binding protein 1; gene trap Ayu21-T226, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST11714F7)Tigm> | MGI:4027337
 
Name: ralA binding protein 1; gene trap IST11714F7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST12510B12)Tigm> | MGI:4075787
 
Name: ralA binding protein 1; gene trap IST12510B12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(P061B01)Wrst> | MGI:4352062
 
Name: ralA binding protein 1; gene trap P061B01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCE00131f05)Hmgu> | MGI:4379345
 
Name: ralA binding protein 1; gene trap EUCE00131f05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCE0259a05)Hmgu> | MGI:4379404
 
Name: ralA binding protein 1; gene trap EUCE0259a05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCE00105a11)Hmgu> | MGI:4380672
 
Name: ralA binding protein 1; gene trap EUCE00105a11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCG0009a11)Hmgu> | MGI:4385000
 
Name: ralA binding protein 1; gene trap EUCG0009a11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCE0047a11)Hmgu> | MGI:4387381
 
Name: ralA binding protein 1; gene trap EUCE0047a11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCE0075a11)Hmgu> | MGI:4387665
 
Name: ralA binding protein 1; gene trap EUCE0075a11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCJ0059e07)Hmgu> | MGI:4872045
 
Name: ralA binding protein 1; gene trap EUCJ0059e07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCJ0056a04)Hmgu> | MGI:4875111
 
Name: ralA binding protein 1; gene trap EUCJ0056a04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCJ0024b02)Hmgu> | MGI:4875818
 
Name: ralA binding protein 1; gene trap EUCJ0024b02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(EUCJ0178e09)Hmgu> | MGI:4876544
 
Name: ralA binding protein 1; gene trap EUCJ0178e09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Strain
MGI:5603869 | C57BL/6N-Ralbp1<tm1(KOMP)Vlcg>/J
Attribute String: mutant strain, targeted mutation
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Allele
Ralbp1<Gt(410G6)Cmhd> | MGI:4953284
 
Name: ralA binding protein 1; gene trap 410G6, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Ralbp1<tm2e(EUCOMM)Wtsi> | MGI:5050909
Name: ralA binding protein 1; targeted mutation 2e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ralbp1<tm2a(EUCOMM)Wtsi> | MGI:5050955
Name: ralA binding protein 1; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ralbp1<Gt(IST13178F9)Tigm> | MGI:5152348
 
Name: ralA binding protein 1; gene trap IST13178F9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13179E4)Tigm> | MGI:5152398
 
Name: ralA binding protein 1; gene trap IST13179E4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13353G8)Tigm> | MGI:5158928
 
Name: ralA binding protein 1; gene trap IST13353G8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13328D11)Tigm> | MGI:5159576
 
Name: ralA binding protein 1; gene trap IST13328D11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13270G4)Tigm> | MGI:5161251
 
Name: ralA binding protein 1; gene trap IST13270G4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13240H6)Tigm> | MGI:5165247
 
Name: ralA binding protein 1; gene trap IST13240H6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13452D3)Tigm> | MGI:5172734
 
Name: ralA binding protein 1; gene trap IST13452D3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13531F1)Tigm> | MGI:5173392
 
Name: ralA binding protein 1; gene trap IST13531F1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13668A6)Tigm> | MGI:5176213
 
Name: ralA binding protein 1; gene trap IST13668A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13666E9)Tigm> | MGI:5176138
 
Name: ralA binding protein 1; gene trap IST13666E9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13666F10)Tigm> | MGI:5176139
 
Name: ralA binding protein 1; gene trap IST13666F10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13666F9)Tigm> | MGI:5176143
 
Name: ralA binding protein 1; gene trap IST13666F9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13548B3)Tigm> | MGI:5176604
 
Name: ralA binding protein 1; gene trap IST13548B3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13577F1)Tigm> | MGI:5179811
 
Name: ralA binding protein 1; gene trap IST13577F1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13811A11)Tigm> | MGI:5189927
 
Name: ralA binding protein 1; gene trap IST13811A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13718E3)Tigm> | MGI:5192218
 
