|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 461 out of 461 for Ttc3

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
D3Z330
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
•
•
•
•
•
Protein
A0A338P789
Organism: Mus musculus/domesticus
Length: 16  
Fragment?: true
•
•
•
•
•
Protein
A0A338P718
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
•
•
•
•
•
Protein
D3Z502
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
•
•
•
•
•
Protein
A0A338P6J6
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
•
•
•
•
•
Protein
G5E8U3
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
•
•
•
•
•
Protein
D3YZA6
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
•
•
•
•
•
Protein
D6REF1
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
•
•
•
•
•
Protein
E9QAH3
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
•
•
•
•
•
Protein
A0A338P6H3
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
•
•
•
•
•
Protein
F7DAQ7
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
•
•
•
•
•
Protein
F6ZS17
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
•
•
•
•
•
Publication
20059950 | -
First Author: Suizu F
Year: 2009
Journal: Dev Cell
Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
Volume: 17
Issue: 6
Pages: 800-10
•
•
•
•
•
Interaction Experiment
Suizu F (2009)
Description: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
•
•
•
•
•
Interaction Experiment
Berto G (2007)
Description: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
•
•
•
•
•
Publication
30696809 | -
First Author: Kim JH
Year: 2019
Journal: Cell Death Dis
Title: TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.
Volume: 10
Issue: 2
Pages: 92
•
•
•
•
•
Allele
Tg(CEPHY141G6)28Hgc | MGI:5293437
Name: transgene insertion 28, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(CEPHY141G6)4Hgc | MGI:5293441
Name: transgene insertion 4, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:5293438 | FVB-Tg(CEPHY141G6)28Hgc/Orl
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:5293443 | FVB-Tg(CEPHY141G6)4Hgc/Orl
Attribute String: transgenic, mutant strain, coisogenic
•
•
•
•
•
Allele
Tg(CEPHY152F7)12Hgc | MGI:5293446
Name: transgene insertion 12, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CEPHY141G6)28Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CEPHY141G6)4Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Strain
MGI:5320338 | FVB-Tg(CEPHY152F7)12Hgc
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:5293449 | FVB-Tg(CEPHY152F7)12Hgc/Orl
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Strain
MGI:5424162 | B6.FVB-Tg(CEPHY152F7)12Hgc/Orl
Attribute String: transgenic, mutant strain, congenic
•
•
•
•
•
Publication
19218269 | J:146836
First Author: Lepagnol-Bestel AM
Year: 2009
Journal: Hum Mol Genet
Title: DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.
Volume: 18
Issue: 8
Pages: 1405-14
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: FVB-Tg(CEPHY152F7)12Hgc
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Protein
F6XYB0
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
•
•
•
•
•
Publication
10816250 | -
First Author: Madaule P
Year: 2000
Journal: Microsc Res Tech
Title: Citron, a Rho target that affects contractility during cytokinesis.
Volume: 49
Issue: 2
Pages: 123-6
•
•
•
•
•
Publication
11932363 | -
First Author: Sarkisian MR
Year: 2002
Journal: J Neurosci
Title: Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.
Volume: 22
Issue: 8
Pages: RC217
•
•
•
•
•
Protein Domain
IPR043866 | TTC3/DZIP3_dom
Type: Domain
Description: This domain is found in E3 ubiquitin-protein ligase TTC3 and DZIP3, its function is unknown.TTC3 mediates ubiquitination and degradation of phosphorylated Akt, which seems to be its preferable target [].DZIP3 is able to bind RNA through a Lys-rich region, which enhances its ubiquitination activity. It is suggested that RNA-binding proteins or ribonucleoprotein particles (RNPs) might be physiological targets for this enzyme, which could be important during viral infections as the ubiquitin process also mediates virus budding, especially for those replicating through RNA intermediates [].
•
•
•
•
•
Protein Domain
IPR037708 | CRIK_dom
Type: Domain
Description: CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process []. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors []. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension [].CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs.
•
•
•
•
•
Publication
18231969 | J:289033
First Author: Sebrié C
Year: 2008
Journal: Anat Rec (Hoboken)
Title: Increased dosage of DYRK1A and brain volumetric alterations in a YAC model of partial trisomy 21.
Volume: 291
Issue: 3
Pages: 254-62
•
•
•
•
•
Publication
12538761 | -
First Author: Kreft SG
Year: 2003
Journal: J Cell Sci
Title: hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase.
Volume: 116
Issue: Pt 4
Pages: 605-16
•
•
•
•
•
Publication
7558023 | J:128897
First Author: Smith DJ
Year: 1995
Journal: Genomics
Title: Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.
Volume: 27
Issue: 3
Pages: 425-34
•
•
•
•
•
Publication
15520513 | J:129154
First Author: Chabert C
Year: 2004
Journal: Behav Genet
Title: Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down Syndrome Chromosomal Region-1 (DCR-1).
Volume: 34
Issue: 6
Pages: 559-69
•
•
•
•
•
Publication
16514474 | J:124732
First Author: Roubertoux PL
Year: 2006
Journal: Behav Genet
Title: Pre-weaning sensorial and motor development in mice transpolygenic for the critical region of trisomy 21.
Volume: 36
Issue: 3
Pages: 377-86
•
•
•
•
•
Publication
9140392 | J:128896
First Author: Smith DJ
Year: 1997
Journal: Nat Genet
Title: Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.
Volume: 16
Issue: 1
Pages: 28-36
•
•
•
•
•
Protein
D3YZ03
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: true
•
•
•
•
•
Protein
D3Z2K0
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: true
•
•
•
•
•
Publication
28204906 | J:346590
First Author: Roubertoux PL
Year: 2017
Journal: Behav Genet
Title: Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice.
Volume: 47
Issue: 3
Pages: 305-322
•
•
•
•
•
Protein
Q7TPV2
Organism: Mus musculus/domesticus
Length: 1204  
Fragment?: false
•
•
•
•
•
Protein
D6RFU5
Organism: Mus musculus/domesticus
Length: 1197  
Fragment?: true
•
•
•
•
•
Protein
D6RD03
Organism: Mus musculus/domesticus
Length: 1179  
Fragment?: true
•
•
•
•
•
Protein
D6RHT6
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: true
•
•
•
•
•
Protein
D6RDD2
Organism: Mus musculus/domesticus
Length: 1162  
Fragment?: true
•
•
•
•
•
Protein
A0A0R4J1T2
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: true
•
•
•
•
•
Protein
D3Z485
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: true
•
•
•
•
•
Protein
E9QNZ2
Organism: Mus musculus/domesticus
Length: 1204  
Fragment?: false
•
•
•
•
•
Protein
G5E8T2
Organism: Mus musculus/domesticus
Length: 1979  
Fragment?: false
•
•
•
•
•
Protein
A0A338P6W3
Organism: Mus musculus/domesticus
Length: 1624  
Fragment?: false
•
•
•
•
•
Protein
P49025
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
•
•
•
•
•
Protein
D3Z1U0
Organism: Mus musculus/domesticus
Length: 2028  
Fragment?: false
•
•
•
•
•
Protein
D3YU89
Organism: Mus musculus/domesticus
Length: 2070  
Fragment?: false
•
•
•
•
•
Protein
E9QL53
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
•
•
•
•
•
Protein
F6SBR5
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: false
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•
Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
•
•
•
•
•
Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom