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Search results 401 to 500 out of 540 for Stim1

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0.396s

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Type Details Score
Publication
29925524 | J:341082
First Author: Casari C
Year: 2018
Journal: Blood Adv
Title: Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.
Volume: 2
Issue: 12
Pages: 1417-1428
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Publication
38131301 | J:344137
   
First Author: He Y
Year: 2023
Journal: Elife
Title: Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner.
Volume: 12
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Publication
26916731 | J:246464
First Author: Pachel C
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury.
Volume: 36
Issue: 4
Pages: 629-35
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Publication
38878778 | J:350991
First Author: Woo MS
Year: 2024
Journal: Cell
Title: STING orchestrates the neuronal inflammatory stress response in multiple sclerosis.
Volume: 187
Issue: 15
Pages: 4043-4060.e30
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Publication
33127885 | J:297769
First Author: Moon H
Year: 2020
Journal: Nat Commun
Title: Crbn modulates calcium influx by regulating Orai1 during efferocytosis.
Volume: 11
Issue: 1
Pages: 5489
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Publication
31637311 | J:288625
 
First Author: Boutry M
Year: 2019
Journal: Commun Biol
Title: Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis.
Volume: 2
Pages: 380
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Publication
27399837 | J:236096
First Author: Tremblay MG
Year: 2016
Journal: Cell Cycle
Title: Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility.
Volume: 15
Issue: 17
Pages: 2360-6
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Publication
25737585 | J:259457
First Author: Shanmughapriya S
Year: 2015
Journal: Sci Signal
Title: Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.
Volume: 8
Issue: 366
Pages: ra23
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Publication
11698278 | J:98123
First Author: Geiger H
Year: 2001
Journal: Blood
Title: Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.
Volume: 98
Issue: 10
Pages: 2966-72
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Publication
38191655 | J:344186
First Author: Muñoz-Gallardo MDM
Year: 2024
Journal: Sci Rep
Title: miR-195b is required for proper cellular homeostasis in the elderly.
Volume: 14
Issue: 1
Pages: 810
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Publication
38653356 | J:347984
First Author: Naillat F
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model.
Volume: 1870
Issue: 5
Pages: 167180
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26184105 | J:224453
 
First Author: Ma G
Year: 2015
Journal: Nat Commun
Title: Inside-out Ca(2+) signalling prompted by STIM1 conformational switch.
Volume: 6
Pages: 7826
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HT Experiment
GSE158513 | Purkinje neurons with loss of STIM1 exhibit age-dependent changes in gene expression and synaptic components
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
24621671 | J:213878
First Author: Wang S
Year: 2014
Journal: J Dent Res
Title: STIM1 and SLC24A4 Are Critical for Enamel Maturation.
Volume: 93
Issue: 7 Suppl
Pages: 94S-100S
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Publication
20929812 | J:164873
First Author: Park CY
Year: 2010
Journal: Science
Title: The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels.
Volume: 330
Issue: 6000
Pages: 101-5
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Publication
25587190 | J:260222
First Author: Ong HL
Year: 2015
Journal: Sci Signal
Title: STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.
Volume: 8
Issue: 359
Pages: ra3
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Publication
38060449 | J:360104
First Author: Carreras-Sureda A
Year: 2023
Journal: Cell Rep
Title: The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation.
Volume: 42
Issue: 12
Pages: 113540
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DO Term
DOID:0111970 | immunodeficiency 10
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Publication
21220420 | J:171160
First Author: Singaravelu K
Year: 2011
Journal: J Biol Chem
Title: Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria.
Volume: 286
Issue: 14
Pages: 12189-201
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Publication
28588080 | J:260005
 
First Author: Liu X
Year: 2017
Journal: Sci Signal
Title: Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway.
Volume: 10
Issue: 482
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Publication
33813142 | J:328014
 
First Author: Prabakaran T
Year: 2021
Journal: EBioMedicine
Title: A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology.
Volume: 66
Pages: 103314
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Allele
Stim1<em2Smoc> | MGI:7292620
Name: stromal interaction molecule 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
GSE218388 | Deciphering the functions of Stromal Interaction Molecule-1 in Amelogenesis using Amelx-iCre mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18166150 | -
First Author: Zheng L
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2.
Volume: 369
Issue: 1
Pages: 240-6
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Strain
MGI:6476398 | C57BL/6JSmoc-Stim1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Stim1<tm1.1Pg> | MGI:7449270
Name: stromal interaction molecule 1; targeted mutation 1.1, PolyGene AG
Allele Type: Targeted
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Stim1/Stim1<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0080089 | tubular aggregate myopathy 1
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Allele
Tg(ACTA1-STIM1)4Jmol | MGI:5550401
Name: transgene insertion 4, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Stim1<em1Smoc> | MGI:7292619
Name: stromal interaction molecule 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
17218360 | -
First Author: Lorin-Nebel C
Year: 2007
Journal: J Physiol
Title: CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.
Volume: 580
Issue: Pt 1
Pages: 67-85
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Publication
16208375 | -
First Author: Zhang SL
Year: 2005
Journal: Nature
Title: STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.
Volume: 437
Issue: 7060
Pages: 902-5
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Protein Domain
IPR032393 | SOAR
Type: Domain
Description: This domain, also known as SOAR, is the Orai1-activating region of STIM1 (stromal interaction molecule 1). STIM1 is a Ca2+ sensor in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region forms a dimer, and is essential for oligomerisation of the whole of STIM1 [].
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Publication
26322679 | -
First Author: Jing J
Year: 2015
Journal: Nat Cell Biol
Title: Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx.
Volume: 17
Issue: 10
Pages: 1339-47
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Protein
Q3UF25
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A0A2I3BRU1
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Protein
A0A2I3BQH7
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
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Protein Domain
IPR022127 | STIMATE/YPL162C
Type: Family
Description: This entry includes STIMATE from animals and uncharacterised vacuolar membrane protein YPL162C from budding yeasts. STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch [].
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Strain
MGI:5550402 | FVB/N-Tg(ACTA1-STIM1)4Jmol/J
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(ACTA1-STIM1)4Jmol/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Allele
Stim1<tm3Ics> | MGI:7622053
 
Name: stromal interaction molecule 1; targeted mutation 3, Mouse Clinical Institute
Allele Type: Targeted
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Genotype
Genotype
Symbol: Stim1/Stim1<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(ACTA1-STIM1)2Jmol | MGI:5550399
Name: transgene insertion 2, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Protein
Q8BIM2
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
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Protein
F6WBP9
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
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Protein
A0A1B0GQZ3
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Strain
MGI:5550394 | FVB/N-Tg(ACTA1-STIM1)2Jmol/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(ACTA1-STIM1)2Jmol/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
22451904 | -
First Author: Yang X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
Volume: 109
Issue: 15
Pages: 5657-62
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Publication
19019825 | -
First Author: Stathopulos PB
Year: 2009
Journal: J Biol Chem
Title: Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics.
Volume: 284
Issue: 2
Pages: 728-32
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Protein Domain
IPR037608 | STIM
Type: Family
Description: STIM proteins contain a single SAM (sterile alpha-motif) domain and an unpaired EF hand within the highly conserved extracellular region, and the coiled-coil domains thatare conserved in structure and position within the cytoplasmic region []. The EF-hand and SAM domain of the STIM proteins serves as a Ca2+ sensory region []. "Hidden"EF hand and SAM domains have a stable intramolecular association. Destabilization of the EF-SAM association during Ca2+ depletion leads to partial unfolding and aggregation (homooligomerization) []. STIM oligomerization is a key induction step in the activation of Ca(2+)-permeable channels on the plasma membrane. In human cells, STIM1 and STIM2 are regulators of store-operated calcium (Ca(2+)) entry as well as basal cytoplasmic Ca(2+) levels [].
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Protein Domain
IPR037610 | STIM2_SAM
Type: Domain
Description: STIM proteins contain a single SAM (sterile alpha-motif) domain and an unpaired EF hand within the highly conserved extracellular region, and the coiled-coil domains that are conserved in structure and position within the cytoplasmic region []. The EF-hand and SAM domain of the STIM proteins serves as a Ca2+ sensory region []. "Hidden"EF hand and SAM domains have a stable intramolecular association. Destabilization of the EF-SAM association during Ca2+ depletion leads to partial unfolding and aggregation (homooligomerization) []. STIM oligomerization is a key induction step in the activation of Ca(2+)-permeable channels on the plasma membrane. In human cells, STIM1 and STIM2 are regulators of store-operated calcium (Ca(2+)) entry as well as basal cytoplasmic Ca(2+) levels [].This entry represents the SAM domain of STIM2.
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Protein
P83093
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
A5CVE4
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
B2RQE3
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
I1E4X8
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
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Protein
B7ZN44
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Publication
18854159 | -
First Author: Stathopulos PB
Year: 2008
Journal: Cell
Title: Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.
Volume: 135
Issue: 1
Pages: 110-22
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Protein
P70302
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
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Protein
A0A1B0GR78
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q3TUX9
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
A0A1B0GRA5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Publication
20887894 | J:167918
First Author: Feng M
Year: 2010
Journal: Cell
Title: Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Volume: 143
Issue: 1
Pages: 84-98
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Publication
32750041 | J:302510
First Author: Volz J
Year: 2020
Journal: J Clin Invest
Title: BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
Volume: 130
Issue: 11
Pages: 6064-6079
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Publication
31833196 | J:284048
First Author: Wang WP
Year: 2020
Journal: Aging Cell
Title: Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.
Volume: 19
Issue: 2
Pages: e13090
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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