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Search results 401 to 500 out of 556 for Scn5a

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Type Details Score
Publication
22706305 | J:190769
First Author: van den Boogaard M
Year: 2012
Journal: J Clin Invest
Title: Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.
Volume: 122
Issue: 7
Pages: 2519-30
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Publication
32109384 | J:286588
First Author: Misra C
Year: 2020
Journal: Dev Cell
Title: Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.
Volume: 52
Issue: 6
Pages: 748-763.e6
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Publication
25217174 | J:237455
First Author: Lodder EM
Year: 2014
Journal: Circ Cardiovasc Genet
Title: Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.
Volume: 7
Issue: 6
Pages: 790-8
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Publication
17724025 | J:126818
First Author: Zhang MM
Year: 2007
Journal: J Biol Chem
Title: Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.
Volume: 282
Issue: 42
Pages: 30699-706
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Publication
22875929 | J:186617
First Author: Hao MM
Year: 2012
Journal: J Neurosci
Title: Early development of electrical excitability in the mouse enteric nervous system.
Volume: 32
Issue: 32
Pages: 10949-60
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Publication
15746173 | J:109097
First Author: Haufe V
Year: 2005
Journal: J Physiol
Title: Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.
Volume: 564
Issue: Pt 3
Pages: 683-96
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Publication
31320323 | J:293668
 
First Author: Li H
Year: 2019
Journal: Development
Title: Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice.
Volume: 146
Issue: 14
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Publication
15272007 | J:93341
First Author: Malhotra JD
Year: 2004
Journal: J Biol Chem
Title: Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.
Volume: 279
Issue: 39
Pages: 40748-54
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Publication
15123669 | J:333673
First Author: Fotia AB
Year: 2004
Journal: J Biol Chem
Title: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
Volume: 279
Issue: 28
Pages: 28930-5
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Publication
26897459 | J:231297
First Author: Furtado MB
Year: 2016
Journal: Differentiation
Title: A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.
Volume: 91
Issue: 1-3
Pages: 29-41
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Publication
30175250 | J:268565
   
First Author: Ogiwara I
Year: 2018
Journal: Commun Biol
Title: Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Volume: 1
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Publication
22992950 | J:189007
First Author: Gaborit N
Year: 2012
Journal: Development
Title: Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
Volume: 139
Issue: 21
Pages: 4007-19
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Publication
32492036 | J:289625
First Author: Shawer H
Year: 2020
Journal: PLoS One
Title: A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure.
Volume: 15
Issue: 6
Pages: e0233007
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Publication
17884088 | J:127606
First Author: Lopez-Santiago LF
Year: 2007
Journal: J Mol Cell Cardiol
Title: Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.
Volume: 43
Issue: 5
Pages: 636-47
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Publication
30936836 | J:314288
 
First Author: Samal E
Year: 2019
Journal: Front Physiol
Title: Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.
Volume: 10
Pages: 235
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Publication
30151366 | J:293579
 
First Author: Moumne O
Year: 2018
Journal: Front Cardiovasc Med
Title: Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies.
Volume: 5
Pages: 100
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Publication
32672536 | J:293906
   
First Author: van Weerd JH
Year: 2020
Journal: Elife
Title: Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.
Volume: 9
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Publication
27775552 | J:239700
First Author: Shekhar A
Year: 2016
Journal: J Clin Invest
Title: Transcription factor ETV1 is essential for rapid conduction in the heart.
Volume: 126
Issue: 12
Pages: 4444-4459
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Publication
25599332 | J:252755
First Author: Gillers BS
Year: 2015
Journal: Circ Res
Title: Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.
Volume: 116
Issue: 3
Pages: 398-406
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
21511879 | J:172665
First Author: Chinchilla A
Year: 2011
Journal: Circ Cardiovasc Genet
Title: PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.
Volume: 4
Issue: 3
Pages: 269-79
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Publication
27180262 | J:250657
 
First Author: Greulich F
Year: 2016
Journal: J Mol Cell Cardiol
Title: Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
Volume: 97
Pages: 140-9
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Publication
21266775 | J:171828
First Author: Aanhaanen WT
Year: 2011
Journal: J Clin Invest
Title: Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.
Volume: 121
Issue: 2
Pages: 534-44
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Publication
23542581 | J:211437
First Author: de la Rosa AJ
Year: 2013
Journal: Cardiovasc Res
Title: Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.
Volume: 98
Issue: 3
Pages: 504-14
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Publication
17473172 | J:121230
First Author: Hoogaars WM
Year: 2007
Journal: Genes Dev
Title: Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
Volume: 21
Issue: 9
Pages: 1098-112
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Publication
28302382 | J:251389
 
First Author: Zakariyah AF
Year: 2017
Journal: J Mol Cell Cardiol
Title: Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.
Volume: 105
Pages: 89-98
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Publication
33443158 | J:299975
 
First Author: Gharibeh L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: GATA6 is a regulator of sinus node development and heart rhythm.
Volume: 118
Issue: 1
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Publication
30787001 | J:273025
 
