| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng G |
| Year: |
1996 |
| Journal: |
Genes Dev |
| Title: |
TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. |
| Volume: |
10 |
| Issue: |
8 |
| Pages: |
963-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu CJ |
| Year: |
2005 |
| Journal: |
EMBO J |
| Title: |
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. |
| Volume: |
24 |
| Issue: |
10 |
| Pages: |
1886-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xia P |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. |
| Volume: |
277 |
| Issue: |
10 |
| Pages: |
7996-8003 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1323
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1289
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1276
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1331
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1305
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1297
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1360
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
227
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1352
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsu H |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. |
| Volume: |
272 |
| Issue: |
21 |
| Pages: |
13471-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bulfone-Paus S |
| Year: |
1999 |
| Journal: |
FASEB J |
| Title: |
Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
1575-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Masuda M |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
TNIK inhibition abrogates colorectal cancer stemness. |
| Volume: |
7 |
|
| Pages: |
12586 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tzeng HP |
| Year: |
2014 |
| Journal: |
J Am Heart Assoc |
| Title: |
Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury. |
| Volume: |
3 |
| Issue: |
1 |
| Pages: |
e000662 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu Z |
| Year: |
2021 |
| Journal: |
Mol Immunol |
| Title: |
HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis. |
| Volume: |
129 |
|
| Pages: |
78-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawabe H |
| Year: |
2010 |
| Journal: |
Neuron |
| Title: |
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. |
| Volume: |
65 |
| Issue: |
3 |
| Pages: |
358-72 |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; wild type |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Phung HT |
| Year: |
2020 |
| Journal: |
Immunohorizons |
| Title: |
TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells. |
| Volume: |
4 |
| Issue: |
3 |
| Pages: |
129-139 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jaeger-Ruckstuhl CA |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
TNIK signaling imprints CD8+ T cell memory formation early after priming. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
1632 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruspi G |
| Year: |
2014 |
| Journal: |
Cell Signal |
| Title: |
TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
683-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu P |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
3071-84 |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; mutation 1, Australian National University |
| Allele Type: |
Chemically induced (ENU) |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 1.1, Alain Burette |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 1, Tesshi Yamada |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; endonuclease-mediated mutation 1, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown KD |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of TRAF2 signaling by self-induced degradation. |
| Volume: |
277 |
| Issue: |
22 |
| Pages: |
19433-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mahmoudi T |
| Year: |
2009 |
| Journal: |
EMBO J |
| Title: |
The kinase TNIK is an essential activator of Wnt target genes. |
| Volume: |
28 |
| Issue: |
21 |
| Pages: |
3329-40 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation. |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 1e, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 3e, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 3a, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 1, Seth G N Grant |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, chemically induced mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 3d, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; targeted mutation 3c, Wellcome Trust Sanger Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; endonuclease-mediated mutation 13, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
TRAF2 and NCK interacting kinase; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnik/Tnik |
| Background: |
C57BL/6NCrlAnu-Tnik/Anu |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnik/Tnik |
| Background: |
involves: C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
508
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamaguchi T |
| Year: |
2009 |
| Journal: |
Cell Biol Int |
| Title: |
JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1. |
| Volume: |
33 |
| Issue: |
3 |
| Pages: |
364-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hadweh P |
| Year: |
2014 |
| Journal: |
Cell Signal |
| Title: |
The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation. |
| Volume: |
26 |
| Issue: |
12 |
| Pages: |
2730-7 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shkoda A |
| Year: |
2012 |
| Journal: |
PLoS Biol |
| Title: |
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. |
| Volume: |
10 |
| Issue: |
8 |
| Pages: |
e1001376 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aizawa S |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. |
| Volume: |
272 |
| Issue: |
4 |
| Pages: |
2042-5 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnik/Tnik |
| Background: |
involves: 129P2/OlaHsd * 129S5/SvEvBrd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tnik/Tnik |
| Background: |
C57BL/6N-Tnik/Wtsi |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|