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Search results 401 to 500 out of 631 for Tert

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Type Details Score
Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15731767 | J:96945
First Author: Cayuela ML
Year: 2005
Journal: EMBO Rep
Title: The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.
Volume: 6
Issue: 3
Pages: 268-74
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HT Experiment
GSE239686 | Genomic analysis of mice with endothelium-specific TERT knockout (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tert<tm1.1Phan> | MGI:5829569
Name: telomerase reverse transcriptase; targeted mutation 1.1, Sem Phan
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
25589350 | J:219806
First Author: Pandita RK
Year: 2015
Journal: Cancer Res
Title: Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.
Volume: 75
Issue: 5
Pages: 858-69
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Publication
28447668 | J:250569
 
First Author: Fang J
Year: 2017
Journal: Nat Commun
Title: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.
Volume: 8
Pages: 15034
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Publication
20493811 | J:160600
First Author: Tejera AM
Year: 2010
Journal: Dev Cell
Title: TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.
Volume: 18
Issue: 5
Pages: 775-89
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Publication
17141279 | J:155923
First Author: Ghosh U
Year: 2007
Journal: Mutat Res
Title: Inhibition of telomerase activity by reduction of poly(ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa cells with knocked down poly(ADP-ribose) polymerase-1 (PARP-1) gene.
Volume: 615
Issue: 1-2
Pages: 66-74
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Publication
15735002 | J:96788
First Author: Ritz JM
Year: 2005
Journal: Cancer Res
Title: A novel transgenic mouse model reveals humanlike regulation of an 8-kbp human TERT gene promoter fragment in normal and tumor tissues.
Volume: 65
Issue: 4
Pages: 1187-96
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Interaction Experiment
Vorovich E (2009)
Description: Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha.
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Publication
20357774 | -
First Author: Mitchell M
Year: 2010
Journal: Nat Struct Mol Biol
Title: Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA.
Volume: 17
Issue: 4
Pages: 513-8
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DO Term
DOID:0070016 | autosomal dominant dyskeratosis congenita 2
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DO Term
DOID:0070021 | autosomal recessive dyskeratosis congenita 4
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Allele
Tg(TERT)C10Hode | MGI:3700152
Name: transgene insertion C10, Richard J Hodes
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
30447097 | -
First Author: Amisaki M
Year: 2019
Journal: Cancer Sci
Title: Identification of genes involved in the regulation of TERT in hepatocellular carcinoma.
Volume: 110
Issue: 2
Pages: 550-560
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Publication
20157588 | -
First Author: Vorovich E
Year: 2008
Journal: Aging (Albany NY)
Title: Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha.
Volume: 1
Issue: 1
Pages: 58-67
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HT Experiment
GSE157815 | Transcription landscape of adipose tissue changes in response to telomerase knockout in mesenchymal progenitors
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:3700649 | C57BL/6-Tg(TERT)C10Hode/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(TERT)C10Hode/?
Background: involves: C57BL/6 * SPRET/Ei
Zygosity: ot
Has Mutant Allele: true
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Allele
Tert<em1(cre/ERT2)Smoc> | MGI:6758061
Name: telomerase reverse transcriptase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:6355245 | C57BL/6JSmoc-Tert<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(KRT5-Tert)8043Blas | MGI:2429416
Name: transgene insertion 8043, Maria A Blasco
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(KRT5-Tert)7664Blas | MGI:3719158
Name: transgene insertion 7664, Maria A Blasco
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
21135040 | J:182426
First Author: Jia W
Year: 2011
Journal: FASEB J
Title: A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.
Volume: 25
Issue: 3
Pages: 979-89
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Publication
27297181 | J:334523
First Author: Hidema S
Year: 2016
Journal: Biosci Biotechnol Biochem
Title: Transgenic expression of Telomerase reverse transcriptase (Tert) improves cell proliferation of primary cells and enhances reprogramming efficiency into the induced pluripotent stem cell.
