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Search results 401 to 436 out of 436 for Vps39

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0.019s

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Type Details Score
Publication
9545258 | -
First Author: Charng MJ
Year: 1998
Journal: J Biol Chem
Title: A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor.
Volume: 273
Issue: 16
Pages: 9365-8
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Publication
11278302 | -
First Author: Wurthner JU
Year: 2001
Journal: J Biol Chem
Title: Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.
Volume: 276
Issue: 22
Pages: 19495-502
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Protein Domain
IPR019453 | VPS39/TGF_beta_rcpt-assoc_2
Type: Domain
Description: This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [, ]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange []. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [, ]. The precise function of this domain has not been characterised In Vps39 this domain is involved in localisation and in mediating the interactions with Vps11 [].
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Protein Domain
IPR019452 | VPS39/TGF_beta_rcpt-assoc_1
Type: Domain
Description: This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [, ]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange []. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [, ]. The precise function of this domain has not been characterised.
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Protein
A0A087WQF3
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Publication
25266290 | J:222663
First Author: Perini ED
Year: 2014
Journal: Traffic
Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.
Volume: 15
Issue: 12
Pages: 1366-89
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Protein
A0A087WR01
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Protein
A0A087WQX7
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Publication
19748353 | -
First Author: Binda M
Year: 2009
Journal: Mol Cell
Title: The Vam6 GEF controls TORC1 by activating the EGO complex.
Volume: 35
Issue: 5
Pages: 563-73
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Publication
23167963 | -
First Author: Pols MS
Year: 2013
Journal: Traffic
Title: The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.
Volume: 14
Issue: 2
Pages: 219-32
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Publication
19748348 | -
First Author: Li L
Year: 2009
Journal: Mol Cell
Title: Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF.
Volume: 35
Issue: 5
Pages: 543-5
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Protein Domain
IPR032914 | Vam6/VPS39/TRAP1
Type: Family
Description: This entry includes fungal Vam6/Vps3 and animal Vps39/TRAP1. Vps39 is also known as Vam6 or TRAP1-Like-Protein (TLP) []. Vam6/Vps39 acts as a component of the HOPS complex that functions during the docking stage of vacuole fusion. It is required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes [, ]. In addition to its regulatory role in homotypic vacuolar fusion and vacuole protein sorting within the HOPS complex, Vam6 also controls the function of the central regulator of eukaryotic cell growth TORC1 by activating the Gtr1 subunit of the EGO complex [, ].TRAP1 plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway [].
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Publication
9111041 | -
First Author: Nakamura N
Year: 1997
Journal: J Biol Chem
Title: Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.
Volume: 272
Issue: 17
Pages: 11344-9
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Protein
Q3UR70
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Protein
Q8R5L3
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
Q6ZQ51
Organism: Mus musculus/domesticus
Length: 889  
Fragment?: true
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Protein
Q3USV9
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
Q3TC98
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q8BY36
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
Q3URK7
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
Q5KU38
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Publication
33157038 | J:302472
First Author: Ghosh S
Year: 2020
Journal: Cell
Title: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Volume: 183
Issue: 6
Pages: 1520-1535.e14
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Publication
16014971 | -
First Author: Tan YJ
Year: 2005
Journal: J Virol
Title: The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells.
Volume: 79
Issue: 15
Pages: 10083-7
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Publication
16474139 | -
First Author: Oostra M
Year: 2006
Journal: J Virol
Title: Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M.
Volume: 80
Issue: 5
Pages: 2326-36
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Publication
16894145 | -
First Author: Lu W
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release.
Volume: 103
Issue: 33
Pages: 12540-5
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Publication
15135062 | -
First Author: Yu CJ
Year: 2004
Journal: FEBS Lett
Title: Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus.
Volume: 565
Issue: 1-3
Pages: 111-6
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Publication
15781262 | -
First Author: Shen S
Year: 2005
Journal: Biochem Biophys Res Commun
Title: The severe acute respiratory syndrome coronavirus 3a is a novel structural protein.
Volume: 330
Issue: 1
Pages: 286-92
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Publication
20020050 | -
First Author: Minakshi R
Year: 2009
Journal: PLoS One
Title: The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor.
Volume: 4
Issue: 12
Pages: e8342
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Publication
31034780 | -
First Author: Siu KL
Year: 2019
Journal: FASEB J
Title: Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.
Volume: 33
Issue: 8
Pages: 8865-8877
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Publication
32156572 | -
 
First Author: Farag NS
Year: 2020
Journal: Int J Biochem Cell Biol
Title: Viroporins and inflammasomes: A key to understand virus-induced inflammation.
Volume: 122
Pages: 105738
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Publication
33422265 | -
First Author: Miao G
Year: 2021
Journal: Dev Cell
Title: ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Volume: 56
Issue: 4
Pages: 427-442.e5
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Publication
34158638 | -
First Author: Kern DM
Year: 2021
Journal: Nat Struct Mol Biol
Title: Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Volume: 28
Issue: 7
Pages: 573-582
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Protein Domain
IPR024407 | Protein_3a_bCoV
Type: Family
Description: Coronavirus encodes two viroporins, E protein and protein 3a, which act as ion-conductive pores in planar lipid bilayers and are required for maximal SARS-CoV replication and virulence []. In betacoronavirus, this protein plays a role in viral egress via lysosomal trafficking [, ]. Protein 3a from SARS-CoV-2 also blocks autolysosomes formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes. This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress [].This entry represents protein 3a encoded by Orf3/3a, also known as X1, which forms homotetrameric potassium, sodium or calcium sensitive ion channels (viroporin) and may modulate virus release. It has also been shown to up-regulate expression of fibrinogen subunits FGA, FGBand FGG in host lung epithelial cells [, , , ].3a protein is a pro-apoptosis-inducing protein. It localises to the endoplasmic reticulum (ER)-Golgi compartment. SARS-CoV causes apoptosis of infected cells through NLRP3 inflammasome activation, as ORF3a is a potent activator of the signals required for this activation, pro-IL-1beta gene transcription and protein maturation. This protein also promotes the ubiquitination of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) mediated by its interaction with TNF receptor-associated factor 3 (TRAF3). The expression of ORF3a induces NF-kappa B activation and up-regulates fibrinogen secretion with the consequent high cytokine production [, , , ]. Another apoptosis mechanism described for this protein is the activation of the PERK pathway of unfolded protein response (UPR), which causes phosphorylation of eIF2alpha and leads to reduced translation of cellular proteins as well as the activation of pro-apoptotic downstream effectors (i.e ATF4, CHOP) [].
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Protein
Q8BUJ2
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: true
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Protein
Q8C051
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Publication
11448994 | -
First Author: Caplan S
Year: 2001
Journal: J Cell Biol
Title: Human Vam6p promotes lysosome clustering and fusion in vivo.
Volume: 154
Issue: 1
Pages: 109-22
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