MouseMine: Keyword Search

Publication

First Author:	Majeed M
Year:	2001
Journal:	J Leukoc Biol
Title:	Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.
Volume:	70
Issue:	5
Pages:	801-11

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Publication

21088136 | J:169578

First Author:	Reilly MP
Year:	2011
Journal:	Blood
Title:	PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.
Volume:	117
Issue:	7
Pages:	2241-6

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Publication

9624129 | J:48182

First Author:	Zeitlmann L
Year:	1998
Journal:	J Biol Chem
Title:	T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.
Volume:	273
Issue:	25
Pages:	15445-52

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Publication

16887961 | J:138397

First Author:	Hiragun T
Year:	2006
Journal:	J Immunol
Title:	Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor protein.
Volume:	177
Issue:	4
Pages:	2047-50

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Publication

31873727 | J:289391

First Author:	Davidzohn N
Year:	2020
Journal:	J Exp Med
Title:	Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers.
Volume:	217
Issue:	3

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Publication

19670961 | -

First Author:	Ruzza P
Year:	2009
Journal:	Expert Opin Ther Pat
Title:	Therapeutic prospect of Syk inhibitors.
Volume:	19
Issue:	10
Pages:	1361-76

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Publication

39471181 | J:358451

First Author:	Shao Z
Year:	2024
Journal:	PLoS Pathog
Title:	The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation.
Volume:	20
Issue:	10
Pages:	e1012674

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Publication

20855865 | J:167397

First Author:	Wannemacher KM
Year:	2010
Journal:	Blood
Title:	Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.
Volume:	116
Issue:	25
Pages:	5707-15

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Interaction Experiment

Latour S (1996)

Description:

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.

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Interaction Experiment

Eliopoulos AG (2006)

Description:

The tyrosine kinase Syk regulates TPL2 activation signals.

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Interaction Experiment

Wang X (2021)

Description:

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity.

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Publication

34512311 | J:311098

First Author:	Shen Y
Year:	2021
Journal:	Front Aging Neurosci
Title:	Stress Granules Modulate SYK to Cause Tau-Associated Neurocognitive Deterioration in 5XFAD Mouse After Anesthesia and Surgery.
Volume:	13

Pages:	718701

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Publication

20639876 | J:162535

First Author:	Han C
Year:	2010
Journal:	Nat Immunol
Title:	Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.
Volume:	11
Issue:	8
Pages:	734-42

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Publication

38019655 | J:347517

First Author:	Henry CM
Year:	2023
Journal:	Cell Rep
Title:	SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.
Volume:	42
Issue:	12
Pages:	113506

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Publication

33685996 | J:303645

First Author:	Sun W
Year:	2021
Journal:	J Immunol
Title:	Cutting Edge: EPHB2 Is a Coreceptor for Fungal Recognition and Phosphorylation of Syk in the Dectin-1 Signaling Pathway.
Volume:	206
Issue:	7
Pages:	1419-1423

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Publication

25152235 | J:220102

First Author:	Kotla S
Year:	2014
Journal:	Free Radic Biol Med
Title:	ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.
Volume:	76

Pages:	147-62

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Publication

16574771 | J:109680

First Author:	Canetti C
Year:	2006
Journal:	J Leukoc Biol
Title:	Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
Volume:	79
Issue:	6
Pages:	1234-41

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Publication

23281368 | J:259308

First Author:	Mukherjee S
Year:	2013
Journal:	Sci Signal
Title:	Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
Volume:	6
Issue:	256
Pages:	ra1

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Publication

35337798 | J:345870

First Author:	Liu L
Year:	2022
Journal:	J Biol Chem
Title:	The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs.
Volume:	298
Issue:	5
Pages:	101857

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Publication

10521450 | J:115128

First Author:	Craxton A
Year:	1999
Journal:	J Biol Chem
Title:	Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.
Volume:	274
Issue:	43
Pages:	30644-50

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Publication

17572156 | J:123699

First Author:	Li B
Year:	2007
Journal:	Clin Immunol
Title:	Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways.
Volume:	124
Issue:	2
Pages:	170-81

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Publication

28736076 | J:256326

First Author:	Nam ST
Year:	2017
Journal:	Toxicol Appl Pharmacol
Title:	Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C.
Volume:	332

Pages:	25-31

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Publication

- | J:342817

First Author:	Reis E Sousa C
Year:	2023
Journal:	MGI Direct Data Submission
Title:	SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells.

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Publication

35196496 | J:331828

First Author:	Tanishita Y
Year:	2022
Journal:	Cell Rep
Title:	Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Volume:	38
Issue:	8
Pages:	110414

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Publication

20716772 | J:167259

First Author:	Suljagic M
Year:	2010
Journal:	Blood
Title:	The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Volume:	116
Issue:	23
Pages:	4894-905

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Publication

9233602 | J:41647

First Author:	Jugloff LS
Year:	1997
Journal:	J Immunol
Title:	Cross-linking of the IgM receptor induces rapid translocation of IgM-associated Ig alpha, Lyn, and Syk tyrosine kinases to the membrane skeleton.
Volume:	159
Issue:	3
Pages:	1096-106

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Publication

28614370 | J:248577

First Author:	Liang Y
Year:	2017
Journal:	PLoS One
Title:	The hemagglutinin-neuramidinase protein of Newcastle disease virus upregulates expression of the TRAIL gene in murine natural killer cells through the activation of Syk and NF-κB.
Volume:	12
Issue:	6
Pages:	e0178746

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Interaction Experiment

Zou W (2009)

Description:

Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl.

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Publication

12671034 | -

First Author:	Duan RD
Year:	2003
Journal:	J Lipid Res
Title:	Purification, localization, and expression of human intestinal alkaline sphingomyelinase.
Volume:	44
Issue:	6
Pages:	1241-50

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Publication

22100390 | J:183726

First Author:	Awla D
Year:	2012
Journal:	J Leukoc Biol
Title:	Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis.
Volume:	91
Issue:	5
Pages:	711-9

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Publication

25085626 | J:222069

First Author:	Luo L
Year:	2014
Journal:	Am J Physiol Lung Cell Mol Physiol
Title:	Proinflammatory role of neutrophil extracellular traps in abdominal sepsis.
Volume:	307
Issue:	7
Pages:	L586-96

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Publication

9698567 | -

First Author:	Fütterer K
Year:	1998
Journal:	J Mol Biol
Title:	Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
Volume:	281
Issue:	3
Pages:	523-37

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Publication

12740576 | -

First Author:	Zompi S
Year:	2003
Journal:	Nat Immunol
Title:	NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
Volume:	4
Issue:	6
Pages:	565-72

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Interaction Experiment

Han C (2010)

Description:

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.

•

Interaction Experiment

Lin YC (2013)

Description:

The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3.

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Publication

33911034 | J:309162

First Author:	Umeda M
Year:	2021
Journal:	Proc Natl Acad Sci U S A
Title:	ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.
Volume:	118
Issue:	18

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Publication

16174766 | J:126630

First Author:	Suzuki-Inoue K
Year:	2006
Journal:	Blood
Title:	A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
Volume:	107
Issue:	2
Pages:	542-9

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Publication

18432193 | -

First Author:	Ziegenfuss JS
Year:	2008
Journal:	Nature
Title:	Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.
Volume:	453
Issue:	7197
Pages:	935-9

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Publication

34362877 | -

First Author:	Wang X
Year:	2021
Journal:	Signal Transduct Target Ther
Title:	TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity.
Volume:	6
Issue:	1
Pages:	298

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Protein Coding Gene

MGI:99613 | Zap70

Type:	protein_coding_gene
Organism:	mouse, laboratory

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Publication

20670933 | -

First Author:	Chen X
Year:	2010
Journal:	J Biol Chem
Title:	Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate.
Volume:	285
Issue:	41
Pages:	31268-76

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Publication

31217348 | J:308956

First Author:	Kono M
Year:	2019
Journal:	JCI Insight
Title:	Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
Volume:	4
Issue:	12

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Publication

1874735 | -

First Author:	Taniguchi T
Year:	1991
Journal:	J Biol Chem
Title:	Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
Volume:	266
Issue:	24
Pages:	15790-6

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Publication

7594458 | -

First Author:	Johnson SA
Year:	1995
Journal:	J Immunol
Title:	Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.
Volume:	155
Issue:	10
Pages:	4596-603

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Publication

10327049 | -

First Author:	Maeda A
Year:	1999
Journal:	Oncogene
Title:	Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.
Volume:	18
Issue:	14
Pages:	2291-7

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Publication

19419964 | -

First Author:	Zou W
Year:	2009
Journal:	J Biol Chem
Title:	Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl.
Volume:	284
Issue:	28
Pages:	18833-9

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Publication

18689684 | -

First Author:	Zhang Y
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling.
Volume:	105
Issue:	33
Pages:	11760-5

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Allele

Syk<tm1Paw> | MGI:1857421

Name:	spleen tyrosine kinase; targeted mutation 1, Tony Pawson
Allele Type:	Targeted
Attribute String:	Null/knockout

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Allele

Gt(ROSA)26Sor<tm1(ETV6/SYK)Hjum> | MGI:5568502

Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hassan Jumaa
Allele Type:	Targeted
Attribute String:	Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter

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Publication

15795233 | -

First Author:	Brunati AM
Year:	2005
Journal:	J Biol Chem
Title:	Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein.
Volume:	280
Issue:	22
Pages:	21029-35

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Publication

12450381 | -

First Author:	Folmer RH
Year:	2002
Journal:	Biochemistry
Title:	Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem.
Volume:	41
Issue:	48
Pages:	14176-84

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Publication

20452964 | -

First Author:	Wang H
Year:	2010
Journal:	Cold Spring Harb Perspect Biol
Title:	ZAP-70: an essential kinase in T-cell signaling.
Volume:	2
Issue:	5
Pages:	a002279

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Protein Domain

IPR035838 | SYK/ZAP-70_N_SH2

Type:

Domain

Description:

ZAP-70 and Syk comprise a family of hematopoietic cell specific protein tyrosine kinases (PTKs) that are required for antigen and antibody receptor function. ZAP-70 is expressed in T and natural killer (NK) cells and Syk is expressed in B cells, mast cells, polymorphonuclear leukocytes, platelets, macrophages, and immature T cells. They are required for the proper development of T and B cells, immune receptors, and activating NK cells []. They consist of two N-terminal Src homology 2 (SH2) domains and a C-terminal kinase domain separated from the SH2 domains by a linker or hinge region. Phosphorylation of both tyrosine residues within the Immunoreceptor Tyrosine-based Activation Motifs (ITAM; consensus sequence Yxx[LI]x(7,8)Yxx[LI]) by the Src-family PTKs is required for efficient interaction of ZAP-70 and Syk with the receptor subunits and for receptor function []. ZAP-70 forms two phosphotyrosine binding pockets, one of which is shared by both SH2 domains. In Syk the two SH2 domains do not form such a phosphotyrosine-binding site. The SH2 domains here are believed to function independently. In addition, the two SH2 domains of Syk display flexibility in their relative orientation, allowing Syk to accommodate a greater variety of spacing sequences between the ITAM phosphotyrosines and singly phosphorylated non-classical ITAM ligands []. This entry contains the N terminus SH2 domains of both Syk and Zap70.

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Protein Domain

IPR003110 | Phos_immunorcpt_sig_ITAM

Type:	Repeat
Description:	Phosphorylated immunoreceptor signalling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases []. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.

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Allele

Syk<tm1(Syk)Spwa> | MGI:5750743

Name:	spleen tyrosine kinase; targeted mutation 1, Steve P Watson
Allele Type:	Targeted
Attribute String:	Conditional ready, Inserted expressed sequence

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Genotype

Symbol:	Syk/Syk
Background:	involves: 129S1/Sv * 129X1/SvJ
Zygosity:	hm
Has Mutant Allele:	true

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd79a/Cd79a<+>
Background:	involves: 129S6/SvEvTac * BALB/c
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Syk/Syk<+>
Background:	involves: 129S1/Sv * 129X1/SvJ
Zygosity:	ht
Has Mutant Allele:	true

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd79a/Cd79a<+> Tg(BCL2)22Wehi/?
Background:	involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi
Zygosity:	cn
Has Mutant Allele:	true

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Protein

Q501M1

Organism:	Mus musculus/domesticus
Length:	123
Fragment?:	false

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Protein

E9QA82

Organism:	Mus musculus/domesticus
Length:	155
Fragment?:	true

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Publication

8530383 | J:30125

First Author:	Anderson DM
Year:	1995
Journal:	J Biol Chem
Title:	Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
Volume:	270
Issue:	50
Pages:	29862-9

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Publication

15123770 | -

First Author:	Ratthé C
Year:	2004
Journal:	J Leukoc Biol
Title:	Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.
Volume:	76
Issue:	1
Pages:	162-8

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Protein Domain

IPR042372 | IL15RA

Type:	Family
Description:	IL-15 receptor (IL-15R) composed of IL-15Ralpha, IL-2/15Rbeta (CD122), and gamma(c) (CD132) subunits []. IL-15 is a cytokine that plays an important role in innate and adaptive immunity []. Syk kinase interacts with IL-15Ralpha and may play a key role in mediating IL-15-induced signal transduction [].

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Allele

Syk<m1Btlr> | MGI:5502198

Name:	spleen tyrosine kinase; mutation 1, Bruce Beutler
Allele Type:	Chemically induced (ENU)

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Strain

MGI:5566693 | C57BL/6J-Syk<m1Btlr>/Mmmh

Attribute String:

coisogenic, chemically induced mutation, mutant strain

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Genotype

Symbol:	Syk/Syk
Background:	involves: C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

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Protein

Q9QUJ0

Organism:	Mus musculus/domesticus
Length:	79
Fragment?:	false

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Protein

B7ZNZ7

Organism:	Mus musculus/domesticus
Length:	78
Fragment?:	false

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Publication

18097042 | -

First Author:	Marusina AI
Year:	2008
Journal:	J Immunol
Title:	Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors.
Volume:	180
Issue:	1
Pages:	409-17

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Protein Domain

IPR009861 | HCST

Type:

Family

Description:

Hematopoietic cell signal transducer (HCST, also known as DAP10) is a transmembrane adaptor that associates with an activation receptor, NKG2D, which is found on NK and subsets of T cells. The ligands for this receptor include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins []. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [].

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Publication

25810396 | -

First Author:	Ainsua-Enrich E
Year:	2015
Journal:	J Immunol
Title:	The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.
Volume:	194
Issue:	9
Pages:	4309-18

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Publication

18336269 | -

First Author:	Hatani T
Year:	2008
Journal:	Curr Med Chem
Title:	Adaptor protein 3BP2 and cherubism.
Volume:	15
Issue:	6
Pages:	549-54

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Publication

15751964 | -

First Author:	Qu X
Year:	2005
Journal:	Biochemistry
Title:	Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Volume:	44
Issue:	10
Pages:	3891-8

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Publication

17403031 | -

First Author:	Bourguignon LY
Year:	2007
Journal:	J Neurochem
Title:	Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.
Volume:	101
Issue:	4
Pages:	1002-17

