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Search results 401 to 490 out of 490 for Rbl2

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Type Details Score
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
32973083 | J:299181
First Author: Kim KB
Year: 2020
Journal: Cancer Res
Title: FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer.
Volume: 80
Issue: 22
Pages: 5051-5062
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Allele
Rbl2<tm1Smoc> | MGI:7291989
Name: RB transcriptional corepressor like 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Rbl2<tm1Tyj> | MGI:1857449
Name: RB transcriptional corepressor like 2; targeted mutation 1, Tyler Jacks
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rbl2<tm1Mru> | MGI:1857500
Name: RB transcriptional corepressor like 2; targeted mutation 1, Michael Rudnicki
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6429468 | C57BL/6JSmoc-Rbl2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:3775462 | B6;129S2-Rbl2<tm1Tyj>/J
Attribute String: targeted mutation, mutant stock
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Genotype
Genotype
Symbol: Rbl2/Rbl2
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl2/Rbl2<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl2/Rbl2
Background: involves: 129S4/SvJae * BALB/cJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl2/Rbl2
Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl2/Rbl2<+>
Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl1/Rbl1 Rbl2/Rbl2
Background: involves: 129S2/SvPas * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
16730350 | J:111333
First Author: Sandoval R
Year: 2006
Journal: Exp Cell Res
Title: A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.
Volume: 312
Issue: 13
Pages: 2465-75
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Publication
17075059 | -
First Author: Harrison MM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.
Volume: 103
Issue: 45
Pages: 16782-7
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Publication
15538385 | -
First Author: Gagrica S
Year: 2004
Journal: EMBO J
Title: Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein.
Volume: 23
Issue: 23
Pages: 4627-38
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Publication
1524653 | -
First Author: Presswood R
Year: 1992
Journal: Int J Prosthodont
Title: A philosophy of dental practice.
Volume: 5
Issue: 3
Pages: 291
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Publication
23667535 | -
First Author: Esterlechner J
Year: 2013
Journal: PLoS One
Title: LIN9, a subunit of the DREAM complex, regulates mitotic gene expression and proliferation of embryonic stem cells.
Volume: 8
Issue: 5
Pages: e62882
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Protein Domain
IPR010561 | LIN-9/ALY1
Type: Family
Description: This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [, ].LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses transcription []. DREAM complex undergoes a cell cycle dependent switch of subunits. DREAM core bindsto the E2F4 transcription factor and to the RBL2 (p130) in quiescent cells, while associates with the transcription factor B-MYB in the S-phase []. In humans, LIN-9 acts as a tumor suppressor and plays a role in the expression of genes required for the G1/S transition [, ]. In pluripotent embryonic stem cells (ESC), LIN-9 plays an important role for proliferation and genome stability by activating genes with important functions in mitosis and cytokinesis [].In Arabidopsis thaliana, ALY is expressed ubiquitously in vegetative and reproductive tissues [].
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Publication
26574435 | J:237668
First Author: Shizu R
Year: 2016
Journal: Biochem J
Title: PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.
Volume: 473
Issue: 3
Pages: 257-66
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Publication
31727771 | J:284196
First Author: Oser MG
Year: 2019
Journal: Genes Dev
Title: The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
Volume: 33
Issue: 23-24
Pages: 1718-1738
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Genotype
Genotype
Symbol: Rbl1/Rbl1 Rbl2/Rbl2
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl1/Rbl1<+> Rbl2/Rbl2
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl1/Rbl1 Rbl2/Rbl2<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl2/Rbl2 Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
Background: involves: 129 * 129S2/SvPas * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl2/Rbl2 Tg(Nes-cre)1Atp/?
Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rbl1/Rbl1<+> Rbl2/Rbl2<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
22969435 | J:190456
First Author: Ip J
Year: 2012
Journal: PLoS Genet
Title: Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.
Volume: 8
Issue: 9
Pages: e1002919
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Protein
P48428
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
A0A1Y7VJ48
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
Q5I0U7
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Publication
12054808 | J:76643
First Author: Guasch A
Year: 2002
Journal: J Mol Biol
Title: Three-dimensional structure of human tubulin chaperone cofactor A.
Volume: 318
Issue: 4
Pages: 1139-49
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Publication
11739729 | -
First Author: Abruzzi KC
Year: 2002
Journal: Mol Cell Biol
Title: Protection from free beta-tubulin by the beta-tubulin binding protein Rbl2p.
Volume: 22
Issue: 1
Pages: 138-47
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Publication
15321725 | -
First Author: You L
Year: 2004
Journal: J Mol Biol
Title: Model for the yeast cofactor A-beta-tubulin complex based on computational docking and mutagensis.
Volume: 341
Issue: 5
Pages: 1343-54
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Protein
A0A0A6YWF7
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
A0A0A6YXQ9
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Publication
15246533 | -
First Author: Bhatt AM
Year: 2004
Journal: Gene
Title: Gene structure and molecular analysis of Arabidopsis thaliana ALWAYS EARLY homologs.
Volume: 336
Issue: 2
Pages: 219-29
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Publication
12204530 | -
First Author: Sherr CJ
Year: 2002
Journal: Cancer Cell
Title: The RB and p53 pathways in cancer.
Volume: 2
Issue: 2
Pages: 103-12
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Publication
11545733 | -
First Author: Thomas DM
Year: 2001
Journal: Mol Cell
Title: The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.
Volume: 8
Issue: 2
Pages: 303-16
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Protein Domain
IPR028309 | RB_fam
Type: Family
Description: This entry represents the retinoblastoma protein family, including retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130). Members of this family contain a conserved domain named the 'pocket' that interacts with the LXCXE motif found in viral proteins, such as SV40 large T antigen []. Therefore, this family is also called the pocket protein family.In humans, RB is a tumour suppressor linked to several major cancers []. RB forms complexes with E2Fs and represses gene expression by recruiting chromatin remodeling factors, such as histone deacetylases (HDACs) to E2F-responsive promoters [, ]. This interaction regulates genes necessary for DNA replication and cell cycle. Phosphorylation of RB family by CDK and cyclin complexes leads to release of the repressor complex and enables E2F-dependent gene expression []. Apart from E2Fs, RB also interacts with other transcription factors that govern cell differentiation [, ]. RBL1 and RBL2 are the components of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [, ].
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Protein Domain
IPR004226 | TBCA
Type: Family
Description: The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin binding cofactor A (TBCA) from animal, plants and fungi. Human TBCA functions as a molecular chaperone for beta-tubulin []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. The sequence identity of Rbl2 and human TBCA is only 32%, they appear to be structurally distinct and may interact with beta-tubulin by different mechanisms [].
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Protein Domain
IPR036126 | TBCA_sf
Type: Homologous_superfamily
Description: The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin binding cofactor A (TBCA) from animal, plants and fungi. Human TBCA functions as a molecular chaperone for beta-tubulin []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. The sequence identity of Rbl2 and human TBCA is only 32%, they appear to be structurally distinct and may interact with beta-tubulin by different mechanisms []. The structure of TBCA has three helices forming a bundle closed fold with left-handed twist topology going up-and-down.
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Protein
Q8C735
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
A0A0A6YWD3
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: true
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Protein
Q62017
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Protein
A0A0A6YVZ7
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Publication
11018009 | -
First Author: Harbour JW
Year: 2000
Journal: Genes Dev
Title: The Rb/E2F pathway: expanding roles and emerging paradigms.
Volume: 14
Issue: 19
Pages: 2393-409
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Publication
6320372 | -
First Author: Murphree AL
Year: 1984
Journal: Science
Title: Retinoblastoma: clues to human oncogenesis.
Volume: 223
Issue: 4640
Pages: 1028-33
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Publication
17854503 | -
 
First Author: Dick FA
Year: 2007
Journal: Cell Div
Title: Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
Volume: 2
Pages: 26
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Protein
Q9CT40
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
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Protein
Q3UQT1
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Publication
23973072 | -
 
First Author: Tian G
Year: 2013
Journal: Methods Cell Biol
Title: Tubulin-specific chaperones: components of a molecular machine that assembles the α/β heterodimer.
Volume: 115
Pages: 155-71
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Protein
Q8CCD4
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
Q3UI58
Organism: Mus musculus/domesticus
Length: 817  
Fragment?: false
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Protein
P13405
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
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Protein
Q64700
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
Q64701
Organism: Mus musculus/domesticus
Length: 1063  
Fragment?: false
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Protein
Q3URY9
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
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Protein
Q3V0V3
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q8VCD1
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
Q6PAR4
Organism: Mus musculus/domesticus
Length: 1063  
Fragment?: false
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Protein
A0A1B0GR06
Organism: Mus musculus/domesticus
Length: 1125  
Fragment?: false
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Protein
Q6NTA5
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: true
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Protein
Q3UJG1
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
A0A1B0GRM0
Organism: Mus musculus/domesticus
Length: 1092  
Fragment?: false
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Publication
17531812 | -
First Author: Litovchick L
Year: 2007
Journal: Mol Cell
Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.
Volume: 26
Issue: 4
Pages: 539-51
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Publication
17671431 | -
First Author: Schmit F
Year: 2007
Journal: Cell Cycle
Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.
Volume: 6
Issue: 15
Pages: 1903-13
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom