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Search results 401 to 432 out of 432 for Usp25

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0.017s

Type

Details

Score

Publication

30579117 | -

First Author:	Wen J
Year:	2019
Journal:	Mol Immunol
Title:	USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells.
Volume:	106

Pages:	53-62

•

Publication

30926243 | -

First Author:	Sauer F
Year:	2019
Journal:	Mol Cell
Title:	Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Volume:	74
Issue:	3
Pages:	421-435.e10

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Interaction Experiment

Li J (2023)

Description:

USP25 deficiency promotes T cell dysfunction and transplant acceptance via mitochondrial dynamics.

•

Interaction Experiment

Cai C (2023)

Description:

USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.

•

Publication

16501887 | -

First Author:	Bosch-Comas A
Year:	2006
Journal:	Cell Mol Life Sci
Title:	The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.
Volume:	63
Issue:	6
Pages:	723-34

•

Publication

38875478 | -

First Author:	Fan CX
Year:	2024
Journal:	Brain
Title:	Heterozygous variants in USP25 cause genetic generalized epilepsy.
Volume:	147
Issue:	10
Pages:	3442-3457

•

Publication

29518389 | -

First Author:	Qian G
Year:	2018
Journal:	Biochem Biophys Res Commun
Title:	Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Volume:	498
Issue:	3
Pages:	537-543

•

Allele

Usp25<em1Smoc> | MGI:7293095

Name:	ubiquitin specific peptidase 25; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Conditional ready, No functional change

•

Strain

MGI:8378029 | C57BL/6Smoc-Usp25<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Protein Domain

IPR064550 | USP25_C

Type:

Domain

Description:

This entry represents the C-terminal domain of ubiquitin-specific protease USP25 from chordata, a deubiquitinase (DUB), which shares high similarity with USP28 but varies in cellular function; USP25 is a regulator of the innate immune system and may play a role in tumorigenesis, while USP28 is known for its tumor-promoting role. USP25 regulates inflammatory TRAF signaling, and USP28 stabilizes c-MYC and other nuclear proteins. These two closely related DUBs contain an N-terminal domain harboring a Ub-associated domain (UBA) and two Ub-interacting motifs (UIMs), a central catalytic USP domain, and a C-terminal region of unknown function and variable size due to alternative splicing. In general, USP catalytic domains are around 350 amino acids in length; however, in USP25 and 28, the catalytic domains span around 550 amino acids due to a large, conserved insertion at a common insertion point called the USP25/28 catalytic domain inserted domain (UCID). This C-terminal region has been implicated in substrate binding for USP25 and harbors the splicing site for isoform-specific sequences. Structure studies show that the C-terminally extended USP25 is exclusively tetrameric [, , , , , , ].

•

Publication

29131570 | -

First Author:	Wrigley JD
Year:	2017
Journal:	ACS Chem Biol
Title:	Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily.
Volume:	12
Issue:	12
Pages:	3113-3125

•

Publication

30910399 | -

First Author:	Li F
Year:	2019
Journal:	Exp Cell Res
Title:	USP28 regulates deubiquitination of histone H2A and cell proliferation.
Volume:	379
Issue:	1
Pages:	11-18

•

Publication

30485491 | -

First Author:	Zhao LJ
Year:	2019
Journal:	J Cell Biochem
Title:	USP28 contributes to the proliferation and metastasis of gastric cancer.
Volume:	120
Issue:	5
Pages:	7657-7666

•

Publication

30881015 | -

First Author:	Li P
Year:	2019
Journal:	Onco Targets Ther
Title:	Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer.
Volume:	12

Pages:	1603-1611

•

Publication

29415985 | -

First Author:	Wang X
Year:	2018
Journal:	Cell Death Dis
Title:	Targeting deubiquitinase USP28 for cancer therapy.
Volume:	9
Issue:	2
Pages:	186