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Publication

17679096 | J:134815

First Author:	Mikhailik A
Year:	2007
Journal:	Mol Cell
Title:	A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling.
Volume:	27
Issue:	3
Pages:	486-97

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Publication

22297987 | -

First Author:	Liu W
Year:	2012
Journal:	Acta Crystallogr Sect F Struct Biol Cryst Commun
Title:	Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
Volume:	68
Issue:	Pt 2
Pages:	154-8

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Protein

D3Z107

Organism:	Mus musculus/domesticus
Length:	45
Fragment?:	true

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Publication

7892198 | -

First Author:	Ferrante AW Jr
Year:	1995
Journal:	Proc Natl Acad Sci U S A
Title:	Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.
Volume:	92
Issue:	6
Pages:	1911-5

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Publication

8134129 | -

First Author:	Chan TA
Year:	1994
Journal:	Oncogene
Title:	Identification of a gene encoding a novel protein-tyrosine kinase containing SH2 domains and ankyrin-like repeats.
Volume:	9
Issue:	4
Pages:	1253-9

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Protein Domain

IPR035061 | Shark-like_SH2_N

Type:

Domain

Description:

This entry represents the SH2 domain found in Drosophila shark protein and hydra protein HTK16. Shark and HTK16 are non-receptor protein-tyrosine kinases contain two SH2 domains, five ankyrin (ANK)-like repeats, and a potential tyrosine phosphorylation site in the carboxyl-terminal tail which resembles the phosphorylation site in members of the src family. Like, mammalian non-receptor protein-tyrosine kinases, ZAP-70 and syk proteins, they do not have SH3 domains. However, the presence of ANK makes these unique among protein-tyrosine kinases. Both tyrosine kinases and ANK repeats have been shown to transduce developmental signals, and SH2 domains are known to participate intimately in tyrosine kinase signaling [].Drosophila Shark transduces intracellularly the Crumbs, a protein necessary for proper organization of ectodermal epithelia, intercellular signal []. It is essential for Draper-mediated signalling [].

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Protein Domain

IPR035847 | SH3BP2_SH2

Type:

Domain

Description:

The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].This entry represents the SH2 domain of SH3BP2.

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Protein Domain

IPR015503 | Cortactin

Type:

Family

Description:

Cortactin is a key regulator of actin polymerisation in response to tyrosine kinase signalling []. It was first identified as a tyrosine-phosphorylated protein in v-Src infected fibroblasts []. It contains several domains: an N-terminal acidic (NTA) domain, a central repeat region and a C-terminal Src homology 3 (SH3) domain. The central repeat region binds to actin filaments, the NTA domain binds to the Arp2/3 complex and the SH3 domain interacts with N-WASp, Arg and WIP []. When activated, cortactin can recruit Arp2/3 complex to existing actin filaments to nucleate a new actin filament. Cortactin is involved in the regulation of cell migration, lamellipodia formation, invadopodia formation and endocytosis []. Cortactin can be phosphorylated by Src at several sites, and also binds directly to the SH2 domain of SRC. The non-receptor kinases, such as Fyn, Syk and Fer may also play a role in cortactin tyrosine phosphorylation. The structure of cortactin has been solved [].

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Protein Domain

IPR035632 | UBASH3B_SH3

Type:

Domain

Description:

This entry represents the SH3 domain of UBASH3B. UBASH3B (also known as STS-1 or TULA-2), belongs to the TULA family, is an active phosphatase that is expressed ubiquitously []. The phosphatase activity of UBASH3B is essential for its roles in the suppression of TCR signaling []and the regulation of EGFR []. It also interacts with Syk and functions as a negative regulator of platelet glycoprotein VI signaling in platelets []. The TULA family includes two members termed p70/STS-1/TULA-2 and UBASH3A/STS-2/TULA/Cbl-InteractingProtein 4 (CLIP4). TULA proteins contain an N-terminal UBA domain, a central SH3 domain, and a C-terminal histidine phosphatase domain. They bind c-Cbl (a multidomain adaptor and an E3 ubiquitinligase) through the SH3 domain []and to ubiquitin via UBA [].

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Protein Domain

IPR035848 | SH3BP2

Type:

Family

Description:

The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].

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Protein

Q3V3Q2

Organism:	Mus musculus/domesticus
Length:	280
Fragment?:	false

•

Publication

9697839 | J:53977

First Author:	Fu C
Year:	1998
Journal:	Immunity
Title:	BLNK: a central linker protein in B cell activation.
Volume:	9
Issue:	1
Pages:	93-103

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Publication

11163197 | J:66479

First Author:	Okada T
Year:	2000
Journal:	Immunity
Title:	BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Volume:	13
Issue:	6
Pages:	817-27

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Publication

18408006 | J:172970

First Author:	Huysamen C
Year:	2008
Journal:	J Biol Chem
Title:	CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes.
Volume:	283
Issue:	24
Pages:	16693-701

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Publication

12089510 | J:109153

First Author:	Parravicini V
Year:	2002
Journal:	Nat Immunol
Title:	Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Volume:	3
Issue:	8
Pages:	741-8

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Publication

18056708 | J:131317

First Author:	Gore Y
Year:	2008
Journal:	J Biol Chem
Title:	Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex.
Volume:	283
Issue:	5
Pages:	2784-92

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Publication

10583957 | J:58805

First Author:	Pappu R
Year:	1999
Journal:	Science
Title:	Requirement for B cell linker protein (BLNK) in B cell development.
Volume:	286
Issue:	5446
Pages:	1949-54

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Publication

12871642 | J:161042

First Author:	Chen H
Year:	2003
Journal:	Immunity
Title:	Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.
Volume:	19
Issue:	1
Pages:	95-104

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Publication

8163536 | -

First Author:	Law CL
Year:	1994
Journal:	J Biol Chem
Title:	Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Volume:	269
Issue:	16
Pages:	12310-9

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Protein Domain

IPR012234 | Tyr_kinase_non-rcpt_SYK/ZAP70

Type:

Family

Description:

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the non-receptor tyrosine kinases SYK and ZAP-70 [, , ]:SYK is a positive effector of BCR-stimulated responses. It couples the B-cell antigen receptor (BCR) to the mobilisation of calcium ion, either through a phosphoinositide 3-kinase-dependent pathway (when not phosphorylated on tyrosines of the linker region), or through a phospholipase C-gamma-dependent pathway (when phosphorylated on Tyr-342 and Tyr-346). Therefore, the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion [, ].ZAP70 plays a role in T-cell development and lymphocyte activation. It is essential for TCR-mediated IL-2 production. Isoform 1 of ZAP70 induces TCR-mediated signal transduction, isoform 2 does not [, ].

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Publication

11961256 | -

First Author:	Lynch DT
Year:	2002
Journal:	J Gen Virol
Title:	Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells.
Volume:	83
Issue:	Pt 5
Pages:	1025-35

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Publication

17035319 | -

First Author:	Rovedo M
Year:	2007
Journal:	J Virol
Title:	Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.
Volume:	81
Issue:	1
Pages:	84-94

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Publication

26067064 | -

First Author:	Rancan C
Year:	2015
Journal:	PLoS Pathog
Title:	Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells.
Volume:	11
Issue:	6
Pages:	e1004906

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Publication

15159412 | -

First Author:	Kowanetz K
Year:	2004
Journal:	J Biol Chem
Title:	Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Volume:	279
Issue:	31
Pages:	32786-95

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Publication

18344182 | -

First Author:	Tsygankov AY
Year:	2008
Journal:	IUBMB Life
Title:	Multidomain STS/TULA proteins are novel cellular regulators.
Volume:	60
Issue:	4
Pages:	224-31

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