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Search results 401 to 500 out of 878 for Sf1

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Hits by Strain

Type Details Score
Protein
Q8BTX6
Organism: Mus musculus/domesticus
Length: 993  
Fragment?: true
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Protein
Q8BUI4
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: false
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Protein
Q9D3Z7
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
A0A0R4J217
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Publication
12606717 | -
First Author: Sharma V
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Volume: 100
Issue: 5
Pages: 2243-8
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Publication
16243836 | -
First Author: Papanikou E
Year: 2005
Journal: J Biol Chem
Title: Identification of the preprotein binding domain of SecA.
Volume: 280
Issue: 52
Pages: 43209-17
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Publication
32346490 | -
First Author: Mirza MU
Year: 2020
Journal: J Pharm Anal
Title: Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase.
Volume: 10
Issue: 4
Pages: 320-328
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Publication
32875166 | -
 
First Author: Gurung AB
Year: 2020
Journal: Gene Rep
Title: In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors.
Volume: 21
Pages: 100860
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Publication
32529952 | -
First Author: Yuen CK
Year: 2020
Journal: Emerg Microbes Infect
Title: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
Volume: 9
Issue: 1
Pages: 1418-1428
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Protein Domain
IPR014018 | SecA_motor_DEAD
Type: Domain
Description: SecA is a cytoplasmic protein of 800 to 960 amino acid residues. The eubacterial secA protein []plays an important role in protein export. It interacts with the secY and secE components of the protein translocation system. It has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the membrane.SecA is a superfamily 2 (SF2) helicase that adapted to translocate proteins. It contains the characteristic DEAD/DEXH ATPase core structure with the seven SF2 motifs []. Several structural analyses on secA have been reported [, ]. They show that secA contains two recA-like domains similar to SF1 and SF2 helicases. In helicases, the two recA-like domains move relative to one another during the ATPase cycle, generating domain movements that translocate the helicase along nucleic acids. In secA, it seems that a similar mechanism is used to generate domain movements that are coupled to polypeptide translocation. The N-terminal recA-like domain of secA contains an insert of about 150 residues that forms the preprotein crosslinking domain (PPXD) which has the ability to bind preproteins in solution and which is important for preprotein loading onto SecYEG-containing membranes [].Homologs of secA are also encoded in the chloroplast genome of some algae []as well as in the nuclear genome of plants []. It could be involved in the intraorganellar protein transport into thylakoids.
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Protein Domain
IPR044343 | NSP13_1B_dom_CoV
Type: Domain
Description: Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a vital role in catalysing the unwinding of duplex oligonucleotides into single strands in an NTP-dependent manner. It is a multidomain protein which includes an N-terminal Cys/His rich zinc-binding domain (ZBD), followed by a stalk and 1B domains, and a helicase core that belongs to the superfamily SF1 of helicases, containing two RecA1 and RecA2 domains [, ]. The stalk region connects the ZBD domain and 1B domain. Nsp13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domain form the triangular base, while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [, , ]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist. It is involved in type I interferon (IFN-I) response as it binds and blocks TBK1 phosphorylation to inhibit interferon regulatory factor 3 (IRF3) which results in decreased IRF3 activation [, ].This entry represents the 1B domain, which has a regulatory role modulating the nucleic acid substrate binding. Based on the structures from the related Equine arteritis virus (EAV) NSP10, it is likely that 1B domain forms a channel together with 1A and 2A domains that accommodates the single stranded nucleic acids [, ].
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Protein
Q8K301
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
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Protein
Q62095
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q91VN6
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
Q8VDW0
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q9ESV0
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: false
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Protein
Q921N6
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q9D0R4
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
P16381
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q62167
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
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Protein
Q9JJY4
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
Q9QY15
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
P54823
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q810A7
Organism: Mus musculus/domesticus
Length: 929  
Fragment?: false
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Protein
Q9CWT6
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q9Z1N5
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q4FZF3
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q61496
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
Q61655
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q569Z5
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
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Protein
Q91VC3
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q8R4Z6
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
Q5SVX3
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
Q3V086
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
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Protein
Q8BZY3
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
Q3UVN0
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q3U484
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q3U837
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q3TKX4
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: true
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Protein
D3Z0M9
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
Q3TLR1
Organism: Mus musculus/domesticus
Length: 792  
Fragment?: false
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Protein
Q3UAC4
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
Q3TIE4
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
F8WJA0
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
Q8BRE3
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: true
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Protein
Q8BK66
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
F8WHR6
Organism: Mus musculus/domesticus
Length: 1028  
Fragment?: false
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Protein
S4R1I6
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
A2AFK7
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Protein
Q3TI21
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
A0A0N4SVP8
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q3T9L0
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
B9EKE9
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
B7ZWF1
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
A0A1Y7VKX7
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
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Protein
Q3TPL7
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
A0A1S6GWH2
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q3UXW3
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
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Protein
A0A1S6GWJ4
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Protein
Q3U7R4
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: false
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Protein
Q3TQX5
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
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Protein
E9PV04
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q8R3C7
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
B9EIA2
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q5SXJ3
Organism: Mus musculus/domesticus
Length: 1174  
Fragment?: false
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Protein
Q3TER9
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: true
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Protein
Q6AXC6
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
Q0VGM9
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: false
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Protein
A0A286YCB9
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
A0A2Y9CZM3
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
A2AU08
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
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Protein
A0A286YDY6
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
Q3TE55
Organism: Mus musculus/domesticus
Length: 824  
Fragment?: true
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Protein
Z4YLW7
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: true
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Protein
Q8CFQ3
Organism: Mus musculus/domesticus
Length: 1481  
Fragment?: false
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Protein
P23249
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: false
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Protein
A2AKX3
Organism: Mus musculus/domesticus
Length: 2646  
Fragment?: false
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Protein
Q3TFC0
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: false
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Protein
A2AAU5
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: true
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Protein
Q7TT03
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
F6R186
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
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Protein
Q8BQU5
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: true
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Protein
D3YVL0
Organism: Mus musculus/domesticus
Length: 1077  
Fragment?: false
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Protein
D3Z3E8
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: false
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Protein
Q3UD86
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: false
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Protein
E9PW39
Organism: Mus musculus/domesticus
Length: 1077  
Fragment?: false
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Protein
Q3U0E9
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: true
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Protein
Q69ZE2
Organism: Mus musculus/domesticus
Length: 1027  
Fragment?: true
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Protein
Q922U3
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: true
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Protein
A2AQA7
Organism: Mus musculus/domesticus
Length: 1400  
Fragment?: false
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Publication
10880469 | -
First Author: Kang HY
Year: 2000
Journal: Genetics
Title: Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism.
Volume: 155
Issue: 3
Pages: 1055-67
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Publication
22570407 | -
First Author: Gloor JW
Year: 2012
Journal: Nucleic Acids Res
Title: Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.
Volume: 40
Issue: 14
Pages: 6774-86
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Protein
Q8CHI8
Organism: Mus musculus/domesticus
Length: 3072  
Fragment?: false
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Protein
Q9JIK5
Organism: Mus musculus/domesticus
Length: 851  
Fragment?: false
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Protein
Q6NZQ2
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
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Protein
Q99NG0
Organism: Mus musculus/domesticus
Length: 1466  
Fragment?: false
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Protein
O35286
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q99PU8
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Protein
Q8K363
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q6ZPV2
Organism: Mus musculus/domesticus
Length: 1559  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom