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Search results 401 to 500 out of 525 for Rpe65

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Type Details Score
Publication
27391439 | J:280367
First Author: Rajala A
Year: 2016
Journal: Oncotarget
Title: Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival.
Volume: 7
Issue: 30
Pages: 46924-46942
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Publication
14742273 | J:88451
First Author: Mori M
Year: 2004
Journal: Am J Pathol
Title: Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.
Volume: 164
Issue: 2
Pages: 701-10
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Publication
19544586 | J:151497
First Author: Aoki H
Year: 2009
Journal: Dev Dyn
Title: In vitro and in vivo differentiation of human embryonic stem cells into retina-like organs and comparison with that from mouse pluripotent epiblast stem cells.
Volume: 238
Issue: 9
Pages: 2266-79
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Publication
29596840 | J:263032
First Author: Magella B
Year: 2018
Journal: Dev Biol
Title: Reduced Abd-B Hox function during kidney development results in lineage infidelity.
Volume: 438
Issue: 2
Pages: 84-93
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Publication
26405179 | J:226844
First Author: Collin GB
Year: 2015
Journal: Hum Mol Genet
Title: Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.
Volume: 24
Issue: 24
Pages: 6958-74
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Publication
27008858 | J:234197
First Author: Wong BH
Year: 2016
Journal: J Biol Chem
Title: Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Volume: 291
Issue: 20
Pages: 10501-14
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Publication
26876013 | J:279788
 
First Author: Wen B
Year: 2016
Journal: Sci Rep
Title: Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium.
Volume: 6
Pages: 21208
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Publication
26062936 | J:224079
First Author: Ohana R
Year: 2015
Journal: Development
Title: MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.
Volume: 142
Issue: 14
Pages: 2487-98
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Publication
30446775 | J:317613
First Author: Patnaik SR
Year: 2019
Journal: Cell Mol Life Sci
Title: Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.
Volume: 76
Issue: 4
Pages: 757-775
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Publication
33795534 | J:306330
First Author: Le D
Year: 2021
Journal: Mol Cells
Title: Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.
Volume: 44
Issue: 3
Pages: 168-178
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
34677125 | J:314167
   
First Author: Lim S
Year: 2021
Journal: Elife
Title: mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.
Volume: 10
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Publication
30566624 | J:273652
First Author: Chao CM
Year: 2019
Journal: Hum Mol Genet
Title: Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.
Volume: 28
Issue: 9
Pages: 1429-1444
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Publication
16110338 | J:107820
First Author: Corbo JC
Year: 2005
Journal: PLoS Genet
Title: A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Volume: 1
Issue: 2
Pages: e11
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10386590 | J:55672
First Author: Ma JX
Year: 1999
Journal: FEBS Lett
Title: Identification of RPE65 in transformed kidney cells.
Volume: 452
Issue: 3
Pages: 199-204
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Publication
16411761 | J:106138
First Author: Maiti P
Year: 2006
Journal: Biochemistry
Title: Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation.
Volume: 45
Issue: 3
Pages: 852-60
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Publication
23407971 | J:194257
First Author: Li S
Year: 2013
Journal: J Neurosci
Title: Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.
Volume: 33
Issue: 7
Pages: 3178-89
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Publication
17848510 | -
First Author: Jacobson SG
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Human cone photoreceptor dependence on RPE65 isomerase.
Volume: 104
Issue: 38
Pages: 15123-8
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Publication
27537685 | J:244927
First Author: Sukseree S
Year: 2016
Journal: PLoS One
Title: Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice.
Volume: 11
Issue: 8
Pages: e0161640
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Publication
16777093 | J:116311
First Author: Ham DI
Year: 2006
Journal: Exp Eye Res
Title: The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.
Volume: 83
Issue: 4
Pages: 897-902
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Allele
Rpe65<tm1Lrcb> | MGI:3771723
 
Name: retinal pigment epithelium 65; targeted mutation 1, Christian Grimm
Allele Type: Targeted
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Allele
Rpe65<rd12> | MGI:2388240
 
Name: retinal pigment epithelium 65; retinal degeneration 12
Allele Type: Spontaneous
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Publication
28874556 | -
First Author: Shyam R
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye.
Volume: 114
Issue: 41
Pages: 10882-10887
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Genotype
Genotype
Symbol: Rpe65/Rpe65
Background: 129S6/SvEvTac-Rpe65
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110353 | retinitis pigmentosa 20
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Publication
14532273 | -
First Author: Mata NL
Year: 2004
Journal: J Biol Chem
Title: Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.
Volume: 279
Issue: 1
Pages: 635-43
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Allele
Rpe65<em1Smoc> | MGI:7292107
Name: retinal pigment epithelium 65; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Rpe65/Rpe65
Background: B6(A)-Rpe65/J
Zygosity: hm
Has Mutant Allele: true
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Allele
Rpe65<tm1Tmr> | MGI:2181399
Name: retinal pigment epithelium 65; targeted mutation 1, T Michael Redmond
Allele Type: Targeted
Attribute String: Null/knockout
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DO Term
DOID:0112144 | retinitis pigmentosa 87
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Strain
MGI:6771131 | C57BL/6JSmoc-Rpe65<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Rpe65<em2Cya> | MGI:7657319
Name: retinal pigment epithelium 65; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Cnga3<tm1Biel> | MGI:2388388
Name: cyclic nucleotide gated channel alpha 3; targeted mutation 1, Martin Biel
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Rpe65/Rpe65
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cnga3/Cnga3 Rpe65/Rpe65
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rpe65/Rpe65
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110016 | Leber congenital amaurosis 2
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Allele
Rpe65<450M> | MGI:2680347
 