Name: ralA binding protein 1; gene trap IST13718E3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13930C4)Tigm> | MGI:5193992
 
Name: ralA binding protein 1; gene trap IST13930C4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13889D10)Tigm> | MGI:5194787
 
Name: ralA binding protein 1; gene trap IST13889D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13860G5)Tigm> | MGI:5196666
 
Name: ralA binding protein 1; gene trap IST13860G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST13955G4)Tigm> | MGI:5197410
 
Name: ralA binding protein 1; gene trap IST13955G4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST14131G4)Tigm> | MGI:5212636
 
Name: ralA binding protein 1; gene trap IST14131G4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST14286E4)Tigm> | MGI:5223800
 
Name: ralA binding protein 1; gene trap IST14286E4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST14532D10)Tigm> | MGI:5239202
 
Name: ralA binding protein 1; gene trap IST14532D10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST14680B2)Tigm> | MGI:5251386
 
Name: ralA binding protein 1; gene trap IST14680B2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST14653C10)Tigm> | MGI:5251935
 
Name: ralA binding protein 1; gene trap IST14653C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ralbp1<Gt(IST15091D1)Tigm> | MGI:5277792
 
Name: ralA binding protein 1; gene trap IST15091D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:7382141 | C57BL/6JGpt-Ralbp1<em2Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Ralbp1/Ralbp1
Background: involves: 129S5/SvEvBrd * C57BL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ralbp1/Ralbp1
Background: B6;129S5-Ralbp1/Ieg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ralbp1/Ralbp1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
24165023 | -
First Author: Nakamura T
Year: 2013
Journal: Genes Cells
Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
Volume: 18
Issue: 11
Pages: 1020-31
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Publication
17638889 | J:123138
First Author: Neutzner M
Year: 2007
Journal: Cancer Res
Title: MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.
Volume: 67
Issue: 14
Pages: 6777-85
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Publication
10087204 | J:54030
First Author: Ring HZ
Year: 1999
Journal: Genomics
Title: Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17.
Volume: 56
Issue: 3
Pages: 350-2
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Publication
26498519 | J:318352
First Author: Wurtzel JG
Year: 2015
Journal: Biochem Biophys Res Commun
Title: RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Volume: 467
Issue: 4
Pages: 785-91
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Protein
A2AR50
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Genotype
Genotype
Symbol: Ralbp1/Ralbp1<+>
Background: involves: 129S5/SvEvBrd * C57BL
Zygosity: ht
Has Mutant Allele: true
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Publication
11882656 | J:76839
First Author: Matsuzaki T
Year: 2002
Journal: J Biol Chem
Title: Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway.
Volume: 277
Issue: 21
Pages: 19008-18
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Protein
A2AR50-4
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein
A2AR50-3
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
A2AR50-2
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Publication
9395447 | J:44628
First Author: Yamaguchi A
Year: 1997
Journal: J Biol Chem
Title: An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.
Volume: 272
Issue: 50
Pages: 31230-4
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Publication
15064760 | J:89807
First Author: Meylan E
Year: 2004
Journal: Nat Immunol
Title: RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
Volume: 5
Issue: 5
Pages: 503-7
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Publication
17462996 | J:123526
First Author: Misra RS
Year: 2007
Journal: J Biol Chem
Title: Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Volume: 282
Issue: 27
Pages: 19365-74
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Publication
21746883 | J:175071
First Author: Irrinki KM
Year: 2011
Journal: Mol Cell Biol
Title: Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
Volume: 31
Issue: 18
Pages: 3745-58
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Protein Domain
IPR039930 | RALGAPB
Type: Family
Description: Ral GTPase-activating protein subunit beta (RALGAPB) is a non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB [].
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Publication
15367757 | -
First Author: Colicelli J
Year: 2004
Journal: Sci STKE
Title: Human RAS superfamily proteins and related GTPases.
Volume: 2004
Issue: 250
Pages: RE13
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Publication
