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Search results 401 to 500 out of 525 for Smad7

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Type Details Score
Interaction Experiment
Kamiya Y (2010)
Description: Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
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Interaction Experiment
Gruber T (2013)
Description: Cbl-b mediates TGF sensitivity by downregulating inhibitory SMAD7 in primary T cells.
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Interaction Experiment
Tang Y (2019)
Description: Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.
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Interaction Experiment
Souchelnytskyi S (1998)
Description: Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
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Interaction Experiment
Hong S (2007)
Description: Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.
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Allele
Gt(ROSA)26Sor<tm4(CAG-SMAD7)Thbr> | MGI:6836738
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Thomas Braun
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Protein
O35253
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Publication
10828018 | -
First Author: Kitamura K
Year: 2000
Journal: Blood
Title: Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation.
Volume: 95
Issue: 11
Pages: 3371-9
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Publication
12118366 | -
First Author: Ferrigno O
Year: 2002
Journal: Oncogene
Title: Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
Volume: 21
Issue: 32
Pages: 4879-84
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Publication
15173588 | -
First Author: Fukasawa H
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.
Volume: 101
Issue: 23
Pages: 8687-92
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Publication
20663871 | -
First Author: Kamiya Y
Year: 2010
Journal: J Biol Chem
Title: Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
Volume: 285
Issue: 40
Pages: 30804-13
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Publication
23709694 | -
First Author: Gruber T
Year: 2013
Journal: J Mol Cell Biol
Title: Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
Volume: 5
Issue: 6
Pages: 358-68
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HT Experiment
GSE130841 | Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Smad7-/- E15.5 tooth germ Transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
O35253-2
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Publication
9738003 | -
First Author: Souchelnytskyi S
Year: 1998
Journal: J Biol Chem
Title: Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
Volume: 273
Issue: 39
Pages: 25364-70
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Publication
17384642 | -
First Author: Hong S
Year: 2007
Journal: Nat Immunol
Title: Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.
Volume: 8
Issue: 5
Pages: 504-13
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Allele
Tg(Smad7-cre)1Sjc | MGI:4352679
Name: transgene insertion 1, Simon J Conway
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Rr54<em1Axvi> | MGI:7489588
Name: Regulatory region 54; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Publication
11278814 | -
First Author: Pulaski L
Year: 2001
Journal: J Biol Chem
Title: Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation.
Volume: 276
Issue: 17
Pages: 14344-9
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Allele
Gt(ROSA)26Sor<tm5.1(Smad7-CFP)Mgn> | MGI:5476527
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5.1, Mark A Magnussen
Allele Type: Targeted
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Allele
Gt(ROSA)26Sor<tm6.1(Smad7-CFP)Mgn> | MGI:5476528
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6.1, Mark A Magnussen
Allele Type: Targeted
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Strain
MGI:6348309 | FVB/NCrl-Rr54<em1Axvi>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:7489910 | FVB-Rr54<em1Axvi>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rr54/Rr54
Background: FVB-Rr54
Zygosity: hm
Has Mutant Allele: true
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Publication
33334130 | J:316413
First Author: Wang L
Year: 2021
Journal: Circulation
Title: BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State.
Volume: 143
Issue: 14
Pages: 1394-1410
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Smad7-cre)1Sjc/?
Background: involves: 129S/Sv * C3HeB/FeJ
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-40510 | Expression data from Sip1 cKO and control mice spinal cord
Series Id: GSE40510
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Smad7-cre)1Sjc/?
Background: involves: 129S4/SvJaeSor * C3HeB/FeJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Smad7-cre)1Sjc/?
Background: involves: 129S/Sv * 129S4/SvJaeSor * C3HeB/FeJ
Zygosity: cn
Has Mutant Allele: true
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Publication
15350225 | J:92519
First Author: Bai Y
Year: 2004
Journal: Mol Cell
Title: Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.
Volume: 15
Issue: 5
Pages: 825-31
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Smad7-cre)1Sjc/?
Background: involves: 129S/Sv * 129S4/SvJaeSor * C3HeB/FeJ
Zygosity: cn
Has Mutant Allele: true
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Publication
18448069 | J:136721
First Author: Lee YS
Year: 2008
Journal: Biochem Biophys Res Commun
Title: AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2.
