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Search results 401 to 460 out of 460 for Rock2

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Hprt1<tm4(KRT14-ROCK2*/ERT)Bicrq> | MGI:6771468
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, Cancer Research UK Beatson Institute
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Publication
24675663 | J:260369
First Author: Ikeda S
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice.
Volume: 34
Issue: 6
Pages: 1260-71
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Publication
36621002 | J:341270
 
First Author: Li X
Year: 2023
Journal: Development
Title: Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling.
Volume: 150
Issue: 2
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Protein Domain
IPR037311 | ROCK2_HR1
Type: Domain
Description: Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions []. Two ROCK isoforms have been identified:ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [, , ].This entry represents the HR1 domain found in Rho-associated protein kinase 2 (ROCK2), which is essential for the formation of stress fibres []. ROCK2 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK2 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family [].
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Strain
MGI:6335723 | STOCK Hprt1<tm1(CAG-ROCK2/ERT)Bicrq>/Bircq
Attribute String: mutant strain, targeted mutation
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Allele
Tg(CMV-cat,-ROCK2*)3-1Koba | MGI:5910536
Name: transgene insertion 3-1, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Conditional ready, Dominant negative, Inserted expressed sequence
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Allele
Tg(CMV-cat,-ROCK2*)5-27Koba | MGI:7511875
Name: transgene insertion 5-27, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(CMV-cat,-ROCK2*)3-3Koba | MGI:7511865
Name: transgene insertion 3-3, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(CMV-cat,-ROCK2*)4-9Koba | MGI:7511870
Name: transgene insertion 4-9, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Tg(CMV-cat,-ROCK2*)4-11Koba | MGI:7511873
Name: transgene insertion 4-11, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(CMV-cat,-ROCK2*)5-18Koba | MGI:7522339
Name: transgene insertion 5-18, Kazuto Kobayashi
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Strain
MGI:6144615 | B6.Cg-Tg(CMV-cat,-ROCK2*)3-1Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6145339 | B6.Cg-Tg(CMV-cat,-ROCK2*)5-27Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6145336 | B6.Cg-Tg(CMV-cat,-ROCK2*)3-3Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6145337 | B6.Cg-Tg(CMV-cat,-ROCK2*)4-9Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6145338 | B6.Cg-Tg(CMV-cat,-ROCK2*)4-11Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6144618 | B6.Cg-Tg(CMV-cat,-ROCK2*)5-18Koba/KobaRbrc
Attribute String: mutant strain, congenic, transgenic
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Genotype
Genotype
Symbol: Tg(CMV-cat,-ROCK2*)3-1Koba/? Tg(Myh6-cre)1Jmk/?
Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
23601011 | -
First Author: Schofield AV
Year: 2013
Journal: Crit Rev Biochem Mol Biol
Title: Rho-associated coiled-coil kinase (ROCK) signaling and disease.
Volume: 48
Issue: 4
Pages: 301-16
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Publication
19907920 | -
First Author: Hahmann C
Year: 2010
Journal: Cell Mol Life Sci
Title: Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity.
Volume: 67
Issue: 2
Pages: 171-7
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Publication
23950574 | -
First Author: Amin E
Year: 2013
Journal: Biol Chem
Title: Rho-kinase: regulation, (dys)function, and inhibition.
Volume: 394
Issue: 11
Pages: 1399-410
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Publication
20803696 | -
First Author: Amano M
Year: 2010
Journal: Cytoskeleton (Hoboken)
Title: Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Volume: 67
Issue: 9
Pages: 545-54
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Publication
16043513 | -
First Author: Yoneda A
Year: 2005
Journal: J Cell Biol
Title: The Rho kinases I and II regulate different aspects of myosin II activity.
Volume: 170
Issue: 3
Pages: 443-53
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Publication
25365359 | J:261267
First Author: Noda K
Year: 2014
Journal: PLoS One
Title: Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.
Volume: 9
Issue: 11
Pages: e110446
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Publication
20008297 | J:157776
First Author: Vemula S
Year: 2010
Journal: Blood
Title: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Volume: 115
Issue: 9
Pages: 1785-96
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Publication
25704819 | J:224172
First Author: Zandi S
Year: 2015
Journal: Cell Rep
Title: ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.
Volume: 10
Issue: 7
Pages: 1173-86
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Publication
21665151 | J:173558
First Author: Samuel MS
Year: 2011
Journal: Cancer Cell
Title: Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Volume: 19
Issue: 6
Pages: 776-91
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Publication
26315406 | J:242116
First Author: Ellawindy A
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Rho-Kinase Inhibition During Early Cardiac Development Causes Arrhythmogenic Right Ventricular Cardiomyopathy in Mice.
Volume: 35
Issue: 10
Pages: 2172-84
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Genotype
Genotype
Symbol: Tg(CMV-cat,-ROCK2*)3-1Koba/? Tg(Tagln-cre)1Her/?
Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
25007875 | J:214236
First Author: Matoba K
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells.
Volume: 307
Issue: 5
Pages: F571-80
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Publication
22903063 | J:189922
First Author: Lallemend F
Year: 2012
Journal: EMBO J
Title: Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Volume: 31
Issue: 18
Pages: 3718-29
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Publication
22846914 | J:191321
First Author: Patel RA
Year: 2012
Journal: Cancer Res
Title: RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Volume: 72
Issue: 19
Pages: 5025-34
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Publication
29368549 | J:261377
First Author: Zhou T
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier.
Volume: 314
Issue: 5
Pages: L808-L821
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Publication
25485682 | J:219608
First Author: Xie Z
Year: 2015
Journal: J Clin Invest
Title: Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation.
Volume: 125
Issue: 1
Pages: 324-36
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Publication
31239325 | J:330072
 
