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Search results 401 to 469 out of 469 for Socs1

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Type Details Score
Publication
19508864 | J:150654
First Author: Cho HJ
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.
Volume: 386
Issue: 1
Pages: 175-80
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Publication
30470758 | J:269156
First Author: Yu X
Year: 2018
Journal: Nat Commun
Title: Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity.
Volume: 9
Issue: 1
Pages: 4964
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Publication
27014906 | J:301585
First Author: Yang J
Year: 2016
Journal: Oncotarget
Title: Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.
Volume: 7
Issue: 23
Pages: 33744-64
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Publication
34021046 | J:320463
First Author: Roberts LB
Year: 2021
Journal: J Immunol
Title: MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function.
Volume: 206
Issue: 11
Pages: 2725-2739
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Protein
O35718
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
O35717
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
F6RVG2
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
Q3U9J8
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
Q548Q7
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Publication
10851056 | J:62693
First Author: Wurster AL
Year: 2000
Journal: Oncogene
Title: The biology of Stat4 and Stat6.
Volume: 19
Issue: 21
Pages: 2577-84
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Publication
11266117 | -
First Author: Lee CE
Year: 2001
Journal: Mol Cells
Title: Interleukin-4 induces two distinct GAS-binding complexes containing STAT6: evidence for DNA binding of STAT6 monomer.
Volume: 11
Issue: 1
Pages: 28-34
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Publication
28553931 | -
First Author: Nappo G
Year: 2017
Journal: Oncogenesis
Title: The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling.
Volume: 6
Issue: 5
Pages: e342
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Protein Domain
IPR035857 | STAT6_SH2
Type: Domain
Description: STAT6 mediate signals from the IL-4 receptor. Unlike the other STAT proteins which bind an IFNgamma Activating Sequence (GAS), STAT6 stands out as having a unique binding site preference. This site consists of a palindromic sequence separated by a 3 bp spacer (TTCNNNG-AA)(N3 site). STAT6 is able to bind the GAS site but only at a low affinity upon IL-4-induced activation []. There is speculation that the inappropriate activation of STAT6 is involved in uncontrolled cell growth in an oncogenic state []. IL-4 signaling via STAT6 initially occurs unopposed, but is then dampened by a negative feedback mechanism through the IL-4/Stat6 dependent induction of SOCS1 expression. The IL-4 dependent aspect of Th2 differentiation requires the activation of STAT6. IL-4 signaling and STAT6 appear to play an important role in the immune response. It was shown that large scale chromatin remodeling of the IL-4 gene occurs as cells differentiate into Th2 effectors is STAT6 dependent []. This entry represents the SH2 domain of STAT6.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Publication
25030421 | J:220133
First Author: McCartney-Francis N
Year: 2014
Journal: J Leukoc Biol
Title: Aberrant host defense against Leishmania major in the absence of SLPI.
Volume: 96
Issue: 5
Pages: 917-29
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Publication
15554901 | J:117522
First Author: Sass G
Year: 2005
Journal: Biochem J
Title: Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.
Volume: 385
Issue: Pt 2
Pages: 537-44
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Publication
25012131 | J:227174
First Author: Recio C
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Suppressor of cytokine signaling 1-derived peptide inhibits Janus kinase/signal transducers and activators of transcription pathway and improves inflammation and atherosclerosis in diabetic mice.
Volume: 34
Issue: 9
Pages: 1953-60
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Publication
20062065 | J:157081
First Author: Liu X
Year: 2010
Journal: Nat Med
Title: Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Volume: 16
Issue: 2
Pages: 191-7
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Publication
23487025 | J:197934
First Author: de Bruin AM
Year: 2013
Journal: Blood
Title: Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Volume: 121
Issue: 18
Pages: 3578-85
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Publication
16224059 | J:116822
First Author: Dimayuga PC
Year: 2005
Journal: Arterioscler Thromb Vasc Biol
Title: T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency.
Volume: 25
Issue: 12
Pages: 2528-34
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Publication
25502838 | J:217740
First Author: Chen S
Year: 2015
Journal: Cancer Res
Title: Host miR155 promotes tumor growth through a myeloid-derived suppressor cell-dependent mechanism.
Volume: 75
Issue: 3
Pages: 519-31
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Publication
24489947 | J:225165
First Author: Sriram U
Year: 2014
Journal: PLoS One
Title: IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Volume: 9
Issue: 1
Pages: e87668
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Publication
19877014 | J:155694
First Author: Lawson VJ
Year: 2010
Journal: Eur J Immunol
Title: Early growth response 2 regulates the survival of thymocytes during positive selection.
Volume: 40
Issue: 1
Pages: 232-41
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Publication
35011699 | J:322134
 
First Author: Fernandes A
Year: 2022
Journal: Cells
Title: Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice.
Volume: 11
Issue: 1
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Publication
28122728 | J:240956
First Author: Rocha-Resende C
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels.
Volume: 312
Issue: 4
Pages: C478-C486
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Publication
29122948 | J:256211
First Author: Singh PB
Year: 2017
Journal: J Exp Med
Title: MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
Volume: 214
Issue: 12
Pages: 3627-3643
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Publication
17182563 | J:141934
First Author: Seki Y
Year: 2007
Journal: J Immunol
Title: IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs.
Volume: 178
Issue: 1
Pages: 262-70
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Publication
22861055 | J:191304
First Author: Kim GH
Year: 2012
Journal: Biochem J
Title: Regulation of hepatic insulin sensitivity by activating signal co-integrator-2.
Volume: 447
Issue: 3
Pages: 437-47
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Publication
23572582 | J:196148
First Author: Zawislak CL
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.
Volume: 110
Issue: 17
Pages: 6967-72
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Publication
32052456 | J:304269
First Author: Zahoor A
Year: 2020
Journal: J Cell Physiol
Title: Gas6 negatively regulates the Staphylococcus aureus-induced inflammatory response via TLR signaling in the mouse mammary gland.
Volume: 235
Issue: 10
Pages: 7081-7093
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Publication
23716134 | J:201270
First Author: Miah MA
Year: 2013
Journal: Eur J Immunol
Title: Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity.
Volume: 43
Issue: 9
Pages: 2484-96
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Publication
15199163 | J:91591
First Author: Brender C
Year: 2004
Journal: Mol Cell Biol
Title: SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.
Volume: 24
Issue: 13
Pages: 6094-103
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Publication
35925680 | J:331348
 
First Author: Wang J
Year: 2022
Journal: J Clin Invest
Title: Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and antitumor function.
Volume: 132
Issue: 19
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Publication
23956210 | J:218730
First Author: Heymans S
Year: 2013
Journal: Circulation
Title: Macrophage microRNA-155 promotes cardiac hypertrophy and failure.
Volume: 128
Issue: 13
Pages: 1420-32
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Publication
29774026 | J:311179
 
First Author: Li J
Year: 2018
Journal: Front Immunol
Title: Critical Role of Alternative M2 Skewing in miR-155 Deletion-Mediated Protection of Colitis.
Volume: 9
Pages: 904
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Publication
24969676 | J:318195
First Author: Lin X
Year: 2015
Journal: Inflammation
Title: MicroRNA-155 deficiency promotes nephrin acetylation and attenuates renal damage in hyperglycemia-induced nephropathy.
Volume: 38
Issue: 2
Pages: 546-54
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Publication
25811992 | J:315547
 
First Author: Wen Y
Year: 2015
Journal: Mol Med
Title: Acetylbritannilactone Modulates MicroRNA-155-Mediated Inflammatory Response in Ischemic Cerebral Tissues.
Volume: 21
Pages: 197-209
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Publication
22228213 | J:233281
First Author: Pass C
Year: 2012
Journal: J Bone Miner Res
Title: SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.
Volume: 27
Issue: 5
Pages: 1055-66
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Publication
14764699 | J:88046
First Author: Jackson SH
Year: 2004
Journal: J Immunol
Title: Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling.
Volume: 172
Issue: 4
Pages: 2307-15
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Publication
15850655 | J:98646
First Author: Campbell IL
Year: 2005
Journal: Brain Res Brain Res Rev
Title: Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS.
Volume: 48
Issue: 2
Pages: 166-77
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Publication
17330820 | J:120715
First Author: Uchida T
Year: 2007
Journal: Eur J Immunol
Title: IL-18 time-dependently modulates Th1/Th2 cytokine production by ligand-activated NKT cells.
Volume: 37
Issue: 4
Pages: 966-77
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Publication
20499047 | J:162155
First Author: Lebrun P
Year: 2010
Journal: Diabetologia
Title: The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.
Volume: 53
Issue: 9
Pages: 1935-46
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Publication
21386060 | J:172301
First Author: Wada T
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.
Volume: 300
Issue: 6
Pages: E1112-23
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Publication
21518797 | J:177757
First Author: Oestreich KJ
Year: 2011
Journal: J Exp Med
Title: The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns.
Volume: 208
Issue: 5
Pages: 1001-13
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Publication
22408262 | J:183889
First Author: Akada H
Year: 2012
Journal: Blood
Title: Efficacy of vorinostat in a murine model of polycythemia vera.
Volume: 119
Issue: 16
Pages: 3779-89
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Publication
24319264 | J:207157
First Author: Trilling M
Year: 2014
Journal: J Immunol
Title: "Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
Volume: 192
Issue: 1
Pages: 447-58
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Publication
25231976 | J:217898
First Author: Billeter AT
Year: 2014
Journal: FASEB J
Title: MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production.
Volume: 28
Issue: 12
Pages: 5322-36
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Publication
31208297 | J:295311
First Author: Wang T
Year: 2019
Journal: Cell Cycle
Title: Inhibition of miR-221 alleviates LPS-induced acute lung injury via inactivation of SOCS1/NF-κB signaling pathway.
Volume: 18
Issue: 16
Pages: 1893-1907
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Publication
31354713 | J:297276
 
First Author: Zhang D
Year: 2019
Journal: Front Immunol
Title: Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Volume: 10
Pages: 1550
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Publication
30820436 | J:303426
First Author: Gendo Y
Year: 2019
Journal: Inflamm Intest Dis
Title: Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice.
Volume: 3
Issue: 3
Pages: 145-154
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Publication
32796022 | J:301512
First Author: Huber A
Year: 2020
Journal: J Immunol
Title: Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1.
Volume: 205
Issue: 6
Pages: 1580-1592
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Publication
34418604 | J:310774
 
First Author: Gould RL
Year: 2021
Journal: Redox Biol
Title: Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system.
Volume: 46
Pages: 102093
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Publication
21151569 | J:167736
First Author: Hong CJ
Year: 2010
Journal: PLoS One
Title: ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.
Volume: 5
Issue: 12
Pages: e15333
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Publication
26941017 | J:246383
First Author: Reddy MA
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.
Volume: 36
Issue: 5
Pages: 864-73
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Publication
23019193 | J:193658
First Author: McClellan JL
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1.
Volume: 303
Issue: 10
Pages: G1087-95
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Publication
31497013 | J:284467
 
First Author: Al-Ghezi ZZ
Year: 2019
Journal: Front Immunol
Title: Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways.
Volume: 10
Pages: 1921
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Publication
12388746 | J:120010
First Author: Park DS
Year: 2002
Journal: Mol Biol Cell
Title: Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
Volume: 13
Issue: 10
Pages: 3416-30
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Publication
32747017 | J:303590
First Author: Zahoor A
Year: 2020
Journal: Immunobiology
Title: MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.
Volume: 225
Issue: 4
Pages: 151960
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Publication
11786421 | J:73727
First Author: Maier J
Year: 2002
Journal: Am J Pathol
Title: Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis.
Volume: 160
Issue: 1
Pages: 271-88
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Publication
32968282 | J:297396
First Author: Lawson KA
Year: 2020
Journal: Nature
Title: Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
Volume: 586
Issue: 7827
Pages: 120-126
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Publication
35258130 | J:345015
First Author: Tsiomita S
Year: 2022
Journal: J Leukoc Biol
Title: ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment.
Volume: 112
Issue: 4
Pages: 641-657
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Publication
17114246 | J:143851
First Author: Wang M
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1beta.
Volume: 292
Issue: 4
Pages: H1694-9
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Protein
Q8CCG3
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Protein
D3YZ26
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Publication
17764563 | J:128718
 
First Author: Park ES
Year: 2007
Journal: BMC Genomics
Title: Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia.
Volume: 8
Pages: 302
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Publication
12209125 | -
First Author: Levy DE
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Stats: transcriptional control and biological impact.
Volume: 3
Issue: 9
Pages: 651-62
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Publication
14668806 | -
First Author: Shuai K
Year: 2003
Journal: Nat Rev Immunol
Title: Regulation of JAK-STAT signalling in the immune system.
Volume: 3
Issue: 11
Pages: 900-11
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Publication
23977103 | -
First Author: Takakuma K
Year: 2013
Journal: PLoS One
Title: Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.
Volume: 8
Issue: 8
Pages: e71646
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Protein
P52633
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Protein
Q8R4D4
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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