17018283 | -
First Author: Chien Y
Year: 2006
Journal: Cell
Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Volume: 127
Issue: 1
Pages: 157-70
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Publication
24056301 | -
First Author: Simicek M
Year: 2013
Journal: Nat Cell Biol
Title: The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Volume: 15
Issue: 10
Pages: 1220-30
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Publication
15511640 | -
First Author: Lebreton S
Year: 2004
Journal: Mech Dev
Title: RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development.
Volume: 121
Issue: 12
Pages: 1481-94
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Protein Domain
IPR028412 | Ral
Type: Family
Description: Ral protein family, including RALA and RALB, belongs to the RAS family of small GTPases. Like other RAS GTPases, Ral proteins function as molecular switches alternating between inactive GDP-bound and active GT-bound states [].In humans, RALA and RALB are activated in tumour-derived cell lines. RALA severely impairs the anchorage-independent proliferation of cancer cell lines [], while RALB is required to suppress apoptotic checkpoint activation and is essential for the survival of a variety of tumour-derived cell lines []. RALA and RALB share the same effector molecules, such as SEC5 and EXO84. However, they seem to function in distinct but inter-related biological processes. RALA regulates the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 []. The RALB/Sec5 effector complex is involved in the TBK1-dependent innate immune signaling [], while the interaction between PALB and EXO84 promotes the assembly of catalytically active ULK1 and the beclin-1-VPS34 autophagy initiation complex []. This entry also includes Xenopus RalA and RalB. RalB regulates the actin cytoskeleton during the early development and affects gastrulation [].
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Publication
8094051 | J:25192
First Author: Albright CF
Year: 1993
Journal: EMBO J
Title: Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
Volume: 12
Issue: 1
Pages: 339-47
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Publication
7476171 | -
First Author: King G
Year: 1995
Journal: Mol Microbiol
Title: Restriction alleviation and modification enhancement by the Rac prophage of Escherichia coli K-12.
Volume: 16
Issue: 4
Pages: 769-77
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Publication
10889189 | -
First Author: de Bruyn KM
Year: 2000
Journal: J Biol Chem
Title: RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
Volume: 275
Issue: 38
Pages: 29761-6
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Protein Domain
IPR019908 | Toxin_RalR
Type: Family
Description: RalR was originally thought to inhibit restriction modification []but instead is part of a toxin/antitoxin system and functions as a non-specific DNase []. Toxin RalR functions as a non-specific endonuclease that cleaves methylated and unmethylated DNA. The adjacent gene product, RalA (for RalR antitoxin), functions as an antitoxin for RalR.
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Protein Domain
IPR030708 | RalGPS1/2
Type: Family
Description: This entry includes RalGPS1 (also known as RalGEF2) and RalGPS2. RalGPS1 and RalGPS2 are guanine nucleotide exchange factors for Ral (RalA and RalB), a ubiquitously expressed Ras-like small GTPase [, ]. The PH-PxxP domain of RalGPS2 acts as a negative regulator for RalA GTPase activation and promotes PC12 cellsdifferentiation [].
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Publication
9828140 | J:47260
First Author: Peters LL
Year: 1998
Journal: Genomics
Title: Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.
Volume: 54
Issue: 2
Pages: 348-50
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Publication
14525976 | -
First Author: Moskalenko S
Year: 2003
Journal: J Biol Chem
Title: Ral GTPases regulate exocyst assembly through dual subunit interactions.
Volume: 278
Issue: 51
Pages: 51743-8
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Publication
30989113 | J:287672
First Author: Chen Q
Year: 2019
Journal: Sci Adv
Title: Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control.
Volume: 5
Issue: 4
Pages: eaav4116
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Publication
23604909 | J:198500
First Author: Nakahara M
Year: 2013
Journal: Mamm Genome
Title: Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Volume: 24
Issue: 5-6
Pages: 228-39
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Publication
19520869 | -
First Author: Shirakawa R
Year: 2009
Journal: J Biol Chem
Title: Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.
Volume: 284
Issue: 32
Pages: 21580-8
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Publication
28325821 | J:260011
 
