|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 461 out of 461 for Spo11

<< First    < Previous  |  Next >    Last >>
0.026s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:6122890 | B6;C-Tg(Spo11-cre)D5Mpel/Cnrm
Attribute String: mutant stock, transgenic
•
•
•
•
•
Protein Domain
IPR002815 | Spo11/TopoVI_A
Type: Family
Description: This entry represents Spo11, a meiotic recombination protein found in eukaryotes, and subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [, , , ]. These two types of proteins share structural homology.DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks. They can be divided into two classes: type I enzymes (, topoisomerases I, III and V) break single-strand DNA, and type II enzymes (, topoisomerases II, IV and VI) break double-strand DNA []. Topoisomerase VI is a type IIB enzymes that assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein. Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination through the formation of DNA double-strand breaks by a type II DNA topoisomerase-like activity. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination [].
•
•
•
•
•
Protein Domain
IPR036078 | Spo11/TopoVI_A_sf
Type: Homologous_superfamily
Description: This entry represents Spo11, a meiotic recombination protein found in eukaryotes, and subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [, , , ]. These two types of proteins share structural homology.DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks. They can be divided into two classes: type I enzymes (, topoisomerases I, III and V) break single-strand DNA, and type II enzymes (, topoisomerases II, IV and VI) break double-strand DNA []. Topoisomerase VI is a type IIB enzymes that assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein. Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination through the formation of DNA double-strand breaks by a type II DNA topoisomerase-like activity. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination [].
•
•
•
•
•
Genotype
Genotype
Symbol: Fignl1/Fignl1 Spo11/Spo11 Tg(Stra8-cre)1Osb/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Huwe1/? Tg(Spo11-cre)1Rsw/?
Background: involves: 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
12408862 | -
First Author: Peciña A
Year: 2002
Journal: Cell
Title: Targeted stimulation of meiotic recombination.
Volume: 111
Issue: 2
Pages: 173-84
•
•
•
•
•
Publication
15044957 | -
First Author: Kee K
Year: 2004
Journal: EMBO J
Title: Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes.
Volume: 23
Issue: 8
Pages: 1815-24
•
•
•
•
•
Protein Domain
IPR035349 | Rec104
Type: Family
Description: Rec104 is one of several meiosis specific genes required for generating meiotic DSBs (double strand breaks) []. It is suggested that Rec102 and Rec104 directly promote DSB formation as part of a multiprotein complex with Spo11. Rec102 and Rec104 are mutually dependent for proper sub-cellular localization, and share a requirement for Spo11 and Ski8 for their recruitment to meiotic chromosomes. Moreover, Rec102 is required for Rec104 to accumulate to normal steady-state levels and to be properly phosphorylated. It is likely that Rec102 and Rec104 move freely in and out of the nucleus but are most stably sequestered there only when they can form a complex on chromosomes [].
•
•
•
•
•
Publication
11410368 | -
First Author: Hartung F
Year: 2001
Journal: Gene
Title: Molecular characterization of homologues of both subunits A (SPO11) and B of the archaebacterial topoisomerase 6 in plants.
Volume: 271
Issue: 1
Pages: 81-6
•
•
•
•
•
Publication
7961685 | -
First Author: Bergerat A
Year: 1994
Journal: J Biol Chem
Title: Purification of a DNA topoisomerase II from the hyperthermophilic archaeon Sulfolobus shibatae. A thermostable enzyme with both bacterial and eucaryal features.
Volume: 269
Issue: 44
Pages: 27663-9
•
•
•
•
•
Publication
12437782 | -
First Author: Sharif WD
Year: 2002
Journal: Cell Chromosome
Title: Distinct functions of S. pombe Rec12 (Spo11) protein and Rec12-dependent crossover recombination (chiasmata) in meiosis I; and a requirement for Rec12 in meiosis II.
Volume: 1
Issue: 1
Pages: 1
•
•
•
•
•
Publication
11809802 | -
First Author: Diaz RL
Year: 2002
Journal: Mol Cell Biol
Title: Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation.
Volume: 22
Issue: 4
Pages: 1106-15
•
•
•
•
•
Publication
11413012 | -
First Author: Lichten M
Year: 2001
Journal: Curr Biol
Title: Meiotic recombination: breaking the genome to save it.
Volume: 11
Issue: 7
Pages: R253-6
•
•
•
•
•
Protein Domain
IPR034136 | TOPRIM_Topo6A/Spo11
Type: Domain
Description: This topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain is found in the type II topoisomerase VIA and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VIA (TopoVIA) []and Saccharomyces cerevisiae meiotic recombination factor Spo11 []. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. TopoVI enzymes are heterotetramers found in archaea and plants [, ]. Spo11 plays a role in generating the double strand breaks that initiate homologous recombination during meiosis [, ]. S. shibatae TopoVI relaxes both positive and negative supercoils, and in addition has a strong decatenase activity [].The TOPRIM domain has two conserved motifs, one of which centres at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases, the conserved glutamate is believed to act as a general base in strand joining, and as a general acid in strand cleavage []. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