Name: retinal pigment epithelium 65; 450 Methionine
Allele Type: QTL
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Allele
Rpe65<450L> | MGI:3702572
 
Name: retinal pigment epithelium 65; 450 Leucine
Allele Type: QTL
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Strain
MGI:7657587 | C57BL/6J-Rpe65<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rpe65<450M>/Rpe65<450M>
Background: C57BL/6J-Tyr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rpe65<450L>/Rpe65<450L>
Background: BALB/c
Zygosity: hm
Has Mutant Allele: true
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Publication
21106934 | J:170742
First Author: Amengual J
Year: 2011
Journal: FASEB J
Title: A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.
Volume: 25
Issue: 3
Pages: 948-59
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Genotype
Genotype
Symbol: Rpe65<450M>/Rpe65<450M> Rpgr/Rpgr
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:3511540 | B6(A)-Rpe65<rd12>/J
Attribute String: mutant strain, spontaneous mutation
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Strain
MGI:7618778 | STOCK Rlbp1<tm1Kser>/J
Attribute String: mutant stock, targeted mutation
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Strain
MGI:7620424 | C57BL/6-Mir204<tm1.1Kpal>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:7620427 | STOCK Mir211<tm1.1Kpal>/J
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Rpe65<450L>/Rpe65<450L> Whrn/Whrn
Background: 129.Cg(B6)-Whrn
Zygosity: cx
Has Mutant Allele: true
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Protein
Q9JJS6
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q99NF1
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q91ZQ5
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
Q3KNZ2
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
E9Q321
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Q9CTP3
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: true
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Protein
A0A0G2JG19
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
Q05AC0
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Publication
14704328 | -
First Author: Wyss A
Year: 2004
Journal: J Nutr
Title: Carotene oxygenases: a new family of double bond cleavage enzymes.
Volume: 134
Issue: 1
Pages: 246S-250S
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Publication
12834401 | -
First Author: Tan BC
Year: 2003
Journal: Plant J
Title: Molecular characterization of the Arabidopsis 9-cis epoxycarotenoid dioxygenase gene family.
Volume: 35
Issue: 1
Pages: 44-56
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Publication
15821095 | -
First Author: Kloer DP
Year: 2005
Journal: Science
Title: The structure of a retinal-forming carotenoid oxygenase.
Volume: 308
Issue: 5719
Pages: 267-9
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Publication
1278918 | -
First Author: Hoover DJ
Year: 1976
Journal: Hosp Top
Title: Ozone deterioration.
Volume: 54
Issue: 3
Pages: 45-6
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Publication
20635095 | -
First Author: Chiou CY
Year: 2010
Journal: Planta
Title: Differential expression of carotenoid-related genes determines diversified carotenoid coloration in floral tissues of Oncidium cultivars.
Volume: 232
Issue: 4
Pages: 937-48
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Protein Domain
IPR004294 | Carotenoid_Oase
Type: Family
Description: Carotenoids such as beta-carotene, lycopene, lutein and beta-cryptoxanthine are produced in plants and certain bacteria, algae and fungi, where they function as accessory photosynthetic pigments and as scavengers of oxygen radicals for photoprotection. They are also essential dietary nutrients in animals. Carotenoid oxygenases cleave a variety of carotenoids into a range of biologically important products, including apocarotenoids in plants that function as hormones, pigments, flavours, floral scents and defence compounds, and retinoids in animals that function as vitamins, visual pigments and signalling molecules []. Examples of carotenoid oxygenases include:Beta,beta-carotene 15,15'-dioxygenase (BCDO1) from animals, which cleaves beta-carotene symmetrically at the central double bond to yield two molecules of retinal [].Carotenoid-cleaving dioxygenase, mitochondrial (BCDO2) from animals, which cleaves beta-carotene asymmetrically to apo-10'-beta-carotenal and beta-ionone, the latter being converted to retinoic acid. Lycopene is also oxidatively cleaved [, , ].Carotenoid 9,10(9',10')-cleavage dioxygenase (CCD) from plants, which cleaves a variety of carotenoids symmetrically at both the 9-10 and 9'-10' double bonds and catalyzes the formation of 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dialdehyde from zeaxanthin []. 9-cis-epoxycarotenoid dioxygenase (NCED1/2) from plants, which cleaves 9-cis xanthophylls to xanthoxin, a precursor of the hormone abscisic acid [].Apocarotenoid-15,15'-oxygenase (ACOX) from bacteria and cyanobacteria, which converts beta-apocarotenals rather than beta-carotene into retinal. This protein has a seven-bladed β-propeller structure with four hisitidines that hold the iron active centre [].Retinoid isomerohydrolase (RPE65) from animals, which in its soluble form binds all-trans retinol, and in its membrane-bound form binds all-trans retinyl esters. RPE65 is important for the production of 11-cis retinal during visual pigment regeneration [, , ].
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Publication
34751129 | J:342718
   
First Author: Sethna S
Year: 2021
Journal: Elife
Title: Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome.
Volume: 10
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Strain
MGI:4455136 | B6.Cg-Rpe65<rd12> Rho<Tvrm1>
Attribute String: congenic, chemically induced mutation, mutant strain
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Strain
MGI:4455135 | B6.Cg-Rpe65<rd12> Rho<Tvrm4>
Attribute String: mutant strain, congenic, chemically induced mutation
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Genotype
Genotype
Symbol: Rho/Rho<+> Rpe65/Rpe65
Background: B6.Cg-Rpe65 Rho
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rho/Rho<+> Rpe65/Rpe65
Background: B6.Cg-Rpe65 Rho
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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