Volume: 371
Issue: 3
Pages: 395-400
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Publication
18655107 | J:349130
First Author: Vijayachandra K
Year: 2009
Journal: Mol Carcinog
Title: Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes.
Volume: 48
Issue: 3
Pages: 181-186
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Publication
32393780 | J:292230
First Author: Halder LD
Year: 2020
Journal: Nat Commun
Title: Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles.
Volume: 11
Issue: 1
Pages: 2331
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Publication
33006314 | J:298688
   
First Author: Li M
Year: 2020
Journal: Elife
Title: GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation.
Volume: 9
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Publication
17675459 | J:184671
First Author: Dominitzki S
Year: 2007
Journal: J Immunol
Title: Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Volume: 179
Issue: 4
Pages: 2041-5
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Publication
29749927 | J:356872
   
First Author: Schlereth K
Year: 2018
Journal: Elife
Title: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium.
Volume: 7
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Publication
12557227 | J:81488
First Author: Hohenstein P
Year: 2003
Journal: Genes Chromosomes Cancer
Title: Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene.
Volume: 36
Issue: 3
Pages: 273-82
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Publication
23292313 | J:194766
First Author: Zhong X
Year: 2013
Journal: Diabetologia
Title: miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes.
Volume: 56
Issue: 3
Pages: 663-74
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Publication
33733577 | J:339573
First Author: Dong L
Year: 2021
Journal: J Cell Mol Med
Title: Deletion of Smad3 protects against diabetic myocardiopathy in db/db mice.
Volume: 25
Issue: 10
Pages: 4860-4869
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Publication
18523298 | J:137135
First Author: Reardon C
Year: 2008
Journal: J Immunol
Title: Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death.
Volume: 180
Issue: 12
Pages: 8316-26
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Publication
11984875 | J:76396
First Author: Ito Y
Year: 2002
Journal: Dev Dyn
Title: Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development.
Volume: 224
Issue: 1
Pages: 69-78
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Publication
32807917 | J:296225
First Author: Cho C
Year: 2020
Journal: Oncogene
Title: Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis.
Volume: 39
Issue: 38
Pages: 6129-6137
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Publication
29519942 | J:285163
First Author: Huang X
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling.
Volume: 38
Issue: 5
Pages: 1086-1101
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Publication
22237801 | J:183430
First Author: Liu Z
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Smad3 mediates ANG II-induced hypertensive kidney disease in mice.
Volume: 302
Issue: 8
Pages: F986-97
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Publication
24089514 | J:209044
First Author: El-Gohary Y
Year: 2014
Journal: Diabetes
Title: A smad signaling network regulates islet cell proliferation.
Volume: 63
Issue: 1
Pages: 224-36
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Publication
23527070 | J:199907
First Author: Zhang XY
Year: 2013
Journal: PLoS One
Title: Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice.
Volume: 8
Issue: 3
Pages: e59002
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Publication
27041581 | J:287722
First Author: Wu J
Year: 2016
Journal: Oncogene
Title: Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
Volume: 35
Issue: 42
Pages: 5468-5479
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Publication
21985998 | J:180081
First Author: Sakata-Goto T
Year: 2012
Journal: Bone
Title: Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis.
Volume: 50
Issue: 1
Pages: 69-78
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Publication
26621452 | J:229017
First Author: Pallangyo CK
Year: 2015
Journal: J Exp Med
Title: IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
Volume: 212
Issue: 13
Pages: 2253-66
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Publication
38100642 | J:355495
First Author: Li Y
Year: 2024
Journal: FASEB J
Title: Vascular smooth muscle cell-specific miRNA-214 deficiency alleviates simulated microgravity-induced vascular remodeling.
Volume: 38
Issue: 1
Pages: e23369
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Publication
31483681 | J:281660
First Author: Xylourgidis N
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.
Volume: 317
Issue: 5
Pages: L678-L689
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Publication
16622029 | J:125074
First Author: Ishida Y
Year: 2006
Journal: J Immunol
Title: Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway.
Volume: 176
Issue: 9
Pages: 5598-606
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Publication
20592275 | J:162461
First Author: Giroux M
Year: 2010
Journal: J Immunol
Title: T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
Volume: 185
Issue: 3
Pages: 1568-76
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Publication
24885478 | J:232229
First Author: Tang YJ
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice.
Volume: 51
Issue: 6
Pages: 761-71
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Publication
18216320 | J:150171
First Author: Huang XR
Year: 2008
Journal: J Am Soc Nephrol
Title: Latent TGF-beta1 protects against crescentic glomerulonephritis.
Volume: 19
Issue: 2
Pages: 233-42
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Publication
20507941 | J:185931
First Author: Gai Z
Year: 2010
Journal: J Am Soc Nephrol
Title: Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression.
Volume: 21
Issue: 9
Pages: 1468-76
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Publication
35763560 | J:347441
First Author: Stavropoulos A
Year: 2022
Journal: Sci Signal
Title: Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication.
Volume: 15
Issue: 740
Pages: eabn4395
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Publication
29066540 | J:259042
 
First Author: Gencer S
Year: 2017
Journal: Sci Signal
Title: TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.
Volume: 10
Issue: 502
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Publication
29361523 | J:260515
 
First Author: Sun Q
Year: 2018
Journal: J Cell Sci
Title: The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis.
Volume: 131
Issue: 6
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Publication
25339598 | J:218535
First Author: Almahariq M
Year: 2015
Journal: Biochem J
Title: Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression.
Volume: 465
Issue: 2
Pages: 295-303
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Publication
32808374 | J:307551
First Author: Wang Y
Year: 2020
Journal: FASEB J
Title: 8-Oxoguanine DNA glycosylase modulates the cell transformation process in pulmonary fibrosis by inhibiting Smad2/3 and interacting with Smad7.
Volume: 34
Issue: 10
Pages: 13461-13473
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Publication
29715368 | J:261779
First Author: Seitz R
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature.
Volume: 59
Issue: 6
Pages: 2240-2251
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Publication
28455959 | J:281248
First Author: Wu RS
Year: 2017
Journal: Oncotarget
Title: OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis.
Volume: 8
Issue: 24
Pages: 39401-39416
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Publication
11313978 | J:69221
First Author: He W
Year: 2001
Journal: Oncogene
Title: Smads mediate signaling of the TGFbeta superfamily in normal keratinocytes but are lost during skin chemical carcinogenesis.
Volume: 20
Issue: 4
Pages: 471-83
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Publication
11536370 | J:71728
First Author: Guda K
Year: 2001
Journal: Mol Carcinog
Title: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
Volume: 31
Issue: 4
Pages: 204-13
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Publication
10224044 | J:54891
First Author: Yanagi Y
Year: 1999
Journal: J Biol Chem
Title: Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins.
Volume: 274
Issue: 19
Pages: 12971-4
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Publication
16410076 | J:104727
First Author: Yu Z
Year: 2006
Journal: Biochem Biophys Res Commun
Title: All-trans retinoic acid inhibited chondrogenesis of mouse embryonic palate mesenchymal cells by down-regulation of TGF-beta/Smad signaling.
Volume: 340
Issue: 3
Pages: 929-34
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Publication
16723700 | J:110120
First Author: Saika S
Year: 2006
Journal: Am J Pathol
Title: Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing.
Volume: 168
Issue: 6
Pages: 1848-60
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Publication
17053163 | J:117751
First Author: Jeon SH
Year: 2007
Journal: J Leukoc Biol
Title: Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis.
Volume: 81
Issue: 2
Pages: 557-66
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Publication
17606626 | J:125046
First Author: Chang X
Year: 2007
Journal: Mol Cell Biol
Title: Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor.
Volume: 27
Issue: 17
Pages: 6127-39
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Publication
18334541 | J:136849
First Author: Kim HA
Year: 2008
Journal: J Leukoc Biol
Title: TGF-beta1 and IFN-gamma stimulate mouse macrophages to express BAFF via different signaling pathways.
Volume: 83
Issue: 6
Pages: 1431-9
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Publication
18948405 | J:158097
First Author: Singh R
Year: 2009
Journal: Endocrinology
Title: Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways.
Volume: 150
Issue: 3
Pages: 1259-68
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Publication
20659902 | J:166384
First Author: Seong HA
Year: 2010
Journal: J Biol Chem
Title: Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.
Volume: 285
Issue: 40
Pages: 30959-70
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Publication
22427664 | J:193009
First Author: Ortiz C
Year: 2012
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.
Volume: 287
Issue: 19
Pages: 15263-74
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Publication
25908864 | J:232658
First Author: Taylor-Weiner H
Year: 2015
Journal: J Cell Sci
Title: Traction forces mediated by integrin signaling are necessary for definitive endoderm specification.
Volume: 128
Issue: 10
Pages: 1961-8
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Publication
28943430 | J:251474
First Author: Li X
Year: 2017
Journal: Biochem Biophys Res Commun
Title: MicroRNA-21 promotes osteogenesis of bone marrow mesenchymal stem cells via the Smad7-Smad1/5/8-Runx2 pathway.
Volume: 493
Issue: 2
Pages: 928-933
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Publication
29465312 | J:274272
First Author: Wang R
Year: 2018
Journal: FASEB J
Title: Identification of a TGF-β-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells.
Volume: 32
Issue: 7
Pages: 3936-3945
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Publication
30914199 | J:291674
First Author: Liu X
Year: 2019
Journal: Biochem Biophys Res Commun
Title: IFNγ inhibits fibroblast-leading tumor cell invasion through downregulating N-cadherin.
Volume: 512
Issue: 3
Pages: 544-551
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Publication
22234868 | J:308090
First Author: Bos JM
Year: 2012
Journal: J Cell Biochem
Title: TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.
Volume: 113
Issue: 6
Pages: 1896-903
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Publication
35426367 | J:325019
 
First Author: Igalouzene R
Year: 2022
Journal: J Clin Invest
Title: SMAD4 TGF-β-independent function preconditions naive CD8+ T cells to prevent severe chronic intestinal inflammation.
Volume: 132
Issue: 8
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Protein Domain
IPR036578 | SMAD_MH1_sf
Type: Homologous_superfamily
Description: Smad proteins are signal transducers and transcriptional comodulators of the TGF-beta superfamily of ligands, which play a central role in regulating a broad range of cellular responses, including cell growth, differentiation, and specification of developmental fate, in diverse organisms from Caenorhabditis elegans to humans. Ligand binding to specific transmembrane receptor kinases induces receptor oligomerisation and phosphorylation of the receptor specific Smad protein (R-Smad) in the cytoplasm. The R-Smad proteins regulate distinct signalling pathways. Smad1, 5 and 8 mediate the signals of bone morphogenetic proteins (BMPs), while Smad2 and 3 mediate the signals of activins and TGF-betas. Upon ligand stimulation, R-Smad proteins are phosphorylated at the conserved C-terminal tail sequence, SS*xS* (where S* denotes a site of phosphorylation). The phosphorylated states of R-Smad proteins form heteromeric complexes with Smad4 and are translocated into the nucleus. In the nucleus, the heteromeric complexes function as gene-specific transcription activators by binding to promoters and interacting with transcriptional coactivators. Smad6 and Smad7 are inhibitory Smad proteins that inhibit TGF-beta signalling by interfering with either receptor-mediated phosphorylation or hetero-oligomerisation between Smad4 and R-Smad proteins. Smad proteins comprise two conserved MAD homology domains, one in the N terminus (MH1) and one in the C terminus (MH2), separated by a more variable, proline-rich linker region. The MH1 domain has a role in DNA binding and negatively regulates the functions of MH2 domain, whereas the MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad [, ]. The MH1 domain adopts a compact globular fold, with four alpha helices, six short beta strands, and five loops. The N-terminal half of the sequence consists of three alpha helices, and the C-terminal half contains all six beta strands, which form two small beta sheets and one beta hairpin. The fourth alpha helix is located in the hydrophobic core of the molecule, surrounded by the N-terminal three alpha helices on one side and by the two small beta sheets and the beta hairpin on the other side. These secondary structural elements are connected with five intervening surface loops. The MH1 domain employs a novel DNA-binding motif, an 11-residue β-hairpin formed by strands B2 and B3, to contact DNA in the major groove. Two residues in the L3 loop and immediately preceding strand B2 also contribute significantly to DNA recognition. The beta hairpin appears to protrude outward from the globular MH1 core [].
