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Search results 401 to 500 out of 1806 for Ranbp1

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Hits by Strain

Type Details Score
Protein
D3Z549
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Protein
Q571F3
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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Protein
A0A0G2JE79
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q3TRI2
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
A2AM80
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
F6RCM5
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
E0CYH9
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Protein
A0A0A0MQI4
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
B8JJF3
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
D6RFA7
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
D3Z1E8
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: true
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Protein
F6TQN9
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: true
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Protein
F2Z465
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
Q3TYD2
Organism: Mus musculus/domesticus
Length: 940  
Fragment?: true
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Protein
H7BX82
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: true
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Protein
E9PX84
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
A0A0R4J104
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q3TBZ6
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q0VB06
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
B2RRQ8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Publication
12437929 | -
First Author: Volkman BF
Year: 2002
Journal: Cell
Title: Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.
Volume: 111
Issue: 4
Pages: 565-76
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Publication
17229736 | -
First Author: Peterson FC
Year: 2007
Journal: J Biol Chem
Title: Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.
Volume: 282
Issue: 11
Pages: 8446-53
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Publication
11140379 | -
First Author: Rong SB
Year: 2000
Journal: J Mol Med (Berl)
Title: Structural basis of Wiskott-Aldrich syndrome causing mutations in the WH1 domain.
Volume: 78
Issue: 9
Pages: 530-7
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Publication
9618767 | -
First Author: Ochs HD
Year: 1998
Journal: Springer Semin Immunopathol
Title: The Wiskott-Aldrich syndrome.
Volume: 19
Issue: 4
Pages: 435-58
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Protein Domain
IPR033927 | WASPfam_EVH1
Type: Domain
Description: The entry refers to the EVH1 domain found in WASP family proteins.The EVH1 (WH1, RanBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues [, ].WASP family proteins contain an EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein [, ]. Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin homology (PH) domain. The overall fold consists of a compact parallel β-sandwich, closed along one edge by a long α-helix. A highly conserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecules target ligands. [].The actin nucleation-promoting factor WAS (WASP; also called Bee1p) and its homologue N (neuronal)-WASP are signal transduction proteins that promote actin polymerization in response to upstream intracellular signals []. Wiskott-Aldrich Syndrome (WAS) is an X-linked recessive disease, characterized by eczema, immunodeficiency, and thrombocytopenia []. The majority of patients with WAS, or a milder version of the disorder, X-linked thrombocytopenia (XLT), have point mutations in the EVH1 domain of WASP []. WASP is an actin regulatory protein consisting of an N-terminal EVH1 domain, a basic region (B), a GTP binding domain (GBP), a proline rich region, a WH2 domain, and a verprolin-cofilin-acidic motif (VCA) which activates the actin-related protein (Arp)2/3 actin nucleating complex []. The B, GBD, and the proline-rich region are involved in autoinhibitory interactions that repress or block the activity of the VCA. Yeast members lack the GTP binding domain. The EVH1 domains are part of the PH domain superfamily [].
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Protein
A0A2R8VHK9
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
Q9WVG6
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q8BZI0
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: false
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Protein
Q8K2Y9
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q9ERU9
Organism: Mus musculus/domesticus
Length: 3053  
Fragment?: false
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Protein
Q9QZS3
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q6P2K6
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
Q8BUL6
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: false
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Q3UBG2
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
Q8C886
Organism: Mus musculus/domesticus
Length: 610  
Fragment?: false
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Protein
Q5FWH6
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Q5DU31
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q61189
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q8BSM5
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q8BUP8
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q922R5
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
B2RPU2
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
O08919
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q9Z1S8
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q9D240
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
Q8BH49
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q8K1I7
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
O08969
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
Q9QYE9
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein
Q9ERS5
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Protein
Q8BW88
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q9WV95
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
Q9QZC7
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Protein
Q9DBA9
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
Q8K124
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
Q14B98
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q505A4
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q8R2X2
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: true
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Protein
F8WIK5
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Protein
A0A0R4J1V5
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q8CIU5
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q3ZB57
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
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Protein
Q3U5J8
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
Q8BTJ6
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q9D097
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
F7BZ65
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
A0A2I3BQ18
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
Q8R1D9
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Protein
A0A0J9YV29
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Protein
A0A087WRL5
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
D3YUP1
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
E9QKD9
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
X2CUM2
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Protein
D3YV71
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: false
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A0A5F8MPI5
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
B1AYB9
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
D3YVQ1
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q3UUV3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
F6XNB6
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: true
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Protein
Q8BM51
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
F6ZFQ8
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
A0A087WS68
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
S4R1Y4
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
Q80Y77
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
Q8CIU7
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
F6SX70
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Q9R021
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
Q80VF7
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: true
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Protein
Q3TDN6
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
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Protein
D3YU01
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q3V166
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: true
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Protein
S4R1J2
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
E9PWX4
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Protein
Q3TXH9
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: true
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Protein
Q8C6Z0
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Protein
Q8R1Y7
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
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Protein
D3YZT7
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: true
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Protein
D3Z5X2
Organism: Mus musculus/domesticus
Length: 63  
Fragment?: true
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Protein
D6RCU3
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom