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Search results 401 to 500 out of 551 for Sost

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Type Details Score
Publication
37709732 | J:340391
First Author: Piña JO
Year: 2023
Journal: Nat Commun
Title: Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.
Volume: 14
Issue: 1
Pages: 5687
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Publication
27804995 | J:263575
 
First Author: Ruiz P
Year: 2016
Journal: Sci Rep
Title: CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells.
Volume: 6
Pages: 36201
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Publication
24917674 | J:314657
First Author: Lin S
Year: 2014
Journal: J Biol Chem
Title: Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.
Volume: 289
Issue: 31
Pages: 21533-43
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Publication
35472633 | J:324690
 
First Author: Wang H
Year: 2022
Journal: Matrix Biol
Title: Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened.
Volume: 110
Pages: 76-90
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Publication
19896444 | J:154024
First Author: Paik JH
Year: 2009
Journal: Cell Stem Cell
Title: FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Volume: 5
Issue: 5
Pages: 540-53
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Publication
22886599 | J:225092
First Author: Duverger O
Year: 2013
Journal: J Cell Physiol
Title: In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones.
Volume: 228
Issue: 3
Pages: 654-64
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Publication
21285247 | J:182873
First Author: Jheon AH
Year: 2011
Journal: J Cell Sci
Title: PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
Volume: 124
Issue: Pt 5
Pages: 745-54
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Publication
26925839 | J:320375
First Author: Mirigian LS
Year: 2016
Journal: J Bone Miner Res
Title: Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta.
Volume: 31
Issue: 8
Pages: 1608-1616
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Publication
28880886 | J:264160
First Author: Patoine A
Year: 2017
Journal: PLoS One
Title: The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice.
Volume: 12
Issue: 9
Pages: e0184568
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Publication
29561836 | J:261043
First Author: Chan WL
Year: 2018
Journal: PLoS Genet
Title: Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.
Volume: 14
Issue: 3
Pages: e1007242
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Publication
19389359 | J:149465
First Author: Holmes G
Year: 2009
Journal: Dev Biol
Title: Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology.
Volume: 328
Issue: 2
Pages: 273-84
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Publication
28327634 | J:274387
 
First Author: Yoshimoto Y
Year: 2017
Journal: Sci Rep
Title: Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.
Volume: 7
Pages: 45010
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Publication
25331958 | J:218799
First Author: Yoon J
Year: 2014
Journal: J Biol Chem
Title: Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.
Volume: 289
Issue: 49
Pages: 34250-7
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Publication
38910391 | J:352719
   
First Author: Piña JO
Year: 2024
Journal: J Dent Res
Title: Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'.
Pages: 220345241256600
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Publication
34091985 | J:316483
First Author: Leek CC
Year: 2021
Journal: Dev Dyn
Title: Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.
Volume: 250
Issue: 12
Pages: 1778-1795
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Publication
34260913 | J:320628
First Author: Watanabe-Takano H
Year: 2021
Journal: Cell Rep
Title: Mechanical load regulates bone growth via periosteal Osteocrin.
Volume: 36
Issue: 2
Pages: 109380
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Publication
23918385 | J:200671
First Author: Economides AN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Conditionals by inversion provide a universal method for the generation of conditional alleles.
Volume: 110
Issue: 34
Pages: E3179-88
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Publication
34172578 | J:307192
 
First Author: Yadav PS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.
Volume: 118
Issue: 26
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Publication
26094741 | J:309392
First Author: Amano K
Year: 2015
Journal: J Bone Miner Res
Title: Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.
Volume: 30
Issue: 12
Pages: 2262-72
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Publication
29174564 | J:255349
 
First Author: Rauch F
Year: 2018
Journal: Bone
Title: Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Volume: 107
Pages: 131-142
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Publication
12412008 | J:80135
First Author: Heller RS
Year: 2002
Journal: Dev Dyn
Title: Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.
Volume: 225
Issue: 3
Pages: 260-70
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Publication
34254395 | J:328711
First Author: Fernandez-Guerrero M
Year: 2022
Journal: Dev Dyn
Title: Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis.
Volume: 251
Issue: 9
Pages: 1550-1575
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Publication
34376651 | J:308983
First Author: Farmer DT
Year: 2021
Journal: Nat Commun
Title: The developing mouse coronal suture at single-cell resolution.
Volume: 12
Issue: 1
Pages: 4797
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Publication
33436499 | J:308926
 
First Author: Yang J
Year: 2021
Journal: Sci Signal
Title: Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation.
Volume: 14
Issue: 665
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Publication
18351662 | J:132979
First Author: Potok MA
Year: 2008
Journal: Dev Dyn
Title: WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.
Volume: 237
Issue: 4
Pages: 1006-20
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Publication
26273529 | J:227247
 
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
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Publication
31202927 | J:281175
 