First Author: Uhm M
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.
Volume: 10
Issue: 471
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Publication
23358418 | J:203326
First Author: Nishimura A
Year: 2013
Journal: Mol Cell Biol
Title: Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding.
Volume: 33
Issue: 7
Pages: 1417-29
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Publication
11788587 | J:75453
First Author: Murphy GA
Year: 2002
Journal: J Biol Chem
Title: Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.
Volume: 277
Issue: 12
Pages: 9966-75
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Publication
11865051 | J:74985
First Author: Polzin A
Year: 2002
Journal: Mol Cell Biol
Title: Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.
Volume: 22
Issue: 6
Pages: 1714-22
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Publication
14681219 | J:89016
First Author: Weernink PA
Year: 2004
Journal: J Biol Chem
Title: Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
Volume: 279
Issue: 9
Pages: 7840-9
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Publication
30735546 | J:271985
First Author: Takenaka N
Year: 2019
Journal: PLoS One
Title: Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle.
Volume: 14
Issue: 2
Pages: e0212219
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Publication
30957234 | J:279295
First Author: Cemeli T
Year: 2019
Journal: J Pathol
Title: Cytoplasmic cyclin D1 regulates glioblastoma dissemination.
Volume: 248
Issue: 4
Pages: 501-513
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Protein
B2RX86
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
Q3U5E2
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
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Publication
8806680 | -
First Author: Wienecke R
Year: 1996
Journal: Oncogene
Title: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Volume: 13
Issue: 5
Pages: 913-23
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Protein Domain
IPR027107 | Tuberin/Ral-act_asu
Type: Family
Description: The activity of GTPases is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Tuberin (tuberous sclerosis 2 protein or Tsc2) is believed to be a tumor suppressor and is able to stimulate specific GTPases. It stimulates the intrinsic GTPase activity of the Ras-related protein Rap1A and Rab5 [, ]. In complex with Tsc1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [, ]. Ral GTPase-activating protein subunit alpha is the catalytic subunit of the heterodimeric RalGAP complex which acts as a GTPase activator for the Ras-like small GTPases RalA and RalB []. RalGAP complexes share structural and catalytic similarities with the tuberous sclerosis tumor suppressor complex [].
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Publication
27178121 | J:322735
First Author: Kodama T
Year: 2016
Journal: Gastroenterology
Title: Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma.
Volume: 151
Issue: 2
Pages: 324-337.e12
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Publication
23473774 | J:318170
 
First Author: Rifki OF
Year: 2013
Journal: J Mol Cell Cardiol
Title: RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.
Volume: 59
Pages: 128-38
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Protein
A0A087WQA4
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Publication
18540861 | -
First Author: Ferro E
Year: 2008
Journal: Biochem J
Title: G-protein binding features and regulation of the RalGDS family member, RGL2.
Volume: 415
Issue: 1
Pages: 145-54
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Protein Domain
IPR030749 | RGL2
Type: Family
Description: RGL2 (RalGDS-like 2) belongs to the Ral GDP dissociation stimulator (RalGDS) family []. The C-terminal fragment (Ras/Rap-binding domain) of RGL2 interacts specifically with Ras family proteins that share identical effector domain sequences with Rap1 (H-Ras, R-Ras, Tc21). The binding ability of RGL2 to H-Ras can be regulated through a PKA phosphorylation site identified in this C-terminal domain []. This phoshorylation site is only conserved in the RGL2 murine orthologue, Rlf, but not in RalGDS, RGL and RGL3 []. RGL2 is a guanine nucleotide exchange factor (GEF) for RalA, which plays an important role in the assembly of the exocyst complex. R-Ras regulates exocytosis by RGL2/Rlf-mediated activation of RalA on endosomes [].RalGDS family members can act both as Ras effectors and as guanine nucleotide exchange factors (GEFs) for Ral. They act downstream of Ras and bind to the GTP-bound active form of Ras or Ras family members. They also promote the GDP to GTP exchange for Ral small GTPase, member of the Ras family []. Due to their double action, the RalGDS proteins bridge Ras and Ral [].
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Protein
P63321
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
Q9JIW9
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
F6QC68
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q8CCG5
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
A0A1Y7VL93
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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