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Protein Domain
IPR013019 | MAD_homology_MH1
Type: Domain
Description: Smad proteins are signal transducers and transcriptional comodulators of the TGF-beta superfamily of ligands, which play a central role in regulating a broad range of cellular responses, including cell growth, differentiation, and specification of developmental fate, in diverse organisms from Caenorhabditis elegans to humans. Ligand binding to specific transmembrane receptor kinases induces receptor oligomerisation and phosphorylation of the receptor specific Smad protein (R-Smad) in the cytoplasm. The R-Smad proteins regulate distinct signalling pathways. Smad1, 5 and 8 mediate the signals of bone morphogenetic proteins (BMPs), while Smad2 and 3 mediate the signals of activins and TGF-betas. Upon ligand stimulation, R-Smad proteins are phosphorylated at the conserved C-terminal tail sequence, SS*xS* (where S* denotes a site of phosphorylation). The phosphorylated states of R-Smad proteins form heteromeric complexes with Smad4 and are translocated into the nucleus. In the nucleus, the heteromeric complexes function as gene-specific transcription activators by binding to promoters and interacting with transcriptional coactivators. Smad6 and Smad7 are inhibitory Smad proteins that inhibit TGF-beta signalling by interfering with either receptor-mediated phosphorylation or hetero-oligomerisation between Smad4 and R-Smad proteins. Smad proteins comprise two conserved MAD homology domains, one in the N terminus (MH1) and one in the C terminus (MH2), separated by a more variable, proline-rich linker region. The MH1 domain has a role in DNA binding and negatively regulates the functions of MH2 domain, whereas the MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad [, ]. The MH1 domain adopts a compact globular fold, with four alpha helices, six short beta strands, and five loops. The N-terminal half of the sequence consists of three alpha helices, and the C-terminal half contains all six beta strands, which form two small beta sheets and one beta hairpin. The fourth alpha helix is located in the hydrophobic core of the molecule, surrounded by the N-terminal three alpha helices on one side and by the two small beta sheets and the beta hairpin on the other side. These secondary structural elements are connected with five intervening surface loops. The MH1 domain employs a novel DNA-binding motif, an 11-residue β-hairpin formed by strands B2 and B3, to contact DNA in the major groove. Two residues in the L3 loop and immediately preceding strand B2 also contribute significantly to DNA recognition. The beta hairpin appears to protrude outward from the globular MH1 core [].
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Publication
9741623 | -
First Author: Shi Y
Year: 1998
Journal: Cell
Title: Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Volume: 94
Issue: 5
Pages: 585-94
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Publication
26391411 | J:287473
First Author: Iezaki T
Year: 2016
Journal: J Bone Miner Res
Title: The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
Volume: 31
Issue: 3
Pages: 573-84
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Publication
36147472 | J:328926
First Author: Chung JY
Year: 2022
Journal: Int J Biol Sci
Title: AANG Prevents Smad3-dependent Diabetic Nephropathy by Restoring Pancreatic β-Cell Development in db/db Mice.
Volume: 18
Issue: 14
Pages: 5489-5502
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Publication
19200168 | J:165767
First Author: Latella G
Year: 2009
Journal: Eur J Clin Invest
Title: Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis.
Volume: 39
Issue: 2
Pages: 145-56
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Publication
19422482 | J:166109
First Author: Latella G
Year: 2009
Journal: Liver Int
Title: Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.
Volume: 29
Issue: 7
Pages: 997-1009
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Publication
34637552 | J:323048
First Author: Li Y
Year: 2021
Journal: FASEB J
Title: Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.
Volume: 35
Issue: 11
Pages: e21947
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Publication
26496995 | J:241116
First Author: Su BH
Year: 2016
Journal: J Pathol
Title: Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema.
Volume: 238
Issue: 3
Pages: 412-22
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Publication
16299379 | J:116397
First Author: Shen R
Year: 2006
Journal: J Biol Chem
Title: Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.
Volume: 281
Issue: 6
Pages: 3569-76
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Publication
25665164 | J:221908
First Author: Gu W
Year: 2015
Journal: PLoS Biol
Title: A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.
Volume: 13
Issue: 2
Pages: e1002051
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Publication
27396899 | J:248802
 
First Author: Yamamoto N
Year: 2016
Journal: Mol Cell Endocrinol
Title: Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts.
Volume: 436
Pages: 1-9
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Protein
E9Q5P9
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Protein
Q8CC31
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
Q810W4
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
F7BUP2
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
Q05CN3
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
Q8C2Z0
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
E9PXA8
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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