First Author: Yorgan TA
Year: 2019
Journal: Bone
Title: Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
Volume: 127
Pages: 155-163
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
E-GEOD-44325 | Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
Series Id: GSE44325
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
30664862 | J:278303
First Author: Javaheri B
Year: 2019
Journal: Am J Pathol
Title: Sost Haploinsufficiency Provokes Peracute Lethal Cardiac Tamponade without Rescuing the Osteopenia in a Mouse Model of Excess Glucocorticoids.
Volume: 189
Issue: 4
Pages: 753-761
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Regulatory Region
MGI:5441844 | Rr20
Type: enhancer
Organism: mouse, laboratory
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Allele
Sost<em2(cre/ERT2)Smoc> | MGI:7292534
Name: sclerostin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Sost<tm1Paz> | MGI:3850014
Name: sclerostin; targeted mutation 1, Chris Paszty
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo
Background: FVB-Tg(RP11-209M4)4Gglo
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/?
Background: FVB-Tg(RP11-209M4)4Gglo
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:7623499 | C57BL/6JSmoc-Sost<em2(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Sost<em5Smoc> | MGI:7292537
Name: sclerostin; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Sost/Sost
Background: involves: 129/Sv * Black Swiss
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060756 | sclerosteosis 1
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DO Term
DOID:0080807 | autosomal dominant craniodiaphyseal dysplasia
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Strain
MGI:6429589 | C57BL/6JSmoc-Sost<em5Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Sost<tm1(KOMP)Vlcg> | MGI:3797839
Name: sclerostin; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Rr20<tm1.1Vlcg> | MGI:5441845
Name: regulatory region 20; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Modified regulatory region, Null/knockout
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Allele
Sost<em1Smoc> | MGI:7292533
Name: sclerostin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sost<em3(SOST)Smoc> | MGI:7292535
Name: sclerostin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Sost<em4(SOST)Smoc> | MGI:7292536
Name: sclerostin; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Sost<tm1.1Ozg> | MGI:7430798
Name: sclerostin; targeted mutation 1.1, Ozgene
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Dmp1-SOST)1Btm | MGI:7444919
Name: transgene insertion 1, Teresita Bellido
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Transgene
MGI:5304470 | Tg(RP11-209M4)AGglo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Sost/Sost
Background: involves: C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr20/Rr20
Background: involves: 129S6/SvEvTac * C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0080036 | SOST-related sclerosing bone dysplasia
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HT Experiment
GSE220601 | Effect of Sclerostin Inactivation in a Mouse Model of Severe Dominant Osteogenesis Imperfecta
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Sost<tm1Yako> | MGI:7263279
Name: sclerostin; targeted mutation 1, Yasuhiro Kobayashi
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6348203 | C57BL/6-Tg(Dmp1-SOST)1Btm/Mmnc
Attribute String: transgenic, coisogenic, mutant strain
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Allele
Tg(Dmp1-SOST)#Alegr | MGI:7512802
Name: transgene insertion, Alexander G Robling
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
31585407 | J:305286
 
First Author: Bullock WA
Year: 2019
Journal: iScience
Title: Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo.
Volume: 20
Pages: 205-215
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Strain
MGI:6476351 | C57BL/6JSmoc-Sost<em1(SOST)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7623500 | C57BL/6JSmoc-Sost<em4(SOST)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
21140374 | J:184242
First Author: Rhee Y
Year: 2011
Journal: J Bone Miner Res
Title: PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.
Volume: 26
Issue: 5
Pages: 1035-46
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Publication
28607813 | J:283085
 
First Author: He G
Year: 2017
Journal: Bone Res
Title: Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth.
Volume: 5
Pages: 17016
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Allele
Tg(RP11-209M4*)#Gglo | MGI:5304447
Name: transgene insertion, Gabriela G Loots
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7356356 | B6.FVB-Tg(RP11-209M4)AGglo/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5304679 | FVB-Tg(RP11-209M4)4Gglo
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/?
Background: involves: C57BL/6 * FVB
Zygosity: ot
Has Mutant Allele: true
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Publication
27704638 | J:284501
First Author: Delgado-Calle J
Year: 2017
Journal: J Bone Miner Res
Title: Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor.
Volume: 32
Issue: 3
Pages: 522-535
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Publication
15020244 | -
First Author: Yanagita M
Year: 2004
Journal: Biochem Biophys Res Commun
Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
Volume: 316
Issue: 2
Pages: 490-500
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Protein Domain
IPR008835 | Sclerostin/SOSTDC1
Type: Family
Description: This sclerostin family consists of sclerostin and sclerostin domain-containing protein 1. Sclerostin (SOST) is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterised by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients []. Sclerostin domain-containing protein 1, also known as USAG1, is a bone morphogenetic protein antagonist [].
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Strain
MGI:5304680 | FVB-Tg(RP11-209M4*)#Gglo
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(RP11-209M4*)#Gglo/?
Background: FVB-Tg(RP11-209M4*)#Gglo
Zygosity: ot
Has Mutant Allele: true
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