| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3609854 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-01-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:3610164 |
| Age: |
embryonic day 16.5 |
|
|
| Specimen Label: |
None |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5299084 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2826628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5543068 |
| Age: |
postnatal day 84 |
| Image: |
GUDMAP:14585 |
|
| Specimen Label: |
GUDMAP:14585 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5308760 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-03-16 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3582728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5310940 |
| Age: |
postnatal day 10 |
|
|
| Specimen Label: |
5E |
| Detected: |
false |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5308614 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-03-20 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3582728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5311389 |
| Age: |
postnatal day 10 |
|
|
| Specimen Label: |
5F |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hampton LL |
| Year: |
2000 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus organic anion transporter 2 (Oatp2) mRNA, complete cds |
|
|
| Pages: |
AY007379 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roberts LM |
| Year: |
2008 |
| Journal: |
Endocrinology |
| Title: |
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. |
| Volume: |
149 |
| Issue: |
12 |
| Pages: |
6251-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kersseboom S |
| Year: |
2014 |
| Journal: |
Mol Endocrinol |
| Title: |
In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. |
| Volume: |
28 |
| Issue: |
12 |
| Pages: |
1961-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayerl S |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. |
| Volume: |
124 |
| Issue: |
5 |
| Pages: |
1987-99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. |
| Volume: |
24 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reinwald JR |
| Year: |
2022 |
| Journal: |
Int J Mol Sci |
| Title: |
TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. |
| Volume: |
23 |
| Issue: |
24 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siemes D |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function. |
| Volume: |
12 |
| Issue: |
20 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maity-Kumar G |
| Year: |
2022 |
| Journal: |
Mol Metab |
| Title: |
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome. |
| Volume: |
66 |
|
| Pages: |
101616 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayerl S |
| Year: |
2018 |
| Journal: |
Stem Cell Reports |
| Title: |
Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
1959-1974 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lademann F |
| Year: |
2022 |
| Journal: |
Endocrinology |
| Title: |
The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice. |
| Volume: |
163 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Braun D |
| Year: |
2011 |
| Journal: |
Glia |
| Title: |
Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. |
| Volume: |
59 |
| Issue: |
3 |
| Pages: |
463-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harder L |
| Year: |
2018 |
| Journal: |
J Neuroendocrinol |
| Title: |
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area. |
| Volume: |
30 |
| Issue: |
3 |
| Pages: |
e12573 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharlin DS |
| Year: |
2011 |
| Journal: |
Endocrinology |
| Title: |
Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. |
| Volume: |
152 |
| Issue: |
12 |
| Pages: |
5053-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayerl S |
| Year: |
2021 |
| Journal: |
Cereb Cortex |
| Title: |
Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ferrara AM |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Changes in thyroid status during perinatal development of MCT8-deficient male mice. |
| Volume: |
154 |
| Issue: |
7 |
| Pages: |
2533-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wirth EK |
| Year: |
2009 |
| Journal: |
J Neurosci |
| Title: |
Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. |
| Volume: |
29 |
| Issue: |
30 |
| Pages: |
9439-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jensen P |
| Year: |
2004 |
| Journal: |
Brain Res Mol Brain Res |
| Title: |
A neurogenomics approach to gene expression analysis in the developing brain. |
| Volume: |
132 |
| Issue: |
2 |
| Pages: |
116-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Willnow T |
| Year: |
2005 |
| Journal: |
Organogenesis |
| Title: |
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. |
| Volume: |
2 |
| Issue: |
2 |
| Pages: |
42-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
•
•
•
•
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| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
solute carrier organic anion transporter family, member 1c1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Markus Schwaninger |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, transgenic, congenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Slco1c1-icre)1Mash/? |
| Background: |
involves: C57BL/6 * DBA |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van der Deure WM |
| Year: |
2008 |
| Journal: |
Endocrinology |
| Title: |
Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation. |
| Volume: |
149 |
| Issue: |
10 |
| Pages: |
5307-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wittmann G |
| Year: |
2015 |
| Journal: |
Endocrinology |
| Title: |
Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents. |
| Volume: |
156 |
| Issue: |
4 |
| Pages: |
1552-64 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Solute carrier organic anion transporter family member 1C1 (SLCO1C1, also known as OATP1C1) belongs to the OATP family. It is a specific thyroid hormone transporter []. It mediates the transport of T4, rT3, T4 sulfate, estrone-3-sulfate (E1S), estradiol-17beta-glucuronide, and bromosulfophthalein. It is expressed in the Leydig cells of the testis and in brain capillaries in rat and mice, leading to the suggestion that Oatp1c1 is expressed at the blood-brain barrier []. The expression of SLCO1C1 and another key thyroid hormone transporter, MCT8, are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ridder DA |
| Year: |
2011 |
| Journal: |
J Exp Med |
| Title: |
TAK1 in brain endothelial cells mediates fever and lethargy. |
| Volume: |
208 |
| Issue: |
13 |
| Pages: |
2615-23 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Slco1c1-icre)1Mash/? |
| Background: |
involves: 129S4/SvJaeSor * C57BL/6 * DBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Visser WE |
| Year: |
2011 |
| Journal: |
Mol Endocrinol |
| Title: |
Minireview: thyroid hormone transporters: the knowns and the unknowns. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
1-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eskilsson A |
| Year: |
2017 |
| Journal: |
J Neurosci |
| Title: |
Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain. |
| Volume: |
37 |
| Issue: |
19 |
| Pages: |
5035-5044 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren AA |
| Year: |
2021 |
| Journal: |
Nature |
| Title: |
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. |
| Volume: |
594 |
| Issue: |
7862 |
| Pages: |
271-276 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
544
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
666
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
469
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong CC |
| Year: |
2020 |
| Journal: |
J Exp Med |
| Title: |
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. |
| Volume: |
217 |
| Issue: |
10 |
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
715
 |
| Fragment?: |
false |
|
•
•
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