Type |
Details |
Score |
Pathway |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Publication |
First Author: |
Luong le A |
Year: |
2013 |
Journal: |
Circ Res |
Title: |
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. |
Volume: |
112 |
Issue: |
12 |
Pages: |
1583-91 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The TRAF6 RING finger domain mediates physical interaction with Ubc13. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation. |
|
•
•
•
•
•
|
Publication |
First Author: |
Funakoshi-Tago M |
Year: |
2009 |
Journal: |
Cytokine |
Title: |
TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation. |
Volume: |
45 |
Issue: |
2 |
Pages: |
72-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue J |
Year: |
2005 |
Journal: |
Gene |
Title: |
Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA. |
Volume: |
358 |
|
Pages: |
53-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. |
Volume: |
290 |
Issue: |
21 |
Pages: |
13372-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeshita F |
Year: |
2005 |
Journal: |
Eur J Immunol |
Title: |
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. |
Volume: |
35 |
Issue: |
8 |
Pages: |
2477-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadweh P |
Year: |
2014 |
Journal: |
Cell Signal |
Title: |
The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation. |
Volume: |
26 |
Issue: |
12 |
Pages: |
2730-7 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
NLRX1 negatively regulates TLR-induced NF-B signaling by targeting TRAF6 and IKK. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
(+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Glycogen synthase kinase 3 ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wooff J |
Year: |
2004 |
Journal: |
FEBS Lett |
Title: |
The TRAF6 RING finger domain mediates physical interaction with Ubc13. |
Volume: |
566 |
Issue: |
1-3 |
Pages: |
229-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takaesu G |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. |
Volume: |
5 |
Issue: |
4 |
Pages: |
649-58 |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gentry JJ |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF. |
Volume: |
279 |
Issue: |
16 |
Pages: |
16646-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wooten MW |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. |
Volume: |
280 |
Issue: |
42 |
Pages: |
35625-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. |
Volume: |
105 |
Issue: |
32 |
Pages: |
11335-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ryu J |
Year: |
2005 |
Journal: |
Proteomics |
Title: |
Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function. |
Volume: |
5 |
Issue: |
16 |
Pages: |
4152-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiou WF |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
(+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89159 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu L |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity. |
Volume: |
8 |
Issue: |
1 |
Pages: |
814 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei H |
Year: |
2022 |
Journal: |
Sci China Life Sci |
Title: |
Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells. |
Volume: |
65 |
Issue: |
8 |
Pages: |
1624-1635 |
|
•
•
•
•
•
|
Allele |
Name: |
TNF receptor-associated factor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting TRAF6 and NF-B pathways and protects mice from lethal endotoxin shock. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures. |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Baud V |
Year: |
1999 |
Journal: |
Genes Dev |
Title: |
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1297-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masperone L |
Year: |
2022 |
Journal: |
Mol Neurobiol |
Title: |
The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures. |
Volume: |
59 |
Issue: |
3 |
Pages: |
1577-1588 |
|
•
•
•
•
•
|
Allele |
Name: |
TNF receptor-associated factor 6; targeted mutation 2, Yongwon Choi |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Maruyama K |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. |
Volume: |
287 |
Issue: |
34 |
Pages: |
29114-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chariot A |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. |
Volume: |
277 |
Issue: |
40 |
Pages: |
37029-36 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin Q |
Year: |
2009 |
Journal: |
Nat Struct Mol Biol |
Title: |
E2 interaction and dimerization in the crystal structure of TRAF6. |
Volume: |
16 |
Issue: |
6 |
Pages: |
658-66 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is the second of three zinc fingers of Homo sapiens TNF receptor associated factor 6 (TRAF6). TRAF6 mediates Lys63 (K63)-linked polyubiquitination for Necrosis Factor-kappaB activation. The first three residues and the last Cys of finger 1 form a classical type I β-turn []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TANK-binding kinase 1 (TBK1) and inducible IkappaB-kinase (IKK) are central regulators of type-I interferon induction. TANK (TRAF family member-associated NF-kappa-B activator) is aadaptor protein that connects IKK complexes with IKK epsilon and TBK1 kinases [, ]. It negatively regulates NF-kappaB activation by DNA damage via inhibiting ubiquitination of TRAF6 []. It is also a negative regulator of osteoclastogenesis and bone formation []. |
|
•
•
•
•
•
|
Allele |
Name: |
MALT1 paracaspase; endonuclease-mediated mutation 1, Daniel Krappmann |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Constitutively active |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Traf6/Traf6 Tg(Cd4-cre)1Cwi/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
184
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kulathu Y |
Year: |
2009 |
Journal: |
Nat Struct Mol Biol |
Title: |
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. |
Volume: |
16 |
Issue: |
12 |
Pages: |
1328-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tian Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. |
Volume: |
282 |
Issue: |
23 |
Pages: |
16776-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishitani T |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |
Volume: |
22 |
Issue: |
23 |
Pages: |
6277-88 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ]. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain.The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway []. TAB3 is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2 []. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction []. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD) [].This entry represents the CUE domain found in TAB2 and TAB3. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
37
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalverda AP |
Year: |
2009 |
Journal: |
J Mol Biol |
Title: |
Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3. |
Volume: |
385 |
Issue: |
3 |
Pages: |
843-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schröder M |
Year: |
2008 |
Journal: |
EMBO J |
Title: |
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. |
Volume: |
27 |
Issue: |
15 |
Pages: |
2147-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teferi WM |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation. |
Volume: |
12 |
Issue: |
3 |
Pages: |
e0173056 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benfield CTO |
Year: |
2013 |
Journal: |
J Gen Virol |
Title: |
Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection. |
Volume: |
94 |
Issue: |
Pt 7 |
Pages: |
1647-1657 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
1997 |
Journal: |
Genomics |
Title: |
Genomic organization of the human PP4 gene encoding a serine/threonine protein phosphatase (PP4) suggests a common ancestry with PP2A. |
Volume: |
44 |
Issue: |
3 |
Pages: |
336-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hastie CJ |
Year: |
2000 |
Journal: |
Biochem J |
Title: |
A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. |
Volume: |
347 Pt 3 |
|
Pages: |
845-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kloeker S |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. |
Volume: |
274 |
Issue: |
9 |
Pages: |
5339-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2000 |
Journal: |
J Cell Sci |
Title: |
The FHA domain mediates phosphoprotein interactions. |
Volume: |
113 Pt 23 |
|
Pages: |
4143-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ea CK |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. |
Volume: |
101 |
Issue: |
43 |
Pages: |
15318-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu JW |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. |
Volume: |
108 |
Issue: |
52 |
Pages: |
21004-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiesmann C |
Year: |
2012 |
Journal: |
J Mol Biol |
Title: |
Structural determinants of MALT1 protease activity. |
Volume: |
419 |
Issue: |
1-2 |
Pages: |
4-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schlauderer F |
Year: |
2013 |
Journal: |
Angew Chem Int Ed Engl |
Title: |
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase. |
Volume: |
52 |
Issue: |
39 |
Pages: |
10384-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is an immunoglobulin-like domain which can be found in the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase. Malt1 is a key component of the Carma1/Bcl10/MALT1 signalosome and is critical for NF-kB signaling in multiple contexts. The MALT1 C-terminal Ig domain is suggested to recruit key factors to promote NF-kB activation. It is also proposed to undergo Lys63-linked ubiquitylation via TRAF6 in potentially nine different lysines to recruit the IKK complex [, , ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation []. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TRAF-interacting protein with a forkhead-associated domain (TIFA), also called T2BP, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and c-Jun amino-terminal kinase (JNK) []. TIFA has been shown to induce the oligomerization and polyubiquitination of TRAF6, which in turn activates transforming growth factor-activated kinase (TAK1) and IkappaB kinase (IKK) []. TIFA contains a phosphothreonine and phosphoserine-binding FHA domain []and a consensus TRAF6-binding motif []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
PP4R1 is a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). The catalytic subunit of PP4 (PP4C) belongs to the PP2A family of serine/threonine protein phosphatases []. Although 65% identical to the catalytic subunit of PP2AC, PP4C does not associate with the regulatory subunit of PP2A. Instead, PP4C associates with two other regulatory subunits, PP4R1 []and PP4R2 [].PP4R1 targets TRAF2 and TRAF6 to mediate inhibition of NF-kB activation []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
716
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
693
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
F1 hybrid, mutant stock, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd28/Cd28 Tg(Cd4-cre)1Cwi/? Traf6/Traf6 |
Background: |
involves: 129S2/SvPas * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation. |
Volume: |
172 |
Issue: |
4 |
Pages: |
2559-68 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
203
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Aylwin S |
Year: |
1977 |
Journal: |
Br J Psychol |
Title: |
The structure of visual and kinaesthetic imagery: a free association study. |
Volume: |
68 |
Issue: |
3 |
Pages: |
353-60 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Microtubule-associated serine/threonine-protein kinase 2 (MAST2, also known as MAST205) belongs to the MAST family, which is characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain []. MAST2 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation [, ]. It localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses []. It also functions in spermatid maturation in mammals []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [, , , , , ]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract []. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain. |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
435
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
457
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1493
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
445
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiels H |
Year: |
2000 |
Journal: |
Am J Pathol |
Title: |
TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. |
Volume: |
157 |
Issue: |
2 |
Pages: |
679-88 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
true |
|
•
•
•
•
•
|