Volume: 80
Issue: 10
Pages: 1925-33
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Publication
15511642 | J:95047
First Author: Armstrong L
Year: 2004
Journal: Mech Dev
Title: A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.
Volume: 121
Issue: 12
Pages: 1509-22
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Protein
Q3TMN3
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein Domain
IPR026314 | YLP_motif_con_p1
Type: Family
Description: YLP motif-containing protein 1 plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation [].
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Publication
23022483 | J:196224
First Author: Vera E
Year: 2012
Journal: Cell Rep
Title: The rate of increase of short telomeres predicts longevity in mammals.
Volume: 2
Issue: 4
Pages: 732-7
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Allele
Tg(Tert-cre/ERT2)1Brlt | MGI:4941319
Name: transgene insertion 1, David T Breault
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Tg(TERT-rluc)DJzhu | MGI:5318989
Name: transgene insertion D, Jiyue Zhu
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(CAG-Tert)#Knis | MGI:7460340
Name: transgene insertion, Katsuhiko Nishimori
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(KRT5-Tert)8043Blas/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(Slc6a3-icre/ERT2)2Gloss | MGI:5049906
Name: transgene insertion 2, Bernd Gloss
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:5318990 | FVB-Tg(TERT-rluc)DJzhu/J
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tert<em1(cre/ERT2)Hzhu> | MGI:6704917
Name: telomerase reverse transcriptase; endonuclease-mediated mutation 1, Hao Zhu
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Tert<tm4(cre/ERT2)Sear> | MGI:6704920
Name: telomerase reverse transcriptase; targeted mutation 4, Steven E Artandi
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Terc/Terc Tg(KRT5-Tert)8043Blas/?
Background: involves: 129/Sv * C57BL/6 * C57BL/6J * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
11387197 | J:69757
First Author: González-Suárez E
Year: 2001
Journal: EMBO J
Title: Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.
Volume: 20
Issue: 11
Pages: 2619-30
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Publication
15688016 | J:97040
First Author: González-Suárez E
Year: 2005
Journal: Oncogene
Title: Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.
Volume: 24
Issue: 13
Pages: 2256-70
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Protein
Q9JLM1
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
A0A1Y7VP11
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Publication
10866187 | -
First Author: Wang J
Year: 2000
Journal: Nature
Title: Risky immortalization by telomerase.
Volume: 405
Issue: 6788
Pages: 755-6
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Publication
10860859 | J:63077
First Author: Liu JP
Year: 2000
Journal: Mol Cell Biol Res Commun
Title: Telomerase: not just black and white, but shades of gray.
Volume: 3
Issue: 3
Pages: 129-35
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Publication
9110970 | -
First Author: Lingner J
Year: 1997
Journal: Science
Title: Reverse transcriptase motifs in the catalytic subunit of telomerase.
Volume: 276
Issue: 5312
Pages: 561-7
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Publication
18758444 | -
First Author: Gillis AJ
Year: 2008
Journal: Nature
Title: Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Volume: 455
Issue: 7213
Pages: 633-7
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Protein Domain
IPR041580 | TERT_thumb
Type: Domain
Description: The catalytic subunit of telomerase is structurally similar to retroviral reverse transcriptases, viral RNA polymerases and, to a lesser extent, the bacteriophage B-family DNA polymerases. Like its structural homologues, the core catalytic subunit of telomerase, TERT, contains the fingers, palm and thumb domains required for nucleic acid and nucleotide associations as well as catalysis. The four major TERT domains: the RNA binding domain (TRBD); the fingers domain, implicated in nucleotide binding and processivity; the palm domain, which contains the active site of the enzyme; and the thumb domain, implicated in DNA binding and processivity are organized into a ring configuration similar to that observed for the substrate-free enzyme. This is the thumb domain found in Tribolium castaneum telomerase catalytic subunit, TERT. Contacts between TERT and the DNA substrate are mostly mediated via backbone interactions with the thumb loop and helix. The thumb helix sits in the minor groove of the RNA-DNA heteroduplex, making extensive contacts with the phosphodiester backbone and the ribose groups of the RNA-DNA hybrid [, ].
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Protein Domain
IPR003545 | Telomerase_RT
Type: Family
Description: Telomerase is an enzyme that, in certain cells, maintains the physical endsof chromosomes (telomeres) during replication. In somatic cells, replicationof the lagging strand requires the continual presence of an RNA primerapproximately 200 nucleotides upstream, which is complementary to thetemplate strand. Since there is a region of DNA less than 200 base pairsfrom the end of the chromosome where this is not possible, the chromosome iscontinually shortened. However, there is a surplus of repetitive DNA at the ends, the telomeres, that protects against the erosion of gene-encoding DNA.Telomerase is a ribonucleoprotein (RNP) that synthesises the telomeric DNArepeats. The telomerase RNA subunit provides the template for synthesis ofthese repeats. There are 2 protein components of the RNP: the catalyticsubunit is known as telomerase reverse transcriptase (TERT). The reversetranscriptase domain is located in the C-terminal region of the TERTpolypeptide and single amino acid substitutions in this region lead totelomere shortening and senescence [].Telomerase is not normally expressed in somatic cells and it has beensuggested that exogenous TERT may extend the lifespan of, or evenimmortalise, the cell. However, recent studies have shown that telomeraseactivity can be induced by a number of oncogenes []. Conversely, theoncogene c-myc can be activated in human TERT immortalised cells [].
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Strain
MGI:5049911 | C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
Attribute String: mutant strain, transgenic, coisogenic
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Publication
- | J:173676
     
First Author: Gloss B
Year: 2011
Journal: MGI Direct Data Submission
Title: Generation of an inducible Slc6a3 cre transgene
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Publication
28038425 | J:274467
 
First Author: Rezende F
Year: 2017
Journal: Redox Biol
Title: Knock out of the NADPH oxidase Nox4 has no impact on life span in mice.
Volume: 11
Pages: 312-314
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Protein
Q3UZL9
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Protein
C9W8L2
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q9R266
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: true
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Protein
Q9R0I7
Organism: Mus musculus/domesticus
Length: 1386  
Fragment?: false
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Protein
D3YWX2
Organism: Mus musculus/domesticus
Length: 2139  
Fragment?: false
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Protein
E9Q803
Organism: Mus musculus/domesticus
Length: 1433  
Fragment?: false
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Protein
Q8C8U8
Organism: Mus musculus/domesticus
Length: 818  
Fragment?: false
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Protein
F6YTL8
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: true
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Publication
29804836 | J:263490
First Author: Chen L
Year: 2018
Journal: Cell
Title: An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.
Volume: 174
Issue: 1
Pages: 218-230.e13
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Publication
26299964 | J:277962
First Author: Xiong S
Year: 2015
Journal: Cell Rep
Title: PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases.
Volume: 12
Issue: 9
Pages: 1391-9
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Publication
29880812 | J:266102
First Author: Tang H
Year: 2018
Journal: Nat Commun
Title: HuR regulates telomerase activity through TERC methylation.
Volume: 9
Issue: 1
Pages: 2213
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Publication
28424246 | J:243973
First Author: Moffitt AB
Year: 2017
Journal: J Exp Med
Title: Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
Volume: 214
Issue: 5
Pages: 1371-1386
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Publication
25109806 | J:220111
First Author: Chen WD
Year: 2014
Journal: Biochem Biophys Res Commun
Title: The circadian rhythm controls telomeres and telomerase activity.
Volume: 451
Issue: 3
Pages: 408-14
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Publication
29186692 | J:255239
First Author: Suh HN
Year: 2017
Journal: Cell Rep
Title: Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration.
Volume: 21
Issue: 9
Pages: 2571-2584
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Protein Coding Gene
MGI:2445066 | Hmbox1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0019418 | -
Type: protein_coding_gene
Organism: Mus caroli
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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