Type |
Details |
Score |
Publication |
First Author: |
Chen P |
Year: |
2022 |
Journal: |
J Neurosci |
Title: |
DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. |
Volume: |
42 |
Issue: |
4 |
Pages: |
532-551 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manuylov NL |
Year: |
2008 |
Journal: |
Development |
Title: |
Ovarian development in mice requires the GATA4-FOG2 transcription complex. |
Volume: |
135 |
Issue: |
22 |
Pages: |
3731-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CM |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. |
Volume: |
114 |
Issue: |
4 |
Pages: |
E619-E628 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salti A |
Year: |
2013 |
Journal: |
Stem Cells Dev |
Title: |
Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. |
Volume: |
22 |
Issue: |
3 |
Pages: |
397-411 |
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•
•
•
•
•
|
Publication |
First Author: |
Munton RP |
Year: |
2007 |
Journal: |
Mol Cell Proteomics |
Title: |
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. |
Volume: |
6 |
Issue: |
2 |
Pages: |
283-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sapir T |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung H |
Year: |
2018 |
Journal: |
Nat Neurosci |
Title: |
Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. |
Volume: |
21 |
Issue: |
9 |
Pages: |
1218-1228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Um JW |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. |
Volume: |
6 |
Issue: |
6 |
Pages: |
1096-1109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientfic Curators |
Year: |
2013 |
|
Title: |
Curated associations of genes in MGI and UniProt sequence records |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
International Committee on Standardized Genetic Nomenclature for Mice |
Year: |
1993 |
|
Title: |
Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 57994-1, Yumei Feng |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
synapsin I; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng H |
Year: |
2018 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. |
Volume: |
314 |
Issue: |
3 |
Pages: |
H580-H592 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Timothy J Sargeant |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence, Transactivator |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hexb/Hexb Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/? |
Background: |
involves: 129S4/SvJae * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sargeant TJ |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Characterization of inducible models of Tay-Sachs and related disease. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e1002943 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue D |
Year: |
2012 |
Journal: |
FEBS Lett |
Title: |
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation. |
Volume: |
586 |
Issue: |
10 |
Pages: |
1547-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kao HT |
Year: |
2008 |
Journal: |
J Comp Neurol |
Title: |
Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. |
Volume: |
507 |
Issue: |
6 |
Pages: |
1860-70 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The synapsins are a family of neuron-specific phosphoproteins that coatsynaptic vesicles and are involved in the binding between these vesiclesand the cytoskeleton (including actin filaments). The family comprises 5homologous proteins 1a, 1b, 2a, 2b and 3. Synapsins 1, 2, and 3 areencoded by 3 different genes. The a and b isoforms of synapsin 1 and 2 aresplice variants of the primary transcripts [].This entry represents synapsin-2 (SYN2) and synapsin-3 (SYN3). SYN2 is thought to be involved in noradrenaline secretion by sympathetic neurons []. SYN3 is expressed in cells of the subgranular layer of the hippocampal dentate gyrus []. It may function in neurogenesis and synaptic plasticity []. Unlike SYN1 and SYN2, deletion of SYN3 does not cause seizures or an apparent neurological phenotype and has relatively subtle effects on neurotransmission []. |
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•
•
•
•
•
|
Publication |
First Author: |
Chen C |
Year: |
2020 |
Journal: |
Front Cell Dev Biol |
Title: |
Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. |
Volume: |
8 |
|
Pages: |
624339 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larson ME |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits. |
Volume: |
114 |
Issue: |
23 |
Pages: |
E4648-E4657 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2017 |
Journal: |
Int J Mol Sci |
Title: |
Down-Regulated Drebrin Aggravates Cognitive Impairments in a Mouse Model of Alzheimer's Disease. |
Volume: |
18 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Corradi A |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth. |
Volume: |
23 |
Issue: |
1 |
Pages: |
90-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Basavarajappa D |
Year: |
2023 |
Journal: |
Neural Regen Res |
Title: |
Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma. |
Volume: |
18 |
Issue: |
4 |
Pages: |
840-848 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
48
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
586
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
579
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
313
 |
Fragment?: |
false |
|
•
•
•
•
•
|