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Search results 401 to 459 out of 459 for Shank3

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Type Details Score
Publication
37008785 | J:345242
 
First Author: Ferhat AT
Year: 2023
Journal: Front Mol Neurosci
Title: Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice.
Volume: 16
Pages: 1139118
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Interaction Experiment
Schuetz G (2004)
Description: The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
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Interaction Experiment
Cai Q (2020)
Description: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
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Transgene
MGI:5516001 | Tg(Shank3-EGFP)1Hzo
Type: transgene
Organism: mouse, laboratory
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DO Term
DOID:0060437 | chromosome 22q13 duplication syndrome
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DO Term
DOID:0070091 | schizophrenia 15
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Protein
Q4ACU6-7
Organism: Mus musculus/domesticus
Length: 1198  
Fragment?: false
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Protein
Q4ACU6-2
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q4ACU6-6
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Protein
Q4ACU6-12
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein
Q4ACU6-11
Organism: Mus musculus/domesticus
Length: 1202  
Fragment?: false
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Protein
Q4ACU6-8
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
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Protein
Q4ACU6-10
Organism: Mus musculus/domesticus
Length: 1104  
Fragment?: false
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Protein
Q4ACU6-9
Organism: Mus musculus/domesticus
Length: 1112  
Fragment?: false
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Protein
Q4ACU6
Organism: Mus musculus/domesticus
Length: 1730  
Fragment?: false
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Protein
Q4ACU6-3
Organism: Mus musculus/domesticus
Length: 1322  
Fragment?: false
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Publication
31879129 | -
First Author: Cai Q
Year: 2020
Journal: Structure
Title: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
Volume: 28
Issue: 3
Pages: 290-300.e4
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HT Experiment
GSE201621 | Transcriptome analysis of Shank3-heterozygous and -homozygous mice in different brain regions
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE201853 | Transcriptome analysis of Shank3-homozygous mutant and wild-type mice of different ages
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5515935 | B6.FVB-Tg(Shank3-EGFP)1Hzo/J
Attribute String: congenic, mutant strain, transgenic
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Allele
Shank3<tm5.1Gfng> | MGI:5775650
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 5.1, Guoping Feng
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
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Strain
MGI:5775652 | STOCK Shank3<tm5.1Gfng>/J
Attribute String: mutant stock, targeted mutation
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Allele
Shank3<tm1.1Ics> | MGI:7428383
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Modified isoform(s), Reporter
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Allele
Shank3<em1Yhj> | MGI:7738562
Name: SH3 and multiple ankyrin repeat domains 3; endonuclease-mediated mutation 1, Yong-hui Jiang
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Shank3/Shank3
Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Allele
Shank3<tm2.1Bux> | MGI:6162240
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 3.2, Joseph D Buxbaum
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:7738631 | B6.129(Cg)-Shank3<em1Yhj>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Shank3<tm2Gfng> | MGI:4949738
 
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 2, Guoping Feng
Allele Type: Targeted
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Allele
Shank3<tm3.2Cmpl> | MGI:6438113
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 3.2, Craig M Powell
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Allele
Tcf20<em1Jwji> | MGI:6726263
Name: transcription factor 20; endonuclease-mediated mutation 1, Jianwei Jiao
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0080354 | Phelan-McDermid syndrome
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Genotype
Genotype
Symbol: Shank3/Shank3
Background: B6(Cg)-Shank3
Zygosity: hm
Has Mutant Allele: true
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Allele
Shank3<tm1.1Pfw> | MGI:5085999
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Paul Worley
Allele Type: Targeted
Attribute String: Hypomorph
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Protein Coding Gene
MGI:108399 | Tcf20
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Shank3/Shank3<+>
Background: B6.129-Shank3/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shank3/Shank3
Background: B6.129S6(Cg)-Shank3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shank3/Shank3<+>
Background: B6.129S6(Cg)-Shank3
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tcf20/Tcf20<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:5139910 | B6.129S6-Shank3<tm1.1Pfw>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5317903 | STOCK Shank3<tm1.1Pfw>/J
Attribute String: congenic, mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Shank3/Shank3<+>
Background: B6.129S6-Shank3
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shank3/Shank3
Background: B6.129S6-Shank3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shank3/Shank3 Tg(CAG-cre/Esr1*)1Lbe/?
Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
21048139 | J:166700
First Author: Giza J
Year: 2010
Journal: J Neurosci
Title: Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.
Volume: 30
Issue: 44
Pages: 14805-16
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Publication
35217690 | J:322555
First Author: Stillman M
Year: 2022
Journal: Sci Rep
Title: Activity dependent dissociation of the Homer1 interactome.
Volume: 12
Issue: 1
Pages: 3207
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Publication
35819332 | J:334410
 
First Author: Feng Z
Year: 2022
Journal: J Cell Biol
Title: IRSp53 promotes postsynaptic density formation and actin filament bundling.
Volume: 221
Issue: 8
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Publication
18272690 | J:132277
First Author: Hung AY
Year: 2008
Journal: J Neurosci
Title: Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
Volume: 28
Issue: 7
Pages: 1697-708
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Publication
21695253 | J:174446
First Author: Wöhr M
Year: 2011
Journal: PLoS One
Title: Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
Volume: 6
Issue: 6
Pages: e20631
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Publication
26961412 | J:250172
 
First Author: Matsushita Y
Year: 2016
Journal: Sci Rep
Title: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.
Volume: 6
Pages: 22991
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Publication
23742761 | J:201540
 
First Author: Morice E
Year: 2013
Journal: Neurobiol Dis
Title: Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Volume: 58
Pages: 156-68
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Publication
20573181 | J:174472
First Author: Pham E
Year: 2010
Journal: FEBS J
Title: Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.
Volume: 277
Issue: 14
Pages: 3051-67
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Publication
20305784 | J:158900
First Author: Bertaso F
Year: 2010
Journal: PLoS One
Title: Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons.
Volume: 5
Issue: 3
Pages: e9755
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Publication
31745231 | J:310505
First Author: Han KA
Year: 2019
Journal: Sci Rep
Title: Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.
Volume: 9
Issue: 1
Pages: 17094
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Publication
28130356 | J:239596
First Author: Stephenson JR
Year: 2017
Journal: J Neurosci
Title: A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
Volume: 37
Issue: 8
Pages: 2216-2233
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Publication
30505269 | J:288905
 
First Author: Sungur AÖ
Year: 2018
Journal: Front Mol Neurosci
Title: Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1.
Volume: 11
Pages: 419
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Publication
32269286 | J:331674
First Author: Lee SY
Year: 2020
Journal: Exp Mol Med
Title: PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors.
Volume: 52
Issue: 4
Pages: 604-614
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Publication
33398084 | J:347314
First Author: Yoon S
Year: 2021
Journal: Mol Psychiatry
Title: Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.
Volume: 26
Issue: 6
Pages: 1775-1789
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Publication
35303947 | J:331676
First Author: Lee K
Year: 2022
Journal: Mol Autism
Title: Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders.
Volume: 13
Issue: 1
Pages: 13
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Publication
27147951 | J:310577
 
First Author: Napoli E
Year: 2016
Journal: Front Neurosci
Title: Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.
Volume: 10
Pages: 159
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