First Author: Moreau JLM
Year: 2019
Journal: Development
Title: Gene-environment interaction impacts on heart development and embryo survival.
Volume: 146
Issue: 4
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Publication
39366945 | J:355142
First Author: Gómez-Del Arco P
Year: 2024
Journal: Nat Commun
Title: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
Volume: 15
Issue: 1
Pages: 8602
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Publication
15939374 | J:98707
First Author: Ferguson DA
Year: 2005
Journal: Gene Expr Patterns
Title: eXPRESSION: an in silico tool to predict patterns of gene expression.
Volume: 5
Issue: 5
Pages: 619-28
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Publication
26378152 | J:263568
First Author: Kim GE
Year: 2015
Journal: Cardiovasc Res
Title: LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.
Volume: 108
Issue: 1
Pages: 197-208
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Publication
38196272 | J:347631
First Author: Li C
Year: 2024
Journal: Adv Sci (Weinh)
Title: Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.
Volume: 11
Issue: 11
Pages: e2305992
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Publication
27997827 | J:237617
First Author: Menendez-Montes I
Year: 2016
Journal: Dev Cell
Title: Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Volume: 39
Issue: 6
Pages: 724-739
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Scn5a<tm1.1Tjh> | MGI:5825293
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1.1, Thomas J Hund
Allele Type: Targeted
Attribute String: Constitutively active
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Allele
Scn5a<tm2.1Tjh> | MGI:5825295
 
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 2.1, Thomas J Hund
Allele Type: Targeted
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Publication
26916278 | J:256751
First Author: Zaklyazminskaya E
Year: 2016
Journal: Biochim Biophys Acta
Title: The role of mutations in the SCN5A gene in cardiomyopathies.
Volume: 1863
Issue: 7 Pt B
Pages: 1799-805
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Publication
23818691 | J:214186
First Author: Remme CA
Year: 2013
Journal: J Physiol
Title: Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.
Volume: 591
Issue: 17
Pages: 4099-116
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Allele
Scn5a<tm3(SCN5A*)Rdn> | MGI:5445892
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 3, Dan M Roden
Allele Type: Targeted
Attribute String: Inserted expressed sequence, RMCE-ready
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Genotype
Genotype
Symbol: Scn5a/Scn5a
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE19741 | Genetic background effect on Scn5a mutant cardiac right ventricle gene expression
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
7889574 | -
First Author: Wang Q
Year: 1995
Journal: Cell
Title: SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome.
Volume: 80
Issue: 5
Pages: 805-11
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Genotype
Genotype
Symbol: Scn5a/Scn5a
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx | MGI:5800483
Name: transgene insertion, Steven O Marx
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Myh6-rtTA)8585Jam/? Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/?
Background: involves: C57BL/6 * CBA * FVB/NTac
Zygosity: cx
Has Mutant Allele: true
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Allele
Scn5a<tm1Care> | MGI:3769902
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Carol Ann Remme
Allele Type: Targeted
Attribute String: Humanized sequence, Modified isoform(s)
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Allele
Scn5a<tm1Pec> | MGI:2388158
 
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Peter Carmeliet
Allele Type: Targeted
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Allele
Scn5a<tm1Clhh> | MGI:3765977
 
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Christopher LH Huang
Allele Type: Targeted
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Allele
Scn5a<tm1.1Iba> | MGI:6415584
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1.1, Isabelle Baro
Allele Type: Targeted
Attribute String: Not Specified
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DO Term
DOID:0110433 | dilated cardiomyopathy 1E
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DO Term
DOID:0110218 | Brugada syndrome 1
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Allele
Gt(ROSA)26Sor<tm1(SCN5A/EGFP)Pmal> | MGI:6156904
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul M Allen
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Publication
34122134 | J:321269
 
First Author: Doisne N
Year: 2021
Journal: Front Physiol
Title: In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant.
Volume: 12
Pages: 661413
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Allele
Scn5a<tm1Agrc> | MGI:2179753
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Andrew A Grace
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Scn5a/Scn5a<+>
Background: FVB.129P2-Scn5a/Care
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Scn5a/Scn5a<+>
Background: involves: Swiss
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Scn5a/Scn5a<+>
Background: involves: 129/SvEv
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0110646 | long QT syndrome 3
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Genotype
Genotype
Symbol: Scn5a/Scn5a<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Allele
Del(9Rr207838-Rr207840)6Vmc | MGI:7423612
Name: deletion, Chr 9, Vincent M Christoffels 6
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Transgene
MGI:5800482 | Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Type: transgene
Organism: mouse, laboratory
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Allele
Del(9Rr207840)7Vmc | MGI:7423615
Name: deletion, Chr 9, Vincent M Christoffels 7
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Del(9Rr207838-Rr207840)8Vmc | MGI:7423616
Name: deletion, Chr 9, Vincent M Christoffels 8
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Del(9Rr207838)10Vmc | MGI:7423618
Name: deletion, Chr 9, Vincent M Christoffels 10
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Strain
MGI:7425193 | FVB/NRj-Del(9Rr207838-Rr207840)6Vmc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Del(9Rr207839-Rr207840)9Vmc | MGI:7423617
Name: deletion, Chr 9, Vincent M Christoffels 9
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Genotype
Genotype
Symbol: Del(9Rr207838-Rr207840)6Vmc/+
Background: FVB/NRj-Del(9Rr207838-Rr207840)6Vmc
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(9Rr207838-Rr207840)6Vmc/Del(9Rr207838-Rr207840)6Vmc
Background: FVB/NRj-Del(9Rr207838-Rr207840)6Vmc
Zygosity: hm
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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