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Search results 401 to 500 out of 626 for Tbk1

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGP_DBA2J_G0018859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018848 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018929 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018875 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018105 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018179 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017895 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311989
Note: kidney
Specimen Label: MRC Harwell_1311989
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1666528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311993
Specimen Label: MRC Harwell_1311993
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311988
Specimen Label: MRC Harwell_1311988
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311987
Specimen Label: MRC Harwell_1311987
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311995
Specimen Label: MRC Harwell_1311995
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311989
Specimen Label: MRC Harwell_1311989
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311996
Specimen Label: MRC Harwell_1311996
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311997
Specimen Label: MRC Harwell_1311997
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311990
Specimen Label: MRC Harwell_1311990
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311988
Specimen Label: MRC Harwell_1311988
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
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HT Experiment
GSE116613 | TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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UniProt Feature
UniProt Feature
Begin: 308
Description: Phosphothreonine; by IKKE, PDPK1 and TBK1
Type: modified residue
End: 308
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UniProt Feature
UniProt Feature
Begin: 36
Description: Phosphoserine; by IKKA, IKKB, IKKE and TBK1
Type: modified residue
End: 36
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Publication
35343085 | J:334690
First Author: Luo W
Year: 2022
Journal: Clin Transl Med
Title: MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.
Volume: 12
Issue: 3
Pages: e777
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HT Experiment
E-GEOD-73911 | The tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
Series Id: GSE73911
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
30022064 | J:265033
First Author: Zhu L
Year: 2018
Journal: Nat Commun
Title: TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Volume: 9
Issue: 1
Pages: 2812
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Allele
Tbkbp1<Gt(OST262115)Lex> | MGI:4255766
 
Name: TBK1 binding protein 1; gene trap OST262115, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Tbkbp1<Gt(OST372730)Lex> | MGI:4297823
 
Name: TBK1 binding protein 1; gene trap OST372730, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Tbkbp1<tm1Aki> | MGI:5544313
Name: TBK1 binding protein 1; targeted mutation 1, Shizuo Akira
Allele Type: Targeted
Attribute String: Null/knockout
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Interaction Experiment
Yu Z (2017)
Description: USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
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Interaction Experiment
Lafont E (2018)
Description: TBK1 and IKK prevent TNF-induced cell death by RIPK1 phosphorylation.
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Allele
Tbk1<em1Smoc> | MGI:7292694
Name: TANK-binding kinase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0110069 | frontotemporal dementia and/or amyotrophic lateral sclerosis 4
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Allele
Tbkbp1<tm1a(EUCOMM)Wtsi> | MGI:4842322
Name: TBK1 binding protein 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Tbkbp1<tm1e(EUCOMM)Wtsi> | MGI:4842627
Name: TBK1 binding protein 1; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tbkbp1<tm1b(EUCOMM)Wtsi> | MGI:5548632
Name: TBK1 binding protein 1; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tbkbp1<tm1c(EUCOMM)Wtsi> | MGI:6201554
Name: TBK1 binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Tbkbp1/Tbkbp1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:0039658 | TBK1-IKKE-DDX3 complex
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Protein
A2A9T0
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
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Protein
A2A9T0-2
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Interaction Experiment
Shu C (2013)
Description: Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
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Interaction Experiment
Cooper JM (2017)
Description: TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
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Interaction Experiment
Li L (2022)
Description: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
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Interaction Experiment
Hu Z (2023)
Description: VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
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Allele
Tg(TBK1)#Andm | MGI:6278978
Name: transgene insertion, Michael G Anderson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7623508 | C57BL/6JSmoc-Tbk1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
12133833 | -
First Author: Chariot A
Year: 2002
Journal: J Biol Chem
Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Volume: 277
Issue: 40
Pages: 37029-36
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Publication
27370208 | -
First Author: Thurston TL
Year: 2016
Journal: EMBO J
Title: Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.
Volume: 35
Issue: 16
Pages: 1779-92
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Publication
29138248 | -
First Author: Yu Z
Year: 2017
Journal: J Exp Med
Title: USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Volume: 214
Issue: 12
Pages: 3553-3563
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Interaction Experiment
Ye M (2023)
Description: TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model.
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GO Term
GO:0008384 | IkappaB kinase activity
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Strain
MGI:6143179 | C57BL/6N-A<tm1Brd>/a Tbkbp1<tm1a(EUCOMM)Wtsi>/HMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:5608146 | C57BL/6N-Tbkbp1<tm1b(EUCOMM)Wtsi>/H
Attribute String: coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Tbkbp1/Tbkbp1
Background: C57BL/6N-Tbkbp1/H
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6278979 | B6J.Cg-Tg(TBK1)#Andm
Attribute String: transgenic, mutant strain, congenic
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Genotype
Genotype
Symbol: Tg(TBK1)#Andm/?
Background: B6J.Cg-Tg(TBK1)#Andm
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(TBK1)#Andm/Tg(TBK1)#Andm
Background: B6J.Cg-Tg(TBK1)#Andm
Zygosity: hm
Has Mutant Allele: true
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Publication
22394562 | -
First Author: Tanaka Y
Year: 2012
Journal: Sci Signal
Title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Volume: 5
Issue: 214
Pages: ra20
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Publication
28716898 | -
First Author: Cooper JM
Year: 2017
Journal: Cancer Res
Title: TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
Volume: 77
Issue: 18
Pages: 5077-5094
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Publication
36342281 | -
First Author: Li L
Year: 2022
Journal: Microbiol Spectr
Title: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
Volume: 10
Issue: 6
Pages: e0202822
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Interaction Experiment
Sirohi K (2015)
Description: A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
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Strain
MGI:5557191 | B6NTac;B6N-A<tm1Brd> Tbkbp1<tm1a(EUCOMM)Wtsi>/H
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Azi2/Azi2 Tbkbp1/Tbkbp1
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tbkbp1/Tbkbp1<+>
Background: C57BL/6N-Tbkbp1/H
Zygosity: ht
Has Mutant Allele: true
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Publication
17018283 | -
First Author: Chien Y
Year: 2006
Journal: Cell
Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Volume: 127
Issue: 1
Pages: 157-70
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Publication
37395713 | -
First Author: Ye M
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model.
Volume: 64
Issue: 10
Pages: 1
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Protein Domain
IPR041309 | TBK1_CCD1
Type: Domain
Description: This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region. TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. Deletion of the coiled-coil 1 region in TBK1 lead to a severe impairment in TBK1 function even upon over-expression [].
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Allele
Sting1<em2Zjc> | MGI:7490022
 
Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Zhijian Chen
Allele Type: Endonuclease-mediated
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Publication
31320558 | J:283622
 
First Author: Wang L
Year: 2019
Journal: Science
Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Volume: 365
Issue: 6454
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Publication
26376340 | -
First Author: Sirohi K
Year: 2015
Journal: PLoS One
Title: A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
Volume: 10
Issue: 9
Pages: e0138289
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Publication
28148298 | -
First Author: Oakes JA
Year: 2017
Journal: Mol Brain
Title: TBK1: a new player in ALS linking autophagy and neuroinflammation.
Volume: 10
Issue: 1
Pages: 5
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Publication
22610919 | -
First Author: Li J
Year: 2012
Journal: Protein Cell
Title: Crystal structure of the ubiquitin-like domain of human TBK1.
Volume: 3
Issue: 5
Pages: 383-91
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Protein Domain
IPR041087 | TBK1_ULD
Type: Domain
Description: This is the ubiquitin-like domain (ULD) found in TANK-binding kinase 1 (TBK1). TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. It has been reported that the ULD of TBK1 regulates kinase activity, playing an important role in signaling and mediating interactions with other molecules in the IFN pathway. Deletion of ULD indicates that it is required for the kinase domain to form an enzymatically active conformation. TBK1 ULD has a ubiquitin-like structure and an Ile44 hydrophobic patch, which is conserved among ULDs and IKK and IKK-related proteins. This hydrophobic patch is involved in ULD-SDD interactions in TBK1 and other IKK and IKK-related proteins [].
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Protein
Q9CRA9
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Protein
Q9CPR7
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
F8WGG1
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
D3YTU7
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: false
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Protein
A0A0G2JF91
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Publication
10413050 | -
First Author: Abdeen HH
Year: 1999
Journal: Mol Biochem Parasitol
Title: Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen.
Volume: 101
Issue: 1-2
Pages: 149-59
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Publication
16281057 | -
First Author: Huang J
Year: 2005
Journal: EMBO J
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Volume: 24
Issue: 23
Pages: 4018-28
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Publication
14527947 | -
First Author: Sukotjo C
Year: 2003
Journal: J Biol Chem
Title: Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro.
Volume: 278
Issue: 51
Pages: 51527-34
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Publication
7925469 | -
First Author: Van Dam GJ
Year: 1994
Journal: Eur J Biochem
Title: The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit.
Volume: 225
Issue: 1
Pages: 467-82
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Protein Domain
IPR008555 | SIKE
Type: Family
Description: Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1 []. IKKepsilon and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3).Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke) [, ], and FGFR1 oncogene partner 2, which may be involved in wound healing pathway [].
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