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Search results 401 to 500 out of 527 for Sufu

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Type Details Score
Allele
Sufu<tm1Hui> | MGI:4840420
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1, Chi-chung Hui
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Sufu<tm1e(KOMP)Wtsi> | MGI:4880918
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sufu<tm1a(KOMP)Wtsi> | MGI:4880885
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Sufu<Gt(S10-9A1)Sor> | MGI:4974305
 
Name: SUFU negative regulator of hedgehog signaling; gene trap S10-9A1, Philippe Soriano
Allele Type: Gene trapped
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Allele
Sufu<tm1b(KOMP)Wtsi> | MGI:5569947
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sufu<rgsc2062> | MGI:5770710
 
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2062
Allele Type: Chemically induced (ENU)
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Allele
Sufu<rgsc2075> | MGI:5770712
 
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2075
Allele Type: Chemically induced (ENU)
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Allele
Sufu<tm1Zyzh> | MGI:5825362
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1, Zunyi Zhang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Sufu<tm1.1Zyzh> | MGI:5825364
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1.1, Zunyi Zhang
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Sufu<tm2.1Rto> | MGI:5887123
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 2.1, Rune Toftgard
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph
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Allele
Sufu<tm2Rto> | MGI:5888725
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 2, Rune Toftgard
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Sufu<tm2.2Rto> | MGI:6116851
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 2.2, Rune Toftgard
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Sufu<em10Gpt> | MGI:7306984
Name: SUFU negative regulator of hedgehog signaling; endonuclease-mediated mutation 10, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Sufu<em1Gpt> | MGI:7306985
Name: SUFU negative regulator of hedgehog signaling; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sufu<tm1.1Hui> | MGI:7520232
Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1.1, Chi-chung Hui
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Sufu<Rgsc2070> | MGI:7525918
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2070
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Sufu<Rgsc2071> | MGI:7525938
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2071
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Sufu<Rgsc1185> | MGI:7525853
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 1185
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Sufu<Rgsc2027> | MGI:7525857
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2027
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Sufu<Rgsc2029> | MGI:7525870
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2029
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE155851 | The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:1990788 | GLI-SUFU complex
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Strain
MGI:3778680 | 129S1/Sv-Sufu<tm1Aeb>/J
Attribute String: targeted mutation, coisogenic
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Strain
MGI:3606336 | either: 129S1/Sv-Sufu<tm1Aeb> or (involves: 129S1/Sv * C57BL/6)
Attribute String: Not specified
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Strain
MGI:5615622 | 129S1/Sv-Sufu<tm1Aeb>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:3850231 | B6.129X1-Sufu<tm1Rto>/Kctt
Attribute String: congenic, targeted mutation
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Allele
Sufu<Gt(IST13179H10)Tigm> | MGI:5152414
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST13179H10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<Gt(IST13840G6)Tigm> | MGI:5188220
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST13840G6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<Gt(IST14286C11)Tigm> | MGI:5223777
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST14286C11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<Gt(IST14498A3)Tigm> | MGI:5237744
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST14498A3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<Gt(IST14518F4)Tigm> | MGI:5242620
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST14518F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<Gt(IST14883C5)Tigm> | MGI:5267251
 
Name: SUFU negative regulator of hedgehog signaling; gene trap IST14883C5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sufu<b2b273Clo> | MGI:5313712
 
