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Search results 401 to 500 out of 508 for Vcp

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Vcf2<Gt(IST13136G8)Tigm> | MGI:5151967
 
Name: VCP nuclear cofactor family member 2; gene trap IST13136G8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf1<Gt(IST13352D8)Tigm> | MGI:5158834
 
Name: VCP nuclear cofactor family member 1; gene trap IST13352D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf1<Gt(IST13352E8)Tigm> | MGI:5158843
 
Name: VCP nuclear cofactor family member 1; gene trap IST13352E8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf1<Gt(IST13808A11)Tigm> | MGI:5189737
 
Name: VCP nuclear cofactor family member 1; gene trap IST13808A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf2<Gt(IST13865A3)Tigm> | MGI:5198054
 
Name: VCP nuclear cofactor family member 2; gene trap IST13865A3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf1<Gt(IST14095D2)Tigm> | MGI:5207986
 
Name: VCP nuclear cofactor family member 1; gene trap IST14095D2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf2<Gt(IST14173G6)Tigm> | MGI:5214255
 
Name: VCP nuclear cofactor family member 2; gene trap IST14173G6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf2<Gt(IST14246C4)Tigm> | MGI:5222549
 
Name: VCP nuclear cofactor family member 2; gene trap IST14246C4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf1<Gt(IST14564C6)Tigm> | MGI:5238530
 
Name: VCP nuclear cofactor family member 1; gene trap IST14564C6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vcf2<Gt(IST14514F4)Tigm> | MGI:5241689
 
Name: VCP nuclear cofactor family member 2; gene trap IST14514F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Genotype
Genotype
Symbol: Vcf1/Vcf1
Background: B6JTyr;B6N-Vcf1/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Publication
21949850 | -
First Author: Madsen L
Year: 2011
Journal: PLoS One
Title: The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.
Volume: 6
Issue: 9
Pages: e25061
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Protein Domain
IPR017247 | UBXN8
Type: Family
Description: UBX domain-containing protein 8 is involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane [].
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Strain
MGI:6361082 | FVB/N-Tg(Myh6/tetO-Vcp*K524A)1Jmol/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Thy1-VCP*A232E)BMaki/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5556441 | B6Brd;B6N-Tyr<c-Brd> Vcf1<tm2a(EUCOMM)Wtsi>/WtsiCnbc
Attribute String: mutant strain, targeted mutation, spontaneous mutation
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Publication
1860879 | -
First Author: Fröhlich KU
Year: 1991
Journal: J Cell Biol
Title: Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.
Volume: 114
Issue: 3
Pages: 443-53
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Publication
8890164 | J:169817
First Author: Cloutier JF
Year: 1996
Journal: EMBO J
Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Volume: 15
Issue: 18
Pages: 4909-18
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Publication
15273934 | -
First Author: Kyogoku C
Year: 2004
Journal: Am J Hum Genet
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Volume: 75
Issue: 3
Pages: 504-7
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Protein Domain
IPR016276 | PTPN22
Type: Family
Description: Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [].
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HT Experiment
E-GEOD-34896 | Muscle specific proteasome deficient mice
Series Id: GSE34896
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q9QZ49
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Protein
Q3TTF2
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Publication
28341812 | J:241358
First Author: Berger BS
Year: 2017
Journal: EMBO Rep
Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.
Volume: 18
Issue: 5
Pages: 712-725
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Protein Coding Gene
MGI:1914709 | Nvl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0014989 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:1922994 | Svip
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0029799 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0032308 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016861 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032287 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1922994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031977 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016724 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032134 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013024 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_PahariEiJ_G0028221 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015789 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein Coding Gene
MGP_SPRETEiJ_G0030902 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21983102 | J:177424
First Author: Dolan PJ
Year: 2011
Journal: FEBS Lett
Title: Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.
Volume: 585
Issue: 21
Pages: 3424-9
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Publication
29789581 | J:262921
First Author: Luisier R
Year: 2018
Journal: Nat Commun
Title: Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
Volume: 9
Issue: 1
Pages: 2010
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Publication
23524377 | J:202416
First Author: McGoldrick P
Year: 2013
Journal: Biochim Biophys Acta
Title: Rodent models of amyotrophic lateral sclerosis.
Volume: 1832
Issue: 9
Pages: 1421-36
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Publication
36624844 | J:332497
First Author: Tang X
Year: 2023
Journal: iScience
Title: EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly.
Volume: 26
Issue: 1
Pages: 105667
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Publication
27009270 | J:250229
First Author: Ahmed M
Year: 2016
Journal: Sci Transl Med
Title: Targeting protein homeostasis in sporadic inclusion body myositis.
Volume: 8
Issue: 331
Pages: 331ra41
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Publication
10855792 | J:113897
First Author: Zhang H
Year: 2000
Journal: DNA Cell Biol
Title: VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.
Volume: 19
Issue: 5
Pages: 253-63
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Publication
17953619 | J:127245
First Author: Kina S
Year: 2007
Journal: Eur J Neurosci
Title: Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.
Volume: 26
Issue: 8
Pages: 2269-78
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Publication
17166906 | -
First Author: Jing M
Year: 2007
Journal: J Virol
Title: Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.
Volume: 81
Issue: 5
Pages: 2231-9
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Protein Domain
IPR041783 | PTPN3/4_FERM_C
Type: Domain
Description: Tyrosine-protein phosphatase non-receptor type-4 (PTPN4, also known as PTPMEG) is a cytoplasmic protein-tyrosine phosphatase (PTP) thought to play a role in cerebellar function. PTPMEG-knockout mice have impaired memory formation and cerebellar long-term depression []. Tyrosine-protein phosphatase non-receptor type-3 (PTPN3/PTPH1) is a membrane-associated PTP implicated in regulating tyrosine phosphorylation of growth factor receptors, p97 VCP (valosin-containing protein, or Cdc48 in Saccharomyces cerevisiae), and HBV (Hepatitis B Virus) gene expression; it is mutated in a subset of colon cancers []. PTPN3 and PTPN4 contain an N-terminal FERM domain, a middle PDZ domain, and a C-terminal phosphatase domain. Tyrosine-protein phosphatase 1/PTP1 from nematodes is also included in this entry. The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. Like most other ERM members they have a phosphoinositide-binding site in their FERM domain. The FERM C domain is the third structural domain within the FERM domain. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [, ].
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Publication
32479602 | J:291035
First Author: Humphrey J
Year: 2020
Journal: Nucleic Acids Res
Title: FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
Volume: 48
Issue: 12
Pages: 6889-6905
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Publication
32611769 | J:299134
First Author: Zoabi M
Year: 2020
Journal: J Biol Chem
Title: Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.
Volume: 295
Issue: 33
Pages: 11822-11832
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Publication
33093614 | J:298967
First Author: Zhou N
Year: 2020
Journal: Sci Rep
Title: Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy.
Volume: 10
Issue: 1
Pages: 18098
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Publication
34831118 | J:352045
 
First Author: Sun X
Year: 2021
Journal: Cells
Title: Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model.
Volume: 10
Issue: 11
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Publication
27730320 | J:315426
First Author: Nalbandian A
Year: 2017
Journal: Inflammation
Title: Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.
Volume: 40
Issue: 1
Pages: 21-41
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Publication
32795937 | J:352043
 
First Author: Zhou N
Year: 2020
Journal: Redox Biol
Title: Genomic characterization reveals novel mechanisms underlying the valosin-containing protein-mediated cardiac protection against heart failure.
Volume: 36
Pages: 101662
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Protein Coding Gene
MGI:3042273 | Nsfl1c
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7743560 | J:25289
First Author: Miller CG
Year: 1995
Journal: Cell Immunol
Title: Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.
Volume: 162
Issue: 2
Pages: 326-32
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Protein
P29352
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Publication
16582480 | J:222683
First Author: Kitano K
Year: 2006
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304.
Volume: 62
Issue: Pt 4
Pages: 340-5
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Publication
19596566 | -
First Author: Tepass U
Year: 2009
Journal: Curr Opin Genet Dev
Title: FERM proteins in animal morphogenesis.
Volume: 19
Issue: 4
Pages: 357-67
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Protein
Q14BS5
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q8BQQ4
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
E9Q0S8
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Protein
A2ALK8
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q9WU22
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom