| Type |
Details |
Score |
| Publication |
| First Author: |
Lakshmana MK |
| Year: |
2012 |
| Journal: |
FASEB J |
| Title: |
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
2072-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Puverel S |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
RanBPM is essential for mouse spermatogenesis and oogenesis. |
| Volume: |
138 |
| Issue: |
12 |
| Pages: |
2511-21 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
257
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Steggerda SM |
| Year: |
2001 |
| Journal: |
Traffic |
| Title: |
Identification of a conserved loop in Mog1 that releases GTP from Ran. |
| Volume: |
2 |
| Issue: |
11 |
| Pages: |
804-11 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
185
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zu T |
| Year: |
2020 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice. |
| Volume: |
117 |
| Issue: |
31 |
| Pages: |
18591-18599 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Redondo-Muñoz J |
| Year: |
2015 |
| Journal: |
Mol Cell Biol |
| Title: |
Phosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity. |
| Volume: |
35 |
| Issue: |
1 |
| Pages: |
249-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ayhan F |
| Year: |
2018 |
| Journal: |
EMBO J |
| Title: |
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. |
| Volume: |
37 |
| Issue: |
19 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong SK |
| Year: |
2016 |
| Journal: |
J Mol Biol |
| Title: |
Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development. |
| Volume: |
428 |
| Issue: |
21 |
| Pages: |
4330-4344 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murrin LC |
| Year: |
2007 |
| Journal: |
J Neuroimmune Pharmacol |
| Title: |
RanBPM, a scaffolding protein in the immune and nervous systems. |
| Volume: |
2 |
| Issue: |
3 |
| Pages: |
290-5 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This SPRY domain is found in Ran binding protein M (RanBPM, also known as RanBP9) and RanBP10. RanBPM and RanBP10 arenon-canonical members of the Ran binding protein family that lack the Ran binding domain and do not associate with Ran GTPase in vivo. RanBPM is a scaffolding protein important for a variety of cellular processes [, ]. RanBP10 has been shown to function as a cytosolic guanine exchange factor and microtubule regulator [, ]. Both of these proteins contain a SPRY domain, which has been implicated in mediating protein-protein interactions with a variety of targets, including the DEAD-box containing ATP-dependent RNA helicase (DDX-4) [, , ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2005 |
| Journal: |
Development |
| Title: |
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. |
| Volume: |
132 |
| Issue: |
6 |
| Pages: |
1463-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mahajan R |
| Year: |
1998 |
| Journal: |
J Cell Biol |
| Title: |
Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. |
| Volume: |
140 |
| Issue: |
2 |
| Pages: |
259-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Swaminathan S |
| Year: |
2004 |
| Journal: |
J Cell Biol |
| Title: |
RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. |
| Volume: |
164 |
| Issue: |
7 |
| Pages: |
965-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu S |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes. |
| Volume: |
312 |
| Issue: |
7 |
| Pages: |
1042-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hutten S |
| Year: |
2008 |
| Journal: |
Mol Biol Cell |
| Title: |
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. |
| Volume: |
19 |
| Issue: |
5 |
| Pages: |
2300-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cha K |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
e0141309 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1105
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gopinathan G |
| Year: |
2024 |
| Journal: |
PLoS Biol |
| Title: |
CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation. |
| Volume: |
22 |
| Issue: |
4 |
| Pages: |
e3002574 |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Author |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pay A |
| Year: |
2002 |
| Journal: |
Plant J |
| Title: |
Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells. |
| Volume: |
30 |
| Issue: |
6 |
| Pages: |
699-709 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu XM |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
RanGAP1 is a continuous marker of the Arabidopsis cell division plane. |
| Volume: |
105 |
| Issue: |
47 |
| Pages: |
18637-42 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes RanGAP1/2 mostly from plants. They are GTPase activators for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state []. RanGAP1 may have a role in spatial signaling during plant cell division []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao M |
| Year: |
2022 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling. |
| Volume: |
1868 |
| Issue: |
9 |
| Pages: |
166429 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hiwasa T |
| Year: |
1994 |
|
| Title: |
Inhibition of cysteine proteinases and proteasome by Ras, Ran and cyclin |
|
|
| Pages: |
183-187 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren M |
| Year: |
1995 |
| Journal: |
Mol Cell Biol |
| Title: |
Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
2117-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dörr A |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. |
| Volume: |
290 |
| Issue: |
42 |
| Pages: |
25620-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Woo JA |
| Year: |
2015 |
| Journal: |
Cell Death Dis |
| Title: |
RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. |
| Volume: |
6 |
|
| Pages: |
1676 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Woo JA |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes. |
| Volume: |
26 |
| Issue: |
20 |
| Pages: |
3973-3988 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guglielmi V |
| Year: |
2024 |
| Journal: |
Sci Adv |
| Title: |
Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation. |
| Volume: |
10 |
| Issue: |
23 |
| Pages: |
eadn8963 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patil H |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. |
| Volume: |
289 |
| Issue: |
43 |
| Pages: |
29767-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho KI |
| Year: |
2013 |
| Journal: |
PLoS Genet |
| Title: |
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
e1003555 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arnaoutov A |
| Year: |
2003 |
| Journal: |
Dev Cell |
| Title: |
The Ran GTPase regulates kinetochore function. |
| Volume: |
5 |
| Issue: |
1 |
| Pages: |
99-111 |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hambright WS |
| Year: |
2017 |
| Journal: |
Redox Biol |
| Title: |
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. |
| Volume: |
12 |
|
| Pages: |
8-17 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
491
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
491
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
354
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
558
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
52
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang M |
| Year: |
2024 |
| Journal: |
Cell Signal |
| Title: |
RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development. |
| Volume: |
120 |
|
| Pages: |
111222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bao J |
| Year: |
2014 |
| Journal: |
PLoS Genet |
| Title: |
RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. |
| Volume: |
10 |
| Issue: |
12 |
| Pages: |
e1004825 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Riemslagh FW |
| Year: |
2021 |
| Journal: |
Dis Model Mech |
| Title: |
Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice. |
|
|
|
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|