•
•
•
•
•
Publication
10545127 | -
First Author: Nichols MD
Year: 1999
Journal: EMBO J
Title: Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11.
Volume: 18
Issue: 21
Pages: 6177-88
•
•
•
•
•
Publication
12618182 | -
First Author: Corbett KD
Year: 2003
Journal: Chem Biol
Title: Emerging roles for plant topoisomerase VI.
Volume: 10
Issue: 2
Pages: 107-11
•
•
•
•
•
Publication
28355560 | J:250995
First Author: Deota S
Year: 2017
Journal: Cell Rep
Title: Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.
Volume: 18
Issue: 13
Pages: 3069-3077
•
•
•
•
•
Genotype
Genotype
Symbol: Nbn/Nbn Tg(Spo11-cre)D5Mpel/?
Background: involves: BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Cenpv/Cenpv Tg(Spo11-cre)1Rsw/?
Background: involves: C57BL/6N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
18799790 | J:139646
First Author: Mark M
Year: 2008
Journal: J Cell Sci
Title: STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.
Volume: 121
Issue: Pt 19
Pages: 3233-42
•
•
•
•
•
Publication
20508641 | J:162105
First Author: Getun IV
Year: 2010
Journal: EMBO Rep
Title: Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.
Volume: 11
Issue: 7
Pages: 555-60
•
•
•
•
•
Publication
15031413 | -
First Author: Nonomura K
Year: 2004
Journal: Plant Cell
Title: The novel gene HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1 of rice encodes a putative coiled-coil protein required for homologous chromosome pairing in meiosis.
Volume: 16
Issue: 4
Pages: 1008-20
•
•
•
•
•
Publication
28855712 | -
First Author: Tang Y
Year: 2017
Journal: Sci Rep
Title: MTOPVIB interacts with AtPRD1 and plays important roles in formation of meiotic DNA double-strand breaks in Arabidopsis.
Volume: 7
Issue: 1
Pages: 10007
•
•
•
•
•
Publication
19500302 | -
First Author: Jiang H
Year: 2009
Journal: Plant J
Title: MULTIPOLAR SPINDLE 1 (MPS1), a novel coiled-coil protein of Arabidopsis thaliana, is required for meiotic spindle organization.
Volume: 59
Issue: 6
Pages: 1001-10
•
•
•
•
•
Publication
23049844 | -
First Author: de Oliveira EA
Year: 2012
Journal: PLoS One
Title: Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana.
Volume: 7
Issue: 9
Pages: e45707
•
•
•
•
•
Publication
17762870 | -
First Author: De Muyt A
Year: 2007
Journal: EMBO J
Title: AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.
Volume: 26
Issue: 18
Pages: 4126-37
•
•
•
•
•
Publication
22694475 | -
First Author: Zhang C
Year: 2012
Journal: Plant J
Title: The Arabidopsis thaliana DSB formation (AtDFO) gene is required for meiotic double-strand break formation.
Volume: 72
Issue: 2
Pages: 271-81
•
•
•
•
•
Protein Domain
IPR034546 | PAIR1
Type: Family
Description: The representative of this plant family is PAIR1 (HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1), a protein that plays an essential role in establishment of homologous chromosome pairing in meiosis. Mutations in the gene encoding this protein also affect spindle formation and sporulation []. This family also contains the Putative recombination initiation defects 3 (AtPRD3) involved in the meiotic recombination initiation [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation [].
•
•
•
•
•
Protein Domain
IPR044968 | PRD1
Type: Family
Description: This entry represent a group of plant proteins, including AtPRD1 from Arabidopsis. AtPRD1 is required for meiotic double strand break formation []. AtPRD1 is homologous to MEI1 of humans and mice and contains a conserved N-terminal region that can interact with AtSPO11-1 and itself [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation [].
•
•
•
•
•
Protein Domain
IPR044969 | DFO
Type: Family
Description: This entry represent a group of plant proteins, including AtDFO from Arabidopsis. AtDFO is a plant-specific protein involved in DNA double-strand break formation during meiosis [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation [].
•
•
•
•
•
Protein Domain
IPR037500 | Msp1
Type: Family
Description: The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation. In plants, Msp1 (also known as AtPRD2) has been identified as one of the SAC components []. Msp1 is required for meiotic spindle organization []and DNA double-strand break formation [].In flowering plants, gametophyte formation relies on meiosis. In meiosis I, the homologous chromosomes are separated into two daughter cells. In meiosis II, the sister chromosomes are then separated into newly formed daughter cells. During prophase I, several events occurs: sister chromatid cohesion, homologous chromosome synapsis, recombination, crossover formation and chromosome segregation. Homologous recombination is initiated from the formation of DNA double-strand breaks (DSBs). The formation of DSBs is catalyzed by Spo11 and its homologues. So far, six Arabidopsis proteins, AtSPO11-1, AtSPO11-2, AtPRD1, AtPRD2, AtPRD3 and AtDFO, have been shown to be involved in DSB formation [].
•
•
•
•
•
Publication
19763177 | -
First Author: De Muyt A
Year: 2009
Journal: PLoS Genet
Title: A high throughput genetic screen identifies new early meiotic recombination functions in Arabidopsis thaliana.
Volume: 5
Issue: 9
Pages: e1000654
•
•
•
•
•
Publication
29259204 | J:323709
First Author: Bose R
Year: 2017
Journal: Sci Rep
Title: Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.
Volume: 7
Issue: 1
Pages: 17759
•
•
•
•
•
Publication
33172986 | J:299255
 
