Type |
Details |
Score |
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13846E8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13801C9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13761C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13763H2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13811C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13770E7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13819D3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13888E2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13941G4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13892E10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13900C8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13950C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13855C11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13859A6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13916E6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13976C10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13976C2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13884G7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14111D8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14121D2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14078F10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST13991E4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14041D5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14044H6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14166D7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14170G9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14141C7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14149D11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14266G7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14272F8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14272H8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14332E11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14402B1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14343G1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14374H8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14345A8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14351A3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14386C1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14356G10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14495H4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14416A2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14479F7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14562B11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14532C7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14542D2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14511D3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14558B3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14599F12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14641A2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14640B9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14725H12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14748B5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14705A3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14739E3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14839E8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14864H4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14908E2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14917H7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14945F12, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14980G9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST14981E9, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST15037D4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST15010C11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST15012G7, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST15093H5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; gene trap IST15103B3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
VPS54 GARP complex subunit; endonuclease-mediated mutation 1, Baylor College of Medicine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps54/Vps54 |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps54/Vps54 |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps54/Vps54 |
Background: |
C57BL/6N-Vps54/BayMmucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps54/Vps54<+> |
Background: |
involves: C57BL/Fa * CD-1 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Vps54/Vps54<+> |
Background: |
C57BL/6N-Vps54/BayMmucd |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
612
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not involved in endocytic recycling []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Vps52 complexes with Vps53 and Vps54 to form the Golgi-associated retrograde protein (GARP) complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network, regulating membrane trafficking events [, , ]. It is also part of the EARP (Endosome-Associated Recycling Protein) complex, involved in endocytic recycling []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Vps53 complexes with Vps52 and Vps54 to form a multi-subunit complex called Golgi-Associated Retrograde Protein complex (GARP) involved in retrograde transport from early and late endosomes to late Golgi [, , ]. They are members of the CATCHR (complexes associated with tethering containing helical rods) which includes the exocyst, COG, GARP, and DSL1 complexes which have structural and functional similarities. This is the N-terminal coiled-coil domain []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Syndetin (VPS50) is a component of the endosome-associated recycling protein (EARP) complex. This complex and the Golgi-associated retrograde protein (GARP) complex share four of the five subunits, but EARP contains syndetin in place of the Vps54 subunit of GARP, with the effect that the EARP complex is directed to endosomes rather than the Golgi. EARP in required for membrane-fusion during endocytic recycling of receptors and is described as a tethering complex []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not involved in endocytic recycling [].Proteins containing this domain also includes VPS50 (also known as Syndetin), which is a component of the EARP complex that is involved in endocytic recycling. It is required to tether the EARP complex to recycling endosomes. Nevertheless, it is involved in retrograde transport from early and late endosomes to the TGN []. |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien CE |
Year: |
2023 |
Journal: |
J Cell Biol |
Title: |
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. |
Volume: |
222 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
964
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
163
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
343
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
334
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
123
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
204
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
547
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Conibear E |
Year: |
2000 |
Journal: |
Mol Biol Cell |
Title: |
Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. |
Volume: |
11 |
Issue: |
1 |
Pages: |
305-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berruti G |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
USP8, a regulator of endosomal sorting, is involved in mouse acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. |
Volume: |
82 |
Issue: |
5 |
Pages: |
930-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pérez-Victoria FJ |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. |
Volume: |
29 |
Issue: |
19 |
Pages: |
5251-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paiardi C |
Year: |
2014 |
Journal: |
Histochem Cell Biol |
Title: |
The ESCRT-deubiquitinating enzyme USP8 in the cervical spinal cord of wild-type and Vps54-recessive (wobbler) mutant mice. |
Volume: |
141 |
Issue: |
1 |
Pages: |
57-73 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
832
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
832
 |
Fragment?: |
false |
|
•
•
•
•
•
|