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Search results 401 to 436 out of 436 for Txnip

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0.019s

Type

Details

Score

Allele

Txnip<em1Smoc> | MGI:7293049

Name:	thioredoxin interacting protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Publication

30980800 | J:277219

First Author:	Fertan E
Year:	2019
Journal:	Am J Pathol
Title:	Cognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in a Triple Transgenic Mouse Model of Alzheimer Disease.
Volume:	189
Issue:	7
Pages:	1435-1450

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Interaction Experiment

Wu N (2013)

Description:

AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

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Strain

MGI:6476569 | C57BL/6JSmoc-Txnip<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

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Publication

23453806 | -

First Author:	Wu N
Year:	2013
Journal:	Mol Cell
Title:	AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
Volume:	49
Issue:	6
Pages:	1167-75

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Protein Domain

IPR035880 | VAV2_SH2

Type:

Domain

Description:

This entry represents the SH2 domain of VAV2, which is a member of the VAV family. The SH2 domain of VAV2 has been shown to interact with PPxY motifs of TXNIP (thioredoxin-interacting protein) []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].

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Publication

25017793 | J:218491

First Author:	Gao P
Year:	2014
Journal:	Biochim Biophys Acta
Title:	Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Volume:	1843
Issue:	11
Pages:	2448-60

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Publication

32877674 | J:299203

First Author:	Muraleedharan R
Year:	2020
Journal:	Cell Rep
Title:	AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.
Volume:	32
Issue:	9
Pages:	108092

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Publication

29282201 | J:258313

First Author:	Richards P
Year:	2018
Journal:	Diabetes
Title:	MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.
Volume:	67
Issue:	3
Pages:	461-472

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Publication

28606928 | J:247199

First Author:	Chau GC
Year:	2017
Journal:	J Cell Biol
Title:	mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.
Volume:	216
Issue:	7
Pages:	2091-2105

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Publication

22596053 | J:208456

First Author:	Zhang Y
Year:	2012
Journal:	Diabetes
Title:	Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes.
Volume:	61
Issue:	8
Pages:	2114-25

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Publication

21270263 | J:169785

First Author:	Koenen TB
Year:	2011
Journal:	Diabetes
Title:	Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.
Volume:	60
Issue:	2
Pages:	517-24

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Publication

26154105 | J:325925

First Author:	Gao K
Year:	2015
Journal:	J Cell Mol Med
Title:	A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury.
Volume:	19
Issue:	10
Pages:	2469-80

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Publication

30765336 | J:273784

First Author:	Yuan J
Year:	2019
Journal:	Diabetes
Title:	Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein.
Volume:	68
Issue:	5
Pages:	1040-1053

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Publication

32723174 | J:296859

First Author:	Zhou W
Year:	2020
Journal:	Am J Physiol Endocrinol Metab
Title:	Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein.
Volume:	319
Issue:	3
Pages:	E568-E578

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Publication

29339473 | J:257760

First Author:	Nagaraj K
Year:	2018
Journal:	Proc Natl Acad Sci U S A
Title:	Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action.
Volume:	115
Issue:	5
Pages:	1045-1050

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Publication

33600943 | J:337362

First Author:	Collins JA
Year:	2021
Journal:	Free Radic Biol Med
Title:	Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Volume:	166

Pages:	90-103

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Publication

31813922 | J:301156

First Author:	Suzuki S
Year:	2020
Journal:	Endocr J
Title:	Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney.
Volume:	67
Issue:	3
Pages:	335-345

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Publication

30098377 | J:273237

First Author:	Wu M
Year:	2018
Journal:	Mol Cell Endocrinol
Title:	NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice.
Volume:	478

Pages:	115-125

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Publication

22338092 | J:196242

First Author:	Noordeen NA
Year:	2012
Journal:	Diabetes
Title:	Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.
Volume:	61
Issue:	3
Pages:	574-85

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Publication

25870263 | J:221033

First Author:	Shen L
Year:	2015
Journal:	Proc Natl Acad Sci U S A
Title:	Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.
Volume:	112
Issue:	17
Pages:	5425-30

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Publication

28963352 | J:252286

First Author:	Malone CF
Year:	2017
Journal:	Cancer Discov
Title:	mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.
Volume:	7
Issue:	12
Pages:	1450-1463

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Publication

21074540 | J:280992

First Author:	Adluri RS
Year:	2011
Journal:	J Mol Cell Cardiol
Title:	Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic mice.
Volume:	50
Issue:	1
Pages:	239-47

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Publication

30962862 | J:280179

First Author:	Ji L
Year:	2019
Journal:	Oxid Med Cell Longev
Title:	FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Volume:	2019

Pages:	3286928

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Publication

36436727 | J:344514

First Author:	Wu X
Year:	2023
Journal:	Free Radic Biol Med
Title:	Heme oxygenase-1 ameliorates endotoxin-induced acute lung injury by modulating macrophage polarization via inhibiting TXNIP/NLRP3 inflammasome activation.
Volume:	194

Pages:	12-22

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Publication

37141242 | J:345331

First Author:	Niitsu Y
Year:	2023
Journal:	PLoS One
Title:	Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip.
Volume:	18
Issue:	5
Pages:	e0284989

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Publication

29668323 | J:264254

First Author:	Addinsall AB
Year:	2018
Journal:	Am J Physiol Regul Integr Comp Physiol
Title:	Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles.
Volume:	315
Issue:	2
Pages:	R380-R396

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Publication

28192788 | J:244483

First Author:	Chan LN
Year:	2017
Journal:	Nature
Title:	Metabolic gatekeeper function of B-lymphoid transcription factors.
Volume:	542
Issue:	7642
Pages:	479-483

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Publication

36252682 | J:348347

First Author:	Yuan X
Year:	2022
Journal:	J Lipid Res
Title:	Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia.
Volume:	63
Issue:	12
Pages:	100298

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Publication

10713454 | -

First Author:	Trenkle T
Year:	2000
Journal:	Gene
Title:	Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Volume:	245
Issue:	1
Pages:	139-49

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Publication

10781813 | -

First Author:	Dekel I
Year:	2000
Journal:	FEBS Lett
Title:	Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.
Volume:	472
Issue:	1
Pages:	99-104

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Publication

23525006 | -

First Author:	Fernández-Espartero CH
Year:	2013
Journal:	J Cell Sci
Title:	GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
Volume:	126
Issue:	Pt 10
Pages:	2285-93

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Publication

16106078 | -

First Author:	Swat W
Year:	2005
Journal:	Immunol Res
Title:	The Vav family: at the crossroads of signaling pathways.
Volume:	32
Issue:	1-3
Pages:	259-65

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Publication

14607270 | -

First Author:	Hornstein I
Year:	2004
Journal:	Cell Signal
Title:	Vav proteins, masters of the world of cytoskeleton organization.
Volume:	16
Issue:	1
Pages:	1-11

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Protein

Q60992

Organism:	Mus musculus/domesticus
Length:	868
Fragment?:	false

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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