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Search results 401 to 427 out of 427 for Stx1a

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0.018s

Type

Details

Score

Protein Domain

IPR039077 | SNAP-25

Type:

Family

Description:

SNARE proteins are involved in the fusion of vesicles with their target membranes. Synaptosomal-associated protein 25 (SNAP-25) regulates Kv2.1 voltage-dependent K(+) channels in pancreatic beta cells []. It may also play a role in neurotansmiiter release form the synapse. It is a component of the SNARE core complex, which also includes VAMP2 and STX1A [, ]. In some fish species (goldfish, zebrafish) there are two homologues known as SNAP-25A and SNAP-25B.

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Publication

17270452 | J:134730

First Author:	van Hagen JM
Year:	2007
Journal:	Neurobiol Dis
Title:	Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.
Volume:	26
Issue:	1
Pages:	112-24

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Publication

37432648 | J:344888

First Author:	Rahman MM
Year:	2023
Journal:	FASEB J
Title:	Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
Volume:	37
Issue:	8
Pages:	e23075

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Publication

32312867 | J:293286

First Author:	Liu S
Year:	2020
Journal:	Diabetes
Title:	Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells.
Volume:	69
Issue:	6
Pages:	1178-1192

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Publication

29139159 | J:273770

First Author:	Fujiwara T
Year:	2017
Journal:	Eur J Neurosci
Title:	Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Volume:	46
Issue:	12
Pages:	2867-2874

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Publication

26203110 | J:238616

First Author:	Wu YJ
Year:	2015
Journal:	J Neurophysiol
Title:	Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
Volume:	114
Issue:	4
Pages:	2404-17

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Publication

20150444 | J:158605

First Author:	Groffen AJ
Year:	2010
Journal:	Science
Title:	Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Volume:	327
Issue:	5973
Pages:	1614-8

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Publication

8902635 | J:39762

First Author:	Kojima T
Year:	1996
Journal:	J Biochem
Title:	Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).
Volume:	120
Issue:	3
Pages:	671-6

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Publication

19033398 | J:146942

First Author:	Fukuda N
Year:	2009
Journal:	Diabetes
Title:	DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes.
Volume:	58
Issue:	2
Pages:	377-84

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Publication

9759724 | -

First Author:	Sutton RB
Year:	1998
Journal:	Nature
Title:	Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.
Volume:	395
Issue:	6700
Pages:	347-53

•

Publication

22698913 | J:208531

First Author:	Ramalingam L
Year:	2012
Journal:	Diabetes
Title:	Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.
Volume:	61
Issue:	10
Pages:	2424-32

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Publication

25005332 | J:218125

First Author:	Li J
Year:	2014
Journal:	Diabetologia
Title:	DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.
Volume:	57
Issue:	10
Pages:	2173-82

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Publication

16515538 | J:108537

First Author:	Groffen AJ
Year:	2006
Journal:	J Neurochem
Title:	DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.
Volume:	97
Issue:	3
Pages:	818-33

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Publication

22036572 | J:178686

First Author:	Yao J
Year:	2011
Journal:	Cell
Title:	Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Volume:	147
Issue:	3
Pages:	666-77

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Publication

20403080 | -

First Author:	Sato M
Year:	2010
Journal:	J Neurochem
Title:	Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.
Volume:	114
Issue:	1
Pages:	171-81

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Protein Domain

IPR030535 | Doc2a/b

Type:

Family

Description:

Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ].

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Protein

D3Z126

Organism:	Mus musculus/domesticus
Length:	83
Fragment?:	true

•

Protein

P60879

Organism:	Mus musculus/domesticus
Length:	206
Fragment?:	false

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Protein

D3YZ51

Organism:	Mus musculus/domesticus
Length:	133
Fragment?:	true

•

Protein

Q7TNF0

Organism:	Mus musculus/domesticus
Length:	405
Fragment?:	false

•

Protein

P70169

Organism:	Mus musculus/domesticus
Length:	412
Fragment?:	false

•

Protein

H3BJT3

Organism:	Mus musculus/domesticus
Length:	211
Fragment?:	true

•

Protein

D3YYV2

Organism:	Mus musculus/domesticus
Length:	262
Fragment?:	true

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Protein

O35527

Organism:	Mus musculus/domesticus
Length:	405
Fragment?:	true

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Protein

D3Z1K1

Organism:	Mus musculus/domesticus
Length:	177
Fragment?:	true

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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