Name: SUFU negative regulator of hedgehog signaling; Bench to Bassinet Program (B2B/CVDC), mutation 273 Cecilia Lo
Allele Type: Chemically induced (ENU)
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Strain
MGI:5317198 | C57BL/6J-Sufu<b2b273Clo>/J
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Strain
MGI:5314084 | C57BL/6J-Sufu<b2b273Clo>
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Strain
MGI:5700707 | C57BL/6N-Sufu<tm1b(KOMP)Wtsi>/Ucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:5774705 | B6JJcl(D2JJcl)-Sufu<rgsc2062>
Attribute String: mutant strain, chemically induced mutation
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Strain
MGI:5774704 | B6JJcl(C3JJcl)-Sufu<rgsc2062>
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:6146916 | B6JJcl;D2JJcl-Sufu<Rgsc2062>/Rbrc
Attribute String: mutant stock, chemically induced mutation
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Strain
MGI:5774502 | either: B6JJcl(C3JJcl)-Sufu<rgsc2062> or B6JJcl(D2JJcl)-Sufu<rgsc2062>
Attribute String: chemically induced mutation
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Strain
MGI:6146917 | B6;D2-Sufu<Rgsc2075>/Rbrc
Attribute String: mutant stock, chemically induced mutation
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Strain
MGI:5774805 | B6JJcl(C3JJcl)-Sufu<rgsc2075>
Attribute String: chemically induced mutation, congenic, mutant strain
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Strain
MGI:5774651 | either: B6JJcl(C3JJcl)-Sufu<rgsc2075> or B6JJcl(D2JJcl)-Sufu<rgsc2075>
Attribute String: chemically induced mutation
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Strain
MGI:5774806 | B6JJcl(D2JJcl)-Sufu<rgsc2075>
Attribute String: mutant strain, congenic, chemically induced mutation
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Strain
MGI:6353426 | B6JJcl(D2JJcl)-Sufu<Rgsc2071>/Rbrc
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:6353425 | B6JJcl(D2JJcl)-Sufu<Rgsc2070>/Rbrc
Attribute String: mutant stock, chemically induced mutation
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Strain
MGI:6353422 | B6JJcl(D2JJcl)-Sufu<Rgsc1185>/Rbrc
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:6353423 | B6JJcl(D2JJcl)-Sufu<Rgsc2027>/Rbrc
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:6353424 | B6JJcl(D2JJcl)-Sufu<Rgsc2029>/Rbrc
Attribute String: chemically induced mutation, mutant strain
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: either: 129S1/Sv-Sufu or (involves: 129S1/Sv * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: C57BL/6J-Sufu
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: either: B6JJcl(C3JJcl)-Sufu or B6JJcl(D2JJcl)-Sufu
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: either: B6JJcl(C3JJcl)-Sufu or B6JJcl(D2JJcl)-Sufu
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: C57BL/6N-Sufu/Ucd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu Tg(Atoh1-cre)1Bfri/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
24217340 | J:211322
 
First Author: Zhang Y
Year: 2013
Journal: Nat Commun
Title: Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Volume: 4
Pages: 2608
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Strain
MGI:6345008 | C57BL/6N-A<tm1Brd> Sufu<tm1a(KOMP)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6345009 | C57BL/6N-A<tm1Brd> Sufu<tm1b(KOMP)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Sufu/Sufu<+>
Background: either: 129S1/Sv-Sufu or (involves: 129S1/Sv * C57BL/6)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu<+>
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Sufu/Sufu
Background: involves: 129 * C57BL/6 * CD-1 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu Tg(Fabp4-cre)1Rev/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dzip1l/Dzip1l Sufu/Sufu
Background: involves: 129S6/SvEvTac * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR016591 | Suppressor_of_fused_euk
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry is specific for the eukaryotic Sufu proteins and does not include any homolgous bacterial sequences.
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Protein Domain
IPR017429 | Suppressor_of_fused_bac
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents a set of bacterial Sufu homologues which are predicted to function as transcriptional regulators.
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Allele
Gli2<tm1(Gli2*)Aliu> | MGI:5751722
 
Name: GLI-Kruppel family member GLI2; targeted mutation 1, Aimin Liu
Allele Type: Targeted
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Allele
Gli2<tm1.1(Gli2*)Aliu> | MGI:5751727
Name: GLI-Kruppel family member GLI2; targeted mutation 1.1, Aimin Liu
Allele Type: Targeted
Attribute String: Not Specified
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Genotype
Genotype
Symbol: Sufu/Sufu<+> Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu<+>
Background: C57BL/6N-Sufu/Ucd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sufu/Sufu Tg(Fabp7-cre)1Htz/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Sufu/Sufu
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
12150819 | -
First Author: Rubin JB
Year: 2002
Journal: Cancer Cell
Title: Medulloblastoma: a problem of developmental biology.
Volume: 2
Issue: 1
Pages: 7-8
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Protein
A0A0R4J1M0
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein Domain
IPR007768 | Suppressor_of_fused
Type: Family
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents the eukaryotic suppressor of fused proteins and their bacterial homologues.
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Protein Domain
IPR038489 | SUFU_C_sf
Type: Homologous_superfamily
Description: This entry represents the C-terminal domain of eukaryotic suppressor of fused (Sufu) proteins. It folds into a domain that comprises a four-stranded and a six-stranded β-sheet, both with mixed topologies, which are connected by two antiparallel α-helices [, ].Sufu is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade []. It functions by binding to these proteins and preventing their translocation to the nucleus. The Sufu C-terminal domain binds to the N-terminal of Gli/Ci, while the N-terminal of Sufu binds to the C-terminal of Gli/Ci. This dual binding mechanism is likely to be an evolutionary advancement in this signalling cascade, which is not present in bacterial homologues [].
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Protein Domain
IPR024314 | SUFU_C
Type: Domain
Description: This entry represents the C-terminal domain of eukaryotic suppressor of fused (Sufu) proteins. It folds into a domain that comprises a four-stranded and a six-stranded β-sheet, both with mixed topologies, which are connected by two antiparallel α-helices [, ].Sufu is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade []. It functions by binding to these proteins and preventing their translocation to the nucleus. The Sufu C-terminal domain binds to the N-terminal of Gli/Ci, while the N-terminal of Sufu binds to the C-terminal of Gli/Ci. This dual binding mechanism is likely to be an evolutionary advancement in this signalling cascade, which is not present in bacterial homologues [].
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Publication
24311597 | -
First Author: Cherry AL
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.
Volume: 69
Issue: Pt 12
Pages: 2563-79
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Genotype
Genotype
Symbol: Gli3/? Sufu/Sufu Tg(Fabp7-cre)1Htz/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nkx3-2/Nkx3-2<+> Spop/Spop Sufu/Sufu
Background: involves: 129S7/SvEvBrd * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
15367681 | -
First Author: Merchant M
Year: 2004
Journal: Mol Cell Biol
Title: Suppressor of fused regulates Gli activity through a dual binding mechanism.
Volume: 24
Issue: 19
Pages: 8627-41
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Protein
Q9Z0P7
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
D3Z7B6
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q3U0Z8
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein Domain
IPR037181 | SUFU_N
Type: Homologous_superfamily
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.Sufu contains at least two distinct domains: a highly conserved carboxy-terminal region required for binding to the amino-terminal ends of the Gli proteins and a unique amino-terminal domain that binds the carboxy-terminal tail of Gli1 []. This entry represents the N-terminal domain of Sufu. Its structure has an unusual fold composed of bifurcated β-sheet with left-handed β-α-β unit.
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Protein Domain
IPR020941 | SUFU-like_domain
Type: Domain
Description: Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling []. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway []. Homologues of Sufu have been found in bacteria, though their function is not currently known.This entry represents a domain found in Sufu and its homologues. It is also found in other proteins that are functionally uncharacterised. In eukaryotic Sufu, an additional domain () is found at the C terminus of the protein. This domain binds to the C-terminal domain of the Gli/Ci transcription factors, inhibiting their activity [].This domain is also found in Immunity protein YqcF from B. subtilis, a component of one of 6 LXG toxin-immunity modules. It neutralizes the toxic activity of cognate toxin YqcG [, ].
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nkx3-2/Nkx3-2<+> Spop/Spop Sufu/Sufu
Background: involves: 129 * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE103683 | GLI2-mediated mesenchymal Hh signaling induces stem cell niche signals in intestinal development and tumorigenesis [RNASeq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
22200572 | -
First Author: Holberger LE
Year: 2012
Journal: FEBS Lett
Title: A novel family of toxin/antitoxin proteins in Bacillus species.
Volume: 586
Issue: 2
Pages: 132-6
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Publication
26130651 | J:225591
First Author: Zhao X
Year: 2015
Journal: Cancer Res
Title: RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.
Volume: 75
Issue: 17
Pages: 3623-35
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Publication
27039827 | J:236822
 
First Author: Yan B
Year: 2016
Journal: Nat Commun
Title: mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.
Volume: 7
Pages: 11151
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Publication
35535520 | J:327335
 
First Author: Smit MJ
Year: 2022
Journal: J Cell Sci
Title: The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity.
Volume: 135
Issue: 11
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Publication
32853181 | J:309035
First Author: Feng H
Year: 2020
Journal: J Clin Invest
Title: Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
Volume: 130
Issue: 12
Pages: 6354-6365
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HT Experiment
GSE116514 | Single cell and genetic analyses reveal conserved cell populations and signaling mechanisms of stomach and intestinal stromal stem cell niches
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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