First Author: Henderson BW
Year: 2019
Journal: Sci Signal
Title: Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.
Volume: 12
Issue: 587
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Publication
31323253 | J:295907
 
First Author: Wong SSC
Year: 2019
Journal: Neurosci Lett
Title: Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.
Volume: 709
Pages: 134379
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Publication
35303680 | J:323927
 
First Author: Penumatsa KC
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice.
Volume: 604
Pages: 137-143
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Publication
31611932 | J:288025
First Author: Jiao Y
Year: 2019
Journal: Exp Ther Med
Title: Mechanism of H2S-mediated ROCK inhibition of total flavones of Rhododendra against myocardial ischemia injury.
Volume: 18
Issue: 5
Pages: 3783-3792
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Publication
32139595 | J:291170
First Author: Arima M
Year: 2020
Journal: Diabetes
Title: Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema.
Volume: 69
Issue: 5
Pages: 981-999
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Publication
23913862 | J:203881
First Author: Cencetti F
Year: 2013
Journal: FASEB J
Title: TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation.
Volume: 27
Issue: 11
Pages: 4532-46
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Publication
25858457 | J:221425
First Author: Cao Z
Year: 2015
Journal: Development
Title: Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage.
Volume: 142
Issue: 9
Pages: 1606-15
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Publication
26519207 | J:233203
First Author: Lambert JA
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Ozone-induced airway hyperresponsiveness: roles of ROCK isoforms.
Volume: 309
Issue: 12
Pages: L1394-7
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Publication
29305907 | J:262327
First Author: Lins MP
Year: 2018
Journal: Biochim Biophys Acta
Title: Association between biomechanical alterations and migratory ability of semaphorin-3A-treated thymocytes.
Volume: 1862
Issue: 4
Pages: 816-824
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Publication
28460477 | J:277026
First Author: Park E
Year: 2017
Journal: Oncotarget
Title: Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice.
Volume: 8
Issue: 16
Pages: 27240-27251
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Publication
28674038 | J:283427
First Author: De Silva TM
Year: 2017
Journal: Hypertension
Title: Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.
Volume: 70
Issue: 3
Pages: 559-565
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Publication
35092120 | J:324575
First Author: Wu D
Year: 2022
Journal: J Cell Mol Med
Title: CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.
Volume: 26
Issue: 5
Pages: 1656-1671
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Publication
18174466 | J:147661
First Author: Phillips HM
Year: 2008
Journal: Circ Res
Title: Non-cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation.
Volume: 102
Issue: 5
Pages: 615-23
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Publication
10619026 | -
First Author: Maesaki R
Year: 1999
Journal: Mol Cell
Title: The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Volume: 4
Issue: 5
Pages: 793-803
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Publication
33042276 | J:328136
First Author: Zhang M
Year: 2020
Journal: Theranostics
Title: Rbm24 modulates adult skeletal muscle regeneration via regulation of alternative splicing.
Volume: 10
Issue: 24
Pages: 11159-11177
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Publication
17005937 | J:135839
First Author: Fu P
Year: 2006
Journal: J Am Soc Nephrol
Title: Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Volume: 17
Issue: 11
Pages: 3105-14
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Publication
27246255 | J:234187
First Author: Henderson BW
Year: 2016
Journal: J Neurochem
Title: Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.
Volume: 138
Issue: 4
Pages: 525-31
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Publication
24595357 | J:214645
First Author: Surma M
Year: 2014
Journal: PLoS One
Title: ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment.
Volume: 9
Issue: 3
Pages: e90758
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Publication
27218883 | J:259344
First Author: Otsu K
Year: 2016
Journal: J Bone Miner Res
Title: The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation.
Volume: 31
Issue: 11
Pages: 1943-1954
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Protein
Q3UMT5
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: true
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Protein
A0A1Y7VMN0
Organism: Mus musculus/domesticus
Length: 1444  
Fragment?: true
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Publication
15071095 | J:100207
First Author: Kobayashi K
Year: 2004
Journal: J Neurosci
Title: Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase.
Volume: 24
Issue: 14
Pages: 3480-8
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Publication
28457749 | J:253651
First Author: Hu JK
Year: 2017
Journal: Cell Stem Cell
Title: An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.
Volume: 21
Issue: 1
Pages: 91-106.e6
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Publication
27766308 | J:243706
 
First Author: Choy L
Year: 2016
Journal: Int J Cardiol Heart Vasc
Title: Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.
Volume: 12
Pages: 1-10
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Protein
P70336
Organism: Mus musculus/domesticus
Length: 1388  
Fragment?: false
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Protein
F8VPK5
Organism: Mus musculus/domesticus
Length: 1388  
Fragment?: false
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