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Search results 401 to 500 out of 573 for Sds

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0.03s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
15212842 | J:102351
First Author: Jankowsky JL
Year: 2004
Journal: Neurobiol Aging
Title: APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Volume: 25
Issue: 7
Pages: 885-92
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Strain
MGI:2159982 | SEC/1ReJ
Attribute String: inbred strain
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Strain
MGI:2159978 | SF/CamEiJ
Attribute String: wild-derived, inbred strain
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Strain
MGI:2160109 | SK/CamEi
Attribute String: wild-derived, inbred strain
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Protein
A0A1W2P6H2
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
A0A1B0GRG7
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
A0A1B0GT43
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
B6ZHC3
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
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Protein
Q8BSR4
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A0A1B0GRQ1
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein
Q7TPN6
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
B6ZHC2
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
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Protein
A0A1B0GT70
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Publication
1988044 | -
First Author: Breeze AL
Year: 1991
Journal: Biochemistry
Title: Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.
Volume: 30
Issue: 2
Pages: 575-82
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Protein Domain
IPR036562 | Baculovirus_p35_sf
Type: Homologous_superfamily
Description: The anti-apoptotic protein p35 from baculovirus is thought to prevent the suicidal response ofinfected insect cells by inhibiting caspases. Ectopic expression of p35 in a number of transgenic animals or cell lines is also anti-apoptotic, giving rise to the hypothesis that the protein is a general inhibitor of caspases. This protein belongs to MEROPS proteinase inhibitor family I50, clan IQ. Purified recombinant p35 inhibits human caspase-1, -3, -6, -7, -8, and -10 but does not significantly inhibit unrelated serine or cysteine proteases, implying that p35 is a potent caspase-specific inhibitor. The interaction of p35 with caspase-3, as a model of the inhibitory mechanism,revealed classic slow-binding inhibition, with both active-sites of the caspase-3 dimer acting equally and independently. Inhibition resulted from complex formation between the enzyme and inhibitor, which could be visualised under non-denaturing conditions, but was dissociated by SDS to give p35 cleaved at Asp87, the P1 residue of the inhibitor. Complex formation requires the substrate-binding cleft to be unoccupied [].Infecting the insect cell line IPLB-Ld652Y with the baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) results in global translation arrest, which correlates with the presence of the AcMNPV apoptotic suppressor, p35. However, the anti-apoptotic function of p35 in translation arrest is not solely due to caspase inactivation, but its activity enhances signalling to a separate translation arrest pathway, possibly by stimulating the late stages of the baculovirus infection cycle []. The baculovirus p35 structure forms a sandwich composed of 14 strands in 2 sheets with a greek-key topology.
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Protein Domain
IPR003429 | Baculovirus_p35
Type: Family