First Author: Wellard SR
Year: 2020
Journal: J Cell Sci
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Volume: 133
Issue: 23
•
•
•
•
•
Genotype
Genotype
Symbol: Jam3/Jam3 Tg(Spo11-cre)D5Mpel/?
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
20019666 | J:156442
First Author: Kidane D
Year: 2010
Journal: EMBO J
Title: DNA polymerase beta is critical for mouse meiotic synapsis.
Volume: 29
Issue: 2
Pages: 410-23
•
•
•
•
•
Publication
34360715 | J:324166
 
First Author: Waseem S
Year: 2021
Journal: Int J Mol Sci
Title: Protein Arginine Methyltransferase 1 Is Essential for the Meiosis of Male Germ Cells.
Volume: 22
Issue: 15
•
•
•
•
•
Publication
36396648 | J:331787
First Author: Nore A
Year: 2022
Journal: Nat Commun
Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
Volume: 13
Issue: 1
Pages: 7048
•
•
•
•
•
Publication
33619545 | J:313251
First Author: Dereli I
Year: 2021
Journal: Nucleic Acids Res
Title: Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.
Volume: 49
Issue: 5
Pages: 2609-2628
•
•
•
•
•
Protein Domain
IPR005734 | TopoVI_B
Type: Family
Description: DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].This entry represents subunit B of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea, but also in a few eukayotes, such as the plant Arabidopsis thaliana []. This enzyme assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein that mediates double-strand DNA breaks during meiotic recombination in eukaryotes []. Therefore, though related to type IIA topoisomerases, topoisomerase VI may have a distinctive mechanism of action.
•
•
•
•
•
Publication
24891606 | J:215796
First Author: Holloway JK
Year: 2014
Journal: J Cell Biol
Title: Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Volume: 205
Issue: 5
Pages: 633-41
•
•
•
•
•
Publication
36111709 | J:329538
 
First Author: de Castro RO
Year: 2022
Journal: Development
Title: PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse.
Volume: 149
Issue: 18
•
•
•
•
•
Publication
33615678 | J:314448
First Author: Wellard SR
Year: 2021
Journal: EMBO Rep
Title: Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes.
Volume: 22
Issue: 4
Pages: e51023
•
•
•
•
•
Publication
34599968 | J:324061
First Author: Campbell KM
Year: 2021
Journal: J Biol Chem
Title: Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume: 297
Issue: 5
Pages: 101231
•
•
•
•
•
Publication
35857787 | J:327372
First Author: Koornneef L
Year: 2022
Journal: PLoS Genet
Title: Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure.
Volume: 18
Issue: 7
Pages: e1010046
•
•
•
•
•
Protein Domain
IPR004085 | TopoVI_A
Type: Family
Description: DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].This entry represents subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea, but also in a few eukayotes, such as the plant Arabidopsis thaliana []. This enzyme assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein that mediates double-strand DNA breaks during meiotic recombination in eukaryotes []. The core of subunit A is a dimer, with a deep groove in which the DNA molecule is thought to bind, with the monomers separating during DNA transport. Therefore, though related to type IIA topoisomerases, topoisomerase VI may have a distinctive mechanism of action.
•
•
•
•
•
Publication
35297490 | J:324544
 
First Author: Guida E
Year: 2022
Journal: J Cell Sci
Title: MAPK activation drives male and female mouse teratocarcinomas from late primordial germ cells.
Volume: 135
Issue: 8
•
•
•
•
•
Publication
35274968 | J:328688
First Author: Wellard SR
Year: 2022
Journal: Mol Biol Cell
Title: PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis.
Volume: 33
Issue: 5
Pages: ar37
•
•
•
•
•
Publication
33202307 | J:302997
 
First Author: Pryzhkova MV
Year: 2020
Journal: Stem Cell Res
Title: Adaptation of the AID system for stem cell and transgenic mouse research.
Volume: 49
Pages: 102078
•
•
•
•
•
Publication
36809245 | J:336849
First Author: Martinez-Garcia M
Year: 2023
Journal: PLoS Genet
Title: GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.
Volume: 19
Issue: 2
Pages: e1010666
•
•
•
•
•
Publication
23553930 | J:196968
First Author: Campolo F
Year: 2013
Journal: Stem Cells
Title: Essential role of Sox2 for the establishment and maintenance of the germ cell line.
Volume: 31
Issue: 7
Pages: 1408-21
•
•
•
•
•
Publication
32267211 | J:291160
First Author: Little TM
Year: 2020
Journal: Mol Biol Cell
Title: PLK1 is required for chromosome compaction and microtubule organization in mouse oocytes.
Volume: 31
Issue: 12
Pages: 1206-1217
•
•
•
•
•
Publication
30281394 | J:299559
First Author: Hwang G
Year: 2018
Journal: Mol Biol Cell
Title: Depletion of SMC5/6 sensitizes male germ cells to DNA damage.
Volume: 29
Issue: 25
Pages: 3003-3016
•
•
•
•
•
Publication
34764261 | J:314905
First Author: Nabi D
Year: 2021
Journal: Nat Commun
Title: CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.
Volume: 12
Issue: 1
Pages: 6547
•
•
•
•
•
Publication
9722641 | -
First Author: Aravind L
Year: 1998
Journal: Nucleic Acids Res
Title: Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins.
Volume: 26
Issue: 18
Pages: 4205-13
•
•
•
•
•
Publication
12596227 | -
First Author: Gadelle D
Year: 2003
Journal: Bioessays
Title: Phylogenomics of type II DNA topoisomerases.
Volume: 25
Issue: 3
Pages: 232-42
•
•
•
•
•
Publication
7980433 | -
 
First Author: Watt PM
Year: 1994
Journal: Biochem J
Title: Structure and function of type II DNA topoisomerases.
Volume: 303 ( Pt 3)
Pages: 681-95
•
•
•
•
•
Publication
7770916 | -
First Author: Roca J
Year: 1995
Journal: Trends Biochem Sci
Title: The mechanisms of DNA topoisomerases.
Volume: 20
Issue: 4
Pages: 156-60
•
•
•
•
•
Publication
11395412 | -
 
First Author: Champoux JJ
Year: 2001
Journal: Annu Rev Biochem
Title: DNA topoisomerases: structure, function, and mechanism.
Volume: 70
Pages: 369-413
•
•
•
•
•
Publication
12042765 | -
First Author: Wang JC
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Cellular roles of DNA topoisomerases: a molecular perspective.
Volume: 3
Issue: 6
Pages: 430-40
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom