Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:6715341 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-06-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6715494 |
Age: |
embryonic day 13.0 |
Image: |
4B 6-DSP |
|
Specimen Label: |
4B 6-DSP |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takamatsu H |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. |
Volume: |
11 |
Issue: |
7 |
Pages: |
594-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu Z |
Year: |
2017 |
Journal: |
Science |
Title: |
Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. |
Volume: |
357 |
Issue: |
6349 |
Pages: |
400-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jidigam VK |
Year: |
2022 |
Journal: |
Commun Biol |
Title: |
Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice. |
Volume: |
5 |
Issue: |
1 |
Pages: |
792 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun LO |
Year: |
2013 |
Journal: |
Science |
Title: |
On and off retinal circuit assembly by divergent molecular mechanisms. |
Volume: |
342 |
Issue: |
6158 |
Pages: |
1241974 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heisig J |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e1002728 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu X |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line. |
Volume: |
177 |
Issue: |
10 |
Pages: |
7042-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrews WD |
Year: |
2016 |
Journal: |
J Comp Neurol |
Title: |
Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice. |
Volume: |
524 |
Issue: |
3 |
Pages: |
518-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Donovan KJ |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. |
Volume: |
211 |
Issue: |
5 |
Pages: |
801-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costello I |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. |
Volume: |
29 |
Issue: |
20 |
Pages: |
2108-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darwich R |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5. |
Volume: |
26 |
Issue: |
5 |
Pages: |
942-954 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu C |
Year: |
2008 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. |
Volume: |
8 |
Issue: |
7-8 |
Pages: |
502-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coulpier F |
Year: |
2009 |
Journal: |
Glia |
Title: |
Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. |
Volume: |
57 |
Issue: |
13 |
Pages: |
1450-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan K |
Year: |
2023 |
Journal: |
Cereb Cortex |
Title: |
TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1752-1767 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bibollet-Bahena O |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e0177977 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2006 |
Journal: |
Neuron |
Title: |
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. |
Volume: |
52 |
Issue: |
5 |
Pages: |
775-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen B |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. |
Volume: |
102 |
Issue: |
47 |
Pages: |
17184-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oeschger FM |
Year: |
2012 |
Journal: |
Cereb Cortex |
Title: |
Gene expression analysis of the embryonic subplate. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1343-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naba A |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
Volume: |
7 |
|
Pages: |
40495 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
1 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimogori T |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
A genomic atlas of mouse hypothalamic development. |
Volume: |
13 |
Issue: |
6 |
Pages: |
767-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Memic F |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. |
Volume: |
154 |
Issue: |
3 |
Pages: |
624-636 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion EW185, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Rohm B |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A. |
Volume: |
93 |
Issue: |
1-2 |
Pages: |
95-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Connor BP |
Year: |
2008 |
Journal: |
Immunol Res |
Title: |
The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function. |
Volume: |
41 |
Issue: |
3 |
Pages: |
217-22 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion [, ]. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation []. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs) []. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module. |
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•
•
•
•
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Publication |
First Author: |
Naito M |
Year: |
2022 |
Journal: |
Life Sci Alliance |
Title: |
Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung. |
Volume: |
5 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gu Z |
Year: |
2020 |
Journal: |
J Neurosci |
Title: |
Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway. |
Volume: |
40 |
Issue: |
28 |
Pages: |
5402-5412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winberg ML |
Year: |
1998 |
Journal: |
Cell |
Title: |
Plexin A is a neuronal semaphorin receptor that controls axon guidance. |
Volume: |
95 |
Issue: |
7 |
Pages: |
903-16 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1894
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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•
•
•
•
•
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