•

Publication

29880484 | J:264050

First Author:	Saei A
Year:	2018
Journal:	J Exp Med
Title:	Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies.
Volume:	215
Issue:	7
Pages:	1913-1928

•

Protein Domain

IPR059996 | USP28_C

Type:

Domain

Description:

This entry represents the C-terminal domain of ubiquitin-specific protease USP28, a deubiquitinase (DUB), which shares high similarity with USP25 but varies in cellular function [, ]. USP28 is known for its tumor-promoting role while USP25 is a regulator of the innate immune system and may play a role in tumorigenesis [, , , ]. USP28 stabilises c-MYC and other nuclear proteins, and USP25 regulates inflammatory TRAF signalling. These two closely related DUBs contain an N-terminal domain harbouring a Ub-associated domain (UBA) and two Ub-interacting motifs (UIMs), a central catalytic USP domain, and a C-terminal region of unknown function and variable size due to alternative splicing. In general, USP catalytic domains are around 350 amino acids in length; however, in USP25 and 28, the catalytic domains span around 550 amino acids due to a large, conserved insertion at a common insertion point called USP25/28 catalytic domain inserted domain (UCID) [, ].This C-terminal region has been implicated in substrate binding for USP28 and harbours the splicing site for isoform-specific sequences. Structure studies suggest that the C-terminal domain forms an independent entity.

•

Publication

30478318 | -

First Author:	Liu B
Year:	2018
Journal:	Nat Commun
Title:	A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25.
Volume:	9
Issue:	1
Pages:	4973

•

Publication

25755282 | J:385230

First Author:	Kim S
Year:	2015
Journal:	Mol Cell Biol
Title:	Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25.
Volume:	35
Issue:	10
Pages:	1754-62

•

Publication

16901786 | -

First Author:	Zhang D
Year:	2006
Journal:	Cell
Title:	A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Volume:	126
Issue:	3
Pages:	529-42

•

Publication

26268556 | -

First Author:	Wen Y
Year:	2015
Journal:	Biochem J
Title:	The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
Volume:	471
Issue:	2
Pages:	155-65

•

Publication

37683630 | -

First Author:	Teo QW
Year:	2023
Journal:	Dev Cell
Title:	Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.
Volume:	58
Issue:	22
Pages:	2495-2509.e6

•

Protein Domain

IPR054108 | USP25/28_UIM

Type:

Conserved_site

Description:

This entry represents the N-terminal ubiquitin-interacting motif (UIM) found in ubiquitin carboxyl-terminal hydrolase 25 and 28, which are ubiquitin-specific proteases (USP) []. This domain provides a structural basis for the recognition and recruitment of ubiquitin substrates, potentially conferring USP display of catalytic activity [].USP25 functions in various biological processes including inflammation, immune response [, ]. It modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 [, ]. USP25 regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program [].USP28 is involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN []. It is also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. It deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells [].

•

Protein

P57080

Organism:	Mus musculus/domesticus
Length:	1055
Fragment?:	false

•

Protein

A0A5F8MPP4

Organism:	Mus musculus/domesticus
Length:	1125
Fragment?:	false

•

Protein

A0A1L1SSQ8

Organism:	Mus musculus/domesticus
Length:	127
Fragment?:	true

•

Protein

Q8BMT7

Organism:	Mus musculus/domesticus
Length:	474
Fragment?:	false

•

Publication

24623306 | -

First Author:	Serra RW
Year:	2014
Journal:	Elife
Title:	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Volume:	3

Pages:	e02313

•

Protein

Q5I043

Organism:	Mus musculus/domesticus
Length:	1051
Fragment?:	false

•

Protein

Q9CSW6

Organism:	Mus musculus/domesticus
Length:	160
Fragment?:	true

•

Protein

Q3TLH2

Organism:	Mus musculus/domesticus
Length:	207
Fragment?:	true

•

Protein

Q8CBA4

Organism:	Mus musculus/domesticus
Length:	311
Fragment?:	true

•

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