Type |
Details |
Score |
Publication |
First Author: |
Miller AT |
Year: |
2004 |
Journal: |
Immunity |
Title: |
Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. |
Volume: |
21 |
Issue: |
1 |
Pages: |
67-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lepletier A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. |
Volume: |
27 |
Issue: |
13 |
Pages: |
3887-3901.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldfarb Y |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
HDAC3 Is a Master Regulator of mTEC Development. |
Volume: |
15 |
Issue: |
3 |
Pages: |
651-665 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho HS |
Year: |
2020 |
Journal: |
Immunohorizons |
Title: |
CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. |
Volume: |
4 |
Issue: |
2 |
Pages: |
57-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klug DB |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. |
Volume: |
169 |
Issue: |
6 |
Pages: |
2842-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Román E |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. |
Volume: |
185 |
Issue: |
7 |
Pages: |
3819-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh R |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e1005776 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds LF |
Year: |
2002 |
Journal: |
J Exp Med |
Title: |
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. |
Volume: |
195 |
Issue: |
9 |
Pages: |
1103-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2014 |
Journal: |
Sci Signal |
Title: |
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. |
Volume: |
7 |
Issue: |
337 |
Pages: |
ra74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2020 |
Journal: |
Development |
Title: |
NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development. |
Volume: |
147 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Grammer C |
Year: |
2024 |
Journal: |
iScience |
Title: |
Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. |
Volume: |
27 |
Issue: |
7 |
Pages: |
110258 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Z |
Year: |
2017 |
Journal: |
Cancer Cell |
Title: |
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
110-126 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yue S |
Year: |
2019 |
Journal: |
Aging Cell |
Title: |
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. |
Volume: |
18 |
Issue: |
4 |
Pages: |
e12952 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheridan JM |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells. |
Volume: |
21 |
Issue: |
4 |
Pages: |
934-942 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirayama T |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Meis1 is required for the maintenance of postnatal thymic epithelial cells. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e89885 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller AT |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. |
Volume: |
168 |
Issue: |
5 |
Pages: |
2163-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li CR |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Itk is not essential for CD28 signaling in naive T cells. |
Volume: |
174 |
Issue: |
8 |
Pages: |
4475-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horai R |
Year: |
2007 |
Journal: |
Immunity |
Title: |
Requirements for selection of conventional and innate T lymphocyte lineages. |
Volume: |
27 |
Issue: |
5 |
Pages: |
775-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lucas B |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Embryonic keratin19(+) progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla. |
Volume: |
14 |
Issue: |
1 |
Pages: |
2066 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schuster C |
Year: |
2015 |
Journal: |
Immunity |
Title: |
The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. |
Volume: |
42 |
Issue: |
5 |
Pages: |
942-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas K |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. |
Volume: |
7 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Jeker LT |
Year: |
2008 |
Journal: |
Blood |
Title: |
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells. |
Volume: |
112 |
Issue: |
9 |
Pages: |
3688-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayer CE |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla. |
Volume: |
46 |
Issue: |
4 |
Pages: |
846-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohigashi I |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. |
Volume: |
13 |
Issue: |
7 |
Pages: |
1432-1443 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchell-Jordan SA |
Year: |
2008 |
Journal: |
Circ Res |
Title: |
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. |
Volume: |
103 |
Issue: |
12 |
Pages: |
1359-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heinlein M |
Year: |
2022 |
Journal: |
Sci Immunol |
Title: |
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. |
Volume: |
7 |
Issue: |
67 |
Pages: |
eabb6032 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klug DB |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Transgenic expression of cyclin D1 in thymic epithelial precursors promotes epithelial and T cell development. |
Volume: |
164 |
Issue: |
4 |
Pages: |
1881-8 |
|
•
•
•
•
•
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Publication |
First Author: |
Colgan J |
Year: |
2004 |
Journal: |
Immunity |
Title: |
Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. |
Volume: |
21 |
Issue: |
2 |
Pages: |
189-201 |
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•
•
•
•
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Publication |
First Author: |
Bhang DH |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Testicular endothelial cells are a critical population in the germline stem cell niche. |
Volume: |
9 |
Issue: |
1 |
Pages: |
4379 |
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•
•
•
•
|
Publication |
First Author: |
Liang Z |
Year: |
2022 |
Journal: |
iScience |
Title: |
The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. |
Volume: |
25 |
Issue: |
10 |
Pages: |
105233 |
|
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•
•
•
•
|
Publication |
First Author: |
O'Neill KE |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0151666 |
|
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•
•
•
•
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Publication |
First Author: |
Shen H |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice. |
Volume: |
116 |
Issue: |
38 |
Pages: |
19090-19097 |
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•
•
•
•
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Publication |
First Author: |
Tao H |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development. |
Volume: |
12 |
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Pages: |
623280 |
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Publication |
First Author: |
Cowan JE |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5498 |
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•
•
•
•
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Publication |
First Author: |
Malin J |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development. |
Volume: |
9 |
Issue: |
46 |
Pages: |
eadg8126 |
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•
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•
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Publication |
First Author: |
Pazirandeh A |
Year: |
1999 |
Journal: |
FASEB J |
Title: |
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. |
Volume: |
13 |
Issue: |
8 |
Pages: |
893-901 |
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•
•
•
•
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Publication |
First Author: |
Min L |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1. |
Volume: |
106 |
Issue: |
50 |
Pages: |
21143-8 |
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•
•
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Publication |
First Author: |
Paavonen K |
Year: |
2004 |
Journal: |
Mol Biol Cell |
Title: |
Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. |
Volume: |
15 |
Issue: |
9 |
Pages: |
4226-33 |
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•
•
•
•
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Publication |
First Author: |
Williams KM |
Year: |
2008 |
Journal: |
Blood |
Title: |
CCL25 increases thymopoiesis after androgen withdrawal. |
Volume: |
112 |
Issue: |
8 |
Pages: |
3255-63 |
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•
•
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Publication |
First Author: |
Ulyanchenko S |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus. |
Volume: |
14 |
Issue: |
12 |
Pages: |
2819-32 |
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Publication |
First Author: |
Song Y |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice. |
Volume: |
46 |
Issue: |
6 |
Pages: |
1518-28 |
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•
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Publication |
First Author: |
St-Pierre C |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
Transcriptome sequencing of neonatal thymic epithelial cells. |
Volume: |
3 |
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Pages: |
1860 |
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Publication |
First Author: |
Zhong X |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
OVOL2 sustains postnatal thymic epithelial cell identity. |
Volume: |
14 |
Issue: |
1 |
Pages: |
7786 |
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Publication |
First Author: |
Onder L |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullary junction. |
Volume: |
45 |
Issue: |
8 |
Pages: |
2218-31 |
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Publication |
First Author: |
Haftmann C |
Year: |
2021 |
Journal: |
Sci Immunol |
Title: |
Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T(reg) development. |
Volume: |
6 |
Issue: |
65 |
Pages: |
eabf3111 |
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Publication |
First Author: |
Klein F |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells. |
Volume: |
14 |
Issue: |
1 |
Pages: |
4071 |
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Publication |
First Author: |
Verhoeven J |
Year: |
2023 |
Journal: |
EMBO Mol Med |
Title: |
Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma. |
Volume: |
15 |
Issue: |
12 |
Pages: |
e18028 |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
290
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
 |
Fragment?: |
false |
|
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•
•
•
•
|
Publication |
First Author: |
Rajantie I |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. |
Volume: |
21 |
Issue: |
14 |
Pages: |
4647-55 |
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•
•
•
•
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Publication |
First Author: |
Hasan M |
Year: |
2008 |
Journal: |
Immunology |
Title: |
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. |
Volume: |
123 |
Issue: |
2 |
Pages: |
239-49 |
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•
•
•
•
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Publication |
First Author: |
Nowell CS |
Year: |
2011 |
Journal: |
PLoS Genet |
Title: |
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. |
Volume: |
7 |
Issue: |
11 |
Pages: |
e1002348 |
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•
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Publication |
First Author: |
Min L |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Disrupting the intermolecular self-association of Itk enhances T cell signaling. |
Volume: |
184 |
Issue: |
8 |
Pages: |
4228-35 |
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Publication |
First Author: |
Qi Q |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell. |
Volume: |
286 |
Issue: |
1 |
Pages: |
138-46 |
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Publication |
First Author: |
Maltais A |
Year: |
2000 |
Journal: |
DNA Cell Biol |
Title: |
Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC. |
Volume: |
19 |
Issue: |
2 |
Pages: |
121-30 |
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Publication |
First Author: |
Hu Q |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. |
Volume: |
270 |
Issue: |
4 |
Pages: |
1928-34 |
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Publication |
First Author: |
Sahu N |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. |
Volume: |
181 |
Issue: |
9 |
Pages: |
6125-31 |
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Publication |
First Author: |
Li J |
Year: |
2023 |
Journal: |
Development |
Title: |
Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution. |
Volume: |
150 |
Issue: |
8 |
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Publication |
First Author: |
Ghezzo MN |
Year: |
2018 |
Journal: |
Carcinogenesis |
Title: |
FoxN1-dependent thymic epithelial cells promote T-cell leukemia development. |
Volume: |
39 |
Issue: |
12 |
Pages: |
1463-1476 |
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First Author: |
Akiyama N |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. |
Volume: |
213 |
Issue: |
8 |
Pages: |
1441-58 |
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Publication |
First Author: |
Chen L |
Year: |
2009 |
Journal: |
Blood |
Title: |
Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner. |
Volume: |
113 |
Issue: |
3 |
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567-74 |
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First Author: |
Xing Y |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho. |
Volume: |
201 |
Issue: |
11 |
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3320-3328 |
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First Author: |
Bosticardo M |
Year: |
2019 |
Journal: |
Am J Hum Genet |
Title: |
Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis. |
Volume: |
105 |
Issue: |
3 |
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549-561 |
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Publication |
First Author: |
Mangla A |
Year: |
2004 |
Journal: |
Blood |
Title: |
Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. |
Volume: |
104 |
Issue: |
4 |
Pages: |
1191-7 |
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Publication |
First Author: |
Lindsley RC |
Year: |
2007 |
Journal: |
Blood |
Title: |
Generation of peripheral B cells occurs via two spatially and temporally distinct pathways. |
Volume: |
109 |
Issue: |
6 |
Pages: |
2521-8 |
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Publication |
First Author: |
Holopainen T |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. |
Volume: |
72 |
Issue: |
14 |
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3512-21 |
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Publication |
First Author: |
Jang MH |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. |
Volume: |
177 |
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6 |
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First Author: |
Lenda DM |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. |
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170 |
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First Author: |
Wada Y |
Year: |
2019 |
Journal: |
J Am Soc Nephrol |
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IL-34-Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice. |
Volume: |
30 |
Issue: |
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