Description: The anti-apoptotic protein p35 from baculovirus is thought to prevent the suicidal response ofinfected insect cells by inhibiting caspases. Ectopic expression of p35 in a number of transgenic animals or cell lines is also anti-apoptotic, giving rise to the hypothesis that the protein is a general inhibitor of caspases. This protein belongs to MEROPS proteinase inhibitor family I50, clan IQ. Purified recombinant p35 inhibits human caspase-1, -3, -6, -7, -8, and -10 but does not significantly inhibit unrelated serine or cysteine proteases, implying that p35 is a potent caspase-specific inhibitor. The interaction of p35 with caspase-3, as a model of the inhibitory mechanism,revealed classic slow-binding inhibition, with both active-sites of the caspase-3 dimer acting equally and independently. Inhibition resulted from complex formation between the enzyme and inhibitor, which could be visualised under non-denaturing conditions, but was dissociated by SDS to give p35 cleaved at Asp87, the P1 residue of the inhibitor. Complex formation requires the substrate-binding cleft to be unoccupied [].Infecting the insect cell line IPLB-Ld652Y with the baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) results in global translation arrest, which correlates with the presence of the AcMNPV apoptotic suppressor, p35. However, the anti-apoptotic function of p35 in translation arrest is not solely due to caspase inactivation, but its activity enhances signalling to a separate translation arrest pathway, possibly by stimulating the late stages of the baculovirus infection cycle [].
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Protein Domain
IPR015476 | Calcitonin_gene-rel_peptide
Type: Family
Description: The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner, producing either the calcium regulatory hormone CT in the thyroid, or the neuropeptide calcitonin gene related peptide (CGRP) in the brain []. In medullary carcinoma of the thyroid, both peptides are produced [].The calcitonin regulatory hormone is a peptide of 32 residues that causes a rapid but short-lived drop in calcium and phosphate levels in the blood by promoting the incorporation of these ions in the bones []. The structure of Oncorhynchus sp. (Salmon) calcitonin has been studied by 2D NMR in SDS micelles []. The main conformational feature of the hormone is an α-helix from residues 6-22, which includes an amphipathic segment. Two cysteine residues (at positions 1 and 7) form an N-terminal loop, and a C-terminal decapeptide forms a loop that folds back towards the helix [].CGRP is a 37-residue peptide produced by alternative splicing of the CT gene. CGRP induces vasodilation in various vessels, including those of the coronary, cerebral and systemic vasculature. A neurotransmitter or neuro-modulator role is suggested by its abundance in the CNS []. The structure of human CGRP has been determined by 1H NMR []. The main conformational feature of the hormone is an N-terminal disulphide-bonded loop (residues 2-7), leading into a well-defined α-helix between residues 8 and 18; thereafter, the structure is predominantly disordered, althoughthere are indications of a preference for a turn-type conformation between residues 19 and 21 [].This entry represents the full-length propeptide (procalcitonin gene-related peptide or proCGRP) before cleavage into the calcitonin peptide.
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Publication
9786090 | J:62147
First Author: Pfister KK
Year: 1998
Journal: Cell Motil Cytoskeleton
Title: Identification and molecular characterization of the p24 dynactin light chain.
Volume: 41
Issue: 2
Pages: 154-67
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Publication
2144875 | J:152750
First Author: Sugimoto S
Year: 1990
Journal: J Neurol Sci
Title: Kinetic properties and isozyme composition of myosin in the mdx mutant mouse.
Volume: 97
Issue: 2-3
Pages: 207-19
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Publication
26057580 | J:224762
First Author: Tourlakis ME
Year: 2015
Journal: PLoS Genet
Title: In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency.
Volume: 11
Issue: 6
Pages: e1005288
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Publication
8221765 | J:17160
First Author: Bashey RI
Year: 1993
Journal: Cardiovasc Res
Title: Increased collagen synthesis and increased content of type VI collagen in myocardium of tight skin mice.
Volume: 27
Issue: 6
Pages: 1061-5
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Publication
22510201 | J:189357
First Author: Tourlakis ME
Year: 2012
Journal: Gastroenterology
Title: Deficiency of Sbds in the mouse pancreas leads to features of Shwachman-Diamond syndrome, with loss of zymogen granules.
Volume: 143
Issue: 2
Pages: 481-92
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Publication
24001940 | J:341670
 
First Author: Gupta MK
Year: 2013
Journal: J Mol Cell Cardiol
Title: Functional dissection of myosin binding protein C phosphorylation.
Volume: 64
Pages: 39-50
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Publication
36731681 | J:358959
 
First Author: Schoknecht K
Year: 2023
Journal: Neurobiol Dis
Title: Transient astrocytic accumulation of fluorescein during spreading depolarizations.
Volume: 178
Pages: 106026
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Publication
25721894 | J:261271
First Author: Fittschen M
Year: 2015
Journal: Neurogenetics
Title: Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.
Volume: 16
Issue: 3
Pages: 181-92
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Publication
31628185 | J:282371
First Author: Jansen NA
Year: 2019
Journal: J Neurosci
Title: Apnea Associated with Brainstem Seizures in Cacna1a S218L Mice Is Caused by Medullary Spreading Depolarization.
Volume: 39
Issue: 48
Pages: 9633-9644
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Publication
34857650 | J:353030
First Author: Suryavanshi P
Year: 2022
Journal: J Neurosci
Title: Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations.
Volume: 42
Issue: 11
Pages: 2371-2383
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Publication
15274632 | J:320147
First Author: Fraering PC
Year: 2004
Journal: Biochemistry
Title: Purification and characterization of the human gamma-secretase complex.
Volume: 43
Issue: 30
Pages: 9774-89
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Publication
10810445 | J:58881
First Author: Clothier B
Year: 2000
Journal: Biochem Pharmacol
Title: Genetic variation of basal iron status, ferritin and iron regulatory protein in mice: potential for modulation of oxidative stress.
Volume: 59
Issue: 2
Pages: 115-22
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Publication
8055909 | J:20177
First Author: Bayard B
Year: 1994
Journal: Eur J Biochem
Title: Affinity purification and characterization of (2'-5')oligo(adenylate)-dependent RNase from mouse spleen.
Volume: 223
Issue: 2
Pages: 403-10
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Publication
9305797 | J:42785
First Author: Scott PG
Year: 1997
Journal: Biochim Biophys Acta
Title: Isolation and characterization of small proteoglycans from different zones of the porcine knee meniscus.
Volume: 1336
Issue: 2
Pages: 254-62
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Publication
21896739 | J:177774
 
First Author: Kumar V
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.
Volume: 108 Suppl 3
Pages: 15557-64
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Strain
MGI:2159897 | A/HeJ
Attribute String: inbred strain
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Publication
21630251 | J:177626
First Author: Lewis CJ
Year: 2011
Journal: Eur J Immunol
Title: Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Volume: 41
Issue: 9
Pages: 2562-72
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Publication
25995356 | J:239367
First Author: Stasiulewicz M
Year: 2015
Journal: Development
Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
Volume: 142
Issue: 13
Pages: 2291-303
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Publication
17913918 | J:125592
First Author: Li T
Year: 2007
Journal: J Neurosci
Title: Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
Volume: 27
Issue: 40
Pages: 10849-59
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Publication
32522344 | J:293057
 
First Author: Kuroda E
Year: 2020
Journal: Neuroscience
Title: Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ.
Volume: 438
Pages: 217-228
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Publication
37213691 | J:338490
 
First Author: Demuth H
Year: 2023
Journal: Front Mol Neurosci
Title: Deletion of p75(NTR) rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Volume: 16
Pages: 1163087
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Protein
O08917
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q99JB2
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
Q540I4
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
A2AG41
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
A2AG39
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: true
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Protein
Q3UEG9
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
Q3TJS0
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
G3UYU4
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
F6WI02
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: true
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Publication
10542406 | -
First Author: Tavernarakis N
Year: 1999
Journal: Trends Biochem Sci
Title: The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins.
Volume: 24
Issue: 11
Pages: 425-7
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Publication
9692966 | -
First Author: Zhou Q
Year: 1998
Journal: Biochemistry
Title: Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Volume: 37
Issue: 30
Pages: 10757-65
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Publication
14980489 | -
First Author: Thiem SM
Year: 2004
Journal: Virology
Title: The role of baculovirus apoptotic suppressors in AcMNPV-mediated translation arrest in Ld652Y cells.
Volume: 319
Issue: 2
Pages: 292-305
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Protein
F6QPR1
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q3V2V2
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q3V048
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
F7BUB8
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
F6S4K9
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: true
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Protein
A0A1W2P7I2
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
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Publication
11213270 | J:106525
First Author: Dozmorov I
Year: 2001
Journal: J Gerontol A Biol Sci Med Sci
Title: Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant Prop1df.
Volume: 56
Issue: 2
Pages: B72-80
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Publication
38259500 | J:348765
 
First Author: Takasu K
Year: 2023
Journal: Front Cell Neurosci
Title: Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect.
Volume: 17
Pages: 1274459
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Publication
38162001 | J:349504
 
First Author: Dell'Orco M
Year: 2023
Journal: Front Cell Neurosci
Title: Repetitive spreading depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways.
Volume: 17
Pages: 1292661
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Publication
8089273 | J:18718
First Author: Mieziewska K
Year: 1994
Journal: J Comp Neurol
Title: Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina.
Volume: 345
Issue: 1
Pages: 115-24
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Publication
- | J:13808
 
First Author: Hjorth JP
Year: 1979
Journal: Mouse News Lett
Title: Salivary amylase.
Volume: 61
Pages: 25
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Strain
MGI:2159737 | BALB/cJ
Attribute String: inbred strain
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Strain
MGI:2159756 | CBA/J
Attribute String: inbred strain
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Strain
MGI:2180845 | SWR/J
Attribute String: inbred strain
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Strain
MGI:2159908 | C57BLKS/J
Attribute String: inbred strain
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Strain
MGI:2159763 | SEA/GnJ
Attribute String: recombinant inbred (RI), spontaneous mutation, mutant strain
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Strain
MGI:2159749 | PL/J
Attribute String: inbred strain
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Strain
MGI:2159771 | BALB/cByJ
Attribute String: inbred strain
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Strain
MGI:2159846 | MA/MyJ
Attribute String: inbred strain
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Strain
MGI:2159792 | C57BR/cdJ
Attribute String: inbred strain
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Strain
MGI:2159787 | SM/J
Attribute String: inbred strain
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Publication
36720219 | J:337501
First Author: Sacirbegovic F
Year: 2023
Journal: Immunity
Title: Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.
Volume: 56
Issue: 2
Pages: 369-385.e6
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Publication
27196744 | J:234011
   
First Author: Deyts C
Year: 2016
Journal: Elife
Title: Loss of presenilin function is associated with a selective gain of APP function.
Volume: 5
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Protein
Q91X05
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
C0LL95
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
C0LL94
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
C0LL99
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A0A6YVZ4
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
C0LL98
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Publication
24782879 | -
 
First Author: Gehl B
Year: 2014
Journal: Front Plant Sci
Title: Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?
Volume: 5
Pages: 141
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Publication
- | J:335832
First Author: Peters MJ
Year: 2022
Journal: Blood
Title: Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model.
Volume: 140
Issue: Suppl 1
Pages: 29442945
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Strain
MGI:2159761 | LP/J
Attribute String: inbred strain
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Strain
MGI:2159757 | CE/J
Attribute String: inbred strain
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Strain
MGI:2159746 | C57L/J
Attribute String: inbred strain
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Strain
MGI:2159751 | ST/bJ
Attribute String: inbred strain
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Strain
MGI:2159907 | BUB/BnJ
Attribute String: inbred strain
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Publication
39047106 | J:353069
First Author: Sung CYW
Year: 2024
Journal: Sci Adv
Title: Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity.
Volume: 10
Issue: 30
Pages: eadk9878
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Strain
MGI:2159750 | RF/J
Attribute String: inbred strain
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Publication
17698590 | J:126088
First Author: Laky K
Year: 2007
Journal: J Exp Med
Title: Presenilins regulate alphabeta T cell development by modulating TCR signaling.
Volume: 204
Issue: 9
Pages: 2115-29
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Publication
25002035 | J:218071
First Author: Orre M
Year: 2014
Journal: Neurobiol Aging
Title: Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.
Volume: 35
Issue: 12
Pages: 2746-2760
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Strain
MGI:2180844 | NZB/BlNJ
Attribute String: inbred strain
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Protein
Q6PE84
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Protein
Q8CI66
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q99L68
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Protein
A0A0B4J1F1
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q3UFS9
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: true
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Protein
B2RS16
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Publication
3060108 | -
First Author: Breimer LH
Year: 1988
Journal: Biochem J
Title: Peptides from the calcitonin genes: molecular genetics, structure and function.
Volume: 255
Issue: 2
Pages: 377-90
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Protein
P54116
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Protein